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Modification of the base excision repair enzyme MBD4 by the small ubiquitin-like molecule SUMO1.

Sannai M, Doneddu V, Giri V, Seeholzer S, Nicolas E, Yip SC, Bassi MR, Mancuso P, Cortellino S, Cigliano A, Lurie R, Ding H, Chernoff J, Sobol RW, Yen TJ, Bagella L, Bellacosa A.

DNA Repair (Amst). 2019 Oct;82:102687. doi: 10.1016/j.dnarep.2019.102687. Epub 2019 Aug 8.


BRCA2 in Ovarian Development and Function.

Turchetti D, Zuntini R, Tricarico R, Bellacosa A.

N Engl J Med. 2019 Mar 14;380(11):1086-1087. doi: 10.1056/NEJMc1813800. No abstract available. Erratum in: N Engl J Med. 2019 Aug 15;381(7):690. Bellacosa, Alfonso [added].


Thymine DNA glycosylase as a novel target for melanoma.

Mancuso P, Tricarico R, Bhattacharjee V, Cosentino L, Kadariya Y, Jelinek J, Nicolas E, Einarson M, Beeharry N, Devarajan K, Katz RA, Dorjsuren DG, Sun H, Simeonov A, Giordano A, Testa JR, Davidson G, Davidson I, Larue L, Sobol RW, Yen TJ, Bellacosa A.

Oncogene. 2019 May;38(19):3710-3728. doi: 10.1038/s41388-018-0640-2. Epub 2019 Jan 23.


Illuminating the route of precision medicine and inhibitor discovery: real-time measurement of DNA repair capacity with molecular beacons.

Bellacosa A, Yen T.

Oncotarget. 2018 Dec 7;9(96):36818-36819. doi: 10.18632/oncotarget.26056. eCollection 2018 Dec 7. No abstract available.


BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance.

Nacson J, Krais JJ, Bernhardy AJ, Clausen E, Feng W, Wang Y, Nicolas E, Cai KQ, Tricarico R, Hua X, DiMarcantonio D, Martinez E, Zong D, Handorf EA, Bellacosa A, Testa JR, Nussenzweig A, Gupta GP, Sykes SM, Johnson N.

Cell Rep. 2018 Oct 30;25(5):1384. doi: 10.1016/j.celrep.2018.10.009. No abstract available.


BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance.

Nacson J, Krais JJ, Bernhardy AJ, Clausen E, Feng W, Wang Y, Nicolas E, Cai KQ, Tricarico R, Hua X, DiMarcantonio D, Martinez E, Zong D, Handorf EA, Bellacosa A, Testa JR, Nussenzweig A, Gupta GP, Sykes SM, Johnson N.

Cell Rep. 2018 Sep 25;24(13):3513-3527.e7. doi: 10.1016/j.celrep.2018.08.086. Erratum in: Cell Rep. 2018 Oct 30;25(5):1384.


Thymine DNA Glycosylase (TDG) is involved in the pathogenesis of intestinal tumors with reduced APC expression.

Xu J, Cortellino S, Tricarico R, Chang WC, Scher G, Devarajan K, Slifker M, Moore R, Bassi MR, Caretti E, Clapper M, Cooper H, Bellacosa A.

Oncotarget. 2017 Sep 23;8(52):89988-89997. doi: 10.18632/oncotarget.21219. eCollection 2017 Oct 27.


An Intrinsic Epigenetic Barrier for Functional Axon Regeneration.

Weng YL, An R, Cassin J, Joseph J, Mi R, Wang C, Zhong C, Jin SG, Pfeifer GP, Bellacosa A, Dong X, Hoke A, He Z, Song H, Ming GL.

Neuron. 2017 Apr 19;94(2):337-346.e6. doi: 10.1016/j.neuron.2017.03.034.


Interaction with the DNA Repair Protein Thymine DNA Glycosylase Regulates Histone Acetylation by p300.

Henry RA, Mancuso P, Kuo YM, Tricarico R, Tini M, Cole PA, Bellacosa A, Andrews AJ.

Biochemistry. 2016 Dec 13;55(49):6766-6775. Epub 2016 Dec 1.


Haploinsufficiency in tumor predisposition syndromes: altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation.

Peri S, Caretti E, Tricarico R, Devarajan K, Cheung M, Sementino E, Menges CW, Nicolas E, Vanderveer LA, Howard S, Conrad P, Crowell JA, Campbell KS, Ross EA, Godwin AK, Yeung AT, Clapper ML, Uzzo RG, Henske EP, Ricketts CJ, Vocke CD, Linehan WM, Testa JR, Bellacosa A, Kopelovich L, Knudson AG.

Oncotarget. 2017 Mar 14;8(11):17628-17642. doi: 10.18632/oncotarget.12192.


Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis.

Tricarico R, Cortellino S, Riccio A, Jagmohan-Changur S, Van der Klift H, Wijnen J, Turner D, Ventura A, Rovella V, Percesepe A, Lucci-Cordisco E, Radice P, Bertario L, Pedroni M, Ponz de Leon M, Mancuso P, Devarajan K, Cai KQ, Klein-Szanto AJ, Neri G, Møller P, Viel A, Genuardi M, Fodde R, Bellacosa A.

Oncotarget. 2015 Dec 15;6(40):42892-904. doi: 10.18632/oncotarget.5740.


A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity.

Conde-Perez A, Gros G, Longvert C, Pedersen M, Petit V, Aktary Z, Viros A, Gesbert F, Delmas V, Rambow F, Bastian BC, Campbell AD, Colombo S, Puig I, Bellacosa A, Sansom O, Marais R, Van Kempen LC, Larue L.

Nat Commun. 2015 Aug 26;6:8093. doi: 10.1038/ncomms9093.


Role of base excision repair in maintaining the genetic and epigenetic integrity of CpG sites.

Bellacosa A, Drohat AC.

DNA Repair (Amst). 2015 Aug;32:33-42. doi: 10.1016/j.dnarep.2015.04.011. Epub 2015 May 1. Review.


Inhibitor of DNA Binding 4 (ID4) is highly expressed in human melanoma tissues and may function to restrict normal differentiation of melanoma cells.

Peretz Y, Wu H, Patel S, Bellacosa A, Katz RA.

PLoS One. 2015 Feb 2;10(2):e0116839. doi: 10.1371/journal.pone.0116839. eCollection 2015.


Complex relationship between mismatch repair proteins and MBD4 during immunoglobulin class switch recombination.

Grigera F, Bellacosa A, Kenter AL.

PLoS One. 2013 Oct 29;8(10):e78370. doi: 10.1371/journal.pone.0078370. eCollection 2013.


A population of Nestin-expressing progenitors in the cerebellum exhibits increased tumorigenicity.

Li P, Du F, Yuelling LW, Lin T, Muradimova RE, Tricarico R, Wang J, Enikolopov G, Bellacosa A, Wechsler-Reya RJ, Yang ZJ.

Nat Neurosci. 2013 Dec;16(12):1737-44. doi: 10.1038/nn.3553. Epub 2013 Oct 20.


Developmental disease and cancer: biological and clinical overlaps.

Bellacosa A.

Am J Med Genet A. 2013 Nov;161A(11):2788-96. doi: 10.1002/ajmg.a.36267. Epub 2013 Oct 7. Review.


BCR-ABL1 kinase inhibits uracil DNA glycosylase UNG2 to enhance oxidative DNA damage and stimulate genomic instability.

Slupianek A, Falinski R, Znojek P, Stoklosa T, Flis S, Doneddu V, Pytel D, Synowiec E, Blasiak J, Bellacosa A, Skorski T.

Leukemia. 2013 Mar;27(3):629-34. doi: 10.1038/leu.2012.294. Epub 2012 Oct 9.


DNA demethylation by TDG.

Dalton SR, Bellacosa A.

Epigenomics. 2012 Aug;4(4):459-67. doi: 10.2217/epi.12.36. Review.


Dose dependent effects on cell cycle checkpoints and DNA repair by bendamustine.

Beeharry N, Rattner JB, Bellacosa A, Smith MR, Yen TJ.

PLoS One. 2012;7(6):e40342. doi: 10.1371/journal.pone.0040342. Epub 2012 Jun 29.


Beta-catenin inhibits melanocyte migration but induces melanoma metastasis.

Gallagher SJ, Rambow F, Kumasaka M, Champeval D, Bellacosa A, Delmas V, Larue L.

Oncogene. 2013 Apr 25;32(17):2230-8. doi: 10.1038/onc.2012.229. Epub 2012 Jun 4.


Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair.

Cortellino S, Xu J, Sannai M, Moore R, Caretti E, Cigliano A, Le Coz M, Devarajan K, Wessels A, Soprano D, Abramowitz LK, Bartolomei MS, Rambow F, Bassi MR, Bruno T, Fanciulli M, Renner C, Klein-Szanto AJ, Matsumoto Y, Kobi D, Davidson I, Alberti C, Larue L, Bellacosa A.

Cell. 2011 Jul 8;146(1):67-79. doi: 10.1016/j.cell.2011.06.020. Epub 2011 Jun 30.


APC +/- alters colonic fibroblast proteome in FAP.

Patel BB, Li XM, Dixon MP, Blagoi EL, Nicolas E, Seeholzer SH, Cheng D, He YA, Coudry RA, Howard SD, Riddle DM, Cooper HC, Boman BM, Conrad P, Crowell JA, Bellacosa A, Knudson A, Yeung AT, Kopelovich L.

Oncotarget. 2011 Mar;2(3):197-208.


Che-1 promotes tumor cell survival by sustaining mutant p53 transcription and inhibiting DNA damage response activation.

Bruno T, Desantis A, Bossi G, Di Agostino S, Sorino C, De Nicola F, Iezzi S, Franchitto A, Benassi B, Galanti S, La Rosa F, Floridi A, Bellacosa A, Passananti C, Blandino G, Fanciulli M.

Cancer Cell. 2010 Aug 9;18(2):122-34. doi: 10.1016/j.ccr.2010.05.027.


Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations.

Bellacosa A, Godwin AK, Peri S, Devarajan K, Caretti E, Vanderveer L, Bove B, Slater C, Zhou Y, Daly M, Howard S, Campbell KS, Nicolas E, Yeung AT, Clapper ML, Crowell JA, Lynch HT, Ross E, Kopelovich L, Knudson AG.

Cancer Prev Res (Phila). 2010 Jan;3(1):48-61. doi: 10.1158/1940-6207.CAPR-09-0078.


Akt increases sarcoplasmic reticulum Ca2+ cycling by direct phosphorylation of phospholamban at Thr17.

Catalucci D, Latronico MV, Ceci M, Rusconi F, Young HS, Gallo P, Santonastasi M, Bellacosa A, Brown JH, Condorelli G.

J Biol Chem. 2009 Oct 9;284(41):28180-7. doi: 10.1074/jbc.M109.036566. Epub 2009 Aug 19.


Growth-inhibitory and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations.

Ciuffreda L, Del Bufalo D, Desideri M, Di Sanza C, Stoppacciaro A, Ricciardi MR, Chiaretti S, Tavolaro S, Benassi B, Bellacosa A, Foà R, Tafuri A, Cognetti F, Anichini A, Zupi G, Milella M.

Neoplasia. 2009 Aug;11(8):720-31.


Epigenetic downregulation of the DNA repair gene MED1/MBD4 in colorectal and ovarian cancer.

Howard JH, Frolov A, Tzeng CW, Stewart A, Midzak A, Majmundar A, Godwin A, Heslin M, Bellacosa A, Arnoletti JP.

Cancer Biol Ther. 2009 Jan;8(1):94-100. Epub 2009 Jan 20.


Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4.

Cortellino S, Wang C, Wang B, Bassi MR, Caretti E, Champeval D, Calmont A, Jarnik M, Burch J, Zaret KS, Larue L, Bellacosa A.

Dev Biol. 2009 Jan 1;325(1):225-37. doi: 10.1016/j.ydbio.2008.10.020. Epub 2008 Oct 29.


Brain atrophy evolution and lesion load accrual in multiple sclerosis: a 2-year follow-up study.

Tedeschi G, Dinacci D, Comerci M, Lavorgna L, Savettieri G, Quattrone A, Livrea P, Patti F, Morra VB, Servillo G, Orefice G, Paciello M, Prinster A, Coniglio G, Bonavita S, Di Costanzo A, Bellacosa A, Valentino P, Quarantelli M, Brunetti A, Salemi G, D'Amelio M, Simone I, Salvatore M, Bonavita V, Alfano B.

Mult Scler. 2009 Feb;15(2):204-11. doi: 10.1177/1352458508098270. Epub 2008 Nov 5.


One-hit effects in cancer: altered proteome of morphologically normal colon crypts in familial adenomatous polyposis.

Yeung AT, Patel BB, Li XM, Seeholzer SH, Coudry RA, Cooper HS, Bellacosa A, Boman BM, Zhang T, Litwin S, Ross EA, Conrad P, Crowell JA, Kopelovich L, Knudson A.

Cancer Res. 2008 Sep 15;68(18):7579-86. doi: 10.1158/0008-5472.CAN-08-0856.


VILIP-1 downregulation in non-small cell lung carcinomas: mechanisms and prediction of survival.

Fu J, Fong K, Bellacosa A, Ross E, Apostolou S, Bassi DE, Jin F, Zhang J, Cairns P, Ibañez de Caceres I, Braunewell KH, Klein-Szanto AJ.

PLoS One. 2008 Feb 27;3(2):e1698. doi: 10.1371/journal.pone.0001698.


Correlation between fatigue and brain atrophy and lesion load in multiple sclerosis patients independent of disability.

Tedeschi G, Dinacci D, Lavorgna L, Prinster A, Savettieri G, Quattrone A, Livrea P, Messina C, Reggio A, Servillo G, Bresciamorra V, Orefice G, Paciello M, Brunetti A, Paolillo A, Coniglio G, Bonavita S, Di Costanzo A, Bellacosa A, Valentino P, Quarantelli M, Patti F, Salemi G, Cammarata E, Simone I, Salvatore M, Bonavita V, Alfano B.

J Neurol Sci. 2007 Dec 15;263(1-2):15-9. Epub 2007 Aug 1.


Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition.

Julien S, Puig I, Caretti E, Bonaventure J, Nelles L, van Roy F, Dargemont C, de Herreros AG, Bellacosa A, Larue L.

Oncogene. 2007 Nov 22;26(53):7445-56. Epub 2007 Jun 11.


Comparison of RNA amplification methods and chip platforms for microarray analysis of samples processed by laser capture microdissection.

Caretti E, Devarajan K, Coudry R, Ross E, Clapper ML, Cooper HS, Bellacosa A.

J Cell Biochem. 2008 Feb 1;103(2):556-63.


Recombinant nucleases CEL I from celery and SP I from spinach for mutation detection.

Pimkin M, Caretti E, Canutescu A, Yeung JB, Cohn H, Chen Y, Oleykowski C, Bellacosa A, Yeung AT.

BMC Biotechnol. 2007 Jun 1;7:29.


Searchable high-resolution 2D gel proteome of the human colon crypt.

Patel BB, Li XM, Dixon MP, Blagoi EL, Seeholzer SH, Chen Y, Miller CG, He YA, Tetruashvily M, Chaudhry AH, Ke E, Xie J, Cooper H, Bellacosa A, Clapper ML, Boman BM, Zhang T, Litwin S, Ross EA, Conrad P, Crowell JA, Kopelovich L, Knudson A, Yeung AT.

J Proteome Res. 2007 Jun;6(6):2232-8. Epub 2007 Apr 20.


Influence of Interferon beta treatment on quality of life in multiple sclerosis patients.

Simone IL, Ceccarelli A, Tortorella C, Bellacosa A, Pellegrini F, Plasmati I, De Caro MF, Lopez M, Girolamo F, Livrea P.

Health Qual Life Outcomes. 2006 Dec 12;4:96.


The DNA N-glycosylase MED1 exhibits preference for halogenated pyrimidines and is involved in the cytotoxicity of 5-iododeoxyuridine.

Turner DP, Cortellino S, Schupp JE, Caretti E, Loh T, Kinsella TJ, Bellacosa A.

Cancer Res. 2006 Aug 1;66(15):7686-93.


Age-related gadolinium-enhancement of MRI brain lesions in multiple sclerosis.

Tortorella C, Bellacosa A, Paolicelli D, Fuiani A, Di Monte E, Simone IL, Giaquinto P, Livrea P, Trojano M.

J Neurol Sci. 2005 Dec 15;239(1):95-9. Epub 2005 Oct 4.


Differential stromal and epithelial localization of cyclooxygenase-2 (COX-2) during colorectal tumorigenesis.

Arnoletti JP, Upson J, Babb JS, Bellacosa A, Watson JC.

J Exp Clin Cancer Res. 2005 Jun;24(2):279-87.


Activation of AKT kinases in cancer: implications for therapeutic targeting.

Bellacosa A, Kumar CC, Di Cristofano A, Testa JR.

Adv Cancer Res. 2005;94:29-86. Review.


Brain atrophy and lesion load in a large population of patients with multiple sclerosis.

Tedeschi G, Lavorgna L, Russo P, Prinster A, Dinacci D, Savettieri G, Quattrone A, Livrea P, Messina C, Reggio A, Bresciamorra V, Orefice G, Paciello M, Brunetti A, Coniglio G, Bonavita S, Di Costanzo A, Bellacosa A, Valentino P, Quarantelli M, Patti F, Salemi G, Cammarata E, Simone IL, Salvatore M, Bonavita V, Alfano B.

Neurology. 2005 Jul 26;65(2):280-5.


[Regulation of E-cadherin by the Akt protein kinase B].

Grille S, Bellacosa A, Larue L.

J Soc Biol. 2004;198(4):375-8. French.


Atypical forms of multiple sclerosis or different phases of a same disease?

Trojano M, Paolicelli D, Bellacosa A, Fuiani A, Cataldi S, Di Monte E.

Neurol Sci. 2004 Nov;25 Suppl 4:S323-5.


Altered gene expression in phenotypically normal renal cells from carriers of tumor suppressor gene mutations.

Stoyanova R, Clapper ML, Bellacosa A, Henske EP, Testa JR, Ross EA, Yeung AT, Nicolas E, Tsichlis N, Li YS, Linehan WM, Howard S, Campbell KS, Godwin AK, Boman BM, Crowell JA, Kopelovich L, Knudson AG.

Cancer Biol Ther. 2004 Dec;3(12):1313-21. Epub 2004 Dec 9.


Optimized procedures for microarray analysis of histological specimens processed by laser capture microdissection.

Upson JJ, Stoyanova R, Cooper HS, Patriotis C, Ross EA, Boman B, Clapper ML, Knudson AG, Bellacosa A.

J Cell Physiol. 2004 Dec;201(3):366-73.


Use of RNA amplification in the optimal characterization of global gene expression using cDNA microarrays.

Stoyanova R, Upson JJ, Patriotis C, Ross EA, Henske EP, Datta K, Boman B, Clapper ML, Knudson AG, Bellacosa A.

J Cell Physiol. 2004 Dec;201(3):359-65.


Ultraviolet irradiation of cells.

Turner DP, Yeung AT, Bellacosa A.

Methods Mol Biol. 2004;285:133-7. Review. No abstract available.


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