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Items: 47


Preparation of Mouse Retinal Cryo-sections for Immunohistochemistry.

Léger H, Santana E, Beltran WA, Luca FC.

J Vis Exp. 2019 Jul 1;(149). doi: 10.3791/59683.


Author Correction: Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration.

Sudharsan R, Beiting DP, Aguirre GD, Beltran WA.

Sci Rep. 2018 Nov 14;8(1):17041. doi: 10.1038/s41598-018-35520-2.


Translational Retinal Research and Therapies.

Hardcastle AJ, Sieving PA, Sahel JA, Jacobson SG, Cideciyan AV, Flannery JG, Beltran WA, Aguirre GD.

Transl Vis Sci Technol. 2018 Sep 13;7(5):8. doi: 10.1167/tvst.7.5.8. eCollection 2018 Sep.


Ndr kinases regulate retinal interneuron proliferation and homeostasis.

Léger H, Santana E, Leu NA, Smith ET, Beltran WA, Aguirre GD, Luca FC.

Sci Rep. 2018 Aug 22;8(1):12544. doi: 10.1038/s41598-018-30492-9.


Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector.

Cideciyan AV, Sudharsan R, Dufour VL, Massengill MT, Iwabe S, Swider M, Lisi B, Sumaroka A, Marinho LF, Appelbaum T, Rossmiller B, Hauswirth WW, Jacobson SG, Lewin AS, Aguirre GD, Beltran WA.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8547-E8556. doi: 10.1073/pnas.1805055115. Epub 2018 Aug 20.


Photoreceptor Outer Segment Isolation from a Single Canine Retina for RPE Phagocytosis Assay.

Sudharsan R, Elliott MH, Dolgova N, Aguirre GD, Beltran WA.

Adv Exp Med Biol. 2018;1074:593-601. doi: 10.1007/978-3-319-75402-4_72.


BEST1 gene therapy corrects a diffuse retina-wide microdetachment modulated by light exposure.

Guziewicz KE, Cideciyan AV, Beltran WA, Komáromy AM, Dufour VL, Swider M, Iwabe S, Sumaroka A, Kendrick BT, Ruthel G, Chiodo VA, Héon E, Hauswirth WW, Jacobson SG, Aguirre GD.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2839-E2848. doi: 10.1073/pnas.1720662115. Epub 2018 Mar 5.


Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration.

Sudharsan R, Beiting DP, Aguirre GD, Beltran WA.

Sci Rep. 2017 Dec 20;7(1):17897. doi: 10.1038/s41598-017-18236-7. Erratum in: Sci Rep. 2018 Nov 14;8(1):17041.


Optimization of Retinal Gene Therapy for X-Linked Retinitis Pigmentosa Due to RPGR Mutations.

Beltran WA, Cideciyan AV, Boye SE, Ye GJ, Iwabe S, Dufour VL, Marinho LF, Swider M, Kosyk MS, Sha J, Boye SL, Peterson JJ, Witherspoon CD, Alexander JJ, Ying GS, Shearman MS, Chulay JD, Hauswirth WW, Gamlin PD, Jacobson SG, Aguirre GD.

Mol Ther. 2017 Aug 2;25(8):1866-1880. doi: 10.1016/j.ymthe.2017.05.004. Epub 2017 May 27.


Acute and Protracted Cell Death in Light-Induced Retinal Degeneration in the Canine Model of Rhodopsin Autosomal Dominant Retinitis Pigmentosa.

Sudharsan R, Simone KM, Anderson NP, Aguirre GD, Beltran WA.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):270-281. doi: 10.1167/iovs.16-20749.


Overlap of abnormal photoreceptor development and progressive degeneration in Leber congenital amaurosis caused by NPHP5 mutation.

Downs LM, Scott EM, Cideciyan AV, Iwabe S, Dufour V, Gardiner KL, Genini S, Marinho LF, Sumaroka A, Kosyk MS, Swider M, Aguirre GK, Jacobson SG, Beltran WA, Aguirre GD.

Hum Mol Genet. 2016 Oct 1;25(19):4211-4226. doi: 10.1093/hmg/ddw254. Epub 2016 Aug 9.


Assessment of visual function and retinal structure following acute light exposure in the light sensitive T4R rhodopsin mutant dog.

Iwabe S, Ying GS, Aguirre GD, Beltran WA.

Exp Eye Res. 2016 May;146:341-53. doi: 10.1016/j.exer.2016.04.006. Epub 2016 Apr 13.


Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease.

Beltran WA, Cideciyan AV, Iwabe S, Swider M, Kosyk MS, McDaid K, Martynyuk I, Ying GS, Shaffer J, Deng WT, Boye SL, Lewin AS, Hauswirth WW, Jacobson SG, Aguirre GD.

Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):E5844-53. doi: 10.1073/pnas.1509914112. Epub 2015 Oct 12.


Exclusion of the unfolded protein response in light-induced retinal degeneration in the canine T4R RHO model of autosomal dominant retinitis pigmentosa.

Marsili S, Genini S, Sudharsan R, Gingrich J, Aguirre GD, Beltran WA.

PLoS One. 2015 Feb 19;10(2):e0115723. doi: 10.1371/journal.pone.0115723. eCollection 2015.


Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells.

Gaub BM, Berry MH, Holt AE, Reiner A, Kienzler MA, Dolgova N, Nikonov S, Aguirre GD, Beltran WA, Flannery JG, Isacoff EY.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):E5574-83. doi: 10.1073/pnas.1414162111. Epub 2014 Dec 8.


Gene augmentation for X-linked retinitis pigmentosa caused by mutations in RPGR.

Beltran WA, Cideciyan AV, Lewin AS, Hauswirth WW, Jacobson SG, Aguirre GD.

Cold Spring Harb Perspect Med. 2014 Oct 9;5(2):a017392. doi: 10.1101/cshperspect.a017392. Review.


Isolation and ex vivo characterization of the immunophenotype and function of microglia/macrophage populations in normal dog retina.

Genini S, Beltran WA, Stein VM, Aguirre GD.

Adv Exp Med Biol. 2014;801:339-45. doi: 10.1007/978-1-4614-3209-8_43.


Canine retina has a primate fovea-like bouquet of cone photoreceptors which is affected by inherited macular degenerations.

Beltran WA, Cideciyan AV, Guziewicz KE, Iwabe S, Swider M, Scott EM, Savina SV, Ruthel G, Stefano F, Zhang L, Zorger R, Sumaroka A, Jacobson SG, Aguirre GD.

PLoS One. 2014 Mar 5;9(3):e90390. doi: 10.1371/journal.pone.0090390. eCollection 2014.


Altered miRNA expression in canine retinas during normal development and in models of retinal degeneration.

Genini S, Guziewicz KE, Beltran WA, Aguirre GD.

BMC Genomics. 2014 Mar 1;15:172. doi: 10.1186/1471-2164-15-172.


Up-regulation of tumor necrosis factor superfamily genes in early phases of photoreceptor degeneration.

Genini S, Beltran WA, Aguirre GD.

PLoS One. 2013 Dec 19;8(12):e85408. doi: 10.1371/journal.pone.0085408. eCollection 2013.


Recombinant AAV-mediated BEST1 transfer to the retinal pigment epithelium: analysis of serotype-dependent retinal effects.

Guziewicz KE, Zangerl B, Komáromy AM, Iwabe S, Chiodo VA, Boye SL, Hauswirth WW, Beltran WA, Aguirre GD.

PLoS One. 2013 Oct 15;8(10):e75666. doi: 10.1371/journal.pone.0075666. eCollection 2013.


Early histopathologic changes in the retina and optic nerve in canine primary angle-closure glaucoma.

Scott EM, Boursiquot N, Beltran WA, Dubielzig RR.

Vet Ophthalmol. 2013 Jul;16 Suppl 1:79-86. doi: 10.1111/vop.12046.


Reply to Townes-Anderson: RPE65 gene therapy does not alter the natural history of retinal degeneration.

Cideciyan AV, Jacobson SG, Beltran WA, Hauswirth WW, Aguirre GD.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):E1706. No abstract available.


Transient photoreceptor deconstruction by CNTF enhances rAAV-mediated cone functional rescue in late stage CNGB3-achromatopsia.

Komáromy AM, Rowlan JS, Corr AT, Reinstein SL, Boye SL, Cooper AE, Gonzalez A, Levy B, Wen R, Hauswirth WW, Beltran WA, Aguirre GD.

Mol Ther. 2013 Jun;21(6):1131-41. doi: 10.1038/mt.2013.50. Epub 2013 Apr 9.


Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement.

Cideciyan AV, Jacobson SG, Beltran WA, Sumaroka A, Swider M, Iwabe S, Roman AJ, Olivares MB, Schwartz SB, Komáromy AM, Hauswirth WW, Aguirre GD.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E517-25. doi: 10.1073/pnas.1218933110. Epub 2013 Jan 22.


Preface: Special 'retina' issue.

Komáromy AM, Beltran WA.

Vet Ophthalmol. 2012 Sep;15 Suppl 2:1-2. doi: 10.1111/j.1463-5224.2012.01060.x. No abstract available.


Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa.

Beltran WA, Cideciyan AV, Lewin AS, Iwabe S, Khanna H, Sumaroka A, Chiodo VA, Fajardo DS, Román AJ, Deng WT, Swider M, Alemán TS, Boye SL, Genini S, Swaroop A, Hauswirth WW, Jacobson SG, Aguirre GD.

Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2132-7. doi: 10.1073/pnas.1118847109. Epub 2012 Jan 23.


Development and validation of a canine-specific profiling array to examine expression of pro-apoptotic and pro-survival genes in retinal degenerative diseases.

Genini S, Beltran WA, Aguirre GD.

Adv Exp Med Biol. 2012;723:353-63. doi: 10.1007/978-1-4614-0631-0_46. No abstract available.


Photoreceptor cell death, proliferation and formation of hybrid rod/S-cone photoreceptors in the degenerating STK38L mutant retina.

Berta ÁI, Boesze-Battaglia K, Genini S, Goldstein O, O'Brien PJ, Szél Á, Acland GM, Beltran WA, Aguirre GD.

PLoS One. 2011;6(9):e24074. doi: 10.1371/journal.pone.0024074. Epub 2011 Sep 30.


Transcriptional profile analysis of RPGRORF15 frameshift mutation identifies novel genes associated with retinal degeneration.

Genini S, Zangerl B, Slavik J, Acland GM, Beltran WA, Aguirre GD.

Invest Ophthalmol Vis Sci. 2010 Nov;51(11):6038-50. doi: 10.1167/iovs.10-5443. Epub 2010 Jun 23.


rAAV2/5 gene-targeting to rods:dose-dependent efficiency and complications associated with different promoters.

Beltran WA, Boye SL, Boye SE, Chiodo VA, Lewin AS, Hauswirth WW, Aguirre GD.

Gene Ther. 2010 Sep;17(9):1162-74. doi: 10.1038/gt.2010.56. Epub 2010 Apr 29.


CREB1/ATF1 activation in photoreceptor degeneration and protection.

Beltran WA, Allore HG, Johnson E, Towle V, Tao W, Acland GM, Aguirre GD, Zeiss CJ.

Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5355-63. doi: 10.1167/iovs.09-3741. Epub 2009 Jul 30.


The use of canine models of inherited retinal degeneration to test novel therapeutic approaches.

Beltran WA.

Vet Ophthalmol. 2009 May-Jun;12(3):192-204. doi: 10.1111/j.1463-5224.2009.00694.x. Review. Erratum in: Vet Ophthalmol. 2011 Nov;14(6):423.


Age-dependent disease expression determines remodeling of the retinal mosaic in carriers of RPGR exon ORF15 mutations.

Beltran WA, Acland GM, Aguirre GD.

Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3985-95. doi: 10.1167/iovs.08-3364. Epub 2009 Feb 28.


Steroids do not prevent photoreceptor degeneration in the light-exposed T4R rhodopsin mutant dog retina irrespective of AP-1 inhibition.

Gu D, Beltran WA, Pearce-Kelling S, Li Z, Acland GM, Aguirre GD.

Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3482-94. doi: 10.1167/iovs.08-3111. Epub 2009 Feb 21.


On the role of CNTF as a potential therapy for retinal degeneration: Dr. Jekyll or Mr. Hyde?

Beltran WA.

Adv Exp Med Biol. 2008;613:45-51. Review. No abstract available.


Human cone photoreceptor dependence on RPE65 isomerase.

Jacobson SG, Aleman TS, Cideciyan AV, Heon E, Golczak M, Beltran WA, Sumaroka A, Schwartz SB, Roman AJ, Windsor EA, Wilson JM, Aguirre GD, Stone EM, Palczewski K.

Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15123-8. Epub 2007 Sep 11.


Ocular findings in two colonies of gray mouse lemurs (Microcebus murinus).

Beltran WA, Vanore M, Ollivet F, Nemoz-Bertholet F, Aujard F, Clerc B, Chahory S.

Vet Ophthalmol. 2007 Jan-Feb;10(1):43-9.


A frameshift mutation in RPGR exon ORF15 causes photoreceptor degeneration and inner retina remodeling in a model of X-linked retinitis pigmentosa.

Beltran WA, Hammond P, Acland GM, Aguirre GD.

Invest Ophthalmol Vis Sci. 2006 Apr;47(4):1669-81.


Comparative analysis and expression of CLUL1, a cone photoreceptor-specific gene.

Zhang Q, Beltran WA, Mao Z, Li K, Johnson JL, Acland GM, Aguirre GD.

Invest Ophthalmol Vis Sci. 2003 Oct;44(10):4542-9.


Cloning, mapping, and retinal expression of the canine ciliary neurotrophic factor receptor alpha (CNTFRalpha).

Beltran WA, Zhang Q, Kijas JW, Gu D, Rohrer H, Jordan JA, Aguirre GD.

Invest Ophthalmol Vis Sci. 2003 Aug;44(8):3642-9.


The electroretinographic phenotype of dogs with Golden Retriever muscular dystrophy.

Beltran WA, Chahory S, Gnirs K, Escriou C, Blot S, Clerc B.

Vet Ophthalmol. 2001 Dec;4(4):277-82.


A case of orbital hemangiopericytoma in a dog.

Beltran WA, Colle MA, Boulouha L, Daude-Lagrave A, Moissonnier P, Clerc B.

Vet Ophthalmol. 2001 Dec;4(4):255-9.


Homonymous hemianopia in a pug with necrotising meningoencephalitis.

Beltran WA, Ollivet FF.

J Small Anim Pract. 2000 Apr;41(4):161-4.


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