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Items: 16

1.

Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance.

Mitchell RK, Hu M, Chabosseau PL, Cane MC, Meur G, Bellomo EA, Carzaniga R, Collinson LM, Li WH, Hodson DJ, Rutter GA.

Mol Endocrinol. 2016 Jan;30(1):77-91. doi: 10.1210/me.2015-1227. Epub 2015 Nov 19.

2.

Intracellular zinc in insulin secretion and action: a determinant of diabetes risk?

Rutter GA, Chabosseau P, Bellomo EA, Maret W, Mitchell RK, Hodson DJ, Solomou A, Hu M.

Proc Nutr Soc. 2016 Feb;75(1):61-72. Epub 2015 Sep 14.

PMID:
26365743
3.

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.

Arredouani A, Ruas M, Collins SC, Parkesh R, Clough F, Pillinger T, Coltart G, Rietdorf K, Royle A, Johnson P, Braun M, Zhang Q, Sones W, Shimomura K, Morgan AJ, Lewis AM, Chuang KT, Tunn R, Gadea J, Teboul L, Heister PM, Tynan PW, Bellomo EA, Rutter GA, Rorsman P, Churchill GC, Parrington J, Galione A.

J Biol Chem. 2015 Aug 28;290(35):21376-92. doi: 10.1074/jbc.M115.671248. Epub 2015 Jul 7.

4.

Sarco(endo)plasmic reticulum ATPase is a molecular partner of Wolfram syndrome 1 protein, which negatively regulates its expression.

Zatyka M, Da Silva Xavier G, Bellomo EA, Leadbeater W, Astuti D, Smith J, Michelangeli F, Rutter GA, Barrett TG.

Hum Mol Genet. 2015 Feb 1;24(3):814-27. doi: 10.1093/hmg/ddu499. Epub 2014 Sep 30.

5.

Mitochondrial and ER-targeted eCALWY probes reveal high levels of free Zn2+.

Chabosseau P, Tuncay E, Meur G, Bellomo EA, Hessels A, Hughes S, Johnson PR, Bugliani M, Marchetti P, Turan B, Lyon AR, Merkx M, Rutter GA.

ACS Chem Biol. 2014 Sep 19;9(9):2111-20. doi: 10.1021/cb5004064. Epub 2014 Jul 17.

6.

Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cells.

Gerber PA, Bellomo EA, Hodson DJ, Meur G, Solomou A, Mitchell RK, Hollinshead M, Chimienti F, Bosco D, Hughes SJ, Johnson PR, Rutter GA.

Diabetologia. 2014 Aug;57(8):1635-44. doi: 10.1007/s00125-014-3266-0. Epub 2014 May 28.

7.

Lipotoxicity disrupts incretin-regulated human β cell connectivity.

Hodson DJ, Mitchell RK, Bellomo EA, Sun G, Vinet L, Meda P, Li D, Li WH, Bugliani M, Marchetti P, Bosco D, Piemonti L, Johnson P, Hughes SJ, Rutter GA.

J Clin Invest. 2013 Oct;123(10):4182-94. doi: 10.1172/JCI68459. Epub 2013 Sep 9.

8.

Animal models of GWAS-identified type 2 diabetes genes.

da Silva Xavier G, Bellomo EA, McGinty JA, French PM, Rutter GA.

J Diabetes Res. 2013;2013:906590. doi: 10.1155/2013/906590. Epub 2013 Apr 11. Review.

9.

The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells.

Tarasov AI, Semplici F, Ravier MA, Bellomo EA, Pullen TJ, Gilon P, Sekler I, Rizzuto R, Rutter GA.

PLoS One. 2012;7(7):e39722. doi: 10.1371/journal.pone.0039722. Epub 2012 Jul 19.

10.

Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR).

Li D, Chen S, Bellomo EA, Tarasov AI, Kaut C, Rutter GA, Li WH.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21063-8. doi: 10.1073/pnas.1109773109. Epub 2011 Dec 12.

11.

Glucose regulates free cytosolic Zn²⁺ concentration, Slc39 (ZiP), and metallothionein gene expression in primary pancreatic islet β-cells.

Bellomo EA, Meur G, Rutter GA.

J Biol Chem. 2011 Jul 22;286(29):25778-89. doi: 10.1074/jbc.M111.246082. Epub 2011 May 25.

12.

Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis.

Vinkenborg JL, Nicolson TJ, Bellomo EA, Koay MS, Rutter GA, Merkx M.

Nat Methods. 2009 Oct;6(10):737-40. doi: 10.1038/nmeth.1368. Epub 2009 Aug 30.

13.

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.

Nicolson TJ, Bellomo EA, Wijesekara N, Loder MK, Baldwin JM, Gyulkhandanyan AV, Koshkin V, Tarasov AI, Carzaniga R, Kronenberger K, Taneja TK, da Silva Xavier G, Libert S, Froguel P, Scharfmann R, Stetsyuk V, Ravassard P, Parker H, Gribble FM, Reimann F, Sladek R, Hughes SJ, Johnson PR, Masseboeuf M, Burcelin R, Baldwin SA, Liu M, Lara-Lemus R, Arvan P, Schuit FC, Wheeler MB, Chimienti F, Rutter GA.

Diabetes. 2009 Sep;58(9):2070-83. doi: 10.2337/db09-0551. Epub 2009 Jun 19.

14.

Ca2+ signalling: a new route to NAADP.

Rutter GA, Bellomo EA.

Biochem J. 2008 Apr 1;411(1):e1-3. doi: 10.1042/BJ20080282. Review.

PMID:
18333834
15.

Characterization of cyclic adenine dinucleotide phosphate ribose levels in human spermatozoa.

Billington RA, Harper C, Bellomo EA, Publicover S, Barratt CL, Genazzani AA.

Fertil Steril. 2006 Oct;86(4):891-8. Epub 2006 Aug 9.

PMID:
16904113
16.

A transport mechanism for NAADP in a rat basophilic cell line.

Billington RA, Bellomo EA, Floriddia EM, Erriquez J, Distasi C, Genazzani AA.

FASEB J. 2006 Mar;20(3):521-3. Epub 2006 Jan 10.

PMID:
16403787

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