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Items: 1 to 50 of 63

1.

Mining large databases to find new leads with low similarity to known actives: application to find new DPP-IV inhibitors.

Ojeda-Montes MJ, Casanova-Martí À, Gimeno A, Tomás-Hernández S, Cereto-Massagué A, Wolber G, Beltrán-Debón R, Valls C, Mulero M, Pinent M, Pujadas G, Garcia-Vallvé S.

Future Med Chem. 2019 Jul 12. doi: 10.4155/fmc-2018-0597. [Epub ahead of print]

PMID:
31298576
2.

Grape-Seed Proanthocyanidins are Able to Reverse Intestinal Dysfunction and Metabolic Endotoxemia Induced by a Cafeteria Diet in Wistar Rats.

González-Quilen C, Gil-Cardoso K, Ginés I, Beltrán-Debón R, Pinent M, Ardévol A, Terra X, Blay MT.

Nutrients. 2019 Apr 29;11(5). pii: E979. doi: 10.3390/nu11050979.

3.

The Light and Dark Sides of Virtual Screening: What Is There to Know?

Gimeno A, Ojeda-Montes MJ, Tomás-Hernández S, Cereto-Massagué A, Beltrán-Debón R, Mulero M, Pujadas G, Garcia-Vallvé S.

Int J Mol Sci. 2019 Mar 19;20(6). pii: E1375. doi: 10.3390/ijms20061375. Review.

4.

Anti-inflammatory and Proapoptotic Properties of the Natural Compound o-Orsellinaldehyde.

Tomas-Hernandez S, Garcia-Vallvé S, Pujadas G, Valls C, Ojeda-Montes MJ, Gimeno A, Cereto-Massagué A, Roca-Martinez J, Suárez M, Arola L, Blanco J, Mulero M, Beltran-Debón R.

J Agric Food Chem. 2018 Oct 24;66(42):10952-10963. doi: 10.1021/acs.jafc.8b00782. Epub 2018 Oct 11.

PMID:
30269491
5.

Fluorinated triazole-containing sphingosine analogues. Syntheses and in vitro evaluation as SPHK inhibitors.

Escudero-Casao M, Cardona A, Beltrán-Debón R, Díaz Y, Matheu MI, Castillón S.

Org Biomol Chem. 2018 Oct 10;16(39):7230-7235. doi: 10.1039/c8ob01867g.

PMID:
30255187
6.

Combined Ligand- and Receptor-Based Virtual Screening Methodology to Identify Structurally Diverse Protein Tyrosine Phosphatase 1B Inhibitors.

Gimeno A, Ardid-Ruiz A, Ojeda-Montes MJ, Tomás-Hernández S, Cereto-Massagué A, Beltrán-Debón R, Mulero M, Valls C, Aragonès G, Suárez M, Pujadas G, Garcia-Vallvé S.

ChemMedChem. 2018 Sep 19;13(18):1939-1948. doi: 10.1002/cmdc.201800267. Epub 2018 Aug 23.

PMID:
30024103
7.

Circulating metabolomic profile can predict dyslipidemia in HIV patients undergoing antiretroviral therapy.

Rodríguez-Gallego E, Gómez J, Domingo P, Ferrando-Martínez S, Peraire J, Viladés C, Veloso S, López-Dupla M, Beltrán-Debón R, Alba V, Vargas M, Castellano AJ, Leal M, Pacheco YM, Ruiz-Mateos E, Gutiérrez F, Vidal F, Rull A; CORIS-NADES events Study Group.

Atherosclerosis. 2018 Jun;273:28-36. doi: 10.1016/j.atherosclerosis.2018.04.008. Epub 2018 Apr 9.

8.

Activity and selectivity cliffs for DPP-IV inhibitors: Lessons we can learn from SAR studies and their application to virtual screening.

Ojeda-Montes MJ, Gimeno A, Tomas-Hernández S, Cereto-Massagué A, Beltrán-Debón R, Valls C, Mulero M, Pujadas G, Garcia-Vallvé S.

Med Res Rev. 2018 Sep;38(6):1874-1915. doi: 10.1002/med.21499. Epub 2018 Apr 16. Review.

PMID:
29660786
9.

Resveratrol Potently Counteracts Quercetin Starvation-Induced Autophagy and Sensitizes HepG2 Cancer Cells to Apoptosis.

Tomas-Hernández S, Blanco J, Rojas C, Roca-Martínez J, Ojeda-Montes MJ, Beltrán-Debón R, Garcia-Vallvé S, Pujadas G, Arola L, Mulero M.

Mol Nutr Food Res. 2018 Mar;62(5). doi: 10.1002/mnfr.201700610. Epub 2018 Feb 22.

PMID:
29336118
10.

A baseline metabolomic signature is associated with immunological CD4+ T-cell recovery after 36 months of antiretroviral therapy in HIV-infected patients.

Rodríguez-Gallego E, Gómez J, Pacheco YM, Peraire J, Viladés C, Beltrán-Debón R, Mallol R, López-Dupla M, Veloso S, Alba V, Blanco J, Cañellas N, Rull A, Leal M, Correig X, Domingo P, Vidal F.

AIDS. 2018 Mar 13;32(5):565-573. doi: 10.1097/QAD.0000000000001730.

11.

Ephedrine as a lead compound for the development of new DPP-IV inhibitors.

Ojeda-Montes MJ, Ardid-Ruiz A, Tomás-Hernández S, Gimeno A, Cereto-Massagué A, Beltrán-Debón R, Mulero M, Garcia-Vallvé S, Pujadas G, Valls C.

Future Med Chem. 2017 Dec;9(18):2129-2146. doi: 10.4155/fmc-2017-0080. Epub 2017 Nov 27.

PMID:
29172693
12.

MicroRNAs Clustered within the 14q32 Locus Are Associated with Endothelial Damage and Microparticle Secretion in Bicuspid Aortic Valve Disease.

Martínez-Micaelo N, Beltrán-Debón R, Aragonés G, Faiges M, Alegret JM.

Front Physiol. 2017 Sep 5;8:648. doi: 10.3389/fphys.2017.00648. eCollection 2017.

13.

Specific circulating microRNA signature of bicuspid aortic valve disease.

Martínez-Micaelo N, Beltrán-Debón R, Baiges I, Faiges M, Alegret JM.

J Transl Med. 2017 Apr 11;15(1):76. doi: 10.1186/s12967-017-1176-x.

14.

Inferring propagation paths for sparsely observed perturbations on complex networks.

Massucci FA, Wheeler J, Beltrán-Debón R, Joven J, Sales-Pardo M, Guimerà R.

Sci Adv. 2016 Oct 21;2(10):e1501638. eCollection 2016 Oct.

15.

Data on the circulating levels of endothelial microparticles are elevated in patients with bicuspid aortic valve and are related to aortic dilation.

Alegret JM, Martínez-Micaelo N, Aragonès G, Beltrán-Debón R.

Data Brief. 2016 Jun 23;8:666-9. doi: 10.1016/j.dib.2016.06.026. eCollection 2016 Sep.

16.

Circulating endothelial microparticles are elevated in bicuspid aortic valve disease and related to aortic dilation.

Alegret JM, Martínez-Micaelo N, Aragonès G, Beltrán-Debón R.

Int J Cardiol. 2016 Aug 15;217:35-41. doi: 10.1016/j.ijcard.2016.04.184. Epub 2016 May 3.

PMID:
27179206
17.

HIV-1/HAART-Related Lipodystrophy Syndrome (HALS) Is Associated with Decreased Circulating sTWEAK Levels.

López-Dupla M, Maymó-Masip E, Martínez E, Domingo P, Leal M, Peraire J, Viladés C, Veloso S, Arnedo M, Ferrando-Martínez S, Beltrán-Debón R, Alba V, Gatell JM, Vendrell J, Vidal F, Chacón MR.

PLoS One. 2015 Dec 14;10(12):e0144789. doi: 10.1371/journal.pone.0144789. eCollection 2015.

18.

The acute impact of polyphenols from Hibiscus sabdariffa in metabolic homeostasis: an approach combining metabolomics and gene-expression analyses.

Beltrán-Debón R, Rodríguez-Gallego E, Fernández-Arroyo S, Senan-Campos O, Massucci FA, Hernández-Aguilera A, Sales-Pardo M, Guimerà R, Camps J, Menendez JA, Joven J.

Food Funct. 2015 Sep;6(9):2957-66. doi: 10.1039/c5fo00696a.

PMID:
26234931
19.

Liver fat deposition and mitochondrial dysfunction in morbid obesity: An approach combining metabolomics with liver imaging and histology.

Calvo N, Beltrán-Debón R, Rodríguez-Gallego E, Hernández-Aguilera A, Guirro M, Mariné-Casadó R, Millá L, Alegret JM, Sabench F, del Castillo D, Vinaixa M, Rodríguez MÀ, Correig X, García-Álvarez R, Menendez JA, Camps J, Joven J.

World J Gastroenterol. 2015 Jun 28;21(24):7529-44. doi: 10.3748/wjg.v21.i24.7529.

20.

HIV/antiretroviral therapy-related lipodystrophy syndrome (HALS) is associated with higher RBP4 and lower omentin in plasma.

Peraire J, López-Dupla M, Alba V, Beltrán-Debón R, Martinez E, Domingo P, Asensi V, Leal M, Viladés C, Inza MI, Escoté X, Arnedo M, Mateo G, Valle-Garay E, Ferrando-Martinez S, Veloso S, Vendrell J, Gatell JM, Vidal F; HIV-1 Lipodystrophy Study Group.

Clin Microbiol Infect. 2015 Jul;21(7):711.e1-8. doi: 10.1016/j.cmi.2015.04.002. Epub 2015 Apr 14.

21.

Significant in vivo anti-inflammatory activity of Pytren4Q-Mn a superoxide dismutase 2 (SOD2) mimetic scorpiand-like Mn (II) complex.

Serena C, Calvo E, Clares MP, Diaz ML, Chicote JU, Beltrán-Debon R, Fontova R, Rodriguez A, García-España E, García-España A.

PLoS One. 2015 Mar 5;10(3):e0119102. doi: 10.1371/journal.pone.0119102. eCollection 2015.

22.

LDL cholesterol and apolipoprotein B are associated with ascending aorta dilatation in bicuspid aortic valve patients.

Alegret JM, Masana L, Martinez-Micaelo N, Heras M, Beltrán-Debón R.

QJM. 2015 Oct;108(10):795-801. doi: 10.1093/qjmed/hcv032. Epub 2015 Feb 5.

PMID:
25660598
23.

Acute effect of static exercise on the cardiovascular system: assessment by cardiovascular magnetic resonance.

Alegret JM, Beltrán-Debón R, La Gerche A, Franco-Bonafonte L, Rubio-Pérez F, Calvo N, Montero M.

Eur J Appl Physiol. 2015 Jun;115(6):1195-203. doi: 10.1007/s00421-015-3101-4. Epub 2015 Jan 10.

PMID:
25576263
24.

Mapping of the circulating metabolome reveals α-ketoglutarate as a predictor of morbid obesity-associated non-alcoholic fatty liver disease.

Rodríguez-Gallego E, Guirro M, Riera-Borrull M, Hernández-Aguilera A, Mariné-Casadó R, Fernández-Arroyo S, Beltrán-Debón R, Sabench F, Hernández M, del Castillo D, Menendez JA, Camps J, Ras R, Arola L, Joven J.

Int J Obes (Lond). 2015 Feb;39(2):279-87. doi: 10.1038/ijo.2014.53. Epub 2014 Mar 28.

PMID:
24675715
25.

Hibiscus sabdariffa extract lowers blood pressure and improves endothelial function.

Joven J, March I, Espinel E, Fernández-Arroyo S, Rodríguez-Gallego E, Aragonès G, Beltrán-Debón R, Alonso-Villaverde C, Rios L, Martin-Paredero V, Menendez JA, Micol V, Segura-Carretero A, Camps J.

Mol Nutr Food Res. 2014 Jun;58(6):1374-8. doi: 10.1002/mnfr.201300774. Epub 2014 Feb 24.

PMID:
24668839
26.

Rosiglitazone and fenofibrate exacerbate liver steatosis in a mouse model of obesity and hyperlipidemia. A transcriptomic and metabolomic study.

Rull A, Geeraert B, Aragonès G, Beltrán-Debón R, Rodríguez-Gallego E, García-Heredia A, Pedro-Botet J, Joven J, Holvoet P, Camps J.

J Proteome Res. 2014 Mar 7;13(3):1731-43. doi: 10.1021/pr401230s. Epub 2014 Jan 30.

PMID:
24479691
27.

Ubiquitous transgenic overexpression of C-C chemokine ligand 2: a model to assess the combined effect of high energy intake and continuous low-grade inflammation.

Rodríguez-Gallego E, Riera-Borrull M, Hernández-Aguilera A, Mariné-Casadó R, Rull A, Beltrán-Debón R, Luciano-Mateo F, Menendez JA, Vazquez-Martin A, Sirvent JJ, Martín-Paredero V, Corbí AL, Sierra-Filardi E, Aragonès G, García-Heredia A, Camps J, Alonso-Villaverde C, Joven J.

Mediators Inflamm. 2013;2013:953841. doi: 10.1155/2013/953841. Epub 2013 Dec 15.

28.

A possible role for CCR5 in the progression of atherosclerosis in HIV-infected patients: a cross-sectional study.

Fernández-Sender L, Alonso-Villaverde C, Rull A, Rodríguez-Gallego E, Riera-Borrull M, Hernández-Aguilera A, Camps J, Beltrán-Debón R, Aragonès G, Menendez JA, Joven J.

AIDS Res Ther. 2013 May 9;10(1):11. doi: 10.1186/1742-6405-10-11.

29.

The relevance of the association between inflammation and atrial fibrillation.

Alegret JM, Aragonès G, Elosua R, Beltrán-Debón R, Hernández-Aguilera A, Romero-Menor C, Camps J, Joven J.

Eur J Clin Invest. 2013 Apr;43(4):324-31. doi: 10.1111/eci.12047. Epub 2013 Feb 11.

PMID:
23397981
30.

Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil: a new family of gerosuppressant agents.

Menendez JA, Joven J, Aragonès G, Barrajón-Catalán E, Beltrán-Debón R, Borrás-Linares I, Camps J, Corominas-Faja B, Cufí S, Fernández-Arroyo S, Garcia-Heredia A, Hernández-Aguilera A, Herranz-López M, Jiménez-Sánchez C, López-Bonet E, Lozano-Sánchez J, Luciano-Mateo F, Martin-Castillo B, Martin-Paredero V, Pérez-Sánchez A, Oliveras-Ferraros C, Riera-Borrull M, Rodríguez-Gallego E, Quirantes-Piné R, Rull A, Tomás-Menor L, Vazquez-Martin A, Alonso-Villaverde C, Micol V, Segura-Carretero A.

Cell Cycle. 2013 Feb 15;12(4):555-78. doi: 10.4161/cc.23756. Epub 2013 Jan 31.

31.

Factors related to the need for surgery after the diagnosis of bicuspid aortic valve: one center´s experience under a conservative approach.

Alegret JM, Ligero C, Vernis JM, Beltrán-Debón R, Aragonés G, Duran I, Palazón O, Hernández-Aparicio A.

Int J Med Sci. 2013;10(2):176-82. doi: 10.7150/ijms.5399. Epub 2013 Jan 9.

32.

Metformin: a cheap and well-tolerated drug that provides benefits for viral infections.

Joven J, Menéndez JA, Fernandez-Sender L, Espinel E, Rull A, Beltrán-Debón R, Rodríguez-Gallego E, Riera-Borrull M, Pedro-Botet J, Alonso-Villaverde C, Camps J, Aragonès G.

HIV Med. 2013 Apr;14(4):233-40. doi: 10.1111/hiv.12000. Epub 2012 Nov 21.

33.

Exploring PPAR modulation in experimental mice.

Rull A, Aragonès G, Beltrán-Debón R, Rodríguez-Gallego E, Camps J, Joven J.

Methods Mol Biol. 2013;952:253-73. doi: 10.1007/978-1-62703-155-4_19.

PMID:
23100239
34.

Bioavailability study of a polyphenol-enriched extract from Hibiscus sabdariffa in rats and associated antioxidant status.

Fernández-Arroyo S, Herranz-López M, Beltrán-Debón R, Borrás-Linares I, Barrajón-Catalán E, Joven J, Fernández-Gutiérrez A, Segura-Carretero A, Micol V.

Mol Nutr Food Res. 2012 Oct;56(10):1590-5. doi: 10.1002/mnfr.201200091. Epub 2012 Aug 15.

PMID:
22893520
35.

The deleterious influence of tenofovir-based therapies on the progression of atherosclerosis in HIV-infected patients.

Aragonès G, Pardo-Reche P, Fernández-Sender L, Rull A, Beltrán-Debón R, Rodríguez-Gallego E, Camps J, Joven J, Alonso-Villaverde C.

Mediators Inflamm. 2012;2012:372305. doi: 10.1155/2012/372305. Epub 2012 May 7.

36.

Plant-derived polyphenols regulate expression of miRNA paralogs miR-103/107 and miR-122 and prevent diet-induced fatty liver disease in hyperlipidemic mice.

Joven J, Espinel E, Rull A, Aragonès G, Rodríguez-Gallego E, Camps J, Micol V, Herranz-López M, Menéndez JA, Borrás I, Segura-Carretero A, Alonso-Villaverde C, Beltrán-Debón R.

Biochim Biophys Acta. 2012 Jul;1820(7):894-9. doi: 10.1016/j.bbagen.2012.03.020. Epub 2012 Apr 5.

PMID:
22503922
37.

The level of DING proteins is increased in HIV-infected patients: in vitro and in vivo studies.

Djeghader A, Aragonès G, Darbinian N, Elias M, Gonzalez D, García-Heredia A, Beltrán-Debón R, Kaminski R, Gotthard G, Hiblot J, Rull A, Rohr O, Schwartz C, Alonso-Villaverde C, Joven J, Camps J, Chabriere E.

PLoS One. 2012;7(3):e33062. doi: 10.1371/journal.pone.0033062. Epub 2012 Mar 9.

38.

Human Duffy blood group alloantigen system influences the measurement of monocyte chemoattractant protein-1 (MCP-1) in serum but not in plasma.

Aragonès G, Ercilla A, Barreda M, Rull A, Beltrán-Debón R, Rodríguez-Gallego E, Alonso-Villaverde C, Camps J, Joven J.

Clin Lab. 2012;58(1-2):185-8.

PMID:
22372364
39.

PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways.

Camps J, García-Heredia A, Rull A, Alonso-Villaverde C, Aragonès G, Beltrán-Debón R, Rodríguez-Gallego E, Joven J.

PPAR Res. 2012;2012:616371. doi: 10.1155/2012/616371. Epub 2012 Jan 24.

40.

Synergism of plant-derived polyphenols in adipogenesis: perspectives and implications.

Herranz-López M, Fernández-Arroyo S, Pérez-Sanchez A, Barrajón-Catalán E, Beltrán-Debón R, Menéndez JA, Alonso-Villaverde C, Segura-Carretero A, Joven J, Micol V.

Phytomedicine. 2012 Feb 15;19(3-4):253-61. doi: 10.1016/j.phymed.2011.12.001. Epub 2012 Jan 24.

PMID:
22280831
41.

Serum paraoxonase-3 concentration is associated with insulin sensitivity in peripheral artery disease and with inflammation in coronary artery disease.

Rull A, García R, Fernández-Sender L, García-Heredia A, Aragonès G, Beltrán-Debón R, Marsillach J, Alegret JM, Martín-Paredero V, Mackness B, Mackness M, Joven J, Camps J.

Atherosclerosis. 2012 Feb;220(2):545-51. doi: 10.1016/j.atherosclerosis.2011.11.021. Epub 2011 Nov 22.

PMID:
22153698
42.

Serum paraoxonase-3 concentration in HIV-infected patients. Evidence for a protective role against oxidation.

Aragonès G, García-Heredia A, Guardiola M, Rull A, Beltrán-Debón R, Marsillach J, Alonso-Villaverde C, Mackness B, Mackness M, Pedro-Botet J, Pardo-Reche P, Joven J, Camps J.

J Lipid Res. 2012 Jan;53(1):168-74. doi: 10.1194/jlr.P018457. Epub 2011 Oct 14.

43.

Antiretroviral treatment-induced dyslipidemia in HIV-infected patients is influenced by the APOC3-related rs10892151 polymorphism.

Aragonès G, Alonso-Villaverde C, Pardo-Reche P, Rull A, Beltrán-Debón R, Rodríguez-Gallego E, Fernández-Sender L, Camps J, Joven J.

BMC Med Genet. 2011 Sep 22;12:120. doi: 10.1186/1471-2350-12-120.

44.

Serum paraoxonase-3 concentration is associated with the severity of hepatic impairment in patients with chronic liver disease.

García-Heredia A, Marsillach J, Aragonès G, Guardiola M, Rull A, Beltrán-Debón R, Folch A, Mackness B, Mackness M, Pedro-Botet J, Joven J, Camps J.

Clin Biochem. 2011 Nov;44(16):1320-4. doi: 10.1016/j.clinbiochem.2011.08.003. Epub 2011 Aug 10.

PMID:
21854763
45.

The role of combined assessment of defense against oxidative stress and inflammation in the evaluation of peripheral arterial disease.

Rull A, García R, Fernández-Sender L, Beltrán-Debón R, Aragonès G, Alegret JM, Alonso-Villaverde C, Mackness B, Mackness M, Camps J, Martin-Paredero V, Joven J.

Curr Mol Med. 2011 Aug;11(6):453-64.

PMID:
21663591
46.

Serum fatty acid synthase concentration is increased in patients with hepatitis viral infection and may assist in the prediction of liver steatosis.

Joven J, Espinel E, Rull A, Beltrán-Debón R, Aragonès G, Rodríguez-Gallego E, Camps J, Pedro-Botet J, Sans T, Menéndez JA, Alonso-Villaverde C.

J Clin Virol. 2011 Jul;51(3):199-201. doi: 10.1016/j.jcv.2011.04.003. Epub 2011 May 8.

PMID:
21555238
47.

Identification of phenolic compounds in aqueous and ethanolic rooibos extracts (Aspalathus linearis) by HPLC-ESI-MS (TOF/IT).

Iswaldi I, Arráez-Román D, Rodríguez-Medina I, Beltrán-Debón R, Joven J, Segura-Carretero A, Fernández-Gutiérrez A.

Anal Bioanal Chem. 2011 Jul;400(10):3643-54. doi: 10.1007/s00216-011-4998-z. Epub 2011 Apr 21.

PMID:
21509483
48.

Measurement of serum PON-3 concentration: method evaluation, reference values, and influence of genotypes in a population-based study.

Aragonès G, Guardiola M, Barreda M, Marsillach J, Beltrán-Debón R, Rull A, Mackness B, Mackness M, Joven J, Simó JM, Camps J.

J Lipid Res. 2011 May;52(5):1055-61. doi: 10.1194/jlr.D014134. Epub 2011 Feb 17.

49.

Continuous administration of polyphenols from aqueous rooibos (Aspalathus linearis) extract ameliorates dietary-induced metabolic disturbances in hyperlipidemic mice.

Beltrán-Debón R, Rull A, Rodríguez-Sanabria F, Iswaldi I, Herranz-López M, Aragonès G, Camps J, Alonso-Villaverde C, Menéndez JA, Micol V, Segura-Carretero A, Joven J.

Phytomedicine. 2011 Mar 15;18(5):414-24. doi: 10.1016/j.phymed.2010.11.008. Epub 2011 Jan 5.

PMID:
21211952
50.

Paraoxonase-1 is only present in traceable amounts in seminal fluid and does not show any relationship with male subfertility.

Marsillach J, Lafuente R, Checa MA, Maestre-Martínez C, Fabián E, Brassesco M, Beltrán-Debón R, Aragonès G, Carreras R, Pedro-Botet J, Joven J, Camps J.

BJU Int. 2011 Aug;108(4):566-70. doi: 10.1111/j.1464-410X.2010.09888.x. Epub 2010 Nov 23.

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