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Items: 20


Longitudinal bioluminescent imaging of HIV-1 infection during antiretroviral therapy and treatment interruption in humanized mice.

Ventura JD, Beloor J, Allen E, Zhang T, Haugh KA, Uchil PD, Ochsenbauer C, Kieffer C, Kumar P, Hope TJ, Mothes W.

PLoS Pathog. 2019 Dec 5;15(12):e1008161. doi: 10.1371/journal.ppat.1008161. [Epub ahead of print]


A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System.

Ullah I, Chung K, Beloor J, Lee SK, Kumar P.

J Vis Exp. 2019 Aug 15;(150). doi: 10.3791/59201.


Structural and pharmacological evaluation of a novel non-nucleoside reverse transcriptase inhibitor as a promising long acting nanoformulation for treating HIV.

Kudalkar SN, Ullah I, Bertoletti N, Mandl HK, Cisneros JA, Beloor J, Chan AH, Quijano E, Saltzman WM, Jorgensen WL, Kumar P, Anderson KS.

Antiviral Res. 2019 Jul;167:110-116. doi: 10.1016/j.antiviral.2019.04.010. Epub 2019 Apr 26.


Intranasal delivery of a Fas-blocking peptide attenuates Fas-mediated apoptosis in brain ischemia.

Ullah I, Chung K, Oh J, Beloor J, Bae S, Lee SC, Lee M, Kumar P, Lee SK.

Sci Rep. 2018 Oct 9;8(1):15041. doi: 10.1038/s41598-018-33296-z.


Reply to Pandey et al.: Understanding the efficacy of a potential antiretroviral drug candidate in humanized mouse model of HIV infection.

Kudalkar SN, Beloor J, Quijano E, Spasov KA, Lee WG, Cisneros JA, Saltzman WM, Kumar P, Jorgensen WL, Anderson KS.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8114-E8115. doi: 10.1073/pnas.1810136115. Epub 2018 Aug 10. No abstract available.


Small Interfering RNA-Mediated Control of Virus Replication in the CNS Is Therapeutic and Enables Natural Immunity to West Nile Virus.

Beloor J, Maes N, Ullah I, Uchil P, Jackson A, Fikrig E, Lee SK, Kumar P.

Cell Host Microbe. 2018 Apr 11;23(4):549-556.e3. doi: 10.1016/j.chom.2018.03.001. Epub 2018 Mar 29.


From in silico hit to long-acting late-stage preclinical candidate to combat HIV-1 infection.

Kudalkar SN, Beloor J, Quijano E, Spasov KA, Lee WG, Cisneros JA, Saltzman WM, Kumar P, Jorgensen WL, Anderson KS.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E802-E811. doi: 10.1073/pnas.1717932115. Epub 2017 Dec 26. Erratum in: Proc Natl Acad Sci U S A. 2018 Mar 12;:.


Structural and Preclinical Studies of Computationally Designed Non-Nucleoside Reverse Transcriptase Inhibitors for Treating HIV infection.

Kudalkar SN, Beloor J, Chan AH, Lee WG, Jorgensen WL, Kumar P, Anderson KS.

Mol Pharmacol. 2017 Apr;91(4):383-391. doi: 10.1124/mol.116.107755. Epub 2017 Feb 6.


Trileucine residues in a ligand-CPP-based siRNA delivery platform improve endosomal escape of siRNA.

Ullah I, Chung K, Beloor J, Kim J, Cho M, Kim N, Lee KY, Kumar P, Lee SK.

J Drug Target. 2017 Apr;25(4):320-329. doi: 10.1080/1061186X.2016.1258566. Epub 2016 Nov 22.


In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery.

Bahal R, Ali McNeer N, Quijano E, Liu Y, Sulkowski P, Turchick A, Lu YC, Bhunia DC, Manna A, Greiner DL, Brehm MA, Cheng CJ, López-Giráldez F, Ricciardi A, Beloor J, Krause DS, Kumar P, Gallagher PG, Braddock DT, Mark Saltzman W, Ly DH, Glazer PM.

Nat Commun. 2016 Oct 26;7:13304. doi: 10.1038/ncomms13304.


Silencing CCR2 in Macrophages Alleviates Adipose Tissue Inflammation and the Associated Metabolic Syndrome in Dietary Obese Mice.

Kim J, Chung K, Choi C, Beloor J, Ullah I, Kim N, Lee KY, Lee SK, Kumar P.

Mol Ther Nucleic Acids. 2016 Jan 26;5:e280. doi: 10.1038/mtna.2015.51.


Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection.

Sewald X, Ladinsky MS, Uchil PD, Beloor J, Pi R, Herrmann C, Motamedi N, Murooka TT, Brehm MA, Greiner DL, Shultz LD, Mempel TR, Bjorkman PJ, Kumar P, Mothes W.

Science. 2015 Oct 30;350(6260):563-567. doi: 10.1126/science.aab2749. Epub 2015 Oct 1.


Cationic cell-penetrating peptides as vehicles for siRNA delivery.

Beloor J, Zeller S, Choi CS, Lee SK, Kumar P.

Ther Deliv. 2015;6(4):491-507. doi: 10.4155/tde.15.2. Review.


Adenovirus-Vectored Broadly Neutralizing Antibodies Directed Against gp120 Prevent Human Immunodeficiency Virus Type 1 Acquisition in Humanized Mice.

Liu S, Jackson A, Beloor J, Kumar P, Sutton RE.

Hum Gene Ther. 2015 Sep;26(9):622-34. doi: 10.1089/hum.2014.146. Epub 2015 Aug 11.


Liver-targeted cyclosporine A-encapsulated poly (lactic-co-glycolic) acid nanoparticles inhibit hepatitis C virus replication.

Jyothi KR, Beloor J, Jo A, Nguyen MN, Choi TG, Kim JH, Akter S, Lee SK, Maeng CH, Baik HH, Kang I, Ha J, Kim SS.

Int J Nanomedicine. 2015 Jan 30;10:903-21. doi: 10.2147/IJN.S74723. eCollection 2015.


Effective gene delivery into human stem cells with a cell-targeting Peptide-modified bioreducible polymer.

Beloor J, Ramakrishna S, Nam K, Seon Choi C, Kim J, Kim SH, Cho HJ, Shin H, Kim H, Kim SW, Lee SK, Kumar P.

Small. 2015 May 6;11(17):2069-79. doi: 10.1002/smll.201402933. Epub 2014 Dec 16.


Arginine-grafted biodegradable polymer: a versatile transfection reagent for both DNA and siRNA.

Beloor J, Nam HY, Lee SK, Kumar P.

Methods Mol Biol. 2014;1176:115-26. doi: 10.1007/978-1-4939-0992-6_10.


Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA.

Ramakrishna S, Kwaku Dad AB, Beloor J, Gopalappa R, Lee SK, Kim H.

Genome Res. 2014 Jun;24(6):1020-7. doi: 10.1101/gr.171264.113. Epub 2014 Apr 2.


Cell-specific siRNA delivery by peptides and antibodies.

Lee SK, Siefert A, Beloor J, Fahmy TM, Kumar P.

Methods Enzymol. 2012;502:91-122. doi: 10.1016/B978-0-12-416039-2.00005-7. Review.


Arginine-engrafted biodegradable polymer for the systemic delivery of therapeutic siRNA.

Beloor J, Choi CS, Nam HY, Park M, Kim SH, Jackson A, Lee KY, Kim SW, Kumar P, Lee SK.

Biomaterials. 2012 Feb;33(5):1640-50. doi: 10.1016/j.biomaterials.2011.11.008. Epub 2011 Nov 23.


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