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"Truth is ever to be found in simplicity, and not in the multiplicity and confusion of things" - Sir Isaac Newton.

Smith JA, Wortley MA, Bonvini S, Birrell M, Belvisi MG.

Eur Respir J. 2020 Feb 6;55(2). pii: 1901566. doi: 10.1183/13993003.01566-2019. Print 2020 Feb. No abstract available.


Effects of aerobic exercise on molecular aspects of asthma: involvement of SOCS-JAK-STAT.

Almeida-Oliveira AR, Aquino-Junior J, Abbasi A, Santos-Dias A, Oliveira-Junior MC, Alberca-Custodio RW, Rigonato-Oliveira NC, Salles-Dias LP, Damaceno-Rodrigues NR, Caldini EG, Arantes-Costa FM, Ligeiro-Oliveira AP, Belvisi MG, Vieira RP.

Exerc Immunol Rev. 2019;25:50-62.


Modelling the asthma phenotype: impact of cigarette smoke exposure.

Belvisi MG, Baker K, Malloy N, Raemdonck K, Dekkak B, Pieper M, Nials AT, Birrell MA.

Respir Res. 2018 May 10;19(1):89. doi: 10.1186/s12931-018-0799-7.


Exercise Inhibits the Effects of Smoke-Induced COPD Involving Modulation of STAT3.

Rodrigues Brandao-Rangel MA, Bachi ALL, Oliveira-Junior MC, Abbasi A, Silva-Renno A, Aparecida de Brito A, Ligeiro de Oliveira AP, Choqueta Toledo-Arruda A, Belvisi MG, Paula Vieira R.

Oxid Med Cell Longev. 2017;2017:6572714. doi: 10.1155/2017/6572714. Epub 2017 Oct 18.


Targeting fatty acid amide hydrolase as a therapeutic strategy for antitussive therapy.

Wortley MA, Adcock JJ, Dubuis ED, Maher SA, Bonvini SJ, Delescluse I, Kinloch R, McMurray G, Perros-Huguet C, Papakosta M, Birrell MA, Belvisi MG.

Eur Respir J. 2017 Sep 20;50(3). pii: 1700782. doi: 10.1183/13993003.00782-2017. Print 2017 Sep.


The emerging role of transient receptor potential channels in chronic lung disease.

Belvisi MG, Birrell MA.

Eur Respir J. 2017 Aug 3;50(2). pii: 1601357. doi: 10.1183/13993003.01357-2016. Print 2017 Aug. Review.


Downregulation of MicroRNA-126 Augments DNA Damage Response in Cigarette Smokers and Patients with Chronic Obstructive Pulmonary Disease.

Paschalaki KE, Zampetaki A, Baker JR, Birrell MA, Starke RD, Belvisi MG, Donnelly LE, Mayr M, Randi AM, Barnes PJ.

Am J Respir Crit Care Med. 2018 Mar 1;197(5):665-668. doi: 10.1164/rccm.201706-1304LE. No abstract available.


ATP and cough reflex hypersensitivity: a confusion of goals?

Belvisi MG, Smith JA.

Eur Respir J. 2017 Jul 5;50(1). pii: 1700579. doi: 10.1183/13993003.00579-2017. Print 2017 Jul. No abstract available.


Cough and airway disease: The role of ion channels.

Bonvini SJ, Belvisi MG.

Pulm Pharmacol Ther. 2017 Dec;47:21-28. doi: 10.1016/j.pupt.2017.06.009. Epub 2017 Jun 29. Review.


XEN-D0501, a Novel Transient Receptor Potential Vanilloid 1 Antagonist, Does Not Reduce Cough in Patients with Refractory Cough.

Belvisi MG, Birrell MA, Wortley MA, Maher SA, Satia I, Badri H, Holt K, Round P, McGarvey L, Ford J, Smith JA.

Am J Respir Crit Care Med. 2017 Nov 15;196(10):1255-1263. doi: 10.1164/rccm.201704-0769OC.


Mechanistic link between diesel exhaust particles and respiratory reflexes.

Robinson RK, Birrell MA, Adcock JJ, Wortley MA, Dubuis ED, Chen S, McGilvery CM, Hu S, Shaffer MSP, Bonvini SJ, Maher SA, Mudway IS, Porter AE, Carlsten C, Tetley TD, Belvisi MG.

J Allergy Clin Immunol. 2018 Mar;141(3):1074-1084.e9. doi: 10.1016/j.jaci.2017.04.038. Epub 2017 May 19.


Addressing unmet needs in understanding asthma mechanisms: From the European Asthma Research and Innovation Partnership (EARIP) Work Package (WP)2 collaborators.

Edwards MR, Saglani S, Schwarze J, Skevaki C, Smith JA, Ainsworth B, Almond M, Andreakos E, Belvisi MG, Chung KF, Cookson W, Cullinan P, Hawrylowicz C, Lommatzsch M, Jackson D, Lutter R, Marsland B, Moffatt M, Thomas M, Virchow JC, Xanthou G, Edwards J, Walker S, Johnston SL; members of the EARIP WP2 working group.

Eur Respir J. 2017 May 1;49(5). pii: 1602448. doi: 10.1183/13993003.02448-2016. Print 2017 May. Review.


Characterisation of a murine model of the late asthmatic response.

Baker K, Raemdonck K, Snelgrove RJ, Belvisi MG, Birrell MA.

Respir Res. 2017 Apr 11;18(1):55. doi: 10.1186/s12931-017-0541-x.


Modulation of the TRPV4 ion channel as a therapeutic target for disease.

Grace MS, Bonvini SJ, Belvisi MG, McIntyre P.

Pharmacol Ther. 2017 Sep;177:9-22. doi: 10.1016/j.pharmthera.2017.02.019. Epub 2017 Feb 12. Review.


Drugs Affecting TRP Channels.

Wortley MA, Birrell MA, Belvisi MG.

Handb Exp Pharmacol. 2017;237:213-241. doi: 10.1007/164_2016_63. Review.


The ever-expanding ERS fellowship programmes: achievements over the past 3 years.

Belvisi MG, Morty RE, Rohde G, Miravitlles M, Forrest KA, Genton C, Ritter N, Luludi N, Jimenez A, Rigau D, Tonia T, Vaccaro V, Pannetier C, Brusselle GG, Holgate ST.

Eur Respir J. 2016 Sep;48(3):595-9. doi: 10.1183/13993003.01146-2016. No abstract available.


Lung-resident eosinophils represent a distinct regulatory eosinophil subset.

Mesnil C, Raulier S, Paulissen G, Xiao X, Birrell MA, Pirottin D, Janss T, Starkl P, Ramery E, Henket M, Schleich FN, Radermecker M, Thielemans K, Gillet L, Thiry M, Belvisi MG, Louis R, Desmet C, Marichal T, Bureau F.

J Clin Invest. 2016 Sep 1;126(9):3279-95. doi: 10.1172/JCI85664. Epub 2016 Aug 22.


Role of the ion channel, transient receptor potential cation channel subfamily V member 1 (TRPV1), in allergic asthma.

Baker K, Raemdonck K, Dekkak B, Snelgrove RJ, Ford J, Shala F, Belvisi MG, Birrell MA.

Respir Res. 2016 Jun 2;17(1):67. doi: 10.1186/s12931-016-0384-x.


CD4⁺ and CD8⁺ T cells play a central role in a HDM driven model of allergic asthma.

Raemdonck K, Baker K, Dale N, Dubuis E, Shala F, Belvisi MG, Birrell MA.

Respir Res. 2016 Apr 25;17:45. doi: 10.1186/s12931-016-0359-y.


Transient receptor potential cation channel, subfamily V, member 4 and airway sensory afferent activation: Role of adenosine triphosphate.

Bonvini SJ, Birrell MA, Grace MS, Maher SA, Adcock JJ, Wortley MA, Dubuis E, Ching YM, Ford AP, Shala F, Miralpeix M, Tarrason G, Smith JA, Belvisi MG.

J Allergy Clin Immunol. 2016 Jul;138(1):249-261.e12. doi: 10.1016/j.jaci.2015.10.044. Epub 2016 Jan 11.


Neurophenotypes in Airway Diseases. Insights from Translational Cough Studies.

Belvisi MG, Birrell MA, Khalid S, Wortley MA, Dockry R, Coote J, Holt K, Dubuis E, Kelsall A, Maher SA, Bonvini S, Woodcock A, Smith JA.

Am J Respir Crit Care Med. 2016 Jun 15;193(12):1364-72. doi: 10.1164/rccm.201508-1602OC.


Role of EP2 and EP4 receptors in airway microvascular leak induced by prostaglandin E2.

Jones VC, Birrell MA, Maher SA, Griffiths M, Grace M, O'Donnell VB, Clark SR, Belvisi MG.

Br J Pharmacol. 2016 Mar;173(6):992-1004. doi: 10.1111/bph.13400.


DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease.

Birch J, Anderson RK, Correia-Melo C, Jurk D, Hewitt G, Marques FM, Green NJ, Moisey E, Birrell MA, Belvisi MG, Black F, Taylor JJ, Fisher AJ, De Soyza A, Passos JF.

Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1124-37. doi: 10.1152/ajplung.00293.2015. Epub 2015 Sep 18.


The role of CRAC channel in asthma.

Kaur M, Birrell MA, Dekkak B, Reynolds S, Wong S, De Alba J, Raemdonck K, Hall S, Simpson K, Begg M, Belvisi MG, Singh D.

Pulm Pharmacol Ther. 2015 Dec;35:67-74. doi: 10.1016/j.pupt.2015.09.002. Epub 2015 Sep 4.


In vivo bioimaging with tissue-specific transcription factor activated luciferase reporters.

Buckley SM, Delhove JM, Perocheau DP, Karda R, Rahim AA, Howe SJ, Ward NJ, Birrell MA, Belvisi MG, Arbuthnot P, Johnson MR, Waddington SN, McKay TR.

Sci Rep. 2015 Jul 3;5:11842. doi: 10.1038/srep11842.


JAK-STAT pathway activation in COPD.

Yew-Booth L, Birrell MA, Lau MS, Baker K, Jones V, Kilty I, Belvisi MG.

Eur Respir J. 2015 Sep;46(3):843-5. doi: 10.1183/09031936.00228414. Epub 2015 Jun 25. No abstract available.


Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema.

Lilburn DM, Lesbats C, Six JS, Dubuis E, Yew-Booth L, Shaw DE, Belvisi MG, Birrell MA, Pavlovskaya GE, Meersmann T.

J R Soc Interface. 2015 Jun 6;12(107). pii: 20150192. doi: 10.1098/rsif.2015.0192.


Anti-inflammatory effects of PGE2 in the lung: role of the EP4 receptor subtype.

Birrell MA, Maher SA, Dekkak B, Jones V, Wong S, Brook P, Belvisi MG.

Thorax. 2015 Aug;70(8):740-7. doi: 10.1136/thoraxjnl-2014-206592. Epub 2015 May 4.


Cough hypersensitivity syndrome: clinical measurement is the key to progress.

Morice AH, Millqvist E, Belvisi MG, Bieksiene K, Birring SS, Chung KF, Dal Negro RW, Dicpinigaitis P, Kantar A, McGarvey LP, Pacheco A, Sakalauskas R, Smith JA.

Eur Respir J. 2015 May;45(5):1509-10. doi: 10.1183/09031936.00014215. No abstract available.


Barriers to new drug development in respiratory disease.

Barnes PJ, Bonini S, Seeger W, Belvisi MG, Ward B, Holmes A.

Eur Respir J. 2015 May;45(5):1197-207. doi: 10.1183/09031936.00007915. No abstract available.


Targeting TRP channels for chronic cough: from bench to bedside.

Bonvini SJ, Birrell MA, Smith JA, Belvisi MG.

Naunyn Schmiedebergs Arch Pharmacol. 2015 Apr;388(4):401-20. doi: 10.1007/s00210-014-1082-1. Epub 2015 Jan 10. Review.


Therapeutic advances for treatment-resistant cough.

Belvisi MG.

Lancet. 2015 Mar 28;385(9974):1160-2. doi: 10.1016/S0140-6736(14)61740-2. Epub 2014 Nov 25. No abstract available.


Role of the inflammasome-caspase1/11-IL-1/18 axis in cigarette smoke driven airway inflammation: an insight into the pathogenesis of COPD.

Eltom S, Belvisi MG, Stevenson CS, Maher SA, Dubuis E, Fitzgerald KA, Birrell MA.

PLoS One. 2014 Nov 18;9(11):e112829. doi: 10.1371/journal.pone.0112829. eCollection 2014.


Prostaglandin D2 and the role of the DP1, DP2 and TP receptors in the control of airway reflex events.

Maher SA, Birrell MA, Adcock JJ, Wortley MA, Dubuis ED, Bonvini SJ, Grace MS, Belvisi MG.

Eur Respir J. 2015 Apr;45(4):1108-18. doi: 10.1183/09031936.00061614. Epub 2014 Oct 16.


Role of transient receptor potential and pannexin channels in cigarette smoke-triggered ATP release in the lung.

Baxter M, Eltom S, Dekkak B, Yew-Booth L, Dubuis ED, Maher SA, Belvisi MG, Birrell MA.

Thorax. 2014 Dec;69(12):1080-9. doi: 10.1136/thoraxjnl-2014-205467. Epub 2014 Oct 9.


The role of adenylyl cyclase isoform 6 in β-adrenoceptor signalling in murine airways.

Birrell MA, Bonvini SJ, Wortley MA, Buckley J, Yew-Booth L, Maher SA, Dale N, Dubuis ED, Belvisi MG.

Br J Pharmacol. 2015 Jan;172(1):131-41. doi: 10.1111/bph.12905. Epub 2014 Nov 24.


Expert opinion on the cough hypersensitivity syndrome in respiratory medicine.

Morice AH, Millqvist E, Belvisi MG, Bieksiene K, Birring SS, Chung KF, Dal Negro RW, Dicpinigaitis P, Kantar A, McGarvey LP, Pacheco A, Sakalauskas R, Smith JA.

Eur Respir J. 2014 Nov;44(5):1132-48. doi: 10.1183/09031936.00218613. Epub 2014 Aug 19.


TLR4 activation induces IL-1β release via an IPAF dependent but caspase 1/11/8 independent pathway in the lung.

Eltom S, Belvisi MG, Yew-Booth L, Dekkak B, Maher SA, Dubuis ED, Jones V, Fitzgerald KA, Birrell MA.

Respir Res. 2014 Aug 2;15:87. doi: 10.1186/s12931-014-0087-0.


Respiratory infections cause the release of extracellular vesicles: implications in exacerbation of asthma/COPD.

Eltom S, Dale N, Raemdonck KR, Stevenson CS, Snelgrove RJ, Sacitharan PK, Recchi C, Wavre-Shapton S, McAuley DF, O'Kane C, Belvisi MG, Birrell MA.

PLoS One. 2014 Jun 27;9(6):e101087. doi: 10.1371/journal.pone.0101087. eCollection 2014.


Harvesting, isolation, and functional assessment of primary vagal ganglia cells.

Dubuis E, Grace M, Wortley MA, Birrell MA, Belvisi MG.

Curr Protoc Pharmacol. 2013 Oct 8;62:12.15.1-12.15.27. doi: 10.1002/0471141755.ph1215s62.


Tiotropium modulates transient receptor potential V1 (TRPV1) in airway sensory nerves: A beneficial off-target effect?

Birrell MA, Bonvini SJ, Dubuis E, Maher SA, Wortley MA, Grace MS, Raemdonck K, Adcock JJ, Belvisi MG.

J Allergy Clin Immunol. 2014 Mar;133(3):679-87.e9. doi: 10.1016/j.jaci.2013.12.003. Epub 2014 Feb 5.


Theophylline inhibits the cough reflex through a novel mechanism of action.

Dubuis E, Wortley MA, Grace MS, Maher SA, Adcock JJ, Birrell MA, Belvisi MG.

J Allergy Clin Immunol. 2014 Jun;133(6):1588-98. doi: 10.1016/j.jaci.2013.11.017. Epub 2014 Jan 7.


Transient receptor potential (TRP) channels in the airway: role in airway disease.

Grace MS, Baxter M, Dubuis E, Birrell MA, Belvisi MG.

Br J Pharmacol. 2014 May;171(10):2593-607. doi: 10.1111/bph.12538. Review.


Pre-clinical studies in cough research: role of Transient Receptor Potential (TRP) channels.

Grace MS, Dubuis E, Birrell MA, Belvisi MG.

Pulm Pharmacol Ther. 2013 Oct;26(5):498-507. doi: 10.1016/j.pupt.2013.02.007. Epub 2013 Mar 6. Review.


Cigarette smoke induced airway inflammation is independent of NF-κB signalling.

Rastrick JM, Stevenson CS, Eltom S, Grace M, Davies M, Kilty I, Evans SM, Pasparakis M, Catley MC, Lawrence T, Adcock IM, Belvisi MG, Birrell MA.

PLoS One. 2013;8(1):e54128. doi: 10.1371/journal.pone.0054128. Epub 2013 Jan 22. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/754d7b19-2dac-479b-a23c-db9fed0431be.


Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking.

Shenker NS, Polidoro S, van Veldhoven K, Sacerdote C, Ricceri F, Birrell MA, Belvisi MG, Brown R, Vineis P, Flanagan JM.

Hum Mol Genet. 2013 Mar 1;22(5):843-51. doi: 10.1093/hmg/dds488. Epub 2012 Nov 21.


Selectivity profiling of the novel EP2 receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the guinea pig EP2 receptor.

Birrell MA, Maher SA, Buckley J, Dale N, Bonvini S, Raemdonck K, Pullen N, Giembycz MA, Belvisi MG.

Br J Pharmacol. 2013 Jan;168(1):129-38. doi: 10.1111/j.1476-5381.2012.02088.x.


Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin.

Grace M, Birrell MA, Dubuis E, Maher SA, Belvisi MG.

Thorax. 2012 Oct;67(10):891-900. doi: 10.1136/thoraxjnl-2011-201443. Epub 2012 Jun 12.


Maps and legends: the quest for dissociated ligands of the glucocorticoid receptor.

Clark AR, Belvisi MG.

Pharmacol Ther. 2012 Apr;134(1):54-67. doi: 10.1016/j.pharmthera.2011.12.004. Epub 2011 Dec 23. Review.


Transient receptor potential A1 channels: insights into cough and airway inflammatory disease.

Belvisi MG, Dubuis E, Birrell MA.

Chest. 2011 Oct;140(4):1040-1047. doi: 10.1378/chest.10-3327.

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