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Global extracellular vesicle proteomic signature defines U87-MG glioma cell hypoxic status with potential implications for non-invasive diagnostics.

Indira Chandran V, Welinder C, Gonçalves de Oliveira K, Cerezo-Magaña M, Månsson AS, Johansson MC, Marko-Varga G, Belting M.

J Neurooncol. 2019 Sep;144(3):477-488. doi: 10.1007/s11060-019-03262-4. Epub 2019 Aug 14.


Low-molecular-weight heparin adherence and effects on survival within a randomised phase III lung cancer trial (RASTEN).

Gezelius E, Bendahl PO, Gonçalves de Oliveira K, Ek L, Bergman B, Sundberg J, Strandberg K, Krämer R, Belting M.

Eur J Cancer. 2019 Sep;118:82-90. doi: 10.1016/j.ejca.2019.06.015. Epub 2019 Jul 18.


The pleiotropic role of proteoglycans in extracellular vesicle mediated communication in the tumor microenvironment.

Cerezo-Magaña M, Bång-Rudenstam A, Belting M.

Semin Cancer Biol. 2019 Jul 2. pii: S1044-579X(19)30162-2. doi: 10.1016/j.semcancer.2019.07.001. [Epub ahead of print] Review.


Extracellular lipid loading augments hypoxic paracrine signaling and promotes glioma angiogenesis and macrophage infiltration.

Offer S, Menard JA, Pérez JE, de Oliveira KG, Chandran VI, Johansson MC, Bång-Rudenstam A, Siesjö P, Ebbesson A, Hedenfalk I, Sundgren PC, Darabi A, Belting M.

J Exp Clin Cancer Res. 2019 Jun 7;38(1):241. doi: 10.1186/s13046-019-1228-6.


Biomarkers of venous thromboembolism in cancer: a silent echo from local events?

Gezelius E, Belting M.

Biomark Med. 2019 May;13(7):507-509. doi: 10.2217/bmm-2019-0132. Epub 2019 May 29. No abstract available.


Pro-metastatic functions of lipoproteins and extracellular vesicles in the acidic tumor microenvironment.

Bång-Rudenstam A, Cerezo-Magaña M, Belting M.

Cancer Metastasis Rev. 2019 Jun;38(1-2):79-92. doi: 10.1007/s10555-019-09786-5. Review.


Ultrasensitive Immunoprofiling of Plasma Extracellular Vesicles Identifies Syndecan-1 as a Potential Tool for Minimally Invasive Diagnosis of Glioma.

Indira Chandran V, Welinder C, Månsson AS, Offer S, Freyhult E, Pernemalm M, Lund SM, Pedersen S, Lehtiö J, Marko-Varga G, Johansson MC, Englund E, Sundgren PC, Belting M.

Clin Cancer Res. 2019 May 15;25(10):3115-3127. doi: 10.1158/1078-0432.CCR-18-2946. Epub 2019 Jan 24.


Protein array profiling of circulating angiogenesis-related factors during bevacizumab containing treatment in metastatic colorectal cancer.

Hagman H, Bendahl PO, Lidfeldt J, Belting M, Johnsson A.

PLoS One. 2018 Dec 28;13(12):e0209838. doi: 10.1371/journal.pone.0209838. eCollection 2018.


Coagulation biomarkers and prediction of venous thromboembolism and survival in small cell lung cancer: A sub-study of RASTEN - A randomized trial with low molecular weight heparin.

Gezelius E, Flou Kristensen A, Bendahl PO, Hisada Y, Risom Kristensen S, Ek L, Bergman B, Wallberg M, Falkmer U, Mackman N, Pedersen S, Belting M.

PLoS One. 2018 Nov 9;13(11):e0207387. doi: 10.1371/journal.pone.0207387. eCollection 2018.


Durable response to mTOR inhibition in a patient with relapsing papillary tumor of the pineal region.

Belting M, Bång-Rudenstam A, Englund E, Pietsch T.

Neuro Oncol. 2019 Jan 1;21(1):137-138. doi: 10.1093/neuonc/noy153. No abstract available.


Functional role of extracellular vesicles and lipoproteins in the tumour microenvironment.

Menard JA, Cerezo-Magaña M, Belting M.

Philos Trans R Soc Lond B Biol Sci. 2018 Jan 5;373(1737). pii: 20160480. doi: 10.1098/rstb.2016.0480. Review.


Randomized phase III trial of low-molecular-weight heparin enoxaparin in addition to standard treatment in small-cell lung cancer: the RASTEN trial.

Ek L, Gezelius E, Bergman B, Bendahl PO, Anderson H, Sundberg J, Wallberg M, Falkmer U, Verma S, Belting M; Swedish Lung Cancer Study Group (SLUSG).

Ann Oncol. 2018 Feb 1;29(2):398-404. doi: 10.1093/annonc/mdx716.


Tumor antigen glycosaminoglycan modification regulates antibody-drug conjugate delivery and cytotoxicity.

Christianson HC, Menard JA, Chandran VI, Bourseau-Guilmain E, Shevela D, Lidfeldt J, Månsson AS, Pastorekova S, Messinger J, Belting M.

Oncotarget. 2017 Apr 7;8(40):66960-66974. doi: 10.18632/oncotarget.16921. eCollection 2017 Sep 15.


Mitochondria chaperone GRP75 moonlighting as a cell cycle controller to derail endocytosis provides an opportunity for nanomicrosphere intracellular delivery.

Gao Z, Niu X, Zhang Q, Chen H, Gao A, Qi S, Xiang R, Belting M, Zhang S.

Oncotarget. 2017 Apr 19;8(35):58536-58552. doi: 10.18632/oncotarget.17234. eCollection 2017 Aug 29.


Syncytiotrophoblast derived extracellular vesicles transfer functional placental miRNAs to primary human endothelial cells.

Cronqvist T, Tannetta D, Mörgelin M, Belting M, Sargent I, Familari M, Hansson SR.

Sci Rep. 2017 Jul 4;7(1):4558. doi: 10.1038/s41598-017-04468-0.


Vasoactive peptides associate with treatment outcome ofbevacizumab-containing therapy in metastatic colorectal cancer.

Hagman H, Bendahl PO, Melander O, Sundberg J, Johnsson A, Belting M.

Acta Oncol. 2017 May;56(5):653-660. doi: 10.1080/0284186X.2017.1302098. Epub 2017 Mar 17.


Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis.

Evans CE, Palazon A, Sim J, Tyrakis PA, Prodger A, Lu X, Chan S, Bendahl PO, Belting M, Von Euler L, Rundqvist H, Johnson RS, Branco C.

Biol Open. 2017 May 15;6(5):688-697. doi: 10.1242/bio.024653.


Nucleolin is a nuclear target of heparan sulfate derived from glypican-1.

Cheng F, Belting M, Fransson LÅ, Mani K.

Exp Cell Res. 2017 May 1;354(1):31-39. doi: 10.1016/j.yexcr.2017.03.021. Epub 2017 Mar 12.


Targeting of non-cycling cells of hypoxic tumors.

Bourseau-Guilmain E, Menard JA, Belting M.

Cell Cycle. 2016 Nov;15(21):2848-2849. Epub 2016 Jun 29. No abstract available.


Metastasis Stimulation by Hypoxia and Acidosis-Induced Extracellular Lipid Uptake Is Mediated by Proteoglycan-Dependent Endocytosis.

Menard JA, Christianson HC, Kucharzewska P, Bourseau-Guilmain E, Svensson KJ, Lindqvist E, Indira Chandran V, Kjellén L, Welinder C, Bengzon J, Johansson MC, Belting M.

Cancer Res. 2016 Aug 15;76(16):4828-40. doi: 10.1158/0008-5472.CAN-15-2831. Epub 2016 May 19.


Hypoxia regulates global membrane protein endocytosis through caveolin-1 in cancer cells.

Bourseau-Guilmain E, Menard JA, Lindqvist E, Indira Chandran V, Christianson HC, Cerezo Magaña M, Lidfeldt J, Marko-Varga G, Welinder C, Belting M.

Nat Commun. 2016 Apr 20;7:11371. doi: 10.1038/ncomms11371.


GRP75 upregulates clathrin-independent endocytosis through actin cytoskeleton reorganization mediated by the concurrent activation of Cdc42 and RhoA.

Chen H, Gao Z, He C, Xiang R, van Kuppevelt TH, Belting M, Zhang S.

Exp Cell Res. 2016 May 1;343(2):223-236. doi: 10.1016/j.yexcr.2016.04.009. Epub 2016 Apr 22.


Hypoxia induces NO-dependent release of heparan sulfate in fibroblasts from the Alzheimer mouse Tg2576 by activation of nitrite reduction.

Cheng F, Bourseau-Guilmain E, Belting M, Fransson LÅ, Mani K.

Glycobiology. 2016 Jun;26(6):623-34. doi: 10.1093/glycob/cww007. Epub 2016 Jan 20.


Diverse roles of cell-specific hypoxia-inducible factor 1 in cancer-associated hypercoagulation.

Evans CE, Bendahl PO, Belting M, Branco C, Johnson RS.

Blood. 2016 Mar 10;127(10):1355-60. doi: 10.1182/blood-2015-09-671982. Epub 2015 Dec 23.


Protease Activated Receptors 1 and 2 Correlate Differently with Breast Cancer Aggressiveness Depending on Tumor ER Status.

Lidfeldt J, Bendahl PO, Forsare C, Malmström P, Fernö M, Belting M.

PLoS One. 2015 Aug 5;10(8):e0134932. doi: 10.1371/journal.pone.0134932. eCollection 2015.


Stable Peptide of the Endogenous Opioid Enkephalin Precursor and Breast Cancer Risk.

Melander O, Orho-Melander M, Manjer J, Svensson T, Almgren P, Nilsson PM, Engström G, Hedblad B, Borgquist S, Hartmann O, Struck J, Bergmann A, Belting M.

J Clin Oncol. 2015 Aug 20;33(24):2632-8. doi: 10.1200/JCO.2014.59.7682. Epub 2015 Jul 13.


Role of exosomes and microvesicles in hypoxia-associated tumour development and cardiovascular disease.

Belting M, Christianson HC.

J Intern Med. 2015 Sep;278(3):251-63. doi: 10.1111/joim.12393. Epub 2015 Jul 8. Review.


Extracellular vesicles, tissue factor, cancer and thrombosis - discussion themes of the ISEV 2014 Educational Day.

Gardiner C, Harrison P, Belting M, Böing A, Campello E, Carter BS, Collier ME, Coumans F, Ettelaie C, van Es N, Hochberg FH, Mackman N, Rennert RC, Thaler J, Rak J, Nieuwland R.

J Extracell Vesicles. 2015 Mar 13;4:26901. doi: 10.3402/jev.v4.26901. eCollection 2015.


Global profiling of metabolic adaptation to hypoxic stress in human glioblastoma cells.

Kucharzewska P, Christianson HC, Belting M.

PLoS One. 2015 Jan 29;10(1):e0116740. doi: 10.1371/journal.pone.0116740. eCollection 2015.


EVpedia: a community web portal for extracellular vesicles research.

Kim DK, Lee J, Kim SR, Choi DS, Yoon YJ, Kim JH, Go G, Nhung D, Hong K, Jang SC, Kim SH, Park KS, Kim OY, Park HT, Seo JH, Aikawa E, Baj-Krzyworzeka M, van Balkom BW, Belting M, Blanc L, Bond V, Bongiovanni A, Borràs FE, Buée L, Buzás EI, Cheng L, Clayton A, Cocucci E, Dela Cruz CS, Desiderio DM, Di Vizio D, Ekström K, Falcon-Perez JM, Gardiner C, Giebel B, Greening DW, Gross JC, Gupta D, Hendrix A, Hill AF, Hill MM, Nolte-'t Hoen E, Hwang DW, Inal J, Jagannadham MV, Jayachandran M, Jee YK, Jørgensen M, Kim KP, Kim YK, Kislinger T, Lässer C, Lee DS, Lee H, van Leeuwen J, Lener T, Liu ML, Lötvall J, Marcilla A, Mathivanan S, Möller A, Morhayim J, Mullier F, Nazarenko I, Nieuwland R, Nunes DN, Pang K, Park J, Patel T, Pocsfalvi G, Del Portillo H, Putz U, Ramirez MI, Rodrigues ML, Roh TY, Royo F, Sahoo S, Schiffelers R, Sharma S, Siljander P, Simpson RJ, Soekmadji C, Stahl P, Stensballe A, Stępień E, Tahara H, Trummer A, Valadi H, Vella LJ, Wai SN, Witwer K, Yáñez-Mó M, Youn H, Zeidler R, Gho YS.

Bioinformatics. 2015 Mar 15;31(6):933-9. doi: 10.1093/bioinformatics/btu741. Epub 2014 Nov 10.


Deubiquitination of γ-tubulin by BAP1 prevents chromosome instability in breast cancer cells.

Zarrizi R, Menard JA, Belting M, Massoumi R.

Cancer Res. 2014 Nov 15;74(22):6499-508. doi: 10.1158/0008-5472.CAN-14-0221. Epub 2014 Sep 16.


Validation of plasma proneurotensin as a novel biomarker for the prediction of incident breast cancer.

Melander O, Belting M, Manjer J, Maisel AS, Hedblad B, Engström G, Nilsson P, Struck J, Hartmann O, Bergmann A, Orho-Melander M.

Cancer Epidemiol Biomarkers Prev. 2014 Aug;23(8):1672-6. doi: 10.1158/1055-9965.EPI-13-1200. Epub 2014 Jun 12.


Glycosaminoglycans in cancer treatment.

Belting M.

Thromb Res. 2014 May;133 Suppl 2:S95-101. doi: 10.1016/S0049-3848(14)50016-3. Review.


Exosome and microvesicle mediated phene transfer in mammalian cells.

Christianson HC, Svensson KJ, Belting M.

Semin Cancer Biol. 2014 Oct;28:31-8. doi: 10.1016/j.semcancer.2014.04.007. Epub 2014 Apr 23. Review.


Heparan sulfate proteoglycan as a cell-surface endocytosis receptor.

Christianson HC, Belting M.

Matrix Biol. 2014 Apr;35:51-5. doi: 10.1016/j.matbio.2013.10.004. Epub 2013 Oct 18. Review.


Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity.

Christianson HC, Svensson KJ, van Kuppevelt TH, Li JP, Belting M.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17380-5. doi: 10.1073/pnas.1304266110. Epub 2013 Oct 7.


Emerging roles of extracellular vesicles in the adaptive response of tumour cells to microenvironmental stress.

Kucharzewska P, Belting M.

J Extracell Vesicles. 2013 Mar 5;2. doi: 10.3402/jev.v2i0.20304. Review.


Exosome uptake depends on ERK1/2-heat shock protein 27 signaling and lipid Raft-mediated endocytosis negatively regulated by caveolin-1.

Svensson KJ, Christianson HC, Wittrup A, Bourseau-Guilmain E, Lindqvist E, Svensson LM, Mörgelin M, Belting M.

J Biol Chem. 2013 Jun 14;288(24):17713-24. doi: 10.1074/jbc.M112.445403. Epub 2013 May 7.


Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development.

Kucharzewska P, Christianson HC, Welch JE, Svensson KJ, Fredlund E, Ringnér M, Mörgelin M, Bourseau-Guilmain E, Bengzon J, Belting M.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7312-7. doi: 10.1073/pnas.1220998110. Epub 2013 Apr 15.


G protein-coupled estrogen receptor is apoptotic and correlates with increased distant disease-free survival of estrogen receptor-positive breast cancer patients.

Broselid S, Cheng B, Sjöström M, Lövgren K, Klug-De Santiago HL, Belting M, Jirström K, Malmström P, Olde B, Bendahl PO, Hartman L, Fernö M, Leeb-Lundberg LM.

Clin Cancer Res. 2013 Apr 1;19(7):1681-92. doi: 10.1158/1078-0432.CCR-12-2376.


Role of extracellular membrane vesicles in intercellular communication of the tumour microenvironment.

Svensson KJ, Belting M.

Biochem Soc Trans. 2013 Feb 1;41(1):273-6. doi: 10.1042/BST20120248.


Plasma proneurotensin and incidence of diabetes, cardiovascular disease, breast cancer, and mortality.

Melander O, Maisel AS, Almgren P, Manjer J, Belting M, Hedblad B, Engström G, Kilger U, Nilsson P, Bergmann A, Orho-Melander M.

JAMA. 2012 Oct 10;308(14):1469-75. doi: 10.1001/jama.2012.12998.


Standardization and utilization of biobank resources in clinical protein science with examples of emerging applications.

Marko-Varga G, Végvári Á, Welinder C, Lindberg H, Rezeli M, Edula G, Svensson KJ, Belting M, Laurell T, Fehniger TE.

J Proteome Res. 2012 Nov 2;11(11):5124-34. doi: 10.1021/pr300185k. Epub 2012 May 25.


Dermatan sulfate is involved in the tumorigenic properties of esophagus squamous cell carcinoma.

Thelin MA, Svensson KJ, Shi X, Bagher M, Axelsson J, Isinger-Ekstrand A, van Kuppevelt TH, Johansson J, Nilbert M, Zaia J, Belting M, Maccarana M, Malmström A.

Cancer Res. 2012 Apr 15;72(8):1943-52. doi: 10.1158/0008-5472.CAN-11-1351. Epub 2012 Feb 20.


Vasoactive peptides with angiogenesis-regulating activity predict cancer risk in males.

Belting M, Almgren P, Manjer J, Hedblad B, Struck J, Wang TJ, Bergmann A, Melander O.

Cancer Epidemiol Biomarkers Prev. 2012 Mar;21(3):513-22. doi: 10.1158/1055-9965.EPI-11-0840. Epub 2012 Jan 20.


Chondroitin sulfate expression predicts poor outcome in breast cancer.

Svensson KJ, Christianson HC, Kucharzewska P, Fagerström V, Lundstedt L, Borgquist S, Jirström K, Belting M.

Int J Oncol. 2011 Dec;39(6):1421-8. doi: 10.3892/ijo.2011.1164. Epub 2011 Aug 17.


Overexpression of podocalyxin-like protein is an independent factor of poor prognosis in colorectal cancer.

Larsson A, Johansson ME, Wangefjord S, Gaber A, Nodin B, Kucharzewska P, Welinder C, Belting M, Eberhard J, Johnsson A, Uhlén M, Jirström K.

Br J Cancer. 2011 Aug 23;105(5):666-72. doi: 10.1038/bjc.2011.295. Epub 2011 Aug 9.


Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells.

Svensson KJ, Kucharzewska P, Christianson HC, Sköld S, Löfstedt T, Johansson MC, Mörgelin M, Bengzon J, Ruf W, Belting M.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13147-52. doi: 10.1073/pnas.1104261108. Epub 2011 Jul 25.

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