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Items: 1 to 50 of 234

1.

Association of sustained supraphysiologic hyperinsulinemia and inflammatory signaling within the digital lamellae in light-breed horses.

Watts MR, Hegedus OC, Eades SC, Belknap JK, Burns TA.

J Vet Intern Med. 2019 May;33(3):1483-1492. doi: 10.1111/jvim.15480. Epub 2019 Mar 25.

2.

Continuous digital hypothermia prevents lamellar failure in the euglycaemic hyperinsulinaemic clamp model of equine laminitis.

Stokes SM, Belknap JK, Engiles JB, Stefanovski D, Bertin FR, Medina-Torres CE, Horn R, van Eps AW.

Equine Vet J. 2019 Jan 13. doi: 10.1111/evj.13072. [Epub ahead of print]

PMID:
30636340
3.

Case-control study of risk factors for pasture-and endocrinopathy-associated laminitis in North American horses.

Coleman MC, Belknap JK, Eades SC, Galantino-Homer HL, Hunt RJ, Geor RJ, McCue ME, McIlwraith CW, Moore RM, Peroni JF, Townsend HG, White NA, Cummings KJ, Ivanek-Miojevic R, Cohen ND.

J Am Vet Med Assoc. 2018 Aug 15;253(4):470-478. doi: 10.2460/javma.253.4.470.

PMID:
30058970
4.

A novel model to assess lamellar signaling relevant to preferential weight bearing in the horse.

Gardner AK, van Eps AW, Watts MR, Burns TA, Belknap JK.

Vet J. 2017 Mar;221:62-67. doi: 10.1016/j.tvjl.2017.02.005. Epub 2017 Feb 14.

PMID:
28283083
5.

Lamellar events related to insulin-like growth factor-1 receptor signalling in two models relevant to endocrinopathic laminitis.

Lane HE, Burns TA, Hegedus OC, Watts MR, Weber PS, Woltman KA, Geor RJ, McCutcheon LJ, Eades SC, Mathes LE, Belknap JK.

Equine Vet J. 2017 Sep;49(5):643-654. doi: 10.1111/evj.12663. Epub 2017 Mar 2.

PMID:
28078757
6.

The effect of hypothermia on influx of leukocytes in the digital lamellae of horses with oligofructose-induced laminitis.

Godman JD, Burns TA, Kelly CS, Watts MR, Leise BS, Schroeder EL, van Eps AW, Belknap JK.

Vet Immunol Immunopathol. 2016 Oct 1;178:22-8. doi: 10.1016/j.vetimm.2016.05.013. Epub 2016 May 24.

PMID:
27496739
7.

Mechanical nociceptive thresholds of dorsal laminae in horses after local anaesthesia of the palmar digital nerves or dorsal branches of the digital nerve.

Paz CF, Magalhães JF, Mendes HM, Rocha Junior S, Belknap JK, Alves GE, Faleiros RR.

Vet J. 2016 Aug;214:102-8. doi: 10.1016/j.tvjl.2016.05.005. Epub 2016 May 11.

PMID:
27387735
8.

Genetic Polymorphisms Affect Mouse and Human Trace Amine-Associated Receptor 1 Function.

Shi X, Walter NA, Harkness JH, Neve KA, Williams RW, Lu L, Belknap JK, Eshleman AJ, Phillips TJ, Janowsky A.

PLoS One. 2016 Mar 31;11(3):e0152581. doi: 10.1371/journal.pone.0152581. eCollection 2016.

9.

Mitogen-activated kinase pathway activation in epidermal lamellae in the acute stages of carbohydrate overload laminitis models and the effect of regional deep hypothermia on signalling pathways.

Gardner AK, Kelly CS, van Eps AW, Burns TA, Watts MR, Belknap JK.

Equine Vet J. 2016 Sep;48(5):633-40. doi: 10.1111/evj.12488. Epub 2015 Aug 29.

PMID:
26222495
10.

Equine insulin receptor and insulin-like growth factor-1 receptor expression in digital lamellar tissue and insulin target tissues.

Kullmann A, Weber PS, Bishop JB, Roux TM, Norby B, Burns TA, McCutcheon LJ, Belknap JK, Geor RJ.

Equine Vet J. 2016 Sep;48(5):626-32. doi: 10.1111/evj.12474. Epub 2015 Aug 21.

PMID:
26095356
11.

Dual-trait selection for ethanol consumption and withdrawal: genetic and transcriptional network effects.

Metten P, Iancu OD, Spence SE, Walter NA, Oberbeck D, Harrington CA, Colville A, McWeeney S, Phillips TJ, Buck KJ, Crabbe JC, Belknap JK, Hitzemann RJ.

Alcohol Clin Exp Res. 2014 Dec;38(12):2915-24. doi: 10.1111/acer.12574.

12.

Quantitative assessment of the equine hoof using digital radiography and magnetic resonance imaging.

Grundmann IN, Drost WT, Zekas LJ, Belknap JK, Garabed RB, Weisbrode SE, Parks AH, Knopp MV, Maierl J.

Equine Vet J. 2015 Sep;47(5):542-7. doi: 10.1111/evj.12340. Epub 2014 Nov 3.

PMID:
25187085
13.

Laminar inflammatory events in lean and obese ponies subjected to high carbohydrate feeding: Implications for pasture-associated laminitis.

Burns TA, Watts MR, Weber PS, McCutcheon LJ, Geor RJ, Belknap JK.

Equine Vet J. 2015 Jul;47(4):489-93. doi: 10.1111/evj.12314. Epub 2014 Sep 10.

PMID:
24963607
14.

Use of laser capture microdissection for the assessment of equine lamellar basal epithelial cell signalling in the early stages of laminitis.

Leise BS, Watts MR, Roy S, Yilmaz AS, Alder H, Belknap JK.

Equine Vet J. 2015 Jul;47(4):478-88. doi: 10.1111/evj.12283. Epub 2014 Aug 19.

15.

Effect of dietary nonstructural carbohydrate content on activation of 5'-adenosine monophosphate-activated protein kinase in liver, skeletal muscle, and digital laminae of lean and obese ponies.

Burns TA, Watts MR, Weber PS, McCutcheon LJ, Geor RJ, Belknap JK.

J Vet Intern Med. 2014 Jul-Aug;28(4):1280-8. doi: 10.1111/jvim.12356. Epub 2014 Apr 20.

16.

Expression and activity of collagenases in the digital laminae of horses with carbohydrate overload-induced acute laminitis.

Wang L, Pawlak EA, Johnson PJ, Belknap JK, Alfandari D, Black SJ.

J Vet Intern Med. 2014 Jan-Feb;28(1):215-22. doi: 10.1111/jvim.12252. Epub 2013 Nov 25.

17.

Progress in a replicated selection for elevated blood ethanol concentrations in HDID mice.

Crabbe JC, Metten P, Belknap JK, Spence SE, Cameron AJ, Schlumbohm JP, Huang LC, Barkley-Levenson AM, Ford MM, Phillips TJ.

Genes Brain Behav. 2014 Feb;13(2):236-46. doi: 10.1111/gbb.12105. Epub 2013 Dec 6.

18.

Genetic factors involved in risk for methamphetamine intake and sensitization.

Belknap JK, McWeeney S, Reed C, Burkhart-Kasch S, McKinnon CS, Li N, Baba H, Scibelli AC, Hitzemann R, Phillips TJ.

Mamm Genome. 2013 Dec;24(11-12):446-58. doi: 10.1007/s00335-013-9484-9. Epub 2013 Nov 13.

19.

Continuous digital hypothermia initiated after the onset of lameness prevents lamellar failure in the oligofructose laminitis model.

van Eps AW, Pollitt CC, Underwood C, Medina-Torres CE, Goodwin WA, Belknap JK.

Equine Vet J. 2014 Sep;46(5):625-30. doi: 10.1111/evj.12180. Epub 2013 Nov 29.

PMID:
24004323
20.

Impaired memory and reduced sensitivity to the circadian period lengthening effects of methamphetamine in mice selected for high methamphetamine consumption.

Olsen RH, Allen CN, Derkach VA, Phillips TJ, Belknap JK, Raber J.

Behav Brain Res. 2013 Nov 1;256:197-204. doi: 10.1016/j.bbr.2013.08.015. Epub 2013 Aug 14.

21.

Regulation of hypoxia-inducible factor-1α and related genes in equine digital lamellae and in cultured keratinocytes.

Pawlak EA, Geor RJ, Watts MR, Black SJ, Johnson PJ, Belknap JK.

Equine Vet J. 2014 Mar;46(2):203-9. doi: 10.1111/evj.12092. Epub 2013 Jul 22.

PMID:
23663159
22.

Impact of laminitis on the canonical Wnt signaling pathway in basal epithelial cells of the equine digital laminae.

Wang L, Pawlak EA, Johnson PJ, Belknap JK, Eades S, Stack S, Cousin H, Black SJ.

PLoS One. 2013;8(2):e56025. doi: 10.1371/journal.pone.0056025. Epub 2013 Feb 6.

23.

Sepsis-related laminitis.

Belknap JK, Black SJ.

Equine Vet J. 2012 Nov;44(6):738-40. doi: 10.1111/j.2042-3306.2012.00668.x. No abstract available.

PMID:
23106625
24.

Distribution of insulin receptor and insulin-like growth factor-1 receptor in the digital laminae of mixed-breed ponies: an immunohistochemical study.

Burns TA, Watts MR, Weber PS, McCutcheon LJ, Geor RJ, Belknap JK.

Equine Vet J. 2013 May;45(3):326-32. doi: 10.1111/j.2042-3306.2012.00631.x. Epub 2012 Aug 24.

PMID:
22924550
25.

Laminar regulation of STAT1 and STAT3 in black walnut extract and carbohydrate overload induced models of laminitis.

Leise BS, Watts M, Tanhoff E, Johnson PJ, Black SJ, Belknap JK.

J Vet Intern Med. 2012 Jul-Aug;26(4):996-1004. doi: 10.1111/j.1939-1676.2012.00944.x.

26.
27.

Distribution and processing of a disintegrin and metalloproteinase with thrombospondin motifs-4, aggrecan, versican, and hyaluronan in equine digital laminae.

Pawlak E, Wang L, Johnson PJ, Nuovo G, Taye A, Belknap JK, Alfandari D, Black SJ.

Am J Vet Res. 2012 Jul;73(7):1035-46. doi: 10.2460/ajvr.73.7.1035.

28.

NMDA alters rotenone toxicity in rat substantia nigra zona compacta and ventral tegmental area dopamine neurons.

Munhall AC, Wu YN, Belknap JK, Meshul CK, Johnson SW.

Neurotoxicology. 2012 Jun;33(3):429-35. doi: 10.1016/j.neuro.2012.04.006. Epub 2012 Apr 15.

PMID:
22521663
29.

Congenic mice provide in vivo evidence for a genetic locus that modulates intrinsic transforming growth factor β1-mediated signaling and bone acquisition.

Mukherjee A, Larson EA, Carlos AS, Belknap JK, Rotwein P, Klein RF.

J Bone Miner Res. 2012 Jun;27(6):1345-56. doi: 10.1002/jbmr.1590.

30.

Hindlimb laminar inflammatory response is similar to that present in forelimbs after carbohydrate overload in horses.

Leise BS, Faleiros RR, Watts M, Johnson PJ, Black SJ, Belknap JK.

Equine Vet J. 2012 Nov;44(6):633-9. doi: 10.1111/j.2042-3306.2011.00531.x. Epub 2011 Dec 30.

PMID:
22212091
31.

Digital hypothermia inhibits early lamellar inflammatory signalling in the oligofructose laminitis model.

van Eps AW, Leise BS, Watts M, Pollitt CC, Belknap JK.

Equine Vet J. 2012 Mar;44(2):230-7. doi: 10.1111/j.2042-3306.2011.00416.x. Epub 2011 Sep 5.

PMID:
21895750
32.

Detection of calprotectin and apoptotic activity within the equine colon from horses with black walnut extract-induced laminitis.

Chiavaccini L, Hassel DM, Shoemaker ML, Charles JB, Belknap JK, Ehrhart EJ.

Vet Immunol Immunopathol. 2011 Dec 15;144(3-4):366-73. doi: 10.1016/j.vetimm.2011.08.006. Epub 2011 Aug 17.

PMID:
21890218
33.

Laminar chemokine mRNA concentrations in horses with carbohydrate overload-induced laminitis.

Faleiros RR, Leise BS, Watts M, Johnson PJ, Black SJ, Belknap JK.

Vet Immunol Immunopathol. 2011 Nov 15;144(1-2):45-51. doi: 10.1016/j.vetimm.2011.07.005. Epub 2011 Jul 28.

PMID:
21889804
34.

Protein database and quantitative analysis considerations when integrating genetics and proteomics to compare mouse strains.

Fei SS, Wilmarth PA, Hitzemann RJ, McWeeney SK, Belknap JK, David LL.

J Proteome Res. 2011 Jul 1;10(7):2905-12. doi: 10.1021/pr200133p. Epub 2011 May 9.

35.

Role of oxidative tissue injury in the pathophysiology of experimentally induced equine laminitis: a comparison of 2 models.

Burns TA, Westerman T, Nuovo GJ, Watts MR, Pettigrew A, Yin C, Belknap JK.

J Vet Intern Med. 2011 May-Jun;25(3):540-8. doi: 10.1111/j.1939-1676.2011.0706.x. Epub 2011 Mar 21.

36.

Naturally occurring compensated insulin resistance selectively alters glucose transporters in visceral and subcutaneous adipose tissues without change in AS160 activation.

Waller AP, Kohler K, Burns TA, Mudge MC, Belknap JK, Lacombe VA.

Biochim Biophys Acta. 2011 Sep;1812(9):1098-103. doi: 10.1016/j.bbadis.2011.02.007. Epub 2011 Feb 23.

37.

Insulin resistance selectively alters cell-surface glucose transporters but not their total protein expression in equine skeletal muscle.

Waller AP, Burns TA, Mudge MC, Belknap JK, Lacombe VA.

J Vet Intern Med. 2011 Mar-Apr;25(2):315-21. doi: 10.1111/j.1939-1676.2010.0674.x. Epub 2011 Feb 11.

38.

Genomic loci and candidate genes underlying inflammatory nociception.

Nair HK, Hain H, Quock RM, Philip VM, Chesler EJ, Belknap JK, Lariviere WR.

Pain. 2011 Mar;152(3):599-606. doi: 10.1016/j.pain.2010.11.029. Epub 2010 Dec 30.

39.

Laminar inflammatory gene expression in the carbohydrate overload model of equine laminitis.

Leise BS, Faleiros RR, Watts M, Johnson PJ, Black SJ, Belknap JK.

Equine Vet J. 2011 Jan;43(1):54-61. doi: 10.1111/j.2042-3306.2010.00122.x.

PMID:
21143634
40.

Presence of mononuclear cells in normal and affected laminae from the black walnut extract model of laminitis.

Faleiros RR, Nuovo GJ, Flechtner AD, Belknap JK.

Equine Vet J. 2011 Jan;43(1):45-53. doi: 10.1111/j.2042-3306.2010.00121.x.

PMID:
21143633
41.

Laminar leukocyte accumulation in horses with carbohydrate overload-induced laminitis.

Faleiros RR, Johnson PJ, Nuovo GJ, Messer NT, Black SJ, Belknap JK.

J Vet Intern Med. 2011 Jan-Feb;25(1):107-15. doi: 10.1111/j.1939-1676.2010.0650.x. Epub 2010 Dec 8.

42.

In vivo priming and ex vivo activation of equine neutrophils in black walnut extract-induced equine laminitis is not attenuated by systemic lidocaine administration.

Loftus JP, Williams JM, Belknap JK, Black SJ.

Vet Immunol Immunopathol. 2010 Nov 15;138(1-2):60-9. doi: 10.1016/j.vetimm.2010.06.016. Epub 2010 Jun 30.

PMID:
20667603
43.

Proinflammatory cytokine and chemokine gene expression profiles in subcutaneous and visceral adipose tissue depots of insulin-resistant and insulin-sensitive light breed horses.

Burns TA, Geor RJ, Mudge MC, McCutcheon LJ, Hinchcliff KW, Belknap JK.

J Vet Intern Med. 2010 Jul-Aug;24(4):932-9. doi: 10.1111/j.1939-1676.2010.0551.x.

44.

The complexity of alcohol drinking: studies in rodent genetic models.

Crabbe JC, Phillips TJ, Belknap JK.

Behav Genet. 2010 Nov;40(6):737-50. doi: 10.1007/s10519-010-9371-z. Epub 2010 Jun 15. Review.

45.

Proinflammatory cytokine responses of cultured equine keratinocytes to bacterial pathogen-associated molecular pattern motifs.

Leise BS, Yin C, Pettigrew A, Belknap JK.

Equine Vet J. 2010 May;42(4):294-303. doi: 10.2746/042516409X478523.

PMID:
20525046
46.

Effect of intravenous lidocaine administration on laminar inflammation in the black walnut extract model of laminitis.

Williams JM, Lin YJ, Loftus JP, Faleiros RR, Peroni JF, Hubbell JA, Ravis WR, Belknap JK.

Equine Vet J. 2010 Apr;42(3):261-9. doi: 10.2746/042516409X475760.

PMID:
20486984
47.

The pharmacologic basis for the treatment of developmental and acute laminitis.

Belknap JK.

Vet Clin North Am Equine Pract. 2010 Apr;26(1):115-24. doi: 10.1016/j.cveq.2010.01.003. Review.

PMID:
20381740
48.

Black walnut extract: an inflammatory model.

Belknap JK.

Vet Clin North Am Equine Pract. 2010 Apr;26(1):95-101. doi: 10.1016/j.cveq.2009.12.007. Review.

PMID:
20381738
49.

A method for mapping intralocus interactions influencing excessive alcohol drinking.

Phillips TJ, Reed C, Burkhart-Kasch S, Li N, Hitzemann R, Yu CH, Brown LL, Helms ML, Crabbe JC, Belknap JK.

Mamm Genome. 2010 Feb;21(1-2):39-51. doi: 10.1007/s00335-009-9239-9. Epub 2009 Dec 22.

50.

Hybrid mice as genetic models of high alcohol consumption.

Blednov YA, Ozburn AR, Walker D, Ahmed S, Belknap JK, Harris RA.

Behav Genet. 2010 Jan;40(1):93-110. doi: 10.1007/s10519-009-9298-4. Epub 2009 Oct 2.

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