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Items: 1 to 50 of 201

1.

Inhaled Submicron Particle Paclitaxel (NanoPac) Induces Tumor Regression and Immune Cell Infiltration in an Orthotopic Athymic Nude Rat Model of Non-Small Cell Lung Cancer.

Verco J, Johnston W, Frost M, Baltezor M, Kuehl PJ, Lopez A, Gigliotti A, Belinsky SA, Wolff R, diZerega G.

J Aerosol Med Pulm Drug Deliv. 2019 Jul 26. doi: 10.1089/jamp.2018.1517. [Epub ahead of print]

PMID:
31347939
2.

DNA-PKc deficiency drives pre-malignant transformation by reducing DNA repair capacity in concert with reprogramming the epigenome in human bronchial epithelial cells.

Teneng I, Picchi MA, Leng S, Dagucon CP, Ramalingam S, Tellez CS, Belinsky SA.

DNA Repair (Amst). 2019 Jul;79:1-9. doi: 10.1016/j.dnarep.2019.04.006. Epub 2019 Apr 27.

PMID:
31055244
3.

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.

Sakornsakolpat P, Prokopenko D, Lamontagne M, Reeve NF, Guyatt AL, Jackson VE, Shrine N, Qiao D, Bartz TM, Kim DK, Lee MK, Latourelle JC, Li X, Morrow JD, Obeidat M, Wyss AB, Bakke P, Barr RG, Beaty TH, Belinsky SA, Brusselle GG, Crapo JD, de Jong K, DeMeo DL, Fingerlin TE, Gharib SA, Gulsvik A, Hall IP, Hokanson JE, Kim WJ, Lomas DA, London SJ, Meyers DA, O'Connor GT, Rennard SI, Schwartz DA, Sliwinski P, Sparrow D, Strachan DP, Tal-Singer R, Tesfaigzi Y, Vestbo J, Vonk JM, Yim JJ, Zhou X, Bossé Y, Manichaikul A, Lahousse L, Silverman EK, Boezen HM, Wain LV, Tobin MD, Hobbs BD, Cho MH; SpiroMeta Consortium; International COPD Genetics Consortium.

Nat Genet. 2019 Mar;51(3):494-505. doi: 10.1038/s41588-018-0342-2. Epub 2019 Feb 25.

4.

Inhibition of the hexosamine biosynthesis pathway potentiates cisplatin cytotoxicity by decreasing BiP expression in non-small-cell lung cancer cells.

Chen W, Do KC, Saxton B, Leng S, Filipczak P, Tessema M, Belinsky SA, Lin Y.

Mol Carcinog. 2019 Jun;58(6):1046-1055. doi: 10.1002/mc.22992. Epub 2019 Mar 6.

PMID:
30790354
5.

p53-Suppressed Oncogene TET1 Prevents Cellular Aging in Lung Cancer.

Filipczak PT, Leng S, Tellez CS, Do KC, Grimes MJ, Thomas CL, Walton-Filipczak SR, Picchi MA, Belinsky SA.

Cancer Res. 2019 Apr 15;79(8):1758-1768. doi: 10.1158/0008-5472.CAN-18-1234. Epub 2019 Jan 8.

PMID:
30622117
6.

Lung Adenocarcinoma Syndecan-2 Potentiates Cell Invasiveness.

Tsoyi K, Osorio JC, Chu SG, Fernandez IE, De Frias SP, Sholl L, Cui Y, Tellez CS, Siegfried JM, Belinsky SA, Perrella MA, El-Chemaly S, Rosas IO.

Am J Respir Cell Mol Biol. 2019 Jun;60(6):659-666. doi: 10.1165/rcmb.2018-0118OC.

PMID:
30562054
7.

Pharmacokinetic Profile of Inhaled Submicron Particle Paclitaxel (NanoPac®) in a Rodent Model.

Verco J, Johnston W, Baltezor M, Kuehl PJ, Gigliotti A, Belinsky SA, Lopez A, Wolff R, Hylle L, diZerega G.

J Aerosol Med Pulm Drug Deliv. 2019 Apr;32(2):99-109. doi: 10.1089/jamp.2018.1467. Epub 2018 Oct 25.

8.

Differences in microRNA expression in breast cancer between women of African and European ancestry.

Gong Z, Wang J, Wang D, Buas MF, Ren X, Freudenheim JL, Belinsky SA, Liu S, Ambrosone CB, Higgins MJ.

Carcinogenesis. 2019 Mar 12;40(1):61-69. doi: 10.1093/carcin/bgy134.

PMID:
30321299
9.

Common cancer-driver mutations and their association with abnormally methylated genes in lung adenocarcinoma from never-smokers.

Tessema M, Rossi MR, Picchi MA, Yingling CM, Lin Y, Ramalingam SS, Belinsky SA.

Lung Cancer. 2018 Sep;123:99-106. doi: 10.1016/j.lungcan.2018.07.011. Epub 2018 Jul 11.

10.

Inhalation delivery of topotecan is superior to intravenous exposure for suppressing lung cancer in a preclinical model.

Kuehl PJ, Grimes MJ, Dubose D, Burke M, Revelli DA, Gigliotti AP, Belinsky SA, Tessema M.

Drug Deliv. 2018 Nov;25(1):1127-1136. doi: 10.1080/10717544.2018.1469688.

11.

Gene Promoter Hypermethylation Detected in Sputum Predicts FEV1 Decline and All-Cause Mortality in Smokers.

Leng S, Diergaarde B, Picchi MA, Wilson DO, Gilliland FD, Yuan JM, Siegfried JM, Belinsky SA.

Am J Respir Crit Care Med. 2018 Jul 15;198(2):187-196. doi: 10.1164/rccm.201708-1659OC.

12.

Dietary nutrients associated with preservation of lung function in Hispanic and non-Hispanic white smokers from New Mexico.

Leng S, Picchi MA, Tesfaigzi Y, Wu G, Gauderman WJ, Xu F, Gilliland FD, Belinsky SA.

Int J Chron Obstruct Pulmon Dis. 2017 Oct 30;12:3171-3181. doi: 10.2147/COPD.S142237. eCollection 2017.

13.

Dietary Nutrient Intake, Ethnicity, and Epigenetic Silencing of Lung Cancer Genes Detected in Sputum in New Mexican Smokers.

Leng S, Picchi MA, Kang H, Wu G, Filipczak PT, Juri DE, Zhang X, Gauderman WJ, Gilliland FD, Belinsky SA.

Cancer Prev Res (Phila). 2018 Feb;11(2):93-102. doi: 10.1158/1940-6207.CAPR-17-0196. Epub 2017 Nov 8.

14.

Gene methylation biomarkers in sputum as a classifier for lung cancer risk.

Leng S, Wu G, Klinge DM, Thomas CL, Casas E, Picchi MA, Stidley CA, Lee SJ, Aisner S, Siegfried JM, Ramalingam S, Khuri FR, Karp DD, Belinsky SA.

Oncotarget. 2017 Jul 15;8(38):63978-63985. doi: 10.18632/oncotarget.19255. eCollection 2017 Sep 8.

15.

ANK1 Methylation regulates expression of MicroRNA-486-5p and discriminates lung tumors by histology and smoking status.

Tessema M, Yingling CM, Picchi MA, Wu G, Ryba T, Lin Y, Bungum AO, Edell ES, Spira A, Belinsky SA.

Cancer Lett. 2017 Dec 1;410:191-200. doi: 10.1016/j.canlet.2017.09.038. Epub 2017 Sep 29.

16.

Gene Methylation Biomarkers in Sputum and Plasma as Predictors for Lung Cancer Recurrence.

Belinsky SA, Leng S, Wu G, Thomas CL, Picchi MA, Lee SJ, Aisner S, Ramalingam S, Khuri FR, Karp DD.

Cancer Prev Res (Phila). 2017 Nov;10(11):635-640. doi: 10.1158/1940-6207.CAPR-17-0177. Epub 2017 Sep 13.

17.

Muc1 knockout potentiates murine lung carcinogenesis involving an epiregulin-mediated EGFR activation feedback loop.

Xu X, Chen W, Leng S, Padilla MT, Saxton B, Hutt J, Tessema M, Kato K, Kim KC, Belinsky SA, Lin Y.

Carcinogenesis. 2017 Jun 1;38(6):604-614. doi: 10.1093/carcin/bgx039.

18.

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.

Hobbs BD, de Jong K, Lamontagne M, Bossé Y, Shrine N, Artigas MS, Wain LV, Hall IP, Jackson VE, Wyss AB, London SJ, North KE, Franceschini N, Strachan DP, Beaty TH, Hokanson JE, Crapo JD, Castaldi PJ, Chase RP, Bartz TM, Heckbert SR, Psaty BM, Gharib SA, Zanen P, Lammers JW, Oudkerk M, Groen HJ, Locantore N, Tal-Singer R, Rennard SI, Vestbo J, Timens W, Paré PD, Latourelle JC, Dupuis J, O'Connor GT, Wilk JB, Kim WJ, Lee MK, Oh YM, Vonk JM, de Koning HJ, Leng S, Belinsky SA, Tesfaigzi Y, Manichaikul A, Wang XQ, Rich SS, Barr RG, Sparrow D, Litonjua AA, Bakke P, Gulsvik A, Lahousse L, Brusselle GG, Stricker BH, Uitterlinden AG, Ampleford EJ, Bleecker ER, Woodruff PG, Meyers DA, Qiao D, Lomas DA, Yim JJ, Kim DK, Hawrylkiewicz I, Sliwinski P, Hardin M, Fingerlin TE, Schwartz DA, Postma DS, MacNee W, Tobin MD, Silverman EK, Boezen HM, Cho MH; COPDGene Investigators; ECLIPSE Investigators; LifeLines Investigators; SPIROMICS Research Group; International COPD Genetics Network Investigators; UK BiLEVE Investigators; International COPD Genetics Consortium.

Nat Genet. 2017 Mar;49(3):426-432. doi: 10.1038/ng.3752. Epub 2017 Feb 6.

19.

TSC2 Deficiency Unmasks a Novel Necrosis Pathway That Is Suppressed by the RIP1/RIP3/MLKL Signaling Cascade.

Filipczak PT, Thomas C, Chen W, Salzman A, McDonald JD, Lin Y, Belinsky SA.

Cancer Res. 2016 Dec 15;76(24):7130-7139. Epub 2016 Oct 18.

20.

Early Detection of Lung Cancer Using DNA Promoter Hypermethylation in Plasma and Sputum.

Hulbert A, Jusue-Torres I, Stark A, Chen C, Rodgers K, Lee B, Griffin C, Yang A, Huang P, Wrangle J, Belinsky SA, Wang TH, Yang SC, Baylin SB, Brock MV, Herman JG.

Clin Cancer Res. 2017 Apr 15;23(8):1998-2005. doi: 10.1158/1078-0432.CCR-16-1371. Epub 2016 Oct 11.

21.

A prospective and retrospective analysis of smoking behavior changes in ever smokers with high risk for lung cancer from New Mexico and Pennsylvania.

Leng S, Weissfeld JL, Picchi MA, Styn MA, Claus ED, Clark VP, Wu G, Thomas CL, Gilliland FD, Yuan J, Siegfried JM, Belinsky SA.

Int J Mol Epidemiol Genet. 2016 Jun 1;7(2):95-104. eCollection 2016.

22.

miR-196b Is Epigenetically Silenced during the Premalignant Stage of Lung Carcinogenesis.

Tellez CS, Juri DE, Do K, Picchi MA, Wang T, Liu G, Spira A, Belinsky SA.

Cancer Res. 2016 Aug 15;76(16):4741-51. doi: 10.1158/0008-5472.CAN-15-3367. Epub 2016 Jun 14.

23.

Methylation in benign prostate and risk of disease progression in men subsequently diagnosed with prostate cancer.

Rybicki BA, Rundle A, Kryvenko ON, Mitrache N, Do KC, Jankowski M, Chitale DA, Trudeau S, Belinsky SA, Tang D.

Int J Cancer. 2016 Jun 15;138(12):2884-93. doi: 10.1002/ijc.30038. Epub 2016 Mar 2.

24.

Whole exome sequencing identifies novel candidate genes that modify chronic obstructive pulmonary disease susceptibility.

Bruse S, Moreau M, Bromberg Y, Jang JH, Wang N, Ha H, Picchi M, Lin Y, Langley RJ, Qualls C, Klensney-Tait J, Zabner J, Leng S, Mao J, Belinsky SA, Xing J, Nyunoya T.

Hum Genomics. 2016 Jan 7;10:1. doi: 10.1186/s40246-015-0058-7.

25.

Radon Exposure, IL-6 Promoter Variants, and Lung Squamous Cell Carcinoma in Former Uranium Miners.

Leng S, Thomas CL, Snider AM, Picchi MA, Chen W, Willis DG, Carr TG, Krzeminski J, Desai D, Shantu A, Lin Y, Jacobson MR, Belinsky SA.

Environ Health Perspect. 2016 Apr;124(4):445-51. doi: 10.1289/ehp.1409437. Epub 2015 Sep 15.

26.

Epigenetic Repression of CCDC37 and MAP1B Links Chronic Obstructive Pulmonary Disease to Lung Cancer.

Tessema M, Yingling CM, Picchi MA, Wu G, Liu Y, Weissfeld JL, Siegfried JM, Tesfaigzi Y, Belinsky SA.

J Thorac Oncol. 2015 Aug;10(8):1181-8. doi: 10.1097/JTO.0000000000000592.

27.

Implication of a Chromosome 15q15.2 Locus in Regulating UBR1 and Predisposing Smokers to MGMT Methylation in Lung.

Leng S, Wu G, Collins LB, Thomas CL, Tellez CS, Jauregui AR, Picchi MA, Zhang X, Juri DE, Desai D, Amin SG, Crowell RE, Stidley CA, Liu Y, Swenberg JA, Lin Y, Wathelet MG, Gilliland FD, Belinsky SA.

Cancer Res. 2015 Aug 1;75(15):3108-17. doi: 10.1158/0008-5472.CAN-15-0243. Epub 2015 Jul 16.

28.

Low plasma CC16 levels in smokers are associated with a higher risk for chronic bronchitis.

Petersen H, Leng S, Belinsky SA, Miller BE, Tal-Singer R, Owen CA, Celli B, Tesfaigzi Y.

Eur Respir J. 2015 Nov;46(5):1501-3. doi: 10.1183/13993003.00682-2015. Epub 2015 Jul 9. No abstract available.

29.

15q12 variants, sputum gene promoter hypermethylation, and lung cancer risk: a GWAS in smokers.

Leng S, Liu Y, Weissfeld JL, Thomas CL, Han Y, Picchi MA, Edlund CK, Willink RP, Gaither Davis AL, Do KC, Nukui T, Zhang X, Burki EA, Van Den Berg D, Romkes M, Gauderman WJ, Crowell RE, Tesfaigzi Y, Stidley CA, Amos CI, Siegfried JM, Gilliland FD, Belinsky SA.

J Natl Cancer Inst. 2015 Feb 23;107(5). pii: djv035. doi: 10.1093/jnci/djv035.

30.

Unmasking the lung cancer epigenome.

Belinsky SA.

Annu Rev Physiol. 2015;77:453-74. doi: 10.1146/annurev-physiol-021014-072018. Review.

PMID:
25668024
31.

Epigenetic change (GATA-4 gene methylation) is associated with health status in chronic obstructive pulmonary disease.

Meek PM, Sood A, Petersen H, Belinsky SA, Tesfaigzi Y.

Biol Res Nurs. 2015 Mar;17(2):191-8. doi: 10.1177/1099800414538113. Epub 2014 Jun 27.

PMID:
24973415
32.

GATA2 is epigenetically repressed in human and mouse lung tumors and is not requisite for survival of KRAS mutant lung cancer.

Tessema M, Yingling CM, Snider AM, Do K, Juri DE, Picchi MA, Zhang X, Liu Y, Leng S, Tellez CS, Belinsky SA.

J Thorac Oncol. 2014 Jun;9(6):784-93. doi: 10.1097/JTO.0000000000000165.

33.

A Phase I Protocol of Hydralazine and Valproic Acid in Advanced, Previously Treated Solid Cancers.

Bauman J, Shaheen M, Verschraegen CF, Belinsky SA, Houman Fekrazad M, Lee FC, Rabinowitz I, Ravindranathan M, Jones DV Jr.

Transl Oncol. 2014 Apr 17. pii: S1936-5233(14)00020-5. doi: 10.1016/j.tranon.2014.03.001. [Epub ahead of print]

34.

SGI-110 and entinostat therapy reduces lung tumor burden and reprograms the epigenome.

Tellez CS, Grimes MJ, Picchi MA, Liu Y, March TH, Reed MD, Oganesian A, Taverna P, Belinsky SA.

Int J Cancer. 2014 Nov 1;135(9):2223-31. doi: 10.1002/ijc.28865. Epub 2014 Apr 5.

35.

RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1α-mediated mitochondrial oxidative phosphorylation and glycolysis.

Chen W, Wang Q, Bai L, Chen W, Wang X, Tellez CS, Leng S, Padilla MT, Nyunoya T, Belinsky SA, Lin Y.

Cell Death Differ. 2014 Jul;21(7):1061-70. doi: 10.1038/cdd.2014.25. Epub 2014 Feb 28.

36.

Functional identification of cancer-specific methylation of CDO1, HOXA9, and TAC1 for the diagnosis of lung cancer.

Wrangle J, Machida EO, Danilova L, Hulbert A, Franco N, Zhang W, Glöckner SC, Tessema M, Van Neste L, Easwaran H, Schuebel KE, Licchesi J, Hooker CM, Ahuja N, Amano J, Belinsky SA, Baylin SB, Herman JG, Brock MV.

Clin Cancer Res. 2014 Apr 1;20(7):1856-64. doi: 10.1158/1078-0432.CCR-13-2109. Epub 2014 Jan 31.

37.

Global identification of genes targeted by DNMT3b for epigenetic silencing in lung cancer.

Teneng I, Tellez CS, Picchi MA, Klinge DM, Yingling CM, Snider AM, Liu Y, Belinsky SA.

Oncogene. 2015 Jan 29;34(5):621-30. doi: 10.1038/onc.2013.580. Epub 2014 Jan 27.

PMID:
24469050
38.

Increased methylation of lung cancer-associated genes in sputum DNA of former smokers with chronic mucous hypersecretion.

Bruse S, Petersen H, Weissfeld J, Picchi M, Willink R, Do K, Siegfried J, Belinsky SA, Tesfaigzi Y.

Respir Res. 2014 Jan 9;15:2. doi: 10.1186/1465-9921-15-2.

39.

Genome-wide unmasking of epigenetically silenced genes in lung adenocarcinoma from smokers and never smokers.

Tessema M, Yingling CM, Liu Y, Tellez CS, Van Neste L, Baylin SS, Belinsky SA.

Carcinogenesis. 2014 Jun;35(6):1248-57. doi: 10.1093/carcin/bgt494. Epub 2014 Jan 7.

40.

MUC1 in macrophage: contributions to cigarette smoke-induced lung cancer.

Xu X, Padilla MT, Li B, Wells A, Kato K, Tellez C, Belinsky SA, Kim KC, Lin Y.

Cancer Res. 2014 Jan 15;74(2):460-70. doi: 10.1158/0008-5472.CAN-13-1713. Epub 2013 Nov 26.

41.

MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis.

Perdomo C, Campbell JD, Gerrein J, Tellez CS, Garrison CB, Walser TC, Drizik E, Si H, Gower AC, Vick J, Anderlind C, Jackson GR, Mankus C, Schembri F, O'Hara C, Gomperts BN, Dubinett SM, Hayden P, Belinsky SA, Lenburg ME, Spira A.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18946-51. doi: 10.1073/pnas.1220319110. Epub 2013 Oct 24.

42.

Aerosolised 5-azacytidine suppresses tumour growth and reprogrammes the epigenome in an orthotopic lung cancer model.

Reed MD, Tellez CS, Grimes MJ, Picchi MA, Tessema M, Cheng YS, March TH, Kuehl PJ, Belinsky SA.

Br J Cancer. 2013 Oct 1;109(7):1775-81. doi: 10.1038/bjc.2013.575. Epub 2013 Sep 17.

43.

Native American ancestry affects the risk for gene methylation in the lungs of Hispanic smokers from New Mexico.

Leng S, Liu Y, Thomas CL, Gauderman WJ, Picchi MA, Bruse SE, Zhang X, Flores KG, Van Den Berg D, Stidley CA, Gilliland FD, Belinsky SA.

Am J Respir Crit Care Med. 2013 Nov 1;188(9):1110-6. doi: 10.1164/rccm.201305-0925OC.

44.

Rapid lung function decline in smokers is a risk factor for COPD and is attenuated by angiotensin-converting enzyme inhibitor use.

Petersen H, Sood A, Meek PM, Shen X, Cheng Y, Belinsky SA, Owen CA, Washko G, Pinto-Plata V, Kelly E, Celli B, Tesfaigzi Y.

Chest. 2014 Apr;145(4):695-703. doi: 10.1378/chest.13-0799.

45.

Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597.

Karp DD, Lee SJ, Keller SM, Wright GS, Aisner S, Belinsky SA, Johnson DH, Johnston MR, Goodman G, Clamon G, Okawara G, Marks R, Frechette E, McCaskill-Stevens W, Lippman SM, Ruckdeschel J, Khuri FR.

J Clin Oncol. 2013 Nov 20;31(33):4179-87. doi: 10.1200/JCO.2013.49.2173. Epub 2013 Sep 3.

46.

Methylation of the RARB gene increases prostate cancer risk in black Americans.

Tang D, Kryvenko ON, Mitrache N, Do KC, Jankowski M, Chitale DA, Trudeau S, Rundle A, Belinsky SA, Rybicki BA.

J Urol. 2013 Jul;190(1):317-24. doi: 10.1016/j.juro.2013.01.083. Epub 2013 Jan 30.

47.

Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau.

Leng S, Picchi MA, Liu Y, Thomas CL, Willis DG, Bernauer AM, Carr TG, Mabel PT, Han Y, Amos CI, Lin Y, Stidley CA, Gilliland FD, Jacobson MR, Belinsky SA.

Carcinogenesis. 2013 May;34(5):1044-50. doi: 10.1093/carcin/bgt024. Epub 2013 Jan 25. Erratum in: Carcinogenesis. 2013 Jul;34(7):1698.

48.

Low-dose gamma-radiation inhibits benzo[a]pyrene-induced lung adenoma development in a/j mice.

Bruce VR, Belinsky SA, Gott K, Liu Y, March T, Scott B, Wilder J.

Dose Response. 2012 Dec;10(4):516-26. doi: 10.2203/dose-response.12-040.Bruce. Epub 2012 Nov 22.

49.

Softwares and methods for estimating genetic ancestry in human populations.

Liu Y, Nyunoya T, Leng S, Belinsky SA, Tesfaigzi Y, Bruse S.

Hum Genomics. 2013 Jan 5;7:1. doi: 10.1186/1479-7364-7-1. Review.

50.

Sex-specific association of sequence variants in CBS and MTRR with risk for promoter hypermethylation in the lung epithelium of smokers.

Flores KG, Stidley CA, Mackey AJ, Picchi MA, Stabler SP, Siegfried JM, Byers T, Berwick M, Belinsky SA, Leng S.

Carcinogenesis. 2012 Aug;33(8):1542-7. doi: 10.1093/carcin/bgs194. Epub 2012 Jun 4.

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