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Items: 12

1.

Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction.

Simonetta KR, Taygerly J, Boyle K, Basham SE, Padovani C, Lou Y, Cummins TJ, Yung SL, von Soly SK, Kayser F, Kuriyan J, Rape M, Cardozo M, Gallop MA, Bence NF, Barsanti PA, Saha A.

Nat Commun. 2019 Mar 29;10(1):1402. doi: 10.1038/s41467-019-09358-9.

2.

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment.

Hyer ML, Milhollen MA, Ciavarri J, Fleming P, Traore T, Sappal D, Huck J, Shi J, Gavin J, Brownell J, Yang Y, Stringer B, Griffin R, Bruzzese F, Soucy T, Duffy J, Rabino C, Riceberg J, Hoar K, Lublinsky A, Menon S, Sintchak M, Bump N, Pulukuri SM, Langston S, Tirrell S, Kuranda M, Veiby P, Newcomb J, Li P, Wu JT, Powe J, Dick LR, Greenspan P, Galvin K, Manfredi M, Claiborne C, Amidon BS, Bence NF.

Nat Med. 2018 Feb;24(2):186-193. doi: 10.1038/nm.4474. Epub 2018 Jan 15.

PMID:
29334375
3.

Mechanistic study of Uba5 enzyme and the Ufm1 conjugation pathway.

Gavin JM, Hoar K, Xu Q, Ma J, Lin Y, Chen J, Chen W, Bruzzese FJ, Harrison S, Mallender WD, Bump NJ, Sintchak MD, Bence NF, Li P, Dick LR, Gould AE, Chen JJ.

J Biol Chem. 2014 Aug 15;289(33):22648-58. doi: 10.1074/jbc.M114.573972. Epub 2014 Jun 25.

4.

Treatment-emergent mutations in NAEβ confer resistance to the NEDD8-activating enzyme inhibitor MLN4924.

Milhollen MA, Thomas MP, Narayanan U, Traore T, Riceberg J, Amidon BS, Bence NF, Bolen JB, Brownell J, Dick LR, Loke HK, McDonald AA, Ma J, Manfredi MG, Sells TB, Sintchak MD, Yang X, Xu Q, Koenig EM, Gavin JM, Smith PG.

Cancer Cell. 2012 Mar 20;21(3):388-401. doi: 10.1016/j.ccr.2012.02.009.

5.

Mechanistic studies of substrate-assisted inhibition of ubiquitin-activating enzyme by adenosine sulfamate analogues.

Chen JJ, Tsu CA, Gavin JM, Milhollen MA, Bruzzese FJ, Mallender WD, Sintchak MD, Bump NJ, Yang X, Ma J, Loke HK, Xu Q, Li P, Bence NF, Brownell JE, Dick LR.

J Biol Chem. 2011 Nov 25;286(47):40867-77. doi: 10.1074/jbc.M111.279984. Epub 2011 Oct 3.

6.

Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system.

Betarbet R, Canet-Aviles RM, Sherer TB, Mastroberardino PG, McLendon C, Kim JH, Lund S, Na HM, Taylor G, Bence NF, Kopito R, Seo BB, Yagi T, Yagi A, Klinefelter G, Cookson MR, Greenamyre JT.

Neurobiol Dis. 2006 May;22(2):404-20. Epub 2006 Jan 24.

PMID:
16439141
7.

Application and analysis of the GFPu family of ubiquitin-proteasome system reporters.

Bence NF, Bennett EJ, Kopito RR.

Methods Enzymol. 2005;399:481-90.

PMID:
16338377
8.

Formation of morphologically similar globular aggregates from diverse aggregation-prone proteins in mammalian cells.

Mukai H, Isagawa T, Goyama E, Tanaka S, Bence NF, Tamura A, Ono Y, Kopito RR.

Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10887-92. Epub 2005 Jul 22.

9.
10.

A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome system.

Illing ME, Rajan RS, Bence NF, Kopito RR.

J Biol Chem. 2002 Sep 13;277(37):34150-60. Epub 2002 Jun 28.

11.

Specificity in intracellular protein aggregation and inclusion body formation.

Rajan RS, Illing ME, Bence NF, Kopito RR.

Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13060-5. Epub 2001 Oct 30.

12.

Impairment of the ubiquitin-proteasome system by protein aggregation.

Bence NF, Sampat RM, Kopito RR.

Science. 2001 May 25;292(5521):1552-5.

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