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Items: 1 to 50 of 180

1.

Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.

Dendrou CA, Cortes A, Shipman L, Evans HG, Attfield KE, Jostins L, Barber T, Kaur G, Kuttikkatte SB, Leach OA, Desel C, Faergeman SL, Cheeseman J, Neville MJ, Sawcer S, Compston A, Johnson AR, Everett C, Bell JI, Karpe F, Ultsch M, Eigenbrot C, McVean G, Fugger L.

Sci Transl Med. 2016 Nov 2;8(363):363ra149.

2.

Injectable Aorta Tissue Paste for Vocal Fold Medialization: Residence Time, Biocompatibility, and Comparison to Predicates in a Guinea Pig Subdermal Model.

Burns JA, Botelho JL, Bell JI, Faquin W, Lopez-Guerra G, Ackerman JL, Kobler JB.

Ann Otol Rhinol Laryngol. 2016 Nov;125(11):900-911. Epub 2016 Jul 20.

PMID:
27440067
3.

On the Recognition of Global Excellence in Medical Research.

Naylor CD, Bell JI.

JAMA. 2015 Sep 15;314(11):1125-6. doi: 10.1001/jama.2015.10696. No abstract available.

PMID:
26372575
4.

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.

Taylor JC, Martin HC, Lise S, Broxholme J, Cazier JB, Rimmer A, Kanapin A, Lunter G, Fiddy S, Allan C, Aricescu AR, Attar M, Babbs C, Becq J, Beeson D, Bento C, Bignell P, Blair E, Buckle VJ, Bull K, Cais O, Cario H, Chapel H, Copley RR, Cornall R, Craft J, Dahan K, Davenport EE, Dendrou C, Devuyst O, Fenwick AL, Flint J, Fugger L, Gilbert RD, Goriely A, Green A, Greger IH, Grocock R, Gruszczyk AV, Hastings R, Hatton E, Higgs D, Hill A, Holmes C, Howard M, Hughes L, Humburg P, Johnson D, Karpe F, Kingsbury Z, Kini U, Knight JC, Krohn J, Lamble S, Langman C, Lonie L, Luck J, McCarthy D, McGowan SJ, McMullin MF, Miller KA, Murray L, Németh AH, Nesbit MA, Nutt D, Ormondroyd E, Oturai AB, Pagnamenta A, Patel SY, Percy M, Petousi N, Piazza P, Piret SE, Polanco-Echeverry G, Popitsch N, Powrie F, Pugh C, Quek L, Robbins PA, Robson K, Russo A, Sahgal N, van Schouwenburg PA, Schuh A, Silverman E, Simmons A, Sørensen PS, Sweeney E, Taylor J, Thakker RV, Tomlinson I, Trebes A, Twigg SR, Uhlig HH, Vyas P, Vyse T, Wall SA, Watkins H, Whyte MP, Witty L, Wright B, Yau C, Buck D, Humphray S, Ratcliffe PJ, Bell JI, Wilkie AO, Bentley D, Donnelly P, McVean G.

Nat Genet. 2015 Jul;47(7):717-726. doi: 10.1038/ng.3304. Epub 2015 May 18.

5.

A new social contract for medical innovation.

Horne R, Bell JI, Montgomery JR, Ravn MO, Tooke JE.

Lancet. 2015 Mar 28;385(9974):1153-4. doi: 10.1016/S0140-6736(15)60607-9. No abstract available.

PMID:
25845777
6.

A clinical conundrum: the detrimental effect of TNF antagonists in multiple sclerosis.

Dendrou CA, Bell JI, Fugger L.

Pharmacogenomics. 2013 Sep;14(12):1397-404. doi: 10.2217/pgs.13.140.

PMID:
24024893
7.

Weighing in on autoimmune disease: Big data tip the scale.

Dendrou CA, Bell JI, Fugger L.

Nat Med. 2013 Feb;19(2):138-9. doi: 10.1038/nm.3087. No abstract available.

PMID:
23389608
8.

Genomewide association studies and common disease--realizing clinical utility.

Fugger L, McVean G, Bell JI.

N Engl J Med. 2012 Dec 20;367(25):2370-1. doi: 10.1056/NEJMp1212285. No abstract available.

PMID:
23252523
9.

TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis.

Gregory AP, Dendrou CA, Attfield KE, Haghikia A, Xifara DK, Butter F, Poschmann G, Kaur G, Lambert L, Leach OA, Prömel S, Punwani D, Felce JH, Davis SJ, Gold R, Nielsen FC, Siegel RM, Mann M, Bell JI, McVean G, Fugger L.

Nature. 2012 Aug 23;488(7412):508-511. doi: 10.1038/nature11307.

10.

Phenotypic analysis of antigen-specific T lymphocytes. Science. 1996. 274: 94-96.

Altman JD, Moss PA, Goulder PJ, Barouch DH, McHeyzer-Williams MG, Bell JI, McMichael AJ, Davis MM.

J Immunol. 2011 Jul 1;187(1):7-9. No abstract available.

11.

From genes to function: the next challenge to understanding multiple sclerosis.

Fugger L, Friese MA, Bell JI.

Nat Rev Immunol. 2009 Jun;9(6):408-17. doi: 10.1038/nri2554. Review.

PMID:
19444306
12.

Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis.

Friese MA, Jakobsen KB, Friis L, Etzensperger R, Craner MJ, McMahon RM, Jensen LT, Huygelen V, Jones EY, Bell JI, Fugger L.

Nat Med. 2008 Nov;14(11):1227-35. doi: 10.1038/nm.1881. Epub 2008 Oct 26.

PMID:
18953350
13.

The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain.

Ishizuka J, Stewart-Jones GB, van der Merwe A, Bell JI, McMichael AJ, Jones EY.

Immunity. 2008 Feb;28(2):171-82. doi: 10.1016/j.immuni.2007.12.018.

14.

Crystallization and preliminary X-ray structural studies of a Melan-A pMHC-TCR complex.

Yuan F, Georgiou T, Hillon T, Gostick E, Price DA, Sewell AK, Moysey R, Gavarret J, Vuidepot A, Sami M, Bell JI, Gao GF, Rizkallah PJ, Jakobsen BK.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Sep 1;63(Pt 9):758-60. Epub 2007 Aug 25.

15.

DNA repair is limiting for haematopoietic stem cells during ageing.

Nijnik A, Woodbine L, Marchetti C, Dawson S, Lambe T, Liu C, Rodrigues NP, Crockford TL, Cabuy E, Vindigni A, Enver T, Bell JI, Slijepcevic P, Goodnow CC, Jeggo PA, Cornall RJ.

Nature. 2007 Jun 7;447(7145):686-90.

PMID:
17554302
16.

Human TCR-binding affinity is governed by MHC class restriction.

Cole DK, Pumphrey NJ, Boulter JM, Sami M, Bell JI, Gostick E, Price DA, Gao GF, Sewell AK, Jakobsen BK.

J Immunol. 2007 May 1;178(9):5727-34.

17.

Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor.

Cole DK, Rizkallah PJ, Boulter JM, Sami M, Vuidepot AL, Glick M, Gao F, Bell JI, Jakobsen BK, Gao GF.

Proteins. 2007 Apr 1;67(1):65-74.

PMID:
17243170
18.
19.

The structure of the human allo-ligand HLA-B*3501 in complex with a cytochrome p450 peptide: steric hindrance influences TCR allo-recognition.

Hourigan CS, Harkiolaki M, Peterson NA, Bell JI, Jones EY, O'Callaghan CA.

Eur J Immunol. 2006 Dec;36(12):3288-93.

20.

Functional epistasis on a common MHC haplotype associated with multiple sclerosis.

Gregersen JW, Kranc KR, Ke X, Svendsen P, Madsen LS, Thomsen AR, Cardon LR, Bell JI, Fugger L.

Nature. 2006 Oct 5;443(7111):574-7. Epub 2006 Sep 27.

PMID:
17006452
21.

Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence.

Frodsham AJ, Zhang L, Dumpis U, Taib NA, Best S, Durham A, Hennig BJ, Hellier S, Knapp S, Wright M, Chiaramonte M, Bell JI, Graves M, Whittle HC, Thomas HC, Thursz MR, Hill AV.

Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9148-53. Epub 2006 Jun 6.

22.

The value of animal models for drug development in multiple sclerosis.

Friese MA, Montalban X, Willcox N, Bell JI, Martin R, Fugger L.

Brain. 2006 Aug;129(Pt 8):1940-52. Epub 2006 Apr 24. Review.

PMID:
16636022
23.

Complex assembly, crystallization and preliminary X-ray crystallographic studies of rhesus macaque MHC Mamu-A*01 complexed with an immunodominant SIV-Gag nonapeptide.

Chu F, Lou Z, Gao B, Bell JI, Rao Z, Gao GF.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jun 1;61(Pt 6):614-6. Epub 2005 Jun 1.

24.

Refolding, crystallization and preliminary X-ray structural studies of the West Nile virus envelope (E) protein domain III.

Yuan F, Lou Z, Li X, Chen YW, Bell JI, Rao Z, Gao GF.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Apr 1;61(Pt 4):421-3. Epub 2005 Apr 1.

25.

Crystallization and preliminary X-ray structural studies of a high-affinity CD8alphaalpha co-receptor to pMHC.

Cole DK, Rizkallah PJ, Sami M, Lissin NM, Gao F, Bell JI, Boulter JM, Glick M, Vuidepot AL, Jakobsen BK, Gao GF.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Mar 1;61(Pt 3):285-7. Epub 2005 Feb 12.

26.

Crystal structure of HLA-A*2402 complexed with a telomerase peptide.

Cole DK, Rizkallah PJ, Gao F, Watson NI, Boulter JM, Bell JI, Sami M, Gao GF, Jakobsen BK.

Eur J Immunol. 2006 Jan;36(1):170-9.

27.

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity.

Vinuesa CG, Cook MC, Angelucci C, Athanasopoulos V, Rui L, Hill KM, Yu D, Domaschenz H, Whittle B, Lambe T, Roberts IS, Copley RR, Bell JI, Cornall RJ, Goodnow CC.

Nature. 2005 May 26;435(7041):452-8.

PMID:
15917799
28.

Characterization of the heptad repeat regions, HR1 and HR2, and design of a fusion core structure model of the spike protein from severe acute respiratory syndrome (SARS) coronavirus.

Xu Y, Zhu J, Liu Y, Lou Z, Yuan F, Liu Y, Cole DK, Ni L, Su N, Qin L, Li X, Bai Z, Bell JI, Pang H, Tien P, Gao GF, Rao Z.

Biochemistry. 2004 Nov 9;43(44):14064-71.

PMID:
15518555
29.

Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors.

Zhu J, Xiao G, Xu Y, Yuan F, Zheng C, Liu Y, Yan H, Cole DK, Bell JI, Rao Z, Tien P, Gao GF.

Biochem Biophys Res Commun. 2004 Jun 18;319(1):283-8.

PMID:
15158473
30.

Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy.

Siebold C, Hansen BE, Wyer JR, Harlos K, Esnouf RE, Svejgaard A, Bell JI, Strominger JL, Jones EY, Fugger L.

Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1999-2004. Epub 2004 Feb 9.

31.

A structural basis for immunodominant human T cell receptor recognition.

Stewart-Jones GB, McMichael AJ, Bell JI, Stuart DI, Jones EY.

Nat Immunol. 2003 Jul;4(7):657-63. Epub 2003 Jun 8.

PMID:
12796775
32.

New hope for haplotype mapping.

Bell JI.

Arthritis Res Ther. 2003;5(2):51-3. Epub 2003 Jan 13.

33.

The double helix in clinical practice.

Bell JI.

Nature. 2003 Jan 23;421(6921):414-6.

PMID:
12540912
34.

A functional and structural basis for TCR cross-reactivity in multiple sclerosis.

Lang HL, Jacobsen H, Ikemizu S, Andersson C, Harlos K, Madsen L, Hjorth P, Sondergaard L, Svejgaard A, Wucherpfennig K, Stuart DI, Bell JI, Jones EY, Fugger L.

Nat Immunol. 2002 Oct;3(10):940-3. Epub 2002 Sep 3.

PMID:
12244309
35.
36.

Single nucleotide polymorphisms and disease gene mapping.

Bell JI.

Arthritis Res. 2002;4 Suppl 3:S273-8. Epub 2002 May 9. Review.

37.

Novel CD8+ T cell antagonists based on beta 2-microglobulin.

Glick M, Price DA, Vuidepot AL, Andersen TB, Hutchinson SL, Laugel B, Sewell AK, Boulter JM, Dunbar PR, Cerundolo V, Oxenius A, Bell JI, Richards WG, Jakobsen BK.

J Biol Chem. 2002 Jun 7;277(23):20840-6. Epub 2002 Mar 25.

38.

Histocompatibility leucocyte antigens and closely linked immunomodulatory genes in autoimmune thyroid disease.

Hunt PJ, Marshall SE, Weetman AP, Bunce M, Bell JI, Wass JA, Welsh KI.

Clin Endocrinol (Oxf). 2001 Oct;55(4):491-9.

PMID:
11678832
39.

A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q.

Wiltshire S, Hattersley AT, Hitman GA, Walker M, Levy JC, Sampson M, O'Rahilly S, Frayling TM, Bell JI, Lathrop GM, Bennett A, Dhillon R, Fletcher C, Groves CJ, Jones E, Prestwich P, Simecek N, Rao PV, Wishart M, Bottazzo GF, Foxon R, Howell S, Smedley D, Cardon LR, Menzel S, McCarthy MI.

Am J Hum Genet. 2001 Sep;69(3):553-69. Epub 2001 Aug 1. Erratum in: Am J Hum Genet 2002 Apr;70(4):1075.

40.

The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain.

Purbhoo MA, Boulter JM, Price DA, Vuidepot AL, Hourigan CS, Dunbar PR, Olson K, Dawson SJ, Phillips RE, Jakobsen BK, Bell JI, Sewell AK.

J Biol Chem. 2001 Aug 31;276(35):32786-92. Epub 2001 Jul 3.

41.

A functional polymorphism of the stromelysin gene (MMP-3) influences susceptibility to primary sclerosing cholangitis.

Satsangi J, Chapman RW, Haldar N, Donaldson P, Mitchell S, Simmons J, Norris S, Marshall SE, Bell JI, Jewell DP, Welsh KI.

Gastroenterology. 2001 Jul;121(1):124-30.

PMID:
11438501
42.

Direct ex vivo analysis reveals distinct phenotypic patterns of HIV-specific CD8(+) T lymphocyte activation in response to therapeutic manipulation of virus load.

Oxenius A, Günthard HF, Hirschel B, Fidler S, Weber JN, Easterbrook PJ, Bell JI, Phillips RE, Price DA.

Eur J Immunol. 2001 Apr;31(4):1115-21.

43.

Association study designs for complex diseases.

Cardon LR, Bell JI.

Nat Rev Genet. 2001 Feb;2(2):91-9. Review.

PMID:
11253062
44.

Reconstitution of antigen presentation in HLA class I-negative cancer cells with peptide-beta2m fusion molecules.

Tafuro S, Meier UC, Dunbar PR, Jones EY, Layton GT, Hunter MG, Bell JI, McMichael AJ.

Eur J Immunol. 2001 Feb;31(2):440-9.

45.

Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors.

Lepin EJ, Bastin JM, Allan DS, Roncador G, Braud VM, Mason DY, van der Merwe PA, McMichael AJ, Bell JI, Powis SH, O'Callaghan CA.

Eur J Immunol. 2000 Dec;30(12):3552-61.

46.

Functional heterogeneity and high frequencies of cytomegalovirus-specific CD8(+) T lymphocytes in healthy seropositive donors.

Gillespie GM, Wills MR, Appay V, O'Callaghan C, Murphy M, Smith N, Sissons P, Rowland-Jones S, Bell JI, Moss PA.

J Virol. 2000 Sep;74(17):8140-50.

47.

Cytokine gene polymorphisms in autoimmune thyroid disease.

Hunt PJ, Marshall SE, Weetman AP, Bell JI, Wass JA, Welsh KI.

J Clin Endocrinol Metab. 2000 May;85(5):1984-8.

PMID:
10843185
48.

Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8alphaalpha.

Gao GF, Willcox BE, Wyer JR, Boulter JM, O'Callaghan CA, Maenaka K, Stuart DI, Jones EY, Van Der Merwe PA, Bell JI, Jakobsen BK.

J Biol Chem. 2000 May 19;275(20):15232-8.

49.

Production of soluble alphabeta T-cell receptor heterodimers suitable for biophysical analysis of ligand binding.

Willcox BE, Gao GF, Wyer JR, O'Callaghan CA, Boulter JM, Jones EY, van der Merwe PA, Bell JI, Jakobsen BK.

Protein Sci. 1999 Nov;8(11):2418-23.

50.

Clinical research is dead; long live clinical research.

Bell JI.

Nat Med. 1999 May;5(5):477-8. No abstract available.

PMID:
10229217

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