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Items: 1 to 50 of 85

1.

3Rs Friendly Study Designs Facilitate Rat Liver and Blood Micronucleus Assays and Pig-a Gene Mutation Assessments: Proof-of-Concept with Thirteen Reference Chemicals.

Dertinger SD, Avlasevich SL, Torous DK, Singh P, Khanal S, Kirby C, Drake A, MacGregor JT, Bemis JC.

Environ Mol Mutagen. 2019 Jul 11. doi: 10.1002/em.22312. [Epub ahead of print]

PMID:
31294869
2.

Aneugen Molecular Mechanism Assay: Proof of Concept with 27 Reference Chemicals.

Bernacki DT, Bryce SM, Bemis JC, Dertinger SD.

Toxicol Sci. 2019 May 27. pii: kfz123. doi: 10.1093/toxsci/kfz123. [Epub ahead of print]

PMID:
31132080
3.

Predictions of genotoxic potential, mode of action, molecular targets, and potency via a tiered multiflow® assay data analysis strategy.

Dertinger SD, Kraynak AR, Wheeldon RP, Bernacki DT, Bryce SM, Hall N, Bemis JC, Galloway SM, Escobar PA, Johnson GE.

Environ Mol Mutagen. 2019 Jul;60(6):513-533. doi: 10.1002/em.22274. Epub 2019 Feb 27.

PMID:
30702769
4.

Suitability of Long-Term Frozen Rat Blood Samples for the Interrogation of Pig-a Gene Mutation by Flow Cytometry.

Avlasevich SL, Torous DK, Bemis JC, Bhalli JA, Tebbe CC, Noteboom J, Thomas D, Roberts DJ, Barragato M, Schneider B, Prattico J, Richardson M, Gollapudi BB, Dertinger SD.

Environ Mol Mutagen. 2019 Jan;60(1):47-55. doi: 10.1002/em.22249. Epub 2018 Sep 27.

PMID:
30264522
5.

BRAF fusions identified in melanomas have variable treatment responses and phenotypes.

Turner JA, Bemis JGT, Bagby SM, Capasso A, Yacob BW, Chimed TS, Van Gulick R, Lee H, Tobin R, Tentler JJ, Pitts T, McCarter M, Robinson WA, Couts KL.

Oncogene. 2019 Feb;38(8):1296-1308. doi: 10.1038/s41388-018-0514-7. Epub 2018 Sep 25.

PMID:
30254212
6.

BH3 mimetics induce apoptosis independent of DRP-1 in melanoma.

Mukherjee N, Strosnider A, Vagher B, Lambert KA, Slaven S, Robinson WA, Amato CM, Couts KL, Bemis JGT, Turner JA, Norris DA, Shellman YG.

Cell Death Dis. 2018 Sep 5;9(9):907. doi: 10.1038/s41419-018-0932-z.

7.

Integration of liver and blood micronucleus and Pig-a gene mutation endpoints into rat 28-day repeat-treatment studies: Proof-of-principle with diethylnitrosamine.

Khanal S, Singh P, Avlasevich SL, Torous DK, Bemis JC, Dertinger SD.

Mutat Res Genet Toxicol Environ Mutagen. 2018 Apr;828:30-35. doi: 10.1016/j.mrgentox.2018.02.005. Epub 2018 Feb 23.

8.

Flow cytometric method for scoring rat liver micronuclei with simultaneous assessments of hepatocyte proliferation.

Avlasevich SL, Khanal S, Singh P, Torous DK, Bemis JC, Dertinger SD.

Environ Mol Mutagen. 2018 Apr;59(3):176-187. doi: 10.1002/em.22168. Epub 2018 Jan 22.

9.

Glycosylphosphatidylinositol (GPI) anchored protein deficiency serves as a reliable reporter of Pig-a gene Mutation: Support from an in vitro assay based on L5178Y/Tk+/- cells and the CD90.2 antigen.

Bemis JC, Avlasevich SL, Labash C, McKinzie P, Revollo J, Dobrovolsky VN, Dertinger SD.

Environ Mol Mutagen. 2018 Jan;59(1):18-29. doi: 10.1002/em.22154. Epub 2017 Nov 8.

10.

Investigating the Generalizability of the MultiFlow ® DNA Damage Assay and Several Companion Machine Learning Models With a Set of 103 Diverse Test Chemicals.

Bryce SM, Bernacki DT, Smith-Roe SL, Witt KL, Bemis JC, Dertinger SD.

Toxicol Sci. 2018 Mar 1;162(1):146-166. doi: 10.1093/toxsci/kfx235.

11.

ALK Inhibitor Response in Melanomas Expressing EML4-ALK Fusions and Alternate ALK Isoforms.

Couts KL, Bemis J, Turner JA, Bagby SM, Murphy D, Christiansen J, Hintzsche JD, Le A, Pitts TM, Wells K, Applegate A, Amato C, Multani P, Chow-Maneval E, Tentler JJ, Shellman YG, Rioth MJ, Tan AC, Gonzalez R, Medina T, Doebele RC, Robinson WA.

Mol Cancer Ther. 2018 Jan;17(1):222-231. doi: 10.1158/1535-7163.MCT-17-0472. Epub 2017 Oct 20.

12.

In vivo pig-a and micronucleus study of the prototypical aneugen vinblastine sulfate.

Avlasevich SL, Labash C, Torous DK, Bemis JC, MacGregor JT, Dertinger SD.

Environ Mol Mutagen. 2018 Jan;59(1):30-37. doi: 10.1002/em.22122. Epub 2017 Aug 19.

13.

Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay.

Bryce SM, Bernacki DT, Bemis JC, Spellman RA, Engel ME, Schuler M, Lorge E, Heikkinen PT, Hemmann U, Thybaud V, Wilde S, Queisser N, Sutter A, Zeller A, Guérard M, Kirkland D, Dertinger SD.

Environ Mol Mutagen. 2017 Apr;58(3):146-161. doi: 10.1002/em.22083.

14.

Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations.

Dearfield KL, Gollapudi BB, Bemis JC, Benz RD, Douglas GR, Elespuru RK, Johnson GE, Kirkland DJ, LeBaron MJ, Li AP, Marchetti F, Pottenger LH, Rorije E, Tanir JY, Thybaud V, van Benthem J, Yauk CL, Zeiger E, Luijten M.

Environ Mol Mutagen. 2017 Jun;58(5):264-283. doi: 10.1002/em.22045. Epub 2016 Sep 21. Review.

PMID:
27650663
15.

γH2AX and p53 responses in TK6 cells discriminate promutagens and nongenotoxicants in the presence of rat liver S9.

Bernacki DT, Bryce SM, Bemis JC, Kirkland D, Dertinger SD.

Environ Mol Mutagen. 2016 Aug;57(7):546-558. doi: 10.1002/em.22028. Epub 2016 Jul 1.

16.

Empirical analysis of BMD metrics in genetic toxicology part II: in vivo potency comparisons to promote reductions in the use of experimental animals for genetic toxicity assessment.

Wills JW, Long AS, Johnson GE, Bemis JC, Dertinger SD, Slob W, White PA.

Mutagenesis. 2016 May;31(3):265-75. doi: 10.1093/mutage/gew009. Epub 2016 Mar 16.

PMID:
26984301
17.

Synthesis and Characterization of Fatty Acid Conjugates of Niacin and Salicylic Acid.

Vu CB, Bemis JE, Benson E, Bista P, Carney D, Fahrner R, Lee D, Liu F, Lonkar P, Milne JC, Nichols AJ, Picarella D, Shoelson A, Smith J, Ting A, Wensley A, Yeager M, Zimmer M, Jirousek MR.

J Med Chem. 2016 Feb 11;59(3):1217-31. doi: 10.1021/acs.jmedchem.5b01961. Epub 2016 Feb 1.

PMID:
26784936
18.

Best practices for application of attachment cells to in vitro micronucleus assessment by flow cytometry.

Bemis JC, Bryce SM, Nern M, Raschke M, Sutter A.

Mutat Res Genet Toxicol Environ Mutagen. 2016 Jan 1;795:51-9. doi: 10.1016/j.mrgentox.2015.10.007. Epub 2015 Nov 2.

PMID:
26774667
19.

Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach.

Bryce SM, Bernacki DT, Bemis JC, Dertinger SD.

Environ Mol Mutagen. 2016 Apr;57(3):171-89. doi: 10.1002/em.21996. Epub 2016 Jan 13.

20.

Mouse Pig-a and micronucleus assays respond to N-ethyl-N-nitrosourea, benzo[a]pyrene, and ethyl carbamate, but not pyrene or methyl carbamate.

Labash C, Avlasevich SL, Carlson K, Berg A, Torous DK, Bryce SM, Bemis JC, MacGregor JT, Dertinger SD.

Environ Mol Mutagen. 2016 Jan;57(1):28-40. doi: 10.1002/em.21965. Epub 2015 Jul 17.

PMID:
26186091
21.

Comparison of in vitro and in vivo clastogenic potency based on benchmark dose analysis of flow cytometric micronucleus data.

Bemis JC, Wills JW, Bryce SM, Torous DK, Dertinger SD, Slob W.

Mutagenesis. 2016 May;31(3):277-85. doi: 10.1093/mutage/gev041. Epub 2015 Jun 6.

22.

Induction of Pig-a mutant erythrocytes in male and female rats exposed to 1,3-propane sultone, ethyl carbamate, or thiotepa.

Labash C, Carlson K, Avlasevich SL, Berg A, Bemis JC, MacGregor JT, Dertinger SD.

Mutat Res Genet Toxicol Environ Mutagen. 2015 Apr;782:24-9. doi: 10.1016/j.mrgentox.2015.03.011. Epub 2015 Mar 14.

23.

Part 2. Assessment of micronucleus formation in rats after chronic exposure to new-technology diesel exhaust in the ACES bioassay.

Bemis JC, Torous DK, Dertinger SD; HEI Health Review Committee.

Res Rep Health Eff Inst. 2015 Jan;(184):69-82; discussion 141-71.

PMID:
25842616
24.

Rat Pig-a mutation assay responds to the genotoxic carcinogen ethyl carbamate but not the non-genotoxic carcinogen methyl carbamate.

Bemis JC, Labash C, Avlasevich SL, Carlson K, Berg A, Torous DK, Barragato M, MacGregor JT, Dertinger SD.

Mutagenesis. 2015 May;30(3):343-7. doi: 10.1093/mutage/geu084. Epub 2015 Apr 1.

25.

Comparison of male versus female responses in the Pig-a mutation assay.

Labash C, Avlasevich SL, Carlson K, Torous DK, Berg A, Bemis JC, MacGregor JT, Dertinger SD.

Mutagenesis. 2015 May;30(3):349-57. doi: 10.1093/mutage/geu055. Epub 2015 Apr 1.

26.

Human erythrocyte PIG-A assay: an easily monitored index of gene mutation requiring low volume blood samples.

Dertinger SD, Avlasevich SL, Bemis JC, Chen Y, MacGregor JT.

Environ Mol Mutagen. 2015 May;56(4):366-77. doi: 10.1002/em.21924. Epub 2014 Nov 20.

27.

Persistence of cisplatin-induced mutagenicity in hematopoietic stem cells: implications for secondary cancer risk following chemotherapy.

Dertinger SD, Avlasevich SL, Torous DK, Bemis JC, Phonethepswath S, Labash C, Carlson K, Mereness J, Cottom J, Palis J, MacGregor JT.

Toxicol Sci. 2014 Aug 1;140(2):307-14. doi: 10.1093/toxsci/kfu078. Epub 2014 May 5.

28.

Interpreting in vitro micronucleus positive results: simple biomarker matrix discriminates clastogens, aneugens, and misleading positive agents.

Bryce SM, Bemis JC, Mereness JA, Spellman RA, Moss J, Dickinson D, Schuler MJ, Dertinger SD.

Environ Mol Mutagen. 2014 Aug;55(7):542-55. doi: 10.1002/em.21868. Epub 2014 Apr 23.

PMID:
24756928
29.

Diethylnitrosamine genotoxicity evaluated in sprague dawley rats using pig-a mutation and reticulocyte micronucleus assays.

Avlasevich SL, Phonethepswath S, Labash C, Carlson K, Torous DK, Cottom J, Bemis JC, MacGregor JT, Dertinger SD.

Environ Mol Mutagen. 2014 Jun;55(5):400-6. doi: 10.1002/em.21862. Epub 2014 Feb 27.

PMID:
24574022
30.

Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone.

Dertinger SD, Phonethepswath S, Avlasevich SL, Torous DK, Mereness J, Cottom J, Bemis JC, Macgregor JT.

Environ Mol Mutagen. 2014 May;55(4):299-308. doi: 10.1002/em.21846. Epub 2014 Jan 21.

PMID:
24449360
31.

Erythrocyte-based Pig-a gene mutation assay.

Bemis JC, Hall NE, Dertinger SD.

Methods Mol Biol. 2013;1044:51-77. doi: 10.1007/978-1-62703-529-3_3.

PMID:
23896871
32.

Flow cytometric 96-well microplate-based in vitro micronucleus assay with human TK6 cells: protocol optimization and transferability assessment.

Bryce SM, Avlasevich SL, Bemis JC, Tate M, Walmsley RM, Saad F, Van Dijck K, De Boeck M, Van Goethem F, Lukamowicz-Rajska M, Elhajouji A, Dertinger SD.

Environ Mol Mutagen. 2013 Apr;54(3):180-94. doi: 10.1002/em.21760. Epub 2013 Feb 27.

PMID:
23447390
33.

Flow cytometric analysis of Pig-a gene mutation and chromosomal damage induced by procarbazine hydrochloride in CD-1 mice.

Phonethepswath S, Avlasevich SL, Torous DK, Mereness J, Bemis JC, Macgregor JT, Dertinger SD.

Environ Mol Mutagen. 2013 May;54(4):294-8. doi: 10.1002/em.21758. Epub 2013 Feb 21.

PMID:
23427001
34.

Part 2. Assessment of genotoxicity after exposure to diesel exhaust from U.S. 2007-compliant diesel engines: report on 1- and 3-month exposures in the ACES bioassay.

Bemis JC, Torous DK, Dertinger SD; HEI Health Review Committee.

Res Rep Health Eff Inst. 2012 Sep;(166):125-57.

PMID:
23156841
35.

Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds.

Dertinger SD, Phonethepswath S, Avlasevich SL, Torous DK, Mereness J, Bryce SM, Bemis JC, Bell S, Weller P, Macgregor JT.

Toxicol Sci. 2012 Dec;130(2):328-48. doi: 10.1093/toxsci/kfs258. Epub 2012 Aug 24.

36.

EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress.

Peslak SA, Wenger J, Bemis JC, Kingsley PD, Koniski AD, McGrath KE, Palis J.

Blood. 2012 Sep 20;120(12):2501-11. Epub 2012 Aug 13.

37.

In vivo flow cytometric Pig-a and micronucleus assays: highly sensitive discrimination of the carcinogen/noncarcinogen pair benzo(a)pyrene and pyrene using acute and repeated-dose designs.

Torous DK, Phonethepswath S, Avlasevich SL, Mereness J, Bryce SM, Bemis JC, Weller P, Bell S, Gleason C, Custer LL, MacGregor JT, Dertinger SD.

Environ Mol Mutagen. 2012 Jul;53(6):420-8. doi: 10.1002/em.21709. Epub 2012 Jun 22.

PMID:
22730284
38.

Incentive effect on inhibitory control in adolescents with early-life stress: an antisaccade study.

Mueller SC, Hardin MG, Korelitz K, Daniele T, Bemis J, Dozier M, Peloso E, Maheu FS, Pine DS, Ernst M.

Child Abuse Negl. 2012 Mar;36(3):217-25. doi: 10.1016/j.chiabu.2011.10.010. Epub 2012 Mar 15.

39.

Interlaboratory Pig-a gene mutation assay trial: Studies of 1,3-propane sultone with immunomagnetic enrichment of mutant erythrocytes.

Dertinger SD, Phonethepswath S, Weller P, Avlasevich S, Torous DK, Mereness JA, Bryce SM, Bemis JC, Bell S, Portugal S, Aylott M, MacGregor JT.

Environ Mol Mutagen. 2011 Dec;52(9):748-55. doi: 10.1002/em.20671. Epub 2011 Aug 29.

PMID:
22052433
40.

MIR29B regulates expression of MLLT11 (AF1Q), an MLL fusion partner, and low MIR29B expression associates with adverse cytogenetics and poor overall survival in AML.

Xiong Y, Li Z, Ji M, Tan AC, Bemis J, Tse JV, Huang G, Park J, Ji C, Chen J, Bemis LT, Bunting KD, Tse W.

Br J Haematol. 2011 Jun;153(6):753-7. doi: 10.1111/j.1365-2141.2011.08662.x. Epub 2011 Apr 18.

41.

Sublethal radiation injury uncovers a functional transition during erythroid maturation.

Peslak SA, Wenger J, Bemis JC, Kingsley PD, Frame JM, Koniski AD, Chen Y, Williams JP, McGrath KE, Dertinger SD, Palis J.

Exp Hematol. 2011 Apr;39(4):434-45. doi: 10.1016/j.exphem.2011.01.010. Epub 2011 Feb 1.

42.

Not "capitalizing" on social capitalization interactions: the role of attachment insecurity.

Shallcross SL, Howland M, Bemis J, Simpson JA, Frazier P.

J Fam Psychol. 2011 Feb;25(1):77-85. doi: 10.1037/a0021876.

PMID:
21219073
43.

Miniaturized flow cytometry-based CHO-K1 micronucleus assay discriminates aneugenic and clastogenic modes of action.

Bryce SM, Avlasevich SL, Bemis JC, Dertinger SD.

Environ Mol Mutagen. 2011 May;52(4):280-6. doi: 10.1002/em.20618. Epub 2010 Sep 24.

PMID:
20872831
44.

Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose-response relationships.

Bryce SM, Avlasevich SL, Bemis JC, Phonethepswath S, Dertinger SD.

Mutat Res. 2010 Dec 21;703(2):191-9. doi: 10.1016/j.mrgentox.2010.08.020. Epub 2010 Sep 6.

45.

Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies.

Dertinger SD, Phonethepswath S, Franklin D, Weller P, Torous DK, Bryce SM, Avlasevich S, Bemis JC, Hyrien O, Palis J, MacGregor JT.

Toxicol Sci. 2010 Jun;115(2):401-11. doi: 10.1093/toxsci/kfq070. Epub 2010 Mar 4.

46.

Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens.

Phonethepswath S, Franklin D, Torous DK, Bryce SM, Bemis JC, Raja S, Avlasevich S, Weller P, Hyrien O, Palis J, Macgregor JT, Dertinger SD.

Toxicol Sci. 2010 Mar;114(1):59-70. doi: 10.1093/toxsci/kfp289. Epub 2009 Dec 4.

47.

High content flow cytometric micronucleus scoring method is applicable to attachment cell lines.

Bryce SM, Shi J, Nicolette J, Diehl M, Sonders P, Avlasevich S, Raja S, Bemis JC, Dertinger SD.

Environ Mol Mutagen. 2010 Apr;51(3):260-6. doi: 10.1002/em.20544.

48.

Crystal structures of human SIRT3 displaying substrate-induced conformational changes.

Jin L, Wei W, Jiang Y, Peng H, Cai J, Mao C, Dai H, Choy W, Bemis JE, Jirousek MR, Milne JC, Westphal CH, Perni RB.

J Biol Chem. 2009 Sep 4;284(36):24394-405. doi: 10.1074/jbc.M109.014928. Epub 2009 Jun 16.

49.

Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: effect of age.

Dertinger SD, Bemis JC, Phonethepswath S, Tsai Y, Nowak I, Hyrien O, Palis J, Chen Y.

Mutat Res. 2009 Apr 30;675(1-2):77-80. doi: 10.1016/j.mrgentox.2009.02.002. Epub 2009 Feb 11.

50.

A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9.

Nakamaru Y, Vuppusetty C, Wada H, Milne JC, Ito M, Rossios C, Elliot M, Hogg J, Kharitonov S, Goto H, Bemis JE, Elliott P, Barnes PJ, Ito K.

FASEB J. 2009 Sep;23(9):2810-9. doi: 10.1096/fj.08-125468. Epub 2009 Apr 17.

PMID:
19376817

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