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Anti-tumor Activity and Epigenetic Impact of the Polyphenol Oleacein in Multiple Myeloma.

Juli G, Oliverio M, Bellizzi D, Gallo Cantafio ME, Grillone K, Passarino G, Colica C, Nardi M, Rossi M, Procopio A, Tagliaferri P, Tassone P, Amodio N.

Cancers (Basel). 2019 Jul 16;11(7). pii: E990. doi: 10.3390/cancers11070990.


Epigenetic signature: implications for mitochondrial quality control in human aging.

D'Aquila P, Montesanto A, De Rango F, Guarasci F, Passarino G, Bellizzi D.

Aging (Albany NY). 2019 Feb 20;11(4):1240-1251. doi: 10.18632/aging.101832.


Aging and nutrition induce tissue-specific changes on global DNA methylation status in rats.

Guarasci F, D'Aquila P, Mandalà M, Garasto S, Lattanzio F, Corsonello A, Passarino G, Bellizzi D.

Mech Ageing Dev. 2018 Sep;174:47-54. doi: 10.1016/j.mad.2018.02.001. Epub 2018 Feb 7. Review.


rRNA-gene methylation and biological aging.

D'Aquila P, Bellizzi D, Passarino G.

Aging (Albany NY). 2018 Jan 24;10(1):7-8. doi: 10.18632/aging.101369. No abstract available.


A Genetic Variant of ASCT2 Hampers In Vitro RNA Splicing and Correlates with Human Longevity.

D'Aquila P, Crocco P, De Rango F, Indiveri C, Bellizzi D, Rose G, Passarino G.

Rejuvenation Res. 2018 Jun;21(3):193-199. doi: 10.1089/rej.2017.1948. Epub 2017 Sep 8.


Methylation of the ribosomal RNA gene promoter is associated with aging and age-related decline.

D'Aquila P, Montesanto A, Mandalà M, Garasto S, Mari V, Corsonello A, Bellizzi D, Passarino G.

Aging Cell. 2017 Oct;16(5):966-975. doi: 10.1111/acel.12603. Epub 2017 Jun 17.


Estradiol via estrogen receptor beta influences ROS levels through the transcriptional regulation of SIRT3 in human seminoma TCam-2 cells.

Panza S, Santoro M, De Amicis F, Morelli C, Passarelli V, D'Aquila P, Giordano F, Cione E, Passarino G, Bellizzi D, Aquila S.

Tumour Biol. 2017 May;39(5):1010428317701642. doi: 10.1177/1010428317701642.


Centenarians as extreme phenotypes: An ecological perspective to get insight into the relationship between the genetics of longevity and age-associated diseases.

Giuliani C, Pirazzini C, Delledonne M, Xumerle L, Descombes P, Marquis J, Mengozzi G, Monti D, Bellizzi D, Passarino G, Luiselli D, Franceschi C, Garagnani P.

Mech Ageing Dev. 2017 Jul;165(Pt B):195-201. doi: 10.1016/j.mad.2017.02.007. Epub 2017 Feb 27. Review.


The methylation of nuclear and mitochondrial DNA in ageing phenotypes and longevity.

Bacalini MG, D'Aquila P, Marasco E, Nardini C, Montesanto A, Franceschi C, Passarino G, Garagnani P, Bellizzi D.

Mech Ageing Dev. 2017 Jul;165(Pt B):156-161. doi: 10.1016/j.mad.2017.01.006. Epub 2017 Jan 20. Review.


SIRT1-SIRT3 Axis Regulates Cellular Response to Oxidative Stress and Etoposide.

Carnevale I, Pellegrini L, D'Aquila P, Saladini S, Lococo E, Polletta L, Vernucci E, Foglio E, Coppola S, Sansone L, Passarino G, Bellizzi D, Russo MA, Fini M, Tafani M.

J Cell Physiol. 2017 Jul;232(7):1835-1844. doi: 10.1002/jcp.25711. Epub 2017 Jan 6.


Epigenetic modifications in multiple myeloma: recent advances on the role of DNA and histone methylation.

Amodio N, D'Aquila P, Passarino G, Tassone P, Bellizzi D.

Expert Opin Ther Targets. 2017 Jan;21(1):91-101. Review.


Mitochondrial genome and epigenome: two sides of the same coin.

D'Aquila P, Montesanto A, Guarasci F, Passarino G, Bellizzi D.

Front Biosci (Landmark Ed). 2017 Jan 1;22:888-908. Review.


The impact of nutrients on the aging rate: A complex interaction of demographic, environmental and genetic factors.

Dato S, Bellizzi D, Rose G, Passarino G.

Mech Ageing Dev. 2016 Mar;154:49-61. doi: 10.1016/j.mad.2016.02.005. Epub 2016 Feb 10. Review.


miR-23b/SP1/c-myc forms a feed-forward loop supporting multiple myeloma cell growth.

Fulciniti M, Amodio N, Bandi RL, Cagnetta A, Samur MK, Acharya C, Prabhala R, D'Aquila P, Bellizzi D, Passarino G, Adamia S, Neri A, Hunter ZR, Treon SP, Anderson KC, Tassone P, Munshi NC.

Blood Cancer J. 2016 Jan 15;6:e380. doi: 10.1038/bcj.2015.106.


Age-and gender-related pattern of methylation in the MT-RNR1 gene.

D'Aquila P, Giordano M, Montesanto A, De Rango F, Passarino G, Bellizzi D.

Epigenomics. 2015 Aug;7(5):707-16. doi: 10.2217/epi.15.30. Epub 2015 Sep 7.


Mitochondria in health, aging and diseases: the epigenetic perspective.

D'Aquila P, Bellizzi D, Passarino G.

Biogerontology. 2015 Oct;16(5):569-85. doi: 10.1007/s10522-015-9562-3. Epub 2015 Feb 25. Review.


Aging and longevity between genetic background and lifestyle intervention.

Passarino G, Rose G, Bellizzi D, De Luca M, Gonos ES.

Biomed Res Int. 2014;2014:516402. doi: 10.1155/2014/516402. Epub 2014 May 27. No abstract available.


miR-29b induces SOCS-1 expression by promoter demethylation and negatively regulates migration of multiple myeloma and endothelial cells.

Amodio N, Bellizzi D, Leotta M, Raimondi L, Biamonte L, D'Aquila P, Di Martino MT, Calimeri T, Rossi M, Lionetti M, Leone E, Passarino G, Neri A, Giordano A, Tagliaferri P, Tassone P.

Cell Cycle. 2013 Dec 1;12(23):3650-62. doi: 10.4161/cc.26585. Epub 2013 Sep 25.


Exploring the role of genetic variability and lifestyle in oxidative stress response for healthy aging and longevity.

Dato S, Crocco P, D'Aquila P, de Rango F, Bellizzi D, Rose G, Passarino G.

Int J Mol Sci. 2013 Aug 8;14(8):16443-72. doi: 10.3390/ijms140816443. Review.


The control region of mitochondrial DNA shows an unusual CpG and non-CpG methylation pattern.

Bellizzi D, D'Aquila P, Scafone T, Giordano M, Riso V, Riccio A, Passarino G.

DNA Res. 2013 Dec;20(6):537-47. doi: 10.1093/dnares/dst029. Epub 2013 Jun 26.


Directed organization of DNA filaments in a soft matter template.

De Sio L, D'Aquila P, Brunelli E, Strangi G, Bellizzi D, Passarino G, Umeton C, Bartolino R.

Langmuir. 2013 Mar 12;29(10):3398-403. doi: 10.1021/la3035787. Epub 2013 Mar 1.


Epigenetics and aging.

D'Aquila P, Rose G, Bellizzi D, Passarino G.

Maturitas. 2013 Feb;74(2):130-6. doi: 10.1016/j.maturitas.2012.11.005. Epub 2012 Dec 12. Review.


DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma.

Amodio N, Leotta M, Bellizzi D, Di Martino MT, D'Aquila P, Lionetti M, Fabiani F, Leone E, Gullà AM, Passarino G, Caraglia M, Negrini M, Neri A, Giordano A, Tagliaferri P, Tassone P.

Oncotarget. 2012 Oct;3(10):1246-58.


SIRT3 protects from hypoxia and staurosporine-mediated cell death by maintaining mitochondrial membrane potential and intracellular pH.

Pellegrini L, Pucci B, Villanova L, Marino ML, Marfe G, Sansone L, Vernucci E, Bellizzi D, Reali V, Fini M, Russo MA, Tafani M.

Cell Death Differ. 2012 Nov;19(11):1815-25. doi: 10.1038/cdd.2012.62. Epub 2012 May 18.


Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity.

Montesanto A, Dato S, Bellizzi D, Rose G, Passarino G.

Immun Ageing. 2012 Apr 23;9(1):6. doi: 10.1186/1742-4933-9-6.


Global DNA methylation levels are modulated by mitochondrial DNA variants.

Bellizzi D, D'Aquila P, Giordano M, Montesanto A, Passarino G.

Epigenomics. 2012 Feb;4(1):17-27. doi: 10.2217/epi.11.109.


SIRT3 gene expression: a link between inherited mitochondrial DNA variants and oxidative stress.

D'Aquila P, Rose G, Panno ML, Passarino G, Bellizzi D.

Gene. 2012 Apr 15;497(2):323-9. doi: 10.1016/j.gene.2012.01.042. Epub 2012 Jan 27.


Two variants located in the upstream enhancer region of human UCP1 gene affect gene expression and are correlated with human longevity.

Rose G, Crocco P, D'Aquila P, Montesanto A, Bellizzi D, Passarino G.

Exp Gerontol. 2011 Nov;46(11):897-904. doi: 10.1016/j.exger.2011.07.011. Epub 2011 Jul 30.


Global DNA methylation in old subjects is correlated with frailty.

Bellizzi D, D'Aquila P, Montesanto A, Corsonello A, Mari V, Mazzei B, Lattanzio F, Passarino G.

Age (Dordr). 2012 Feb;34(1):169-79. doi: 10.1007/s11357-011-9216-6. Epub 2011 Feb 19.


Mitochondrial function, mitochondrial DNA and ageing: a reappraisal.

Passarino G, Rose G, Bellizzi D.

Biogerontology. 2010 Oct;11(5):575-88. doi: 10.1007/s10522-010-9294-3. Epub 2010 Jul 3. Review.


Identification of GATA2 and AP-1 Activator elements within the enhancer VNTR occurring in intron 5 of the human SIRT3 gene.

Bellizzi D, Covello G, Di Cianni F, Tong Q, De Benedictis G.

Mol Cells. 2009 Aug 31;28(2):87-92. doi: 10.1007/s10059-009-0110-3. Epub 2009 Aug 20.


Experimental testing of a mathematical model relevant to the extrinsic pathway of apoptosis.

Pace V, Bellizzi D, Giordano F, Panno ML, De Benedictis G.

Cell Stress Chaperones. 2010 Jan;15(1):13-23. doi: 10.1007/s12192-009-0118-9. Epub 2009 May 20.


Mitochondrial DNA variability modulates mRNA and intra-mitochondrial protein levels of HSP60 and HSP75: experimental evidence from cybrid lines.

Bellizzi D, Taverna D, D'Aquila P, De Blasi S, De Benedictis G.

Cell Stress Chaperones. 2009 May;14(3):265-71. doi: 10.1007/s12192-008-0081-x. Epub 2008 Sep 25.


Resistance of mtDNA-depleted cells to apoptosis.

Ferraresi R, Troiano L, Pinti M, Roat E, Lugli E, Quaglino D, Taverna D, Bellizzi D, Passarino G, Cossarizza A.

Cytometry A. 2008 Jun;73(6):528-37. doi: 10.1002/cyto.a.20544.


A novel sampling design to explore gene-longevity associations: the ECHA study.

De Rango F, Dato S, Bellizzi D, Rose G, Marzi E, Cavallone L, Franceschi C, Skytthe A, Jeune B, Cournil A, Robine JM, Gampe J, Vaupel JW, Mari V, Feraco E, Passarino G, Novelletto A, De Benedictis G.

Eur J Hum Genet. 2008 Feb;16(2):236-42. Epub 2007 Nov 7.


The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring.

Rose G, Passarino G, Scornaienchi V, Romeo G, Dato S, Bellizzi D, Mari V, Feraco E, Maletta R, Bruni A, Franceschi C, De Benedictis G.

BMC Genomics. 2007 Aug 29;8:293.


Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13.

Bellizzi D, Dato S, Cavalcante P, Covello G, Di Cianni F, Passarino G, Rose G, De Benedictis G.

Genomics. 2007 Jan;89(1):143-50. Epub 2006 Oct 23.


Gene expression of cytokines and cytokine receptors is modulated by the common variability of the mitochondrial DNA in cybrid cell lines.

Bellizzi D, Cavalcante P, Taverna D, Rose G, Passarino G, Salvioli S, Franceschi C, De Benedictis G.

Genes Cells. 2006 Aug;11(8):883-91.


Mitochondrial DNA involvement in human longevity.

Santoro A, Salvioli S, Raule N, Capri M, Sevini F, Valensin S, Monti D, Bellizzi D, Passarino G, Rose G, De Benedictis G, Franceschi C.

Biochim Biophys Acta. 2006 Sep-Oct;1757(9-10):1388-99. Epub 2006 Jun 7. Review.


Evidence that the mouse insulin receptor substrate-1 belongs to the gene family on which the promoter is activated by estrogen receptor alpha through its interaction with Sp1.

Panno ML, Mauro L, Marsico S, Bellizzi D, Rizza P, Morelli C, Salerno M, Giordano F, Andò S.

J Mol Endocrinol. 2006 Feb;36(1):91-105.


A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages.

Bellizzi D, Rose G, Cavalcante P, Covello G, Dato S, De Rango F, Greco V, Maggiolini M, Feraco E, Mari V, Franceschi C, Passarino G, De Benedictis G.

Genomics. 2005 Feb;85(2):258-63.


Association of the mitochondrial DNA haplogroup J with longevity is population specific.

Dato S, Passarino G, Rose G, Altomare K, Bellizzi D, Mari V, Feraco E, Franceschi C, De Benedictis G.

Eur J Hum Genet. 2004 Dec;12(12):1080-2.


Heat shock response by EBV-immortalized B-lymphocytes from centenarians and control subjects: a model to study the relevance of stress response in longevity.

Marini M, Lapalombella R, Canaider S, Farina A, Monti D, De Vescovi V, Morellini M, Bellizzi D, Dato S, De Benedictis G, Passarino G, Moresi R, Tesei S, Franceschi C.

Exp Gerontol. 2004 Jan;39(1):83-90.


Frequency and coverage of trinucleotide repeats in eukaryotes.

Astolfi P, Bellizzi D, Sgaramella V.

Gene. 2003 Oct 23;317(1-2):117-25.


Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly.

Rose G, Dato S, Altomare K, Bellizzi D, Garasto S, Greco V, Passarino G, Feraco E, Mari V, Barbi C, BonaFe M, Franceschi C, Tan Q, Boiko S, Yashin AI, De Benedictis G.

Exp Gerontol. 2003 Oct;38(10):1065-70.


The allele (A)(-110) in the promoter region of the HSP70-1 gene is unfavorable to longevity in women.

Altomare K, Greco V, Bellizzi D, Berardelli M, Dato S, DeRango F, Garasto S, Rose G, Feraco E, Mari V, Passarino G, Franceschi C, De Benedictis G.

Biogerontology. 2003;4(4):215-20.


The influences on human longevity by HUMTHO1.STR polymorphism (Tyrosine Hydroxylase gene). A relative risk approach.

Tan Q, Bellizzi D, Rose G, Garasto S, Franceschi C, Kruse T, Vaupel JW, De Benedictis G, Yashin AI.

Mech Ageing Dev. 2002 Jul;123(10):1403-10.


Triplet repeats, over-expanded in neuromuscular diseases, are under-represented in mammalian DNA: a survey of models.

Astolfi P, Bellizzi D, Losso MA, Sgaramella V.

Brain Res Bull. 2001 Oct-Nov 1;56(3-4):265-71. Review.


Estradiol increases IRS-1 gene expression and insulin signaling in breast cancer cells.

Mauro L, Salerno M, Panno ML, Bellizzi D, Sisci D, Miglietta A, Surmacz E, Andò S.

Biochem Biophys Res Commun. 2001 Nov 2;288(3):685-9. Erratum in: Biochem Biophys Res Commun 2001 Nov 30;289(2):641.


A model for the involvement of Okazaki fragments maturation in the expansion of short tandem repeats.

Bellizzi D, Losso MA, Sgaramella V.

Gene. 2001 Oct 3;276(1-2):153-9.


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