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Physical and Functional Compartmentalization of Archaeal Chromosomes.

Takemata N, Samson RY, Bell SD.

Cell. 2019 Sep 19;179(1):165-179.e18. doi: 10.1016/j.cell.2019.08.036.


Analysis of the Archaeal ESCRT Apparatus.

Samson RY, Duggin IG, Bell SD.

Methods Mol Biol. 2019;1998:1-11. doi: 10.1007/978-1-4939-9492-2_1.


Initiating DNA replication: a matter of prime importance.

Bell SD.

Biochem Soc Trans. 2019 Feb 28;47(1):351-356. doi: 10.1042/BST20180627. Epub 2019 Jan 15. Review.


An archaeal primase functions as a nanoscale caliper to define primer length.

Yan J, Holzer S, Pellegrini L, Bell SD.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6697-6702. doi: 10.1073/pnas.1806351115. Epub 2018 Jun 11.


Initiation of DNA Replication in the Archaea.

Bell SD.

Adv Exp Med Biol. 2017;1042:99-115. doi: 10.1007/978-981-10-6955-0_5. Review.


Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster.

Holzer S, Yan J, Kilkenny ML, Bell SD, Pellegrini L.

Nat Commun. 2017 Nov 23;8(1):1718. doi: 10.1038/s41467-017-01707-w.


A Complex Endomembrane System in the Archaeon Ignicoccus hospitalis Tapped by Nanoarchaeum equitans.

Heimerl T, Flechsler J, Pickl C, Heinz V, Salecker B, Zweck J, Wanner G, Geimer S, Samson RY, Bell SD, Huber H, Wirth R, Wurch L, Podar M, Rachel R.

Front Microbiol. 2017 Jun 13;8:1072. doi: 10.3389/fmicb.2017.01072. eCollection 2017.


The Structure, Function and Roles of the Archaeal ESCRT Apparatus.

Samson RY, Dobro MJ, Jensen GJ, Bell SD.

Subcell Biochem. 2017;84:357-377. doi: 10.1007/978-3-319-53047-5_12. Review.


Identification and characterization of a heterotrimeric archaeal DNA polymerase holoenzyme.

Yan J, Beattie TR, Rojas AL, Schermerhorn K, Gristwood T, Trinidad JC, Albers SV, Roversi P, Gardner AF, Abrescia NGA, Bell SD.

Nat Commun. 2017 May 2;8:15075. doi: 10.1038/ncomms15075.


Archaeal orthologs of Cdc45 and GINS form a stable complex that stimulates the helicase activity of MCM.

Xu Y, Gristwood T, Hodgson B, Trinidad JC, Albers SV, Bell SD.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13390-13395. Epub 2016 Nov 7.


Hydroxyurea-Mediated Cytotoxicity Without Inhibition of Ribonucleotide Reductase.

Liew LP, Lim ZY, Cohen M, Kong Z, Marjavaara L, Chabes A, Bell SD.

Cell Rep. 2016 Nov 1;17(6):1657-1670. doi: 10.1016/j.celrep.2016.10.024.


Archaeal DNA Replication Origins and Recruitment of the MCM Replicative Helicase.

Samson RY, Bell SD.

Enzymes. 2016;39:169-90. doi: 10.1016/bs.enz.2016.03.002. Epub 2016 Apr 19. Review.


Phase II multicenter study of gene-mediated cytotoxic immunotherapy as adjuvant to surgical resection for newly diagnosed malignant glioma.

Wheeler LA, Manzanera AG, Bell SD, Cavaliere R, McGregor JM, Grecula JC, Newton HB, Lo SS, Badie B, Portnow J, Teh BS, Trask TW, Baskin DS, New PZ, Aguilar LK, Aguilar-Cordova E, Chiocca EA.

Neuro Oncol. 2016 Aug;18(8):1137-45. doi: 10.1093/neuonc/now002. Epub 2016 Feb 2.


Mechanism of Archaeal MCM Helicase Recruitment to DNA Replication Origins.

Samson RY, Abeyrathne PD, Bell SD.

Mol Cell. 2016 Jan 21;61(2):287-96. doi: 10.1016/j.molcel.2015.12.005. Epub 2015 Dec 24.


Structural and functional studies of the Pseudomonas aeruginosa minor pilin, PilE.

Nguyen Y, Harvey H, Sugiman-Marangos S, Bell SD, Buensuceso RN, Junop MS, Burrows LL.

J Biol Chem. 2015 Oct 30;290(44):26856-65. doi: 10.1074/jbc.M115.683334. Epub 2015 Sep 10.


Calorie restriction does not restore brain mitochondrial function in P301L tau mice, but it does decrease mitochondrial F0F1-ATPase activity.

Delic V, Brownlow M, Joly-Amado A, Zivkovic S, Noble K, Phan TA, Ta Y, Zhang Y, Bell SD, Kurien C, Reynes C, Morgan D, Bradshaw PC.

Mol Cell Neurosci. 2015 Jul;67:46-54. doi: 10.1016/j.mcn.2015.06.001. Epub 2015 Jun 3.


Pseudomonas aeruginosa minor pilins prime type IVa pilus assembly and promote surface display of the PilY1 adhesin.

Nguyen Y, Sugiman-Marangos S, Harvey H, Bell SD, Charlton CL, Junop MS, Burrows LL.

J Biol Chem. 2015 Jan 2;290(1):601-11. doi: 10.1074/jbc.M114.616904. Epub 2014 Nov 11.


The architecture of an Okazaki fragment-processing holoenzyme from the archaeon Sulfolobus solfataricus.

Cannone G, Xu Y, Beattie TR, Bell SD, Spagnolo L.

Biochem J. 2015 Jan 15;465(2):239-45. doi: 10.1042/BJ20141120.


Unique genome replication mechanism of the archaeal virus AFV1.

Pina M, Basta T, Quax TE, Joubert A, Baconnais S, Cortez D, Lambert S, Le Cam E, Bell SD, Forterre P, Prangishvili D.

Mol Microbiol. 2014 Jun;92(6):1313-25. doi: 10.1111/mmi.12630. Epub 2014 May 23.


Anaplastic papillary glioneuronal tumor with extraneural metastases.

Bourekas EC, Bell SD, Ladwig NR, Gandhe AR, Shilo K, McGregor JM, Lehman NL, Newton HB.

J Neuropathol Exp Neurol. 2014 May;73(5):474-6. doi: 10.1097/NEN.0000000000000061. Review. No abstract available.


Protein-protein interactions leading to recruitment of the host DNA sliding clamp by the hyperthermophilic Sulfolobus islandicus rod-shaped virus 2.

Gardner AF, Bell SD, White MF, Prangishvili D, Krupovic M.

J Virol. 2014 Jun;88(12):7105-8. doi: 10.1128/JVI.00636-14. Epub 2014 Apr 2.


Archaeal chromosome biology.

Samson RY, Bell SD.

J Mol Microbiol Biotechnol. 2014;24(5-6):420-7. doi: 10.1159/000368854. Epub 2015 Feb 17. Review.


The minichromosome maintenance replicative helicase.

Bell SD, Botchan MR.

Cold Spring Harb Perspect Biol. 2013 Nov 1;5(11):a012807. doi: 10.1101/cshperspect.a012807. Review.


Electron cryotomography of ESCRT assemblies and dividing Sulfolobus cells suggests that spiraling filaments are involved in membrane scission.

Dobro MJ, Samson RY, Yu Z, McCullough J, Ding HJ, Chong PL, Bell SD, Jensen GJ.

Mol Biol Cell. 2013 Aug;24(15):2319-27. doi: 10.1091/mbc.E12-11-0785. Epub 2013 Jun 12.


Functional interplay between a virus and the ESCRT machinery in archaea.

Snyder JC, Samson RY, Brumfield SK, Bell SD, Young MJ.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10783-7. doi: 10.1073/pnas.1301605110. Epub 2013 Jun 10.


MCM loading--an open-and-shut case?

Samson RY, Bell SD.

Mol Cell. 2013 May 23;50(4):457-8. doi: 10.1016/j.molcel.2013.05.008.


Specificity and function of archaeal DNA replication initiator proteins.

Samson RY, Xu Y, Gadelha C, Stone TA, Faqiri JN, Li D, Qin N, Pu F, Liang YX, She Q, Bell SD.

Cell Rep. 2013 Feb 21;3(2):485-96. doi: 10.1016/j.celrep.2013.01.002. Epub 2013 Jan 31.


Archaeal orc1/cdc6 proteins.

Bell SD.

Subcell Biochem. 2012;62:59-69. doi: 10.1007/978-94-007-4572-8_4. Review.


Structural and functional analyses of the interaction of archaeal RNA polymerase with DNA.

Wojtas MN, Mogni M, Millet O, Bell SD, Abrescia NG.

Nucleic Acids Res. 2012 Oct;40(19):9941-52. doi: 10.1093/nar/gks692. Epub 2012 Jul 30.


Genome-wide analysis reveals extensive functional interaction between DNA replication initiation and transcription in the genome of Trypanosoma brucei.

Tiengwe C, Marcello L, Farr H, Dickens N, Kelly S, Swiderski M, Vaughan D, Gull K, Barry JD, Bell SD, McCulloch R.

Cell Rep. 2012 Jul 26;2(1):185-97. doi: 10.1016/j.celrep.2012.06.007. Epub 2012 Jul 12.


Identification of ORC1/CDC6-interacting factors in Trypanosoma brucei reveals critical features of origin recognition complex architecture.

Tiengwe C, Marcello L, Farr H, Gadelha C, Burchmore R, Barry JD, Bell SD, McCulloch R.

PLoS One. 2012;7(3):e32674. doi: 10.1371/journal.pone.0032674. Epub 2012 Mar 8.


The sub-cellular localization of Sulfolobus DNA replication.

Gristwood T, Duggin IG, Wagner M, Albers SV, Bell SD.

Nucleic Acids Res. 2012 Jul;40(12):5487-96. doi: 10.1093/nar/gks217. Epub 2012 Mar 8.


Coordination of multiple enzyme activities by a single PCNA in archaeal Okazaki fragment maturation.

Beattie TR, Bell SD.

EMBO J. 2012 Mar 21;31(6):1556-67. doi: 10.1038/emboj.2012.12. Epub 2012 Feb 3.


The complete genome sequence of Thermoproteus tenax: a physiologically versatile member of the Crenarchaeota.

Siebers B, Zaparty M, Raddatz G, Tjaden B, Albers SV, Bell SD, Blombach F, Kletzin A, Kyrpides N, Lanz C, Plagens A, Rampp M, Rosinus A, von Jan M, Makarova KS, Klenk HP, Schuster SC, Hensel R.

PLoS One. 2011;6(10):e24222. doi: 10.1371/journal.pone.0024222. Epub 2011 Oct 7.


Community Markets for Conservation (COMACO) links biodiversity conservation with sustainable improvements in livelihoods and food production.

Lewis D, Bell SD, Fay J, Bothi KL, Gatere L, Kabila M, Mukamba M, Matokwani E, Mushimbalume M, Moraru CI, Lehmann J, Lassoie J, Wolfe D, Lee DR, Buck L, Travis AJ.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):13957-62. doi: 10.1073/pnas.1011538108. Epub 2011 Aug 22.


Molecular machines in archaeal DNA replication.

Beattie TR, Bell SD.

Curr Opin Chem Biol. 2011 Oct;15(5):614-9. doi: 10.1016/j.cbpa.2011.07.017. Epub 2011 Aug 16. Review.


Phase IB study of gene-mediated cytotoxic immunotherapy adjuvant to up-front surgery and intensive timing radiation for malignant glioma.

Chiocca EA, Aguilar LK, Bell SD, Kaur B, Hardcastle J, Cavaliere R, McGregor J, Lo S, Ray-Chaudhuri A, Chakravarti A, Grecula J, Newton H, Harris KS, Grossman RG, Trask TW, Baskin DS, Monterroso C, Manzanera AG, Aguilar-Cordova E, New PZ.

J Clin Oncol. 2011 Sep 20;29(27):3611-9. doi: 10.1200/JCO.2011.35.5222. Epub 2011 Aug 15.


DNA replication: archaeal oriGINS.

Bell SD.

BMC Biol. 2011 May 31;9:36. doi: 10.1186/1741-7007-9-36.


Cell cycles and cell division in the archaea.

Samson RY, Bell SD.

Curr Opin Microbiol. 2011 Jun;14(3):350-6. doi: 10.1016/j.mib.2011.04.005. Epub 2011 May 3. Review.


The interplay of DNA binding, ATP hydrolysis and helicase activities of the archaeal MCM helicase.

Liew LP, Bell SD.

Biochem J. 2011 Jun 1;436(2):409-14. doi: 10.1042/BJ20110084.


The role of the DNA sliding clamp in Okazaki fragment maturation in archaea and eukaryotes.

Beattie TR, Bell SD.

Biochem Soc Trans. 2011 Jan;39(1):70-6. doi: 10.1042/BST0390070. Review.


Archaeal RNA polymerase: the influence of the protruding stalk in crystal packing and preliminary biophysical analysis of the Rpo13 subunit.

Wojtas M, Peralta B, Ondiviela M, Mogni M, Bell SD, Abrescia NG.

Biochem Soc Trans. 2011 Jan;39(1):25-30. doi: 10.1042/BST0390025. Review.


Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division.

Samson RY, Obita T, Hodgson B, Shaw MK, Chong PL, Williams RL, Bell SD.

Mol Cell. 2011 Jan 21;41(2):186-96. doi: 10.1016/j.molcel.2010.12.018.


Molecular determinants of origin discrimination by Orc1 initiators in archaea.

Dueber EC, Costa A, Corn JE, Bell SD, Berger JM.

Nucleic Acids Res. 2011 May;39(9):3621-31. doi: 10.1093/nar/gkq1308. Epub 2011 Jan 11.


Replication termination and chromosome dimer resolution in the archaeon Sulfolobus solfataricus.

Duggin IG, Dubarry N, Bell SD.

EMBO J. 2011 Jan 5;30(1):145-53. doi: 10.1038/emboj.2010.301. Epub 2010 Nov 26.


Evolution of diverse cell division and vesicle formation systems in Archaea.

Makarova KS, Yutin N, Bell SD, Koonin EV.

Nat Rev Microbiol. 2010 Oct;8(10):731-41. doi: 10.1038/nrmicro2406. Epub 2010 Sep 6. Review.


Ancient ESCRTs and the evolution of binary fission.

Samson RY, Bell SD.

Trends Microbiol. 2009 Nov;17(11):507-13. doi: 10.1016/j.tim.2009.08.003. Epub 2009 Sep 23. Review.


The glutamate switch is present in all seven clades of AAA+ protein.

Mogni ME, Costa A, Ioannou C, Bell SD.

Biochemistry. 2009 Sep 22;48(37):8774-5. doi: 10.1021/bi9012512.


Evolution of complex RNA polymerases: the complete archaeal RNA polymerase structure.

Korkhin Y, Unligil UM, Littlefield O, Nelson PJ, Stuart DI, Sigler PB, Bell SD, Abrescia NG.

PLoS Biol. 2009 May;7(5):e1000102. doi: 10.1371/journal.pbio.1000102. Epub 2009 May 5.

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