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Items: 1 to 50 of 124

1.

Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.

Bonnard D, Le Rouzic E, Eiler S, Amadori C, Orlov I, Bruneau JM, Brias J, Barbion J, Chevreuil F, Spehner D, Chasset S, Ledoussal B, Moreau F, Saïb A, Klaholz BP, Emiliani S, Ruff M, Zamborlini A, Benarous R.

J Biol Chem. 2018 Apr 20;293(16):6172-6186. doi: 10.1074/jbc.M117.816793. Epub 2018 Mar 5.

2.

The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity.

Amadori C, van der Velden YU, Bonnard D, Orlov I, van Bel N, Le Rouzic E, Miralles L, Brias J, Chevreuil F, Spehner D, Chasset S, Ledoussal B, Mayr L, Moreau F, García F, Gatell J, Zamborlini A, Emiliani S, Ruff M, Klaholz BP, Moog C, Berkhout B, Plana M, Benarous R.

Retrovirology. 2017 Nov 9;14(1):50. doi: 10.1186/s12977-017-0373-2.

3.

The allosteric HIV-1 integrase inhibitor BI-D affects virion maturation but does not influence packaging of a functional RNA genome.

van Bel N, van der Velden Y, Bonnard D, Le Rouzic E, Das AT, Benarous R, Berkhout B.

PLoS One. 2014 Jul 29;9(7):e103552. doi: 10.1371/journal.pone.0103552. eCollection 2014.

4.

Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.

Le Rouzic E, Bonnard D, Chasset S, Bruneau JM, Chevreuil F, Le Strat F, Nguyen J, Beauvoir R, Amadori C, Brias J, Vomscheid S, Eiler S, Lévy N, Delelis O, Deprez E, Saïb A, Zamborlini A, Emiliani S, Ruff M, Ledoussal B, Moreau F, Benarous R.

Retrovirology. 2013 Nov 21;10:144. doi: 10.1186/1742-4690-10-144.

5.

Mutations affecting interaction of integrase with TNPO3 do not prevent HIV-1 cDNA nuclear import.

Cribier A, Ségéral E, Delelis O, Parissi V, Simon A, Ruff M, Benarous R, Emiliani S.

Retrovirology. 2011 Dec 16;8:104. doi: 10.1186/1742-4690-8-104.

6.

Methodology and early findings of the Diabetes Management Project: a cohort study investigating the barriers to optimal diabetes care in diabetic patients with and without diabetic retinopathy.

Lamoureux EL, Fenwick E, Xie J, Mcauley A, Nicolaou T, Larizza M, Rees G, Qureshi S, Wong TY, Benarous R, Dirani M.

Clin Exp Ophthalmol. 2012 Jan-Feb;40(1):73-82. doi: 10.1111/j.1442-9071.2011.02697.x. Epub 2011 Nov 4.

PMID:
21902788
7.

Differential association of serum lipids with diabetic retinopathy and diabetic macular edema.

Benarous R, Sasongko MB, Qureshi S, Fenwick E, Dirani M, Wong TY, Lamoureux EL.

Invest Ophthalmol Vis Sci. 2011 Sep 27;52(10):7464-9. doi: 10.1167/iovs.11-7598.

PMID:
21862642
8.

Are obesity and anthropometry risk factors for diabetic retinopathy? The diabetes management project.

Dirani M, Xie J, Fenwick E, Benarous R, Rees G, Wong TY, Lamoureux EL.

Invest Ophthalmol Vis Sci. 2011 Jun 22;52(7):4416-21. doi: 10.1167/iovs.11-7208.

PMID:
21482643
9.

Functional interaction between the ubiquitin-specific protease 25 and the SYK tyrosine kinase.

Cholay M, Reverdy C, Benarous R, Colland F, Daviet L.

Exp Cell Res. 2010 Feb 15;316(4):667-75. doi: 10.1016/j.yexcr.2009.10.023. Epub 2009 Nov 10.

PMID:
19909739
10.

Vpu antagonizes BST-2-mediated restriction of HIV-1 release via beta-TrCP and endo-lysosomal trafficking.

Mitchell RS, Katsura C, Skasko MA, Fitzpatrick K, Lau D, Ruiz A, Stephens EB, Margottin-Goguet F, Benarous R, Guatelli JC.

PLoS Pathog. 2009 May;5(5):e1000450. doi: 10.1371/journal.ppat.1000450. Epub 2009 May 29.

11.

Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ.

Bartholomeeusen K, Christ F, Hendrix J, Rain JC, Emiliani S, Benarous R, Debyser Z, Gijsbers R, De Rijck J.

J Biol Chem. 2009 Apr 24;284(17):11467-77. doi: 10.1074/jbc.M807781200. Epub 2009 Feb 25.

12.

Yeast two-hybrid detection of integrase-host factor interactions.

Rain JC, Cribier A, Gérard A, Emiliani S, Benarous R.

Methods. 2009 Apr;47(4):291-7. doi: 10.1016/j.ymeth.2009.02.002. Epub 2009 Feb 20.

PMID:
19232540
13.

Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor.

Michel F, Crucifix C, Granger F, Eiler S, Mouscadet JF, Korolev S, Agapkina J, Ziganshin R, Gottikh M, Nazabal A, Emiliani S, Benarous R, Moras D, Schultz P, Ruff M.

EMBO J. 2009 Apr 8;28(7):980-91. doi: 10.1038/emboj.2009.41. Epub 2009 Feb 19.

14.

Structure of the complex between phosphorylated substrates and the SCF beta-TrCP ubiquitin ligase receptor: a combined NMR, molecular modeling, and docking approach.

Evrard-Todeschi N, Pons J, Gharbi-Benarous J, Bertho G, Benarous R, Girault JP.

J Chem Inf Model. 2008 Dec;48(12):2350-61. doi: 10.1021/ci800248u.

PMID:
19053519
15.

AKAP149 binds to HIV-1 reverse transcriptase and is involved in the reverse transcription.

Lemay J, Maidou-Peindara P, Cancio R, Ennifar E, Coadou G, Maga G, Rain JC, Benarous R, Liu LX.

J Mol Biol. 2008 Nov 21;383(4):783-96. doi: 10.1016/j.jmb.2008.08.055. Epub 2008 Aug 29.

PMID:
18786546
16.

Transportin-SR2 imports HIV into the nucleus.

Christ F, Thys W, De Rijck J, Gijsbers R, Albanese A, Arosio D, Emiliani S, Rain JC, Benarous R, Cereseto A, Debyser Z.

Curr Biol. 2008 Aug 26;18(16):1192-202. doi: 10.1016/j.cub.2008.07.079.

17.

HuR interacts with human immunodeficiency virus type 1 reverse transcriptase, and modulates reverse transcription in infected cells.

Lemay J, Maidou-Peindara P, Bader T, Ennifar E, Rain JC, Benarous R, Liu LX.

Retrovirology. 2008 Jun 10;5:47. doi: 10.1186/1742-4690-5-47.

18.

Transfer-NMR and docking studies identify the binding of the peptide derived from activating transcription factor 4 to protein ubiquitin ligase beta-TrCP. Competition STD-NMR with beta-catenin.

Pons J, Evrard-Todeschi N, Bertho G, Gharbi-Benarous J, Tanchou V, Benarous R, Girault JP.

Biochemistry. 2008 Jan 8;47(1):14-29. Epub 2007 Dec 5.

PMID:
18052253
19.

Phosphorylation-dependent structure of ATF4 peptides derived from a human ATF4 protein, a member of the family of transcription factors.

Pons J, Evrard-Todeschi N, Bertho G, Gharbi-Benarous J, Benarous R, Girault JP.

Peptides. 2007 Dec;28(12):2253-67. Epub 2007 Sep 29.

PMID:
17996332
20.

von Hippel Lindau binding protein 1-mediated degradation of integrase affects HIV-1 gene expression at a postintegration step.

Mousnier A, Kubat N, Massias-Simon A, Ségéral E, Rain JC, Benarous R, Emiliani S, Dargemont C.

Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13615-20. Epub 2007 Aug 13.

21.

Regulated degradation of the HIV-1 Vpu protein through a betaTrCP-independent pathway limits the release of viral particles.

Estrabaud E, Le Rouzic E, Lopez-Vergès S, Morel M, Belaïdouni N, Benarous R, Transy C, Berlioz-Torrent C, Margottin-Goguet F.

PLoS Pathog. 2007 Jul 27;3(7):e104.

22.

Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75.

Bartholomeeusen K, De Rijck J, Busschots K, Desender L, Gijsbers R, Emiliani S, Benarous R, Debyser Z, Christ F.

J Mol Biol. 2007 Sep 14;372(2):407-21. Epub 2007 Jul 12.

PMID:
17669426
23.

A novel Toxoplasma gondii calcium-dependent protein kinase.

Tzen M, Benarous R, Dupouy-Camet J, Roisin MP.

Parasite. 2007 Jun;14(2):141-7.

24.

Involvement of the betaTrCP in the ubiquitination and stability of the HIV-1 Vpu protein.

Belaïdouni N, Marchal C, Benarous R, Besnard-Guérin C.

Biochem Biophys Res Commun. 2007 Jun 8;357(3):688-93. Epub 2007 Apr 9.

PMID:
17445772
25.

Structural studies on 24P-IkappaBalpha peptide derived from a human IkappaB-alpha protein related to the inhibition of the activity of the transcription factor NF-kappaB.

Pons J, Evrard-Todeschi N, Bertho G, Gharbi-Benarous J, Sonois V, Benarous R, Girault JP.

Biochemistry. 2007 Mar 20;46(11):2958-72. Epub 2007 Feb 24.

PMID:
17319651
26.

RASSF1C, an isoform of the tumor suppressor RASSF1A, promotes the accumulation of beta-catenin by interacting with betaTrCP.

Estrabaud E, Lassot I, Blot G, Le Rouzic E, Tanchou V, Quemeneur E, Daviet L, Margottin-Goguet F, Benarous R.

Cancer Res. 2007 Feb 1;67(3):1054-61.

27.

Identification of the LEDGF/p75 binding site in HIV-1 integrase.

Busschots K, Voet A, De Maeyer M, Rain JC, Emiliani S, Benarous R, Desender L, Debyser Z, Christ F.

J Mol Biol. 2007 Feb 2;365(5):1480-92. Epub 2006 Nov 3.

PMID:
17137594
28.

Luman, a new partner of HIV-1 TMgp41, interferes with Tat-mediated transcription of the HIV-1 LTR.

Blot G, Lopez-Vergès S, Treand C, Kubat NJ, Delcroix-Genête D, Emiliani S, Benarous R, Berlioz-Torrent C.

J Mol Biol. 2006 Dec 15;364(5):1034-47. Epub 2006 Oct 3.

PMID:
17054986
29.

Tail-interacting protein TIP47 is a connector between Gag and Env and is required for Env incorporation into HIV-1 virions.

Lopez-Vergès S, Camus G, Blot G, Beauvoir R, Benarous R, Berlioz-Torrent C.

Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14947-52. Epub 2006 Sep 26.

30.

STD and TRNOESY NMR studies for the epitope mapping of the phosphorylation motif of the oncogenic protein beta-catenin recognized by a selective monoclonal antibody.

Megy S, Bertho G, Gharbi-Benarous J, Baleux F, Benarous R, Girault JP.

FEBS Lett. 2006 Oct 2;580(22):5411-22. Epub 2006 Sep 14.

31.

Inhibition of early steps of HIV-1 replication by SNF5/Ini1.

Maroun M, Delelis O, Coadou G, Bader T, Ségéral E, Mbemba G, Petit C, Sonigo P, Rain JC, Mouscadet JF, Benarous R, Emiliani S.

J Biol Chem. 2006 Aug 11;281(32):22736-43. Epub 2006 Jun 13.

32.

Requirement for SWI/SNF chromatin-remodeling complex in Tat-mediated activation of the HIV-1 promoter.

Tréand C, du Chéné I, Brès V, Kiernan R, Benarous R, Benkirane M, Emiliani S.

EMBO J. 2006 Apr 19;25(8):1690-9. Epub 2006 Apr 6.

33.

p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain.

Lassot I, Estrabaud E, Emiliani S, Benkirane M, Benarous R, Margottin-Goguet F.

J Biol Chem. 2005 Dec 16;280(50):41537-45. Epub 2005 Oct 11.

34.

NMR studies for identifying phosphopeptide ligands of the HIV-1 protein Vpu binding to the F-box protein beta-TrCP.

Evrard-Todeschi N, Gharbi-Benarous J, Bertho G, Coadou G, Megy S, Benarous R, Girault JP.

Peptides. 2006 Jan;27(1):194-210. Epub 2005 Sep 13.

PMID:
16165251
35.

STD and TRNOESY NMR studies on the conformation of the oncogenic protein beta-catenin containing the phosphorylated motif DpSGXXpS bound to the beta-TrCP protein.

Megy S, Bertho G, Gharbi-Benarous J, Evrard-Todeschi N, Coadou G, Ségéral E, Iehle C, Quéméneur E, Benarous R, Girault JP.

J Biol Chem. 2005 Aug 12;280(32):29107-16. Epub 2005 May 31.

36.

Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication.

Emiliani S, Mousnier A, Busschots K, Maroun M, Van Maele B, Tempé D, Vandekerckhove L, Moisant F, Ben-Slama L, Witvrouw M, Christ F, Rain JC, Dargemont C, Debyser Z, Benarous R.

J Biol Chem. 2005 Jul 8;280(27):25517-23. Epub 2005 Apr 25.

37.

The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding.

Busschots K, Vercammen J, Emiliani S, Benarous R, Engelborghs Y, Christ F, Debyser Z.

J Biol Chem. 2005 May 6;280(18):17841-7. Epub 2005 Mar 4.

38.

Overexpression of human beta TrCP1 deleted of its F box induces tumorigenesis in transgenic mice.

Belaïdouni N, Peuchmaur M, Perret C, Florentin A, Benarous R, Besnard-Guérin C.

Oncogene. 2005 Mar 24;24(13):2271-6.

PMID:
15735746
39.

Solution structure of a peptide derived from the oncogenic protein beta-Catenin in its phosphorylated and nonphosphorylated states.

Megy S, Bertho G, Gharbi-Benarous J, Baleux F, Benarous R, Girault JP.

Peptides. 2005 Feb;26(2):227-41.

PMID:
15629534
40.

Epitope mapping of the phosphorylation motif of the HIV-1 protein Vpu bound to the selective monoclonal antibody using TRNOESY and STD NMR spectroscopy.

Gharbi-Benarous J, Bertho G, Evrard-Todeschi N, Coadou G, Megy S, Delaunay T, Benarous R, Girault JP.

Biochemistry. 2004 Nov 23;43(46):14555-65.

PMID:
15544326
41.

Human Dlg protein binds to the envelope glycoproteins of human T-cell leukemia virus type 1 and regulates envelope mediated cell-cell fusion in T lymphocytes.

Blot V, Delamarre L, Perugi F, Pham D, Bénichou S, Benarous R, Hanada T, Chishti AH, Dokhélar MC, Pique C.

J Cell Sci. 2004 Aug 1;117(Pt 17):3983-93.

42.

NMR studies of the phosphorylation motif of the HIV-1 protein Vpu bound to the F-box protein beta-TrCP.

Coadou G, Gharbi-Benarous J, Megy S, Bertho G, Evrard-Todeschi N, Segeral E, Benarous R, Girault JP.

Biochemistry. 2003 Dec 23;42(50):14741-51.

PMID:
14674748
43.

Additive activity between the trans-activation response RNA-binding protein, TRBP2, and cyclin T1 on HIV type 1 expression and viral production in murine cells.

Battisti PL, Daher A, Bannwarth S, Voortman J, Peden KW, Hiscott J, Mouland AJ, Benarous R, Gatignol A.

AIDS Res Hum Retroviruses. 2003 Sep;19(9):767-78.

PMID:
14585207
44.

HIV-1 Vpu sequesters beta-transducin repeat-containing protein (betaTrCP) in the cytoplasm and provokes the accumulation of beta-catenin and other SCFbetaTrCP substrates.

Besnard-Guerin C, Belaïdouni N, Lassot I, Segeral E, Jobart A, Marchal C, Benarous R.

J Biol Chem. 2004 Jan 2;279(1):788-95. Epub 2003 Oct 14.

45.

Directed expression of the HIV-1 accessory protein Vpu in Drosophila fat-body cells inhibits Toll-dependent immune responses.

Leulier F, Marchal C, Miletich I, Limbourg-Bouchon B, Benarous R, Lemaitre B.

EMBO Rep. 2003 Oct;4(10):976-81. Epub 2003 Sep 12.

47.

HIV-1 encoded virus protein U (Vpu) solution structure of the 41-62 hydrophilic region containing the phosphorylated sites Ser52 and Ser56.

Coadou G, Evrard-Todeschi N, Gharbi-Benarous J, Benarous R, Girault JP.

Int J Biol Macromol. 2002 Mar 8;30(1):23-40.

PMID:
11893391
48.

Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression.

Daher A, Longuet M, Dorin D, Bois F, Segeral E, Bannwarth S, Battisti PL, Purcell DF, Benarous R, Vaquero C, Meurs EF, Gatignol A.

J Biol Chem. 2001 Sep 7;276(36):33899-905. Epub 2001 Jul 3.

49.
50.

Interaction of human immunodeficiency virus type 1 Vpr with the HHR23A DNA repair protein does not correlate with multiple biological functions of Vpr.

Mansky LM, Preveral S, Le Rouzic E, Bernard LC, Selig L, Depienne C, Benarous R, Benichou S.

Virology. 2001 Mar 30;282(1):176-85.

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