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Comparison of the efficacy and safety of FP-1201-lyo (intravenously administered recombinant human interferon beta-1a) and placebo in the treatment of patients with moderate or severe acute respiratory distress syndrome: study protocol for a randomized controlled trial.

Bellingan G, Brealey D, Mancebo J, Mercat A, Patroniti N, Pettilä V, Quintel M, Vincent JL, Maksimow M, Jalkanen M, Piippo I, Ranieri VM.

Trials. 2017 Nov 13;18(1):536. doi: 10.1186/s13063-017-2234-7.


A multicentre, randomised controlled trial comparing the clinical effectiveness and cost-effectiveness of early nutritional support via the parenteral versus the enteral route in critically ill patients (CALORIES).

Harvey SE, Parrott F, Harrison DA, Sadique MZ, Grieve RD, Canter RR, McLennan BK, Tan JC, Bear DE, Segaran E, Beale R, Bellingan G, Leonard R, Mythen MG, Rowan KM.

Health Technol Assess. 2016 Apr;20(28):1-144. doi: 10.3310/hta20280.


Sepsis biomarkers.

Prucha M, Bellingan G, Zazula R.

Clin Chim Acta. 2015 Feb 2;440:97-103. doi: 10.1016/j.cca.2014.11.012. Epub 2014 Nov 18. Review.


Trial of the route of early nutritional support in critically ill adults.

Harvey SE, Parrott F, Harrison DA, Bear DE, Segaran E, Beale R, Bellingan G, Leonard R, Mythen MG, Rowan KM; CALORIES Trial Investigators.

N Engl J Med. 2014 Oct 30;371(18):1673-84. doi: 10.1056/NEJMoa1409860. Epub 2014 Oct 1.


Management of a mixed overdose of calcium channel blockers, β-blockers and statins.

Thakrar R, Shulman R, Bellingan G, Singer M.

BMJ Case Rep. 2014 Jun 6;2014. pii: bcr2014204732. doi: 10.1136/bcr-2014-204732.


Selective decontamination of the digestive tract in critically ill patients treated in intensive care units: a mixed-methods feasibility study (the SuDDICU study).

Francis JJ, Duncan EM, Prior ME, Maclennan GS, Dombrowski S, Bellingan GU, Campbell MK, Eccles MP, Rose L, Rowan KM, Shulman R, Peter R Wilson A, Cuthbertson BH.

Health Technol Assess. 2014 Apr;18(25):1-170. doi: 10.3310/hta18250.


The views of health care professionals about selective decontamination of the digestive tract: an international, theoretically informed interview study.

Duncan EM, Cuthbertson BH, Prior ME, Marshall AP, Wells EC, Todd LE, Bolsover D, Newlands RS, Webster F, Rose L, Campbell MK, Bellingan G, Seppelt IM, Francis JJ; SuDDICU International Study Group.

J Crit Care. 2014 Aug;29(4):634-40. doi: 10.1016/j.jcrc.2014.03.013. Epub 2014 Mar 21.


Use of interferon beta for acute respiratory distress syndrome: proceed with caution--authors' reply.

Bellingan G, Montgomery H, Maksimow M, Salmi M, Jalkanen S.

Lancet Respir Med. 2014 Apr;2(4):e2-3. doi: 10.1016/S2213-2600(14)70052-9. No abstract available.


The effect of intravenous interferon-beta-1a (FP-1201) on lung CD73 expression and on acute respiratory distress syndrome mortality: an open-label study.

Bellingan G, Maksimow M, Howell DC, Stotz M, Beale R, Beatty M, Walsh T, Binning A, Davidson A, Kuper M, Shah S, Cooper J, Waris M, Yegutkin GG, Jalkanen J, Salmi M, Piippo I, Jalkanen M, Montgomery H, Jalkanen S.

Lancet Respir Med. 2014 Feb;2(2):98-107. doi: 10.1016/S2213-2600(13)70259-5. Epub 2013 Dec 23.


Presence of hypogammaglobulinemia - a risk factor of mortality in patients with severe sepsis, septic shock, and SIRS.

Průcha M, Zazula R, Herold I, Dostál M, Hyánek T, Bellingan G.

Prague Med Rep. 2013;114(4):246-57.


Presence of hypogammaglobulinemia in patients with severe sepsis, septic shock, and SIRS is associated with increased mortality.

Prucha M, Zazula R, Herold I, Dostal M, Hyanek T, Bellingan G.

J Infect. 2014 Mar;68(3):297-9. doi: 10.1016/j.jinf.2013.11.003. Epub 2013 Nov 15. No abstract available.


Clinical stakeholders' opinions on the use of selective decontamination of the digestive tract in critically ill patients in intensive care units: an international Delphi study.

Cuthbertson BH, Campbell MK, MacLennan G, Duncan EM, Marshall AP, Wells EC, Prior ME, Todd L, Rose L, Seppelt IM, Bellingan G, Francis JJ.

Crit Care. 2013 Nov 8;17(6):R266. doi: 10.1186/cc13096.


Comparison of four methods for assessing the importance of attitudinal beliefs: an international Delphi study in intensive care settings.

Francis JJ, Duncan EM, Prior ME, Maclennan G, Marshall AP, Wells EC, Todd L, Rose L, Campbell MK, Webster F, Eccles MP, Bellingan G, Seppelt IM, Grimshaw JM, Cuthbertson BH; SuDDICU study groups.

Br J Health Psychol. 2014 May;19(2):274-91. doi: 10.1111/bjhp.12066. Epub 2013 Sep 23.


Clinical components and associated behavioural aspects of a complex healthcare intervention: multi-methods study of selective decontamination of the digestive tract in critical care.

Dombrowski SU, Prior ME, Duncan E, Cuthbertson BH, Bellingan G, Campbell MK, Rose L, Binning AR, Gordon AC, Wilson P, Shulman R, Francis JJ; SuDDICU UK Study Group.

Aust Crit Care. 2013 Nov;26(4):173-9. doi: 10.1016/j.aucc.2013.04.002. Epub 2013 May 14.


Audit of audit: review of a clinical audit programme in a teaching hospital intensive care unit.

Anderson P, Fee P, Shulman R, Bellingan G, Howell D.

Br J Hosp Med (Lond). 2012 Sep;73(9):526-9.


'Matching Michigan': a 2-year stepped interventional programme to minimise central venous catheter-blood stream infections in intensive care units in England.

Bion J, Richardson A, Hibbert P, Beer J, Abrusci T, McCutcheon M, Cassidy J, Eddleston J, Gunning K, Bellingan G, Patten M, Harrison D; Matching Michigan Collaboration & Writing Committee.

BMJ Qual Saf. 2013 Feb;22(2):110-23. doi: 10.1136/bmjqs-2012-001325. Epub 2012 Sep 20.


A multidisciplinary team approach to weaning from prolonged mechanical ventilation.

Black CJ, Kuper M, Bellingan GJ, Batson S, Matejowsky C, Howell DC.

Br J Hosp Med (Lond). 2012 Aug;73(8):462-6.


The impact of enhanced cleaning within the intensive care unit on contamination of the near-patient environment with hospital pathogens: a randomized crossover study in critical care units in two hospitals.

Wilson AP, Smyth D, Moore G, Singleton J, Jackson R, Gant V, Jeanes A, Shaw S, James E, Cooper B, Kafatos G, Cookson B, Singer M, Bellingan G.

Crit Care Med. 2011 Apr;39(4):651-8. doi: 10.1097/CCM.0b013e318206bc66.


Targeted temperature management in critical care: a report and recommendations from five professional societies.

Nunnally ME, Jaeschke R, Bellingan GJ, Lacroix J, Mourvillier B, Rodriguez-Vega GM, Rubertsson S, Vassilakopoulos T, Weinert C, Zanotti-Cavazzoni S, Buchman TG.

Crit Care Med. 2011 May;39(5):1113-25. doi: 10.1097/CCM.0b013e318206bab2. Review.


Dichotomy in duration and severity of acute inflammatory responses in humans arising from differentially expressed proresolution pathways.

Morris T, Stables M, Colville-Nash P, Newson J, Bellingan G, de Souza PM, Gilroy DW.

Proc Natl Acad Sci U S A. 2010 May 11;107(19):8842-7. doi: 10.1073/pnas.1000373107. Epub 2010 Apr 26.


Effects of low-dose aspirin on acute inflammatory responses in humans.

Morris T, Stables M, Hobbs A, de Souza P, Colville-Nash P, Warner T, Newson J, Bellingan G, Gilroy DW.

J Immunol. 2009 Aug 1;183(3):2089-96. doi: 10.4049/jimmunol.0900477. Epub 2009 Jul 13.


Dissemination of intraperitoneal ovarian cancer: Discussion of mechanisms and demonstration of lymphatic spreading in ovarian cancer model.

Feki A, Berardi P, Bellingan G, Major A, Krause KH, Petignat P, Zehra R, Pervaiz S, Irminger-Finger I.

Crit Rev Oncol Hematol. 2009 Oct;72(1):1-9. doi: 10.1016/j.critrevonc.2008.12.003. Review.


Utility of spa typing for investigating the local epidemiology of MRSA on a UK intensive care ward.

Khandavilli S, Wilson P, Cookson B, Cepeda J, Bellingan G, Brown J.

J Hosp Infect. 2009 Jan;71(1):29-35. doi: 10.1016/j.jhin.2008.09.011. Epub 2008 Nov 17.


Novel biphasic role for lymphocytes revealed during resolving inflammation.

Rajakariar R, Lawrence T, Bystrom J, Hilliard M, Colville-Nash P, Bellingan G, Fitzgerald D, Yaqoob MM, Gilroy DW.

Blood. 2008 Apr 15;111(8):4184-92. doi: 10.1182/blood-2007-08-108936. Epub 2008 Jan 24.


Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyDelta12 14 PGJ2.

Rajakariar R, Hilliard M, Lawrence T, Trivedi S, Colville-Nash P, Bellingan G, Fitzgerald D, Yaqoob MM, Gilroy DW.

Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20979-84. Epub 2007 Dec 5.


Variation in iron homeostasis genes between patients with ARDS and healthy control subjects.

Lagan AL, Quinlan GJ, Mumby S, Melley DD, Goldstraw P, Bellingan GJ, Hill MR, Briggs D, Pantelidis P, du Bois RM, Welsh KI, Evans TW.

Chest. 2008 Jun;133(6):1302-1311. doi: 10.1378/chest.07-1117. Epub 2007 Nov 7.


Importance of the environment for patient acquisition of methicillin-resistant Staphylococcus aureus in the intensive care unit: a baseline study.

Wilson AP, Hayman S, Whitehouse T, Cepeda J, Kibbler C, Shaw S, Zelaya C, Cookson B, Singer M, Bellingan G.

Crit Care Med. 2007 Oct;35(10):2275-9.


Acute respiratory medicine.

Heightma M, Bellingan G.

Clin Med (Lond). 2007 Jun;7(3):267-71. Review. No abstract available.


Effect of linezolid and teicoplanin on skin staphylococci.

Hayman S, Wilson AP, Singer M, Bellingan G.

J Antimicrob Chemother. 2007 Jun;59(6):1281-2. Epub 2007 Apr 5. No abstract available.


TREM-1 promotes survival during septic shock in mice.

Gibot S, Massin F, Marcou M, Taylor V, Stidwill R, Wilson P, Singer M, Bellingan G.

Eur J Immunol. 2007 Feb;37(2):456-66.


Screening for MRSA and GISA in the intensive care unit.

Wilson AP, Hayman S, Cepeda JA, Singer M, Bellingan G.

J Hosp Infect. 2006 Sep;64(1):85-6. Epub 2006 Jul 3. No abstract available.


In vitro susceptibility of Gram-positive pathogens to linezolid and teicoplanin and effect on outcome in critically ill patients.

Wilson AP, Cepeda JA, Hayman S, Whitehouse T, Singer M, Bellingan G.

J Antimicrob Chemother. 2006 Aug;58(2):470-3. Epub 2006 May 30.


Computer keyboards and the spread of MRSA.

Wilson AP, Hayman S, Folan P, Ostro PT, Birkett A, Batson S, Singer M, Bellingan G.

J Hosp Infect. 2006 Mar;62(3):390-2. Epub 2005 Dec 5. No abstract available.


Medication errors: a prospective cohort study of hand-written and computerised physician order entry in the intensive care unit.

Shulman R, Singer M, Goldstone J, Bellingan G.

Crit Care. 2005 Oct 5;9(5):R516-21. Epub 2005 Aug 8.


Door-opening motion can potentially lead to a transient breakdown in negative-pressure isolation conditions: the importance of vorticity and buoyancy airflows.

Tang JW, Eames I, Li Y, Taha YA, Wilson P, Bellingan G, Ward KN, Breuer J.

J Hosp Infect. 2005 Dec;61(4):283-6. Epub 2005 Oct 25.


Hooray for hypoxia?

Bellingan G.

PLoS Med. 2005 Jun;2(6):e130. Epub 2005 Jun 28. No abstract available.


Treatment of pulmonary hypertension in the general adult intensive care unit: a role for oral sildenafil?

Ng J, Finney SJ, Shulman R, Bellingan GJ, Singer M, Glynne PA.

Br J Anaesth. 2005 Jun;94(6):774-7. Epub 2005 Mar 11.


Isolation of patients in single rooms or cohorts to reduce spread of MRSA in intensive-care units: prospective two-centre study.

Cepeda JA, Whitehouse T, Cooper B, Hails J, Jones K, Kwaku F, Taylor L, Hayman S, Cookson B, Shaw S, Kibbler C, Singer M, Bellingan G, Wilson AP.

Lancet. 2005 Jan 22-28;365(9456):295-304.


Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E(2) production.

Hodges RJ, Jenkins RG, Wheeler-Jones CP, Copeman DM, Bottoms SE, Bellingan GJ, Nanthakumar CB, Laurent GJ, Hart SL, Foster ML, McAnulty RJ.

Am J Pathol. 2004 Nov;165(5):1663-76.


R643G polymorphism in PECAM-1 influences transendothelial migration of monocytes and is associated with progression of CHD and CHD events.

Elrayess MA, Webb KE, Bellingan GJ, Whittall RA, Kabir J, Hawe E, Syvänne M, Taskinen MR, Frick MH, Nieminen MS, Kesäniemi YA, Pasternack A, Miller GJ, Humphries SE.

Atherosclerosis. 2004 Nov;177(1):127-35.


Effect of recombinant surfactant protein C-based surfactant on the acute respiratory distress syndrome.

Spragg RG, Lewis JF, Walmrath HD, Johannigman J, Bellingan G, Laterre PF, Witte MC, Richards GA, Rippin G, Rathgeb F, Häfner D, Taut FJ, Seeger W.

N Engl J Med. 2004 Aug 26;351(9):884-92.


Antibiotic-treated infections in intensive care patients in the UK.

Cuthbertson BH, Thompson M, Sherry A, Wright MM, Bellingan GJ; Intensive Care Society.

Anaesthesia. 2004 Sep;59(9):885-90.


The use of oxygen in acute exacerbations of chronic obstructive pulmonary disease: a prospective audit of pre-hospital and hospital emergency management.

Singer M, Bellingan G.

Clin Med (Lond). 2003 Mar-Apr;3(2):184; author reply 185-6. No abstract available.


Large variation in MRSA policies, procedures and prevalence in English intensive care units: a questionnaire analysis.

Hails J, Kwaku F, Wilson AP, Bellingan G, Singer M.

Intensive Care Med. 2003 Mar;29(3):481-3. Epub 2003 Jan 31.


Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation.

Bellingan GJ, Xu P, Cooksley H, Cauldwell H, Shock A, Bottoms S, Haslett C, Mutsaers SE, Laurent GJ.

J Exp Med. 2002 Dec 2;196(11):1515-21.


Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome.

Marshall RP, Webb S, Bellingan GJ, Montgomery HE, Chaudhari B, McAnulty RJ, Humphries SE, Hill MR, Laurent GJ.

Am J Respir Crit Care Med. 2002 Sep 1;166(5):646-50.


Role of plasminogen activators in peritoneal adhesion formation.

Sulaiman H, Dawson L, Laurent GJ, Bellingan GJ, Herrick SE.

Biochem Soc Trans. 2002 Apr;30(2):126-31. Review.


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