Sort by
Items per page

Send to

Choose Destination

Search results

Items: 39


Selective activation of Gs signaling in adipocytes causes striking metabolic improvements in mice.

Wang L, Pydi SP, Cui Y, Zhu L, Meister J, Gavrilova O, Berdeaux R, Fortin JP, Bence KK, Vernochet C, Wess J.

Mol Metab. 2019 Sep;27:83-91. doi: 10.1016/j.molmet.2019.06.018. Epub 2019 Jun 20.


Metabolic Targets in Nonalcoholic Fatty Liver Disease.

Esler WP, Bence KK.

Cell Mol Gastroenterol Hepatol. 2019;8(2):247-267. doi: 10.1016/j.jcmgh.2019.04.007. Epub 2019 Apr 18. Review.


Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia.

Le Sommer S, Morrice N, Pesaresi M, Thompson D, Vickers MA, Murray GI, Mody N, Neel BG, Bence KK, Wilson HM, Delibegović M.

Cancer Res. 2018 Jan 1;78(1):75-87. doi: 10.1158/0008-5472.CAN-17-0946. Epub 2017 Nov 9.


Deletion of Ptpn1 induces myeloproliferative neoplasm.

Jobe F, Patel B, Kuzmanovic T, Makishima H, Yang Y, Przychodzen B, Hutchison RE, Bence KK, Maciejewski JP, Mohi G.

Leukemia. 2017 May;31(5):1229-1234. doi: 10.1038/leu.2017.31. Epub 2017 Jan 23. No abstract available.


Intracellular Signals Mediating the Food Intake-Suppressive Effects of Hindbrain Glucagon-like Peptide-1 Receptor Activation.

Hayes MR, Leichner TM, Zhao S, Lee GS, Chowansky A, Zimmer D, De Jonghe BC, Kanoski SE, Grill HJ, Bence KK.

Cell Metab. 2016 Apr 12;23(4):745. doi: 10.1016/j.cmet.2016.02.010. No abstract available.


Endogenous Leptin Signaling in the Caudal Nucleus Tractus Solitarius and Area Postrema Is Required for Energy Balance Regulation.

Hayes MR, Skibicka KP, Leichner TM, Guarnieri DJ, DiLeone RJ, Bence KK, Grill HJ.

Cell Metab. 2016 Apr 12;23(4):744. doi: 10.1016/j.cmet.2016.02.009. No abstract available.


Astrocytes Regulate GLP-1 Receptor-Mediated Effects on Energy Balance.

Reiner DJ, Mietlicki-Baase EG, McGrath LE, Zimmer DJ, Bence KK, Sousa GL, Konanur VR, Krawczyk J, Burk DH, Kanoski SE, Hermann GE, Rogers RC, Hayes MR.

J Neurosci. 2016 Mar 23;36(12):3531-40. doi: 10.1523/JNEUROSCI.3579-15.2016.


Ptp1b deletion in pro-opiomelanocortin neurons increases energy expenditure and impairs endothelial function via TNF-α dependent mechanisms.

Bruder-Nascimento T, Kennard S, Antonova G, Mintz JD, Bence KK, Belin de Chantemèle EJ.

Clin Sci (Lond). 2016 Jun 1;130(11):881-93. doi: 10.1042/CS20160073. Epub 2016 Mar 2.


Ablation of intact hypothalamic and/or hindbrain TrkB signaling leads to perturbations in energy balance.

Ozek C, Zimmer DJ, De Jonghe BC, Kalb RG, Bence KK.

Mol Metab. 2015 Aug 18;4(11):867-80. doi: 10.1016/j.molmet.2015.08.002. eCollection 2015 Nov.


Deletion of protein tyrosine phosphatase 1b in proopiomelanocortin neurons reduces neurogenic control of blood pressure and protects mice from leptin- and sympatho-mediated hypertension.

Bruder-Nascimento T, Butler BR, Herren DJ, Brands MW, Bence KK, Belin de Chantemèle EJ.

Pharmacol Res. 2015 Dec;102:235-44. doi: 10.1016/j.phrs.2015.10.012. Epub 2015 Oct 30.


Leptin and insulin act on POMC neurons to promote the browning of white fat.

Dodd GT, Decherf S, Loh K, Simonds SE, Wiede F, Balland E, Merry TL, Münzberg H, Zhang ZY, Kahn BB, Neel BG, Bence KK, Andrews ZB, Cowley MA, Tiganis T.

Cell. 2015 Jan 15;160(1-2):88-104. doi: 10.1016/j.cell.2014.12.022.


Protein-tyrosine phosphatase 1B (PTP1B) is a novel regulator of central brain-derived neurotrophic factor and tropomyosin receptor kinase B (TrkB) signaling.

Ozek C, Kanoski SE, Zhang ZY, Grill HJ, Bence KK.

J Biol Chem. 2014 Nov 14;289(46):31682-92. doi: 10.1074/jbc.M114.603621. Epub 2014 Oct 6.


Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis.

Lim MA, Bence KK, Sandesara I, Andreux P, Auwerx J, Ishibashi J, Seale P, Kalb RG.

Hum Mol Genet. 2014 Sep 15;23(18):4995-5008. doi: 10.1093/hmg/ddu214. Epub 2014 May 15.


Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor.

Tsou RC, Rak KS, Zimmer DJ, Bence KK.

Mol Metab. 2014 Jan 19;3(3):301-12. doi: 10.1016/j.molmet.2014.01.008. eCollection 2014 Jun.


Inducible liver-specific knockdown of protein tyrosine phosphatase 1B improves glucose and lipid homeostasis in adult mice.

Owen C, Lees EK, Grant L, Zimmer DJ, Mody N, Bence KK, Delibegović M.

Diabetologia. 2013 Oct;56(10):2286-96. doi: 10.1007/s00125-013-2992-z. Epub 2013 Jul 6.


Central regulation of metabolism by protein tyrosine phosphatases.

Tsou RC, Bence KK.

Front Neurosci. 2013 Jan 7;6:192. doi: 10.3389/fnins.2012.00192. eCollection 2012.


Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies.

Carbone CJ, Zheng H, Bhattacharya S, Lewis JR, Reiter AM, Henthorn P, Zhang ZY, Baker DP, Ukkiramapandian R, Bence KK, Fuchs SY.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19226-31. doi: 10.1073/pnas.1211491109. Epub 2012 Nov 5.


Protein tyrosine phosphatase PTP1B is involved in hippocampal synapse formation and learning.

Fuentes F, Zimmer D, Atienza M, Schottenfeld J, Penkala I, Bale T, Bence KK, Arregui CO.

PLoS One. 2012;7(7):e41536. doi: 10.1371/journal.pone.0041536. Epub 2012 Jul 23.


The Genetics of PTPN1 and Obesity: Insights from Mouse Models of Tissue-Specific PTP1B Deficiency.

Tsou RC, Bence KK.

J Obes. 2012;2012:926857. doi: 10.1155/2012/926857. Epub 2012 Jul 1.


Deficiency of PTP1B in leptin receptor-expressing neurons leads to decreased body weight and adiposity in mice.

Tsou RC, Zimmer DJ, De Jonghe BC, Bence KK.

Endocrinology. 2012 Sep;153(9):4227-37. doi: 10.1210/en.2012-1548. Epub 2012 Jul 16.


Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency.

De Jonghe BC, Hayes MR, Zimmer DJ, Kanoski SE, Grill HJ, Bence KK.

Am J Physiol Endocrinol Metab. 2012 Sep 1;303(5):E644-51. doi: 10.1152/ajpendo.00009.2012. Epub 2012 Jul 3.


Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals.

Kanoski SE, Zhao S, Guarnieri DJ, DiLeone RJ, Yan J, De Jonghe BC, Bence KK, Hayes MR, Grill HJ.

Am J Physiol Endocrinol Metab. 2012 Aug 15;303(4):E496-503. doi: 10.1152/ajpendo.00205.2012. Epub 2012 Jun 12.


Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis.

Owen C, Czopek A, Agouni A, Grant L, Judson R, Lees EK, Mcilroy GD, Göransson O, Welch A, Bence KK, Kahn BB, Neel BG, Mody N, Delibegović M.

PLoS One. 2012;7(2):e32700. doi: 10.1371/journal.pone.0032700. Epub 2012 Feb 28.


Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance.

Loh K, Fukushima A, Zhang X, Galic S, Briggs D, Enriori PJ, Simonds S, Wiede F, Reichenbach A, Hauser C, Sims NA, Bence KK, Zhang S, Zhang ZY, Kahn BB, Neel BG, Andrews ZB, Cowley MA, Tiganis T.

Cell Metab. 2011 Nov 2;14(5):684-99. doi: 10.1016/j.cmet.2011.09.011. Epub 2011 Oct 13. Erratum in: Cell Metab. 2012 Jun 6;15(6):925-6.


Epithelial protein-tyrosine phosphatase 1B contributes to the induction of mammary tumors by HER2/Neu but is not essential for tumor maintenance.

Balavenkatraman KK, Aceto N, Britschgi A, Mueller U, Bence KK, Neel BG, Bentires-Alj M.

Mol Cancer Res. 2011 Oct;9(10):1377-84. doi: 10.1158/1541-7786.MCR-11-0198. Epub 2011 Aug 17.


Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress.

Agouni A, Mody N, Owen C, Czopek A, Zimmer D, Bentires-Alj M, Bence KK, Delibegović M.

Biochem J. 2011 Sep 1;438(2):369-78. doi: 10.1042/BJ20110373.


Melanocortin control of energy balance: evidence from rodent models.

De Jonghe BC, Hayes MR, Bence KK.

Cell Mol Life Sci. 2011 Aug;68(15):2569-88. doi: 10.1007/s00018-011-0707-5. Epub 2011 May 8. Review.


Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure.

De Jonghe BC, Hayes MR, Banno R, Skibicka KP, Zimmer DJ, Bowen KA, Leichner TM, Alhadeff AL, Kanoski SE, Cyr NE, Nillni EA, Grill HJ, Bence KK.

Am J Physiol Endocrinol Metab. 2011 Jun;300(6):E1002-11. doi: 10.1152/ajpendo.00639.2010. Epub 2011 Mar 15.


Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation.

Hayes MR, Leichner TM, Zhao S, Lee GS, Chowansky A, Zimmer D, De Jonghe BC, Kanoski SE, Grill HJ, Bence KK.

Cell Metab. 2011 Mar 2;13(3):320-30. doi: 10.1016/j.cmet.2011.02.001. Erratum in: Cell Metab. 2016 Apr 12;23(4):745.


PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice.

Banno R, Zimmer D, De Jonghe BC, Atienza M, Rak K, Yang W, Bence KK.

J Clin Invest. 2010 Mar;120(3):720-34. doi: 10.1172/JCI39620. Epub 2010 Feb 15.


Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation.

Hayes MR, Skibicka KP, Leichner TM, Guarnieri DJ, DiLeone RJ, Bence KK, Grill HJ.

Cell Metab. 2010 Jan;11(1):77-83. doi: 10.1016/j.cmet.2009.10.009. Erratum in: Cell Metab. 2016 Apr 12;23(4):744.


Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues.

Xue B, Pulinilkunnil T, Murano I, Bence KK, He H, Minokoshi Y, Asakura K, Lee A, Haj F, Furukawa N, Catalano KJ, Delibegovic M, Balschi JA, Cinti S, Neel BG, Kahn BB.

Mol Cell Biol. 2009 Aug;29(16):4563-73. doi: 10.1128/MCB.01914-08. Epub 2009 Jun 15.


Dorsal hindbrain 5'-adenosine monophosphate-activated protein kinase as an intracellular mediator of energy balance.

Hayes MR, Skibicka KP, Bence KK, Grill HJ.

Endocrinology. 2009 May;150(5):2175-82. doi: 10.1210/en.2008-1319. Epub 2008 Dec 30.


Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress.

Delibegovic M, Zimmer D, Kauffman C, Rak K, Hong EG, Cho YR, Kim JK, Kahn BB, Neel BG, Bence KK.

Diabetes. 2009 Mar;58(3):590-9. doi: 10.2337/db08-0913. Epub 2008 Dec 15.


Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways.

Kontaridis MI, Yang W, Bence KK, Cullen D, Wang B, Bodyak N, Ke Q, Hinek A, Kang PM, Liao R, Neel BG.

Circulation. 2008 Mar 18;117(11):1423-35. doi: 10.1161/CIRCULATIONAHA.107.728865. Epub 2008 Mar 3. Erratum in: Circulation.2008 Apr 15;117(15) e314.


Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B.

Delibegovic M, Bence KK, Mody N, Hong EG, Ko HJ, Kim JK, Kahn BB, Neel BG.

Mol Cell Biol. 2007 Nov;27(21):7727-34. Epub 2007 Aug 27.


Neuronal PTP1B regulates body weight, adiposity and leptin action.

Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB.

Nat Med. 2006 Aug;12(8):917-24. Epub 2006 Jul 16. Erratum in: Nat Med. 2010 Feb;16(2):237.


Jellyfish green fluorescent protein: a tool for studying ion channels and second-messenger signaling in neurons.

Blair LA, Bence KK, Marshall J.

Methods Enzymol. 1999;302:213-25. No abstract available.


Supplemental Content

Loading ...
Support Center