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Items: 1 to 50 of 66

1.

IL-35Ig-expressing dendritic cells induce tolerance via Arginase 1.

Panfili E, Mondanelli G, Orabona C, Bianchi R, Gargaro M, Fallarino F, Puccetti P, Grohmann U, Volpi C, Belladonna ML.

J Cell Mol Med. 2019 May;23(5):3757-3761. doi: 10.1111/jcmm.14215. Epub 2019 Feb 22.

2.

Assessment of TILs, IDO-1, and PD-L1 in resected non-small cell lung cancer: an immunohistochemical study with clinicopathological and prognostic implications.

Mandarano M, Bellezza G, Belladonna ML, Van den Eynde BJ, Chiari R, Vannucci J, Mondanelli G, Ludovini V, Ferri I, Bianconi F, Del Sordo R, Cagini L, Albini E, Metro G, Puma F, Sidoni A.

Virchows Arch. 2019 Feb;474(2):159-168. doi: 10.1007/s00428-018-2483-1. Epub 2018 Nov 17.

PMID:
30448912
3.

Identification of a 2-propanol analogue modulating the non-enzymatic function of indoleamine 2,3-dioxygenase 1.

Albini E, Coletti A, Greco F, Pallotta MT, Mondanelli G, Gargaro M, Belladonna ML, Volpi C, Bianchi R, Grohmann U, Macchiarulo A, Orabona C.

Biochem Pharmacol. 2018 Dec;158:286-297. doi: 10.1016/j.bcp.2018.10.033. Epub 2018 Nov 1.

4.

Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes.

Orabona C, Mondanelli G, Pallotta MT, Carvalho A, Albini E, Fallarino F, Vacca C, Volpi C, Belladonna ML, Berioli MG, Ceccarini G, Esposito SM, Scattoni R, Verrotti A, Ferretti A, De Giorgi G, Toni S, Cappa M, Matteoli MC, Bianchi R, Matino D, Iacono A, Puccetti M, Cunha C, Bicciato S, Antognelli C, Talesa VN, Chatenoud L, Fuchs D, Pilotte L, Van den Eynde B, Lemos MC, Romani L, Puccetti P, Grohmann U.

JCI Insight. 2018 Mar 22;3(6). pii: 96244. doi: 10.1172/jci.insight.96244.

5.

Amino-acid sensing and degrading pathways in immune regulation.

Grohmann U, Mondanelli G, Belladonna ML, Orabona C, Pallotta MT, Iacono A, Puccetti P, Volpi C.

Cytokine Growth Factor Rev. 2017 Jun;35:37-45. doi: 10.1016/j.cytogfr.2017.05.004. Epub 2017 May 18. Review.

6.

The Proteasome Inhibitor Bortezomib Controls Indoleamine 2,3-Dioxygenase 1 Breakdown and Restores Immune Regulation in Autoimmune Diabetes.

Mondanelli G, Albini E, Pallotta MT, Volpi C, Chatenoud L, Kuhn C, Fallarino F, Matino D, Belladonna ML, Bianchi R, Vacca C, Bicciato S, Boon L, Ricci G, Grohmann U, Puccetti P, Orabona C.

Front Immunol. 2017 Apr 13;8:428. doi: 10.3389/fimmu.2017.00428. eCollection 2017.

7.

A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells.

Mondanelli G, Bianchi R, Pallotta MT, Orabona C, Albini E, Iacono A, Belladonna ML, Vacca C, Fallarino F, Macchiarulo A, Ugel S, Bronte V, Gevi F, Zolla L, Verhaar A, Peppelenbosch M, Mazza EMC, Bicciato S, Laouar Y, Santambrogio L, Puccetti P, Volpi C, Grohmann U.

Immunity. 2017 Feb 21;46(2):233-244. doi: 10.1016/j.immuni.2017.01.005. Epub 2017 Feb 14.

8.

Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1.

Albini E, Rosini V, Gargaro M, Mondanelli G, Belladonna ML, Pallotta MT, Volpi C, Fallarino F, Macchiarulo A, Antognelli C, Bianchi R, Vacca C, Puccetti P, Grohmann U, Orabona C.

J Cell Mol Med. 2017 Jan;21(1):165-176. doi: 10.1111/jcmm.12954. Epub 2016 Sep 30.

9.

Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells.

Volpi C, Mondanelli G, Pallotta MT, Vacca C, Iacono A, Gargaro M, Albini E, Bianchi R, Belladonna ML, Celanire S, Mordant C, Heroux M, Royer-Urios I, Schneider M, Vitte PA, Cacquevel M, Galibert L, Poli SM, Solari A, Bicciato S, Calvitti M, Antognelli C, Puccetti P, Orabona C, Fallarino F, Grohmann U.

Neuropharmacology. 2016 Mar;102:59-71. doi: 10.1016/j.neuropharm.2015.10.036. Epub 2015 Oct 30.

10.

Islet antigen-pulsed dendritic cells expressing ectopic IL-35Ig protect nonobese diabetic mice from autoimmune diabetes.

Mondanelli G, Volpi C, Bianchi R, Allegrucci M, Talesa VN, Grohmann U, Belladonna ML.

Cytokine. 2015 Oct;75(2):380-8. doi: 10.1016/j.cyto.2015.05.002. Epub 2015 May 21.

PMID:
26003759
11.

Forced IDO1 expression in dendritic cells restores immunoregulatory signalling in autoimmune diabetes.

Pallotta MT, Orabona C, Bianchi R, Vacca C, Fallarino F, Belladonna ML, Volpi C, Mondanelli G, Gargaro M, Allegrucci M, Talesa VN, Puccetti P, Grohmann U.

J Cell Mol Med. 2014 Oct;18(10):2082-91. doi: 10.1111/jcmm.12360. Epub 2014 Sep 12.

12.

Aryl hydrocarbon receptor control of a disease tolerance defence pathway.

Bessede A, Gargaro M, Pallotta MT, Matino D, Servillo G, Brunacci C, Bicciato S, Mazza EM, Macchiarulo A, Vacca C, Iannitti R, Tissi L, Volpi C, Belladonna ML, Orabona C, Bianchi R, Lanz TV, Platten M, Della Fazia MA, Piobbico D, Zelante T, Funakoshi H, Nakamura T, Gilot D, Denison MS, Guillemin GJ, DuHadaway JB, Prendergast GC, Metz R, Geffard M, Boon L, Pirro M, Iorio A, Veyret B, Romani L, Grohmann U, Fallarino F, Puccetti P.

Nature. 2014 Jul 10;511(7508):184-90. doi: 10.1038/nature13323.

13.

Bioengineering heterodimeric cytokines: turning promiscuous proteins into therapeutic agents.

Belladonna ML, Grohmann U.

Biotechnol Genet Eng Rev. 2013;29:149-74. doi: 10.1080/02648725.2013.801228. Epub 2013 Aug 2. Review.

PMID:
24568278
14.

Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice.

Fazio F, Zappulla C, Notartomaso S, Busceti C, Bessede A, Scarselli P, Vacca C, Gargaro M, Volpi C, Allegrucci M, Lionetto L, Simmaco M, Belladonna ML, Nicoletti F, Fallarino F.

Neuropharmacology. 2014 Jun;81:237-43. doi: 10.1016/j.neuropharm.2014.02.011. Epub 2014 Feb 21.

PMID:
24565643
15.

High doses of CpG oligodeoxynucleotides stimulate a tolerogenic TLR9-TRIF pathway.

Volpi C, Fallarino F, Pallotta MT, Bianchi R, Vacca C, Belladonna ML, Orabona C, De Luca A, Boon L, Romani L, Grohmann U, Puccetti P.

Nat Commun. 2013;4:1852. doi: 10.1038/ncomms2874.

PMID:
23673637
16.

A GpC-rich oligonucleotide acts on plasmacytoid dendritic cells to promote immune suppression.

Volpi C, Fallarino F, Bianchi R, Orabona C, De Luca A, Vacca C, Romani L, Gran B, Grohmann U, Puccetti P, Belladonna ML.

J Immunol. 2012 Sep 1;189(5):2283-9. doi: 10.4049/jimmunol.1200497. Epub 2012 Jul 27.

17.

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells.

Pallotta MT, Orabona C, Volpi C, Vacca C, Belladonna ML, Bianchi R, Servillo G, Brunacci C, Calvitti M, Bicciato S, Mazza EM, Boon L, Grassi F, Fioretti MC, Fallarino F, Puccetti P, Grohmann U.

Nat Immunol. 2011 Jul 31;12(9):870-8. doi: 10.1038/ni.2077.

PMID:
21804557
18.

IL-23 gene therapy for mouse bladder tumour cell lines.

Kuramoto T, Fujii R, Nagai H, Belladonna ML, Yoshimoto T, Kohjimoto Y, Inagaki T, Hara I.

BJU Int. 2011 Sep;108(6):914-21. doi: 10.1111/j.1464-410X.2010.10025.x. Epub 2011 Mar 24.

19.

Expression of interleukins-23 and 27 leads to successful gene therapy of hepatocellular carcinoma.

Hu P, Hu HD, Chen M, Peng ML, Tang L, Tang KF, Matsui M, Belladonna ML, Yoshimoto T, Zhang DZ, Xiang R, Ren H.

Mol Immunol. 2009 May;46(8-9):1654-62. doi: 10.1016/j.molimm.2009.02.025. Epub 2009 Mar 18.

PMID:
19299021
20.

TGF-beta and kynurenines as the key to infectious tolerance.

Belladonna ML, Orabona C, Grohmann U, Puccetti P.

Trends Mol Med. 2009 Feb;15(2):41-9. doi: 10.1016/j.molmed.2008.11.006. Epub 2009 Jan 21.

PMID:
19162548
21.

SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis.

Orabona C, Pallotta MT, Volpi C, Fallarino F, Vacca C, Bianchi R, Belladonna ML, Fioretti MC, Grohmann U, Puccetti P.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20828-33. doi: 10.1073/pnas.0810278105. Epub 2008 Dec 16.

22.

Cutting edge: Autocrine TGF-beta sustains default tolerogenesis by IDO-competent dendritic cells.

Belladonna ML, Volpi C, Bianchi R, Vacca C, Orabona C, Pallotta MT, Boon L, Gizzi S, Fioretti MC, Grohmann U, Puccetti P.

J Immunol. 2008 Oct 15;181(8):5194-8.

23.

IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance.

Zelante T, De Luca A, Bonifazi P, Montagnoli C, Bozza S, Moretti S, Belladonna ML, Vacca C, Conte C, Mosci P, Bistoni F, Puccetti P, Kastelein RA, Kopf M, Romani L.

Eur J Immunol. 2007 Oct;37(10):2695-706.

24.

IL-23 enhances host defense against vaccinia virus infection via a mechanism partly involving IL-17.

Kohyama S, Ohno S, Isoda A, Moriya O, Belladonna ML, Hayashi H, Iwakura Y, Yoshimoto T, Akatsuka T, Matsui M.

J Immunol. 2007 Sep 15;179(6):3917-25.

25.

Immunosuppression via tryptophan catabolism: the role of kynurenine pathway enzymes.

Belladonna ML, Puccetti P, Orabona C, Fallarino F, Vacca C, Volpi C, Gizzi S, Pallotta MT, Fioretti MC, Grohmann U.

Transplantation. 2007 Jul 15;84(1 Suppl):S17-20.

PMID:
17632406
26.

Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy.

Grohmann U, Volpi C, Fallarino F, Bozza S, Bianchi R, Vacca C, Orabona C, Belladonna ML, Ayroldi E, Nocentini G, Boon L, Bistoni F, Fioretti MC, Romani L, Riccardi C, Puccetti P.

Nat Med. 2007 May;13(5):579-86. Epub 2007 Apr 8.

PMID:
17417651
27.

Tryptophan catabolism generates autoimmune-preventive regulatory T cells.

Fallarino F, Grohmann U, You S, McGrath BC, Cavener DR, Vacca C, Orabona C, Bianchi R, Belladonna ML, Volpi C, Fioretti MC, Puccetti P.

Transpl Immunol. 2006 Dec;17(1):58-60. Epub 2006 Oct 10.

PMID:
17157218
28.

Induction of potent antitumor immunity by intratumoral injection of interleukin 23-transduced dendritic cells.

Hu J, Yuan X, Belladonna ML, Ong JM, Wachsmann-Hogiu S, Farkas DL, Black KL, Yu JS.

Cancer Res. 2006 Sep 1;66(17):8887-96.

29.

Kynurenine pathway enzymes in dendritic cells initiate tolerogenesis in the absence of functional IDO.

Belladonna ML, Grohmann U, Guidetti P, Volpi C, Bianchi R, Fioretti MC, Schwarcz R, Fallarino F, Puccetti P.

J Immunol. 2006 Jul 1;177(1):130-7.

30.

Interleukin-23 and interleukin-27 exert quite different antitumor and vaccine effects on poorly immunogenic melanoma.

Oniki S, Nagai H, Horikawa T, Furukawa J, Belladonna ML, Yoshimoto T, Hara I, Nishigori C.

Cancer Res. 2006 Jun 15;66(12):6395-404.

31.

IL-23 neutralization protects mice from Gram-negative endotoxic shock.

Belladonna ML, Vacca C, Volpi C, Giampietri A, Fioretti MC, Puccetti P, Grohmann U, Campanile F.

Cytokine. 2006 May;34(3-4):161-9. Epub 2006 Jun 8.

PMID:
16759878
32.

The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells.

Fallarino F, Grohmann U, You S, McGrath BC, Cavener DR, Vacca C, Orabona C, Bianchi R, Belladonna ML, Volpi C, Santamaria P, Fioretti MC, Puccetti P.

J Immunol. 2006 Jun 1;176(11):6752-61.

33.

T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype.

Mathur AN, Chang HC, Zisoulis DG, Kapur R, Belladonna ML, Kansas GS, Kaplan MH.

Blood. 2006 Sep 1;108(5):1595-601. Epub 2006 May 2.

34.
35.

Cutting edge: silencing suppressor of cytokine signaling 3 expression in dendritic cells turns CD28-Ig from immune adjuvant to suppressant.

Orabona C, Belladonna ML, Vacca C, Bianchi R, Fallarino F, Volpi C, Gizzi S, Fioretti MC, Grohmann U, Puccetti P.

J Immunol. 2005 Jun 1;174(11):6582-6.

36.

CTLA-4-Ig activates forkhead transcription factors and protects dendritic cells from oxidative stress in nonobese diabetic mice.

Fallarino F, Bianchi R, Orabona C, Vacca C, Belladonna ML, Fioretti MC, Serreze DV, Grohmann U, Puccetti P.

J Exp Med. 2004 Oct 18;200(8):1051-62.

37.

CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86.

Orabona C, Grohmann U, Belladonna ML, Fallarino F, Vacca C, Bianchi R, Bozza S, Volpi C, Salomon BL, Fioretti MC, Romani L, Puccetti P.

Nat Immunol. 2004 Nov;5(11):1134-42. Epub 2004 Oct 3.

PMID:
15467723
38.
39.

Tryptophan catabolism in nonobese diabetic mice.

Grohmann U, Fallarino F, Bianchi R, Vacca C, Orabona C, Belladonna ML, Fioretti MC, Puccetti P.

Adv Exp Med Biol. 2003;527:47-54.

PMID:
15206715
40.

Potent antitumor activity of interleukin-27.

Hisada M, Kamiya S, Fujita K, Belladonna ML, Aoki T, Koyanagi Y, Mizuguchi J, Yoshimoto T.

Cancer Res. 2004 Feb 1;64(3):1152-6.

41.

Modulation of tryptophan catabolism by regulatory T cells.

Fallarino F, Grohmann U, Hwang KW, Orabona C, Vacca C, Bianchi R, Belladonna ML, Fioretti MC, Alegre ML, Puccetti P.

Nat Immunol. 2003 Dec;4(12):1206-12. Epub 2003 Oct 26.

PMID:
14578884
42.

Effects of IL-12 and IL-23 on antigen-presenting cells at the interface between innate and adaptive immunity.

Puccetti P, Belladonna ML, Grohmann U.

Crit Rev Immunol. 2002;22(5-6):373-90. Review.

PMID:
12803317
43.

CTLA-4-Ig regulates tryptophan catabolism in vivo.

Grohmann U, Orabona C, Fallarino F, Vacca C, Calcinaro F, Falorni A, Candeloro P, Belladonna ML, Bianchi R, Fioretti MC, Puccetti P.

Nat Immunol. 2002 Nov;3(11):1097-101. Epub 2002 Sep 30.

PMID:
12368911
44.

IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells.

Belladonna ML, Renauld JC, Bianchi R, Vacca C, Fallarino F, Orabona C, Fioretti MC, Grohmann U, Puccetti P.

J Immunol. 2002 Jun 1;168(11):5448-54.

45.

Functional expression of indoleamine 2,3-dioxygenase by murine CD8 alpha(+) dendritic cells.

Fallarino F, Vacca C, Orabona C, Belladonna ML, Bianchi R, Marshall B, Keskin DB, Mellor AL, Fioretti MC, Grohmann U, Puccetti P.

Int Immunol. 2002 Jan;14(1):65-8.

PMID:
11751753
46.

IL-6 inhibits the tolerogenic function of CD8 alpha+ dendritic cells expressing indoleamine 2,3-dioxygenase.

Grohmann U, Fallarino F, Bianchi R, Belladonna ML, Vacca C, Orabona C, Uyttenhove C, Fioretti MC, Puccetti P.

J Immunol. 2001 Jul 15;167(2):708-14.

47.

Positive regulatory role of IL-12 in macrophages and modulation by IFN-gamma.

Grohmann U, Belladonna ML, Vacca C, Bianchi R, Fallarino F, Orabona C, Fioretti MC, Puccetti P.

J Immunol. 2001 Jul 1;167(1):221-7.

48.

CD40 ligation ablates the tolerogenic potential of lymphoid dendritic cells.

Grohmann U, Fallarino F, Silla S, Bianchi R, Belladonna ML, Vacca C, Micheletti A, Fioretti MC, Puccetti P.

J Immunol. 2001 Jan 1;166(1):277-83.

49.

IFN-gamma inhibits presentation of a tumor/self peptide by CD8 alpha- dendritic cells via potentiation of the CD8 alpha+ subset.

Grohmann U, Bianchi R, Belladonna ML, Silla S, Fallarino F, Fioretti MC, Puccetti P.

J Immunol. 2000 Aug 1;165(3):1357-63.

50.

IL-12 induces SDS-stable class II alphabeta dimers in murine dendritic cells.

Grohmann U, Orabona C, Bianchi R, Belladonna ML, Fioretti MC, Puccetti P.

Cytokine. 2000 Apr;12(4):401-4.

PMID:
10805223

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