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Items: 41

1.

Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling.

Wagner T, André-Leroux G, Hindie V, Barilone N, Lisa MN, Hoos S, Raynal B, Vulliez-Le Normand B, O'Hare HM, Bellinzoni M, Alzari PM.

Sci Signal. 2019 May 7;12(580). pii: eaav9504. doi: 10.1126/scisignal.aav9504.

PMID:
31064884
2.

Novel mechanistic insights into physiological signaling pathways mediated by mycobacterial Ser/Thr protein kinases.

Bellinzoni M, Wehenkel AM, Durán R, Alzari PM.

Genes Immun. 2019 May;20(5):383-393. doi: 10.1038/s41435-019-0069-9. Epub 2019 Apr 25.

PMID:
31019252
3.

New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents.

Chiarelli LR, Mori M, Beretta G, Gelain A, Pini E, Sammartino JC, Stelitano G, Barlocco D, Costantino L, Lapillo M, Poli G, Caligiuri I, Rizzolio F, Bellinzoni M, Tuccinardi T, Villa S, Meneghetti F.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):823-828. doi: 10.1080/14756366.2019.1589462.

4.

New substrates and interactors of the mycobacterial Serine/Threonine protein kinase PknG identified by a tailored interactomic approach.

Gil M, Lima A, Rivera B, Rossello J, Urdániz E, Cascioferro A, Carrión F, Wehenkel A, Bellinzoni M, Batthyány C, Pritsch O, Denicola A, Alvarez MN, Carvalho PC, Lisa MN, Brosch R, Piuri M, Alzari PM, Durán R.

J Proteomics. 2019 Feb 10;192:321-333. doi: 10.1016/j.jprot.2018.09.013. Epub 2018 Sep 27.

PMID:
30267874
5.

PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis.

Rieck B, Degiacomi G, Zimmermann M, Cascioferro A, Boldrin F, Lazar-Adler NR, Bottrill AR, le Chevalier F, Frigui W, Bellinzoni M, Lisa MN, Alzari PM, Nguyen L, Brosch R, Sauer U, Manganelli R, O'Hare HM.

PLoS Pathog. 2017 May 17;13(5):e1006399. doi: 10.1371/journal.ppat.1006399. eCollection 2017 May.

6.

The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation.

Lisa MN, Wagner T, Alexandre M, Barilone N, Raynal B, Alzari PM, Bellinzoni M.

FEBS J. 2017 Feb;284(4):602-614. doi: 10.1111/febs.14003. Epub 2017 Jan 29.

7.

Ser/Thr Phosphorylation Regulates the Fatty Acyl-AMP Ligase Activity of FadD32, an Essential Enzyme in Mycolic Acid Biosynthesis.

Le NH, Molle V, Eynard N, Miras M, Stella A, Bardou F, Galandrin S, Guillet V, André-Leroux G, Bellinzoni M, Alzari P, Mourey L, Burlet-Schiltz O, Daffé M, Marrakchi H.

J Biol Chem. 2016 Oct 21;291(43):22793-22805. Epub 2016 Sep 2.

8.

CNTN6 mutations are risk factors for abnormal auditory sensory perception in autism spectrum disorders.

Mercati O, Huguet G, Danckaert A, André-Leroux G, Maruani A, Bellinzoni M, Rolland T, Gouder L, Mathieu A, Buratti J, Amsellem F, Benabou M, Van-Gils J, Beggiato A, Konyukh M, Bourgeois JP, Gazzellone MJ, Yuen RK, Walker S, Delépine M, Boland A, Régnault B, Francois M, Van Den Abbeele T, Mosca-Boidron AL, Faivre L, Shimoda Y, Watanabe K, Bonneau D, Rastam M, Leboyer M, Scherer SW, Gillberg C, Delorme R, Cloëz-Tayarani I, Bourgeron T.

Mol Psychiatry. 2017 Apr;22(4):625-633. doi: 10.1038/mp.2016.61. Epub 2016 May 10.

9.

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.

Mori G, Chiarelli LR, Esposito M, Makarov V, Bellinzoni M, Hartkoorn RC, Degiacomi G, Boldrin F, Ekins S, de Jesus Lopes Ribeiro AL, Marino LB, Centárová I, Svetlíková Z, Blaško J, Kazakova E, Lepioshkin A, Barilone N, Zanoni G, Porta A, Fondi M, Fani R, Baulard AR, Mikušová K, Alzari PM, Manganelli R, de Carvalho LP, Riccardi G, Cole ST, Pasca MR.

Chem Biol. 2015 Jul 23;22(7):917-27. doi: 10.1016/j.chembiol.2015.05.016. Epub 2015 Jun 18.

10.

The crystal structure of the catalytic domain of the ser/thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformation.

Wagner T, Alexandre M, Duran R, Barilone N, Wehenkel A, Alzari PM, Bellinzoni M.

Proteins. 2015 May;83(5):982-8. doi: 10.1002/prot.24754. Epub 2015 Mar 25.

11.

Secondary structure reshuffling modulates glycosyltransferase function at the membrane.

Giganti D, Albesa-Jové D, Urresti S, Rodrigo-Unzueta A, Martínez MA, Comino N, Barilone N, Bellinzoni M, Chenal A, Guerin ME, Alzari PM.

Nat Chem Biol. 2015 Jan;11(1):16-8. doi: 10.1038/nchembio.1694. Epub 2014 Nov 17.

PMID:
25402770
12.

Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c.

Bellinzoni M, Haouz A, Miras I, Magnet S, André-Leroux G, Mukherjee R, Shepard W, Cole ST, Alzari PM.

J Struct Biol. 2014 Nov;188(2):156-64. doi: 10.1016/j.jsb.2014.09.003. Epub 2014 Sep 24.

PMID:
25260828
13.

A dual conformation of the post-decarboxylation intermediate is associated with distinct enzyme states in mycobacterial KGD (α-ketoglutarate decarboxylase).

Wagner T, Barilone N, Alzari PM, Bellinzoni M.

Biochem J. 2014 Feb 1;457(3):425-34. doi: 10.1042/BJ20131142. Erratum in: Biochem J. 2014 Mar 1;458(2):419.

PMID:
24171907
14.

GarA is an essential regulator of metabolism in Mycobacterium tuberculosis.

Ventura M, Rieck B, Boldrin F, Degiacomi G, Bellinzoni M, Barilone N, Alzaidi F, Alzari PM, Manganelli R, O'Hare HM.

Mol Microbiol. 2013 Oct;90(2):356-66. doi: 10.1111/mmi.12368. Epub 2013 Sep 8.

15.

Contactin 4, -5 and -6 differentially regulate neuritogenesis while they display identical PTPRG binding sites.

Mercati O, Danckaert A, André-Leroux G, Bellinzoni M, Gouder L, Watanabe K, Shimoda Y, Grailhe R, De Chaumont F, Bourgeron T, Cloëz-Tayarani I.

Biol Open. 2013 Mar 15;2(3):324-34. doi: 10.1242/bio.20133343. Epub 2013 Jan 10.

16.

Tolerance of the archaeal Sac7d scaffold protein to alternative library designs: characterization of anti-immunoglobulin G Affitins.

Béhar G, Bellinzoni M, Maillasson M, Paillard-Laurance L, Alzari PM, He X, Mouratou B, Pecorari F.

Protein Eng Des Sel. 2013 Apr;26(4):267-75. doi: 10.1093/protein/gzs106. Epub 2013 Jan 11.

PMID:
23315487
17.

Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.

Mechaly AE, Haouz A, Miras I, Barilone N, Weber P, Shepard W, Alzari PM, Bellinzoni M.

FEBS Lett. 2012 Jun 4;586(11):1606-11. doi: 10.1016/j.febslet.2012.04.034. Epub 2012 May 3.

18.

Functional plasticity and allosteric regulation of α-ketoglutarate decarboxylase in central mycobacterial metabolism.

Wagner T, Bellinzoni M, Wehenkel A, O'Hare HM, Alzari PM.

Chem Biol. 2011 Aug 26;18(8):1011-20. doi: 10.1016/j.chembiol.2011.06.004.

19.

3-Keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation.

Bellinzoni M, Bastard K, Perret A, Zaparucha A, Perchat N, Vergne C, Wagner T, de Melo-Minardi RC, Artiguenave F, Cohen GN, Weissenbach J, Salanoubat M, Alzari PM.

J Biol Chem. 2011 Aug 5;286(31):27399-405. doi: 10.1074/jbc.M111.253260. Epub 2011 Jun 1.

20.

Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance.

Manina G, Bellinzoni M, Pasca MR, Neres J, Milano A, Ribeiro AL, Buroni S, Skovierová H, Dianišková P, Mikušová K, Marák J, Makarov V, Giganti D, Haouz A, Lucarelli AP, Degiacomi G, Piazza A, Chiarelli LR, De Rossi E, Salina E, Cole ST, Alzari PM, Riccardi G.

Mol Microbiol. 2010 Sep;77(5):1172-85. doi: 10.1111/j.1365-2958.2010.07277.x.

21.

A novel role of malonyl-ACP in lipid homeostasis.

Martinez MA, Zaballa ME, Schaeffer F, Bellinzoni M, Albanesi D, Schujman GE, Vila AJ, Alzari PM, de Mendoza D.

Biochemistry. 2010 Apr 13;49(14):3161-7. doi: 10.1021/bi100136n.

PMID:
20201588
22.

Crystal structure of Mycobacterium tuberculosis LppA, a lipoprotein confined to pathogenic mycobacteria.

Graña M, Bellinzoni M, Bellalou J, Haouz A, Miras I, Buschiazzo A, Winter N, Alzari PM.

Proteins. 2010 Feb 15;78(3):769-72. doi: 10.1002/prot.22603. No abstract available.

PMID:
19899167
23.

Structure of Mycobacterium tuberculosis Rv2714, a representative of a duplicated gene family in Actinobacteria.

Graña M, Bellinzoni M, Miras I, Fiez-Vandal C, Haouz A, Shepard W, Buschiazzo A, Alzari PM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Oct 1;65(Pt 10):972-7. doi: 10.1107/S1744309109035027. Epub 2009 Sep 18.

24.

Structural plasticity and distinct drug-binding modes of LfrR, a mycobacterial efflux pump regulator.

Bellinzoni M, Buroni S, Schaeffer F, Riccardi G, De Rossi E, Alzari PM.

J Bacteriol. 2009 Dec;191(24):7531-7. doi: 10.1128/JB.00631-09. Epub 2009 Oct 9.

25.

Bacterial metabolism under FHA control.

Bellinzoni M, Alzari PM.

Structure. 2009 Apr 15;17(4):487-8. doi: 10.1016/j.str.2009.03.004. No abstract available.

26.

Regulation of glutamate metabolism by protein kinases in mycobacteria.

O'Hare HM, Durán R, Cerveñansky C, Bellinzoni M, Wehenkel AM, Pritsch O, Obal G, Baumgartner J, Vialaret J, Johnsson K, Alzari PM.

Mol Microbiol. 2008 Dec;70(6):1408-23. doi: 10.1111/j.1365-2958.2008.06489.x. Epub 2008 Oct 17.

27.

Structural and binding studies of the three-metal center in two mycobacterial PPM Ser/Thr protein phosphatases.

Wehenkel A, Bellinzoni M, Schaeffer F, Villarino A, Alzari PM.

J Mol Biol. 2007 Dec 7;374(4):890-8. Epub 2007 Oct 2.

PMID:
17961594
28.

Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential.

Wehenkel A, Bellinzoni M, Graña M, Duran R, Villarino A, Fernandez P, Andre-Leroux G, England P, Takiff H, Cerveñansky C, Cole ST, Alzari PM.

Biochim Biophys Acta. 2008 Jan;1784(1):193-202. Epub 2007 Aug 14. Review.

PMID:
17869195
29.
30.

The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria.

Wehenkel A, Fernandez P, Bellinzoni M, Catherinot V, Barilone N, Labesse G, Jackson M, Alzari PM.

FEBS Lett. 2006 May 29;580(13):3018-22. Epub 2006 Apr 27.

31.

The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer.

Bellinzoni M, Haouz A, Graña M, Munier-Lehmann H, Shepard W, Alzari PM.

Protein Sci. 2006 Jun;15(6):1489-93. Epub 2006 May 2.

32.

Conserved autophosphorylation pattern in activation loops and juxtamembrane regions of Mycobacterium tuberculosis Ser/Thr protein kinases.

Durán R, Villarino A, Bellinzoni M, Wehenkel A, Fernandez P, Boitel B, Cole ST, Alzari PM, Cerveñansky C.

Biochem Biophys Res Commun. 2005 Aug 5;333(3):858-67.

PMID:
15967413
33.

Glutamine amidotransferase activity of NAD+ synthetase from Mycobacterium tuberculosis depends on an amino-terminal nitrilase domain.

Bellinzoni M, Buroni S, Pasca MR, Guglierame P, Arcesi F, De Rossi E, Riccardi G.

Res Microbiol. 2005 Mar;156(2):173-7.

PMID:
15748981
34.

Rv2686c-Rv2687c-Rv2688c, an ABC fluoroquinolone efflux pump in Mycobacterium tuberculosis.

Pasca MR, Guglierame P, Arcesi F, Bellinzoni M, De Rossi E, Riccardi G.

Antimicrob Agents Chemother. 2004 Aug;48(8):3175-8.

35.

Techniques and applications: The heterologous expression of Mycobacterium tuberculosis genes is an uphill road.

Bellinzoni M, Riccardi G.

Trends Microbiol. 2003 Aug;11(8):351-8. Review. No abstract available.

PMID:
12915092
36.

The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology.

Terwilliger TC, Park MS, Waldo GS, Berendzen J, Hung LW, Kim CY, Smith CV, Sacchettini JC, Bellinzoni M, Bossi R, De Rossi E, Mattevi A, Milano A, Riccardi G, Rizzi M, Roberts MM, Coker AR, Fossati G, Mascagni P, Coates AR, Wood SP, Goulding CW, Apostol MI, Anderson DH, Gill HS, Eisenberg DS, Taneja B, Mande S, Pohl E, Lamzin V, Tucker P, Wilmanns M, Colovos C, Meyer-Klaucke W, Munro AW, McLean KJ, Marshall KR, Leys D, Yang JK, Yoon HJ, Lee BI, Lee MG, Kwak JE, Han BW, Lee JY, Baek SH, Suh SW, Komen MM, Arcus VL, Baker EN, Lott JS, Jacobs W Jr, Alber T, Rupp B.

Tuberculosis (Edinb). 2003;83(4):223-49. Review.

PMID:
12906835
37.

The multidrug transporters belonging to major facilitator superfamily in Mycobacterium tuberculosis.

De Rossi E, Arrigo P, Bellinzoni M, Silva PA, Martín C, Aínsa JA, Guglierame P, Riccardi G.

Mol Med. 2002 Nov;8(11):714-24.

38.

Reconstitution of T-cell receptor repertoire diversity following non-myeloablative allogeneic stem cell transplantation in an acute myeloid leukemia patient.

Almici C, Imberti L, Lanfranchi A, Verardi R, Bellinzoni M, Berta S, Izzi T.

Haematologica. 2002 Oct;87(10):ECR31. No abstract available.

PMID:
12368174
39.

High prevalence of a variant of SENV in intravenous drug user HIV-infected patients.

Pirovano S, Bellinzoni M, Matteelli A, Ballerini C, Albertini A, Imberti L.

J Med Virol. 2002 Sep;68(1):18-23.

PMID:
12210426
40.

Heterologous expression, purification, and enzymatic activity of Mycobacterium tuberculosis NAD(+) synthetase.

Bellinzoni M, De Rossi E, Branzoni M, Milano A, Peverali FA, Rizzi M, Riccardi G.

Protein Expr Purif. 2002 Aug;25(3):547-57.

PMID:
12182838
41.

Transmission of SEN virus from mothers to their babies.

Pirovano S, Bellinzoni M, Ballerini C, Cariani E, Duse M, Albertini A, Imberti L.

J Med Virol. 2002 Mar;66(3):421-7.

PMID:
11793397

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