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Items: 32

1.

Synthesis and evaluation of 1,4-naphthoquinone ether derivatives as SmTGR inhibitors and new anti-schistosomal drugs.

Johann L, Belorgey D, Huang HH, Day L, Chessé M, Becker K, Williams DL, Davioud-Charvet E.

FEBS J. 2015 Aug;282(16):3199-217. doi: 10.1111/febs.13359. Epub 2015 Aug 3.

2.

Antimalarial NADPH-Consuming Redox-Cyclers As Superior Glucose-6-Phosphate Dehydrogenase Deficiency Copycats.

Bielitza M, Belorgey D, Ehrhardt K, Johann L, Lanfranchi DA, Gallo V, Schwarzer E, Mohring F, Jortzik E, Williams DL, Becker K, Arese P, Elhabiri M, Davioud-Charvet E.

Antioxid Redox Signal. 2015 May 20;22(15):1337-51. doi: 10.1089/ars.2014.6047. Epub 2015 Apr 14.

3.

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway.

Haq I, Irving JA, Faull SV, Dickens JA, Ordóñez A, Belorgey D, Gooptu B, Lomas DA.

Biosci Rep. 2013 Jun 25;33(3). pii: e00046. doi: 10.1042/BSR20130038. Erratum in: Biosci Rep. 2013;33(4):e00046c.

4.

1,4-naphthoquinones and other NADPH-dependent glutathione reductase-catalyzed redox cyclers as antimalarial agents.

Belorgey D, Lanfranchi DA, Davioud-Charvet E.

Curr Pharm Des. 2013;19(14):2512-28. Review.

5.

Exploring the trifluoromenadione core as a template to design antimalarial redox-active agents interacting with glutathione reductase.

Lanfranchi DA, Belorgey D, Müller T, Vezin H, Lanzer M, Davioud-Charvet E.

Org Biomol Chem. 2012 Jun 28;10(24):4795-806. doi: 10.1039/c2ob25229e. Epub 2012 May 23.

PMID:
22618151
6.

The serpinopathies studying serpin polymerization in vivo.

Irving JA, Ekeowa UI, Belorgey D, Haq I, Gooptu B, Miranda E, Pérez J, Roussel BD, Ordóñez A, Dalton LE, Thomas SE, Marciniak SJ, Parfrey H, Chilvers ER, Teckman JH, Alam S, Mahadeva R, Rashid ST, Vallier L, Lomas DA.

Methods Enzymol. 2011;501:421-66. doi: 10.1016/B978-0-12-385950-1.00018-3.

PMID:
22078544
7.

Unravelling the twists and turns of the serpinopathies.

Roussel BD, Irving JA, Ekeowa UI, Belorgey D, Haq I, Ordóñez A, Kruppa AJ, Duvoix A, Rashid ST, Crowther DC, Marciniak SJ, Lomas DA.

FEBS J. 2011 Oct;278(20):3859-67. doi: 10.1111/j.1742-4658.2011.08201.x. Epub 2011 Jun 20. Review.

8.

Characterisation of serpin polymers in vitro and in vivo.

Belorgey D, Irving JA, Ekeowa UI, Freeke J, Roussel BD, Miranda E, Pérez J, Robinson CV, Marciniak SJ, Crowther DC, Michel CH, Lomas DA.

Methods. 2011 Mar;53(3):255-66. doi: 10.1016/j.ymeth.2010.11.008. Epub 2010 Nov 27. Review.

PMID:
21115126
9.

A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency.

Miranda E, Pérez J, Ekeowa UI, Hadzic N, Kalsheker N, Gooptu B, Portmann B, Belorgey D, Hill M, Chambers S, Teckman J, Alexander GJ, Marciniak SJ, Lomas DA.

Hepatology. 2010 Sep;52(3):1078-88. doi: 10.1002/hep.23760.

PMID:
20583215
10.
11.

Probing neuroserpin polymerization and interaction with amyloid-beta peptides using single molecule fluorescence.

Chiou A, Hägglöf P, Orte A, Chen AY, Dunne PD, Belorgey D, Karlsson-Li S, Lomas DA, Klenerman D.

Biophys J. 2009 Oct 21;97(8):2306-15. doi: 10.1016/j.bpj.2009.07.057.

12.

alpha1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies.

Ekeowa UI, Gooptu B, Belorgey D, Hägglöf P, Karlsson-Li S, Miranda E, Pérez J, MacLeod I, Kroger H, Marciniak SJ, Crowther DC, Lomas DA.

Clin Sci (Lond). 2009 May 14;116(12):837-50. doi: 10.1042/CS20080484. Review.

PMID:
19426146
13.

Protein misfolding and the serpinopathies.

Belorgey D, Hägglöf P, Karlsson-Li S, Lomas DA.

Prion. 2007 Jan-Mar;1(1):15-20. Epub 2007 Jan 6. Review.

14.

Inhibitory activity of the Drosophila melanogaster serpin Necrotic is dependent on lysine residues in the D-helix.

Robertson AS, Belorgey D, Gubb D, Dafforn TR, Lomas DA.

J Biol Chem. 2006 Sep 8;281(36):26437-43. Epub 2006 Jul 11.

15.

Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis.

Sharp LK, Mallya M, Kinghorn KJ, Wang Z, Crowther DC, Huntington JA, Belorgey D, Lomas DA.

FEBS J. 2006 Jun;273(11):2540-52.

16.

Immune challenge induces N-terminal cleavage of the Drosophila serpin Necrotic.

Pelte N, Robertson AS, Zou Z, Belorgey D, Dafforn TR, Jiang H, Lomas D, Reichhart JM, Gubb D.

Insect Biochem Mol Biol. 2006 Jan;36(1):37-46. Epub 2005 Nov 8.

17.

Molecular mousetraps and the serpinopathies.

Lomas DA, Belorgey D, Mallya M, Miranda E, Kinghorn KJ, Sharp LK, Phillips RL, Page R, Robertson AS, Crowther DC.

Biochem Soc Trans. 2005 Apr;33(Pt 2):321-30.

PMID:
15787598
18.

Latent S49P neuroserpin forms polymers in the dementia familial encephalopathy with neuroserpin inclusion bodies.

Onda M, Belorgey D, Sharp LK, Lomas DA.

J Biol Chem. 2005 Apr 8;280(14):13735-41. Epub 2005 Jan 21.

19.

Polymerisation underlies alpha1-antitrypsin deficiency, dementia and other serpinopathies.

Lomas DA, Belorgey D, Mallya M, Onda M, Kinghorn KJ, Sharp LK, Phillips RL, Page R, Crowther DC, Miranda E.

Front Biosci. 2004 Sep 1;9:2873-91. Review.

PMID:
15353322
20.
21.

Inhibiting polymerization: new therapeutic strategies for Z alpha1-antitrypsin-related emphysema.

Parfrey H, Dafforn TR, Belorgey D, Lomas DA, Mahadeva R.

Am J Respir Cell Mol Biol. 2004 Aug;31(2):133-9. Epub 2004 Mar 11.

PMID:
15016619
22.

Practical genetics: alpha-1-antitrypsin deficiency and the serpinopathies.

Crowther DC, Belorgey D, Miranda E, Kinghorn KJ, Sharp LK, Lomas DA.

Eur J Hum Genet. 2004 Mar;12(3):167-72. Review.

23.

Characterization of the necrotic protein that regulates the Toll-mediated immune response in Drosophila.

Robertson AS, Belorgey D, Lilley KS, Lomas DA, Gubb D, Dafforn TR.

J Biol Chem. 2003 Feb 21;278(8):6175-80. Epub 2002 Oct 31.

24.

Comparative trajectories of active and S195A inactive trypsin upon binding to serpins.

Mellet P, Mély Y, Hedstrom L, Cahoon M, Belorgey D, Srividya N, Rubin H, Bieth JG.

J Biol Chem. 2002 Oct 11;277(41):38901-14. Epub 2002 Jun 20.

25.

Hypersensitive mousetraps, alpha1-antitrypsin deficiency and dementia.

Lomas DA, Lourbakos A, Cumming SA, Belorgey D.

Biochem Soc Trans. 2002 Apr;30(2):89-92. Review.

PMID:
12023831
26.
27.

Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue.

Estébanez-Perpiña E, Fuentes-Prior P, Belorgey D, Braun M, Kiefersauer R, Maskos K, Huber R, Rubin H, Bode W.

Biol Chem. 2000 Dec;381(12):1203-14.

PMID:
11209755
28.

Effect of DNase on the activity of neutrophil elastase, cathepsin G and proteinase 3 in the presence of DNA.

Duranton J, Belorgey D, Carrère J, Donato L, Moritz T, Bieth JG.

FEBS Lett. 2000 May 12;473(2):154-6.

29.

DNA strongly impairs the inhibition of cathepsin G by alpha(1)-antichymotrypsin and alpha(1)-proteinase inhibitor.

Duranton J, Boudier C, Belorgey D, Mellet P, Bieth JG.

J Biol Chem. 2000 Feb 11;275(6):3787-92.

30.
31.

Inhibition of human pancreatic proteinases by mucus proteinase inhibitor, eglin c and aprotinin.

Belorgey D, Dirrig S, Amouric M, Figarella C, Bieth JG.

Biochem J. 1996 Jan 15;313 ( Pt 2):555-60.

32.

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