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Items: 1 to 50 of 125

1.

YAP and TAZ Mediate Osteocyte Perilacunar/Canalicular Remodeling.

Kegelman CD, Coulombe JC, Jordan KM, Horan DJ, Qin L, Robling AG, Ferguson VL, Bellido TM, Boerckel JD.

J Bone Miner Res. 2019 Oct 14. doi: 10.1002/jbmr.3876. [Epub ahead of print]

PMID:
31610061
2.

Lrp4 Mediates Bone Homeostasis and Mechanotransduction through Interaction with Sclerostin In Vivo.

Bullock WA, Hoggatt AM, Horan DJ, Elmendorf AJ, Sato AY, Bellido T, Loots GG, Pavalko FM, Robling AG.

iScience. 2019 Sep 18;20:205-215. doi: 10.1016/j.isci.2019.09.023. [Epub ahead of print]

3.

Osteocytic miR21 deficiency improves bone strength independent of sex despite having sex divergent effects on osteocyte viability and bone turnover.

Davis HM, Deosthale PJ, Pacheco-Costa R, Essex AL, Atkinson EG, Aref MW, Dilley JE, Bellido T, Ivan M, Allen MR, Plotkin LI.

FEBS J. 2019 Sep 18. doi: 10.1111/febs.15066. [Epub ahead of print]

PMID:
31532878
4.

A Correlation between Wnt/Beta-catenin Signaling and the Rate of Dentin Secretion.

Zhao Y, Yuan X, Bellido T, Helms JA.

J Endod. 2019 Sep 12. pii: S0099-2399(19)30548-5. doi: 10.1016/j.joen.2019.07.014. [Epub ahead of print]

PMID:
31522810
5.

Stat3 in osteocytes mediates osteogenic response to loading.

Corry KA, Zhou H, Brustovetsky T, Himes ER, Bivi N, Horn MR, Kitase Y, Wallace JM, Bellido T, Brustovetsky N, Li J.

Bone Rep. 2019 Jul 29;11:100218. doi: 10.1016/j.bonr.2019.100218. eCollection 2019 Dec.

6.

Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts.

Delgado-Calle J, Kurihara N, Atkinson EG, Nelson J, Miyagawa K, Galmarini CM, Roodman GD, Bellido T.

Oncotarget. 2019 Apr 12;10(28):2709-2721. doi: 10.18632/oncotarget.26831. eCollection 2019 Apr 12.

7.

Glucocorticoid-Induced Bone Fragility Is Prevented in Female Mice by Blocking Pyk2/Anoikis Signaling.

Sato AY, Cregor M, McAndrews K, Li T, Condon KW, Plotkin LI, Bellido T.

Endocrinology. 2019 Jul 1;160(7):1659-1673. doi: 10.1210/en.2019-00237.

PMID:
31081900
8.

Overexpression of WNT16 Does Not Prevent Cortical Bone Loss Due to Glucocorticoid Treatment in Mice.

Alam I, Oakes DK, Reilly AM, Billingsley C, Sbeta S, Gerard-O'Riley RL, Acton D, Sato A, Bellido T, Econs MJ.

JBMR Plus. 2018 Oct 23;3(4):e10084. doi: 10.1002/jbm4.10084. eCollection 2019 Apr.

9.

TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone.

Saito H, Gasser A, Bolamperti S, Maeda M, Matthies L, Jähn K, Long CL, Schlüter H, Kwiatkowski M, Saini V, Pajevic PD, Bellido T, van Wijnen AJ, Mohammad KS, Guise TA, Taipaleenmäki H, Hesse E.

Nat Commun. 2019 Mar 22;10(1):1354. doi: 10.1038/s41467-019-08778-x.

10.

Transferrin receptor 2 controls bone mass and pathological bone formation via BMP and Wnt signaling.

Rauner M, Baschant U, Roetto A, Pellegrino RM, Rother S, Salbach-Hirsch J, Weidner H, Hintze V, Campbell G, Petzold A, Lemaitre R, Henry I, Bellido T, Theurl I, Altamura S, Colucci S, Muckenthaler MU, Schett G, Komla Ebri D, Bassett JHD, Williams GR, Platzbecker U, Hofbauer LC.

Nat Metab. 2019 Jan;1(1):111-124. doi: 10.1038/s42255-018-0005-8. Epub 2019 Jan 7.

11.

Aberrantly elevated Wnt signaling is responsible for cementum overgrowth and dental ankylosis.

Wu Y, Yuan X, Perez KC, Hyman S, Wang L, Pellegrini G, Salmon B, Bellido T, Helms JA.

Bone. 2019 May;122:176-183. doi: 10.1016/j.bone.2018.10.023. Epub 2018 Oct 25.

12.

IL-17 Receptor Signaling in Osteoblasts/Osteocytes Mediates PTH-Induced Bone Loss and Enhances Osteocytic RANKL Production.

Li JY, Yu M, Tyagi AM, Vaccaro C, Hsu E, Adams J, Bellido T, Weitzmann MN, Pacifici R.

J Bone Miner Res. 2019 Feb;34(2):349-360. doi: 10.1002/jbmr.3600. Epub 2018 Nov 6.

PMID:
30399207
13.

Cx43 overexpression in osteocytes prevents osteocyte apoptosis and preserves cortical bone quality in aging mice.

Davis HM, Aref MW, Aguilar-Perez A, Pacheco-Costa R, Allen K, Valdez S, Herrera C, Atkinson EG, Mohammad A, Lopez D, Harris MA, Harris SE, Allen M, Bellido T, Plotkin LI.

JBMR Plus. 2018 Jul;2(4):206-216. doi: 10.1002/jbm4.10035. Epub 2018 Jan 18.

14.

GLUCOCORTICOID EXCESS IN BONE AND MUSCLE.

Sato AY, Peacock M, Bellido T.

Clin Rev Bone Miner Metab. 2018 Mar;16(1):33-47. doi: 10.1007/s12018-018-9242-3. Epub 2018 Feb 5.

15.

Reversal of loss of bone mass in old mice treated with mefloquine.

Pacheco-Costa R, Davis HM, Atkinson EG, Dilley JE, Byiringiro I, Aref MW, Allen MR, Bellido T, Plotkin LI.

Bone. 2018 Sep;114:22-31. doi: 10.1016/j.bone.2018.06.002. Epub 2018 Jun 5.

16.

MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production.

Delgado-Calle J, Hancock B, Likine EF, Sato AY, McAndrews K, Sanudo C, Bruzzaniti A, Riancho JA, Tonra JR, Bellido T.

FASEB J. 2018 May;32(5):2878-2890. doi: 10.1096/fj.201700919RRR. Epub 2018 Jan 17.

17.

Skeletal cell YAP and TAZ combinatorially promote bone development.

Kegelman CD, Mason DE, Dawahare JH, Horan DJ, Vigil GD, Howard SS, Robling AG, Bellido TM, Boerckel JD.

FASEB J. 2018 May;32(5):2706-2721. doi: 10.1096/fj.201700872R. Epub 2018 Jan 10.

18.

Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth.

He G, Shi Y, Lim J, Bellido T, Ni J, Long F.

Bone Res. 2017 Jun 6;5:17016. doi: 10.1038/boneres.2017.16. eCollection 2017.

19.

Genetic deletion of Sost or pharmacological inhibition of sclerostin prevent multiple myeloma-induced bone disease without affecting tumor growth.

Delgado-Calle J, Anderson J, Cregor MD, Condon KW, Kuhstoss SA, Plotkin LI, Bellido T, Roodman GD.

Leukemia. 2017 Dec;31(12):2686-2694. doi: 10.1038/leu.2017.152. Epub 2017 May 22.

20.

Klotho expression in osteocytes regulates bone metabolism and controls bone formation.

Komaba H, Kaludjerovic J, Hu DZ, Nagano K, Amano K, Ide N, Sato T, Densmore MJ, Hanai JI, Olauson H, Bellido T, Larsson TE, Baron R, Lanske B.

Kidney Int. 2017 Sep;92(3):599-611. doi: 10.1016/j.kint.2017.02.014. Epub 2017 Apr 8.

PMID:
28396120
21.

New Insights Into the Local and Systemic Functions of Sclerostin: Regulation of Quiescent Bone Lining Cells and Beige Adipogenesis in Peripheral Fat Depots.

Delgado-Calle J, Bellido T.

J Bone Miner Res. 2017 May;32(5):889-891. doi: 10.1002/jbmr.3141. Epub 2017 Apr 6. No abstract available.

22.

Glucocorticoids Induce Bone and Muscle Atrophy by Tissue-Specific Mechanisms Upstream of E3 Ubiquitin Ligases.

Sato AY, Richardson D, Cregor M, Davis HM, Au ED, McAndrews K, Zimmers TA, Organ JM, Peacock M, Plotkin LI, Bellido T.

Endocrinology. 2017 Mar 1;158(3):664-677. doi: 10.1210/en.2016-1779.

23.

Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging.

Davis HM, Pacheco-Costa R, Atkinson EG, Brun LR, Gortazar AR, Harris J, Hiasa M, Bolarinwa SA, Yoneda T, Ivan M, Bruzzaniti A, Bellido T, Plotkin LI.

Aging Cell. 2017 Jun;16(3):551-563. doi: 10.1111/acel.12586. Epub 2017 Mar 19.

24.

Nrf2 regulates mass accrual and the antioxidant endogenous response in bone differently depending on the sex and age.

Pellegrini GG, Cregor M, McAndrews K, Morales CC, McCabe LD, McCabe GP, Peacock M, Burr D, Weaver C, Bellido T.

PLoS One. 2017 Feb 2;12(2):e0171161. doi: 10.1371/journal.pone.0171161. eCollection 2017.

25.

Hyponatremia and fractures: should hyponatremia be further studied as a potential biochemical risk factor to be included in FRAX algorithms?

Ayus JC, Bellido T, Negri AL.

Osteoporos Int. 2017 May;28(5):1543-1548. doi: 10.1007/s00198-017-3907-5. Epub 2017 Jan 10. Review.

PMID:
28074251
26.

Erratum: Osteocytic signalling pathways as therapeutic targets for bone fragility.

Plotkin LI, Bellido T.

Nat Rev Endocrinol. 2016 Jul 29. doi: 10.1038/nrendo.2016.126. [Epub ahead of print] No abstract available.

PMID:
27469347
27.

Control of Bone Anabolism in Response to Mechanical Loading and PTH by Distinct Mechanisms Downstream of the PTH Receptor.

Delgado-Calle J, Tu X, Pacheco-Costa R, McAndrews K, Edwards R, Pellegrini GG, Kuhlenschmidt K, Olivos N, Robling A, Peacock M, Plotkin LI, Bellido T.

J Bone Miner Res. 2017 Mar;32(3):522-535. doi: 10.1002/jbmr.3011. Epub 2016 Oct 27.

28.

Role and mechanism of action of sclerostin in bone.

Delgado-Calle J, Sato AY, Bellido T.

Bone. 2017 Mar;96:29-37. doi: 10.1016/j.bone.2016.10.007. Epub 2016 Oct 12. Review.

29.

PTHrP-Derived Peptides Restore Bone Mass and Strength in Diabetic Mice: Additive Effect of Mechanical Loading.

Maycas M, McAndrews KA, Sato AY, Pellegrini GG, Brown DM, Allen MR, Plotkin LI, Gortazar AR, Esbrit P, Bellido T.

J Bone Miner Res. 2017 Mar;32(3):486-497. doi: 10.1002/jbmr.3007. Epub 2016 Oct 24.

30.

Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin.

Sato AY, Cregor M, Delgado-Calle J, Condon KW, Allen MR, Peacock M, Plotkin LI, Bellido T.

J Bone Miner Res. 2016 Oct;31(10):1791-1802. doi: 10.1002/jbmr.2869. Epub 2016 Jun 5.

31.

Avenanthramides Prevent Osteoblast and Osteocyte Apoptosis and Induce Osteoclast Apoptosis in Vitro in an Nrf2-Independent Manner.

Pellegrini GG, Morales CC, Wallace TC, Plotkin LI, Bellido T.

Nutrients. 2016 Jul 11;8(7). pii: E423. doi: 10.3390/nu8070423.

32.

Osteocytic signalling pathways as therapeutic targets for bone fragility.

Plotkin LI, Bellido T.

Nat Rev Endocrinol. 2016 Oct;12(10):593-605. doi: 10.1038/nrendo.2016.71. Epub 2016 May 27. Review.

33.

Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma.

Delgado-Calle J, Anderson J, Cregor MD, Hiasa M, Chirgwin JM, Carlesso N, Yoneda T, Mohammad KS, Plotkin LI, Roodman GD, Bellido T.

Cancer Res. 2016 Mar 1;76(5):1089-100. doi: 10.1158/0008-5472.CAN-15-1703. Epub 2016 Feb 1.

34.

Conditional Deletion of Murine Fgf23: Interruption of the Normal Skeletal Responses to Phosphate Challenge and Rescue of Genetic Hypophosphatemia.

Clinkenbeard EL, Cass TA, Ni P, Hum JM, Bellido T, Allen MR, White KE.

J Bone Miner Res. 2016 Jun;31(6):1247-57. doi: 10.1002/jbmr.2792. Epub 2016 Mar 4.

35.

Osteocytes and Skeletal Pathophysiology.

Delgado-Calle J, Bellido T.

Curr Mol Biol Rep. 2015 Dec;1(4):157-167. Epub 2015 Oct 6.

36.

Defective cancellous bone structure and abnormal response to PTH in cortical bone of mice lacking Cx43 cytoplasmic C-terminus domain.

Pacheco-Costa R, Davis HM, Sorenson C, Hon MC, Hassan I, Reginato RD, Allen MR, Bellido T, Plotkin LI.

Bone. 2015 Dec;81:632-643. doi: 10.1016/j.bone.2015.09.011. Epub 2015 Sep 26.

37.

Inhibition of osteocyte apoptosis prevents the increase in osteocytic receptor activator of nuclear factor κB ligand (RANKL) but does not stop bone resorption or the loss of bone induced by unloading.

Plotkin LI, Gortazar AR, Davis HM, Condon KW, Gabilondo H, Maycas M, Allen MR, Bellido T.

J Biol Chem. 2015 Jul 31;290(31):18934-42. doi: 10.1074/jbc.M115.642090. Epub 2015 Jun 17.

38.

High Bone Mass-Causing Mutant LRP5 Receptors Are Resistant to Endogenous Inhibitors In Vivo.

Niziolek PJ, MacDonald BT, Kedlaya R, Zhang M, Bellido T, He X, Warman ML, Robling AG.

J Bone Miner Res. 2015 Oct;30(10):1822-30. doi: 10.1002/jbmr.2514.

39.

Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone.

Tu X, Delgado-Calle J, Condon KW, Maycas M, Zhang H, Carlesso N, Taketo MM, Burr DB, Plotkin LI, Bellido T.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E478-86. doi: 10.1073/pnas.1409857112. Epub 2015 Jan 20.

40.

Single-Limb Irradiation Induces Local and Systemic Bone Loss in a Murine Model.

Wright LE, Buijs JT, Kim HS, Coats LE, Scheidler AM, John SK, She Y, Murthy S, Ma N, Chin-Sinex HJ, Bellido TM, Bateman TA, Mendonca MS, Mohammad KS, Guise TA.

J Bone Miner Res. 2015 Jul;30(7):1268-79. doi: 10.1002/jbmr.2458. Epub 2015 Jun 8.

41.

Prevention of glucocorticoid induced-apoptosis of osteoblasts and osteocytes by protecting against endoplasmic reticulum (ER) stress in vitro and in vivo in female mice.

Sato AY, Tu X, McAndrews KA, Plotkin LI, Bellido T.

Bone. 2015 Apr;73:60-8. doi: 10.1016/j.bone.2014.12.012. Epub 2014 Dec 19.

42.

Role of osteocytes in multiple myeloma bone disease.

Delgado-Calle J, Bellido T, Roodman GD.

Curr Opin Support Palliat Care. 2014 Dec;8(4):407-13. doi: 10.1097/SPC.0000000000000090. Review.

43.

Comment on Osteocytes: masters orchestrators of bone.

Plotkin LI, Bellido T.

Calcif Tissue Int. 2014 Oct;95(4):382-3. doi: 10.1007/s00223-014-9905-0. Epub 2014 Aug 13. No abstract available.

PMID:
25116738
44.

Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent manner.

Wang L, Zhang H, Rodriguez S, Cao L, Parish J, Mumaw C, Zollman A, Kamoka MM, Mu J, Chen DZ, Srour EF, Chitteti BR, HogenEsch H, Tu X, Bellido TM, Boswell HS, Manshouri T, Verstovsek S, Yoder MC, Kapur R, Cardoso AA, Carlesso N.

Cell Stem Cell. 2014 Jul 3;15(1):51-65. doi: 10.1016/j.stem.2014.04.021.

45.

The Sirtuin1 activator SRT3025 down-regulates sclerostin and rescues ovariectomy-induced bone loss and biomechanical deterioration in female mice.

Artsi H, Cohen-Kfir E, Gurt I, Shahar R, Bajayo A, Kalish N, Bellido TM, Gabet Y, Dresner-Pollak R.

Endocrinology. 2014 Sep;155(9):3508-15. doi: 10.1210/en.2014-1334. Epub 2014 Jun 20.

PMID:
24949665
46.

Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes.

Ben-awadh AN, Delgado-Calle J, Tu X, Kuhlenschmidt K, Allen MR, Plotkin LI, Bellido T.

Endocrinology. 2014 Aug;155(8):2797-809. doi: 10.1210/en.2014-1046. Epub 2014 May 30.

47.

Osteoblastic protein tyrosine phosphatases inhibition and connexin 43 phosphorylation by alendronate.

Lezcano V, Bellido T, Plotkin LI, Boland R, Morelli S.

Exp Cell Res. 2014 May 15;324(1):30-9. doi: 10.1016/j.yexcr.2014.03.016. Epub 2014 Mar 31.

48.

Role of TGF-β in a mouse model of high turnover renal osteodystrophy.

Liu S, Song W, Boulanger JH, Tang W, Sabbagh Y, Kelley B, Gotschall R, Ryan S, Phillips L, Malley K, Cao X, Xia TH, Zhen G, Cao X, Ling H, Dechow PC, Bellido TM, Ledbetter SR, Schiavi SC.

J Bone Miner Res. 2014;29(5):1141-57. doi: 10.1002/jbmr.2120.

49.

Osteocyte-driven bone remodeling.

Bellido T.

Calcif Tissue Int. 2014 Jan;94(1):25-34. doi: 10.1007/s00223-013-9774-y. Epub 2013 Sep 4. Review.

50.

Resorption controls bone anabolism driven by parathyroid hormone (PTH) receptor signaling in osteocytes.

Rhee Y, Lee EY, Lezcano V, Ronda AC, Condon KW, Allen MR, Plotkin LI, Bellido T.

J Biol Chem. 2013 Oct 11;288(41):29809-20. doi: 10.1074/jbc.M113.485938. Epub 2013 Aug 20.

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