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Items: 37


Enhancement of Cardiac Store Operated Calcium Entry (SOCE) within Novel Intercalated Disk Microdomains in Arrhythmic Disease.

Bonilla IM, Belevych AE, Baine S, Stepanov A, Mezache L, Bodnar T, Liu B, Volpe P, Priori S, Weisleder N, Sakuta G, Carnes CA, Radwański PB, Veeraraghavan R, Gyorke S.

Sci Rep. 2019 Jul 15;9(1):10179. doi: 10.1038/s41598-019-46427-x.


Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin-Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia.

Liu B, Walton SD, Ho HT, Belevych AE, Tikunova SB, Bonilla I, Shettigar V, Knollmann BC, Priori SG, Volpe P, Radwański PB, Davis JP, Györke S.

J Am Heart Assoc. 2018 May 2;7(10). pii: e008155. doi: 10.1161/JAHA.117.008155.


The role of luminal Ca regulation in Ca signaling refractoriness and cardiac arrhythmogenesis.

Györke S, Belevych AE, Liu B, Kubasov IV, Carnes CA, Radwański PB.

J Gen Physiol. 2017 Sep 4;149(9):877-888. doi: 10.1085/jgp.201711808. Epub 2017 Aug 10. Review. No abstract available.


The role of spatial organization of Ca2+ release sites in the generation of arrhythmogenic diastolic Ca2+ release in myocytes from failing hearts.

Belevych AE, Ho HT, Bonilla IM, Terentyeva R, Schober KE, Terentyev D, Carnes CA, Györke S.

Basic Res Cardiol. 2017 Jul;112(4):44. doi: 10.1007/s00395-017-0633-2. Epub 2017 Jun 13.


Neuronal Na+ Channels Are Integral Components of Pro-arrhythmic Na+/Ca2+ Signaling Nanodomain That Promotes Cardiac Arrhythmias During β-adrenergic Stimulation.

Radwański PB, Ho HT, Veeraraghavan R, Brunello L, Liu B, Belevych AE, Unudurthi SD, Makara MA, Priori SG, Volpe P, Armoundas AA, Dillmann WH, Knollmann BC, Mohler PJ, Hund TJ, Györke S.

JACC Basic Transl Sci. 2016 Jun;1(4):251-266.


Muscarinic Stimulation Facilitates Sarcoplasmic Reticulum Ca Release by Modulating Ryanodine Receptor 2 Phosphorylation Through Protein Kinase G and Ca/Calmodulin-Dependent Protein Kinase II.

Ho HT, Belevych AE, Liu B, Bonilla IM, Radwański PB, Kubasov IV, Valdivia HH, Schober K, Carnes CA, Györke S.

Hypertension. 2016 Nov;68(5):1171-1178. Epub 2016 Sep 19. Review.


Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT.

Liu B, Ho HT, Brunello L, Unudurthi SD, Lou Q, Belevych AE, Qian L, Kim DH, Cho C, Janssen PM, Hund TJ, Knollmann BC, Kranias EG, Györke S.

Cardiovasc Res. 2015 Nov 1;108(2):299-311. doi: 10.1093/cvr/cvv222. Epub 2015 Sep 25.


Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release.

Radwański PB, Brunello L, Veeraraghavan R, Ho HT, Lou Q, Makara MA, Belevych AE, Anghelescu M, Priori SG, Volpe P, Hund TJ, Janssen PM, Mohler PJ, Bridge JH, Poelzing S, Györke S.

Cardiovasc Res. 2015 Apr 1;106(1):143-52. doi: 10.1093/cvr/cvu262. Epub 2014 Dec 23.


Alternating membrane potential/calcium interplay underlies repetitive focal activity in a genetic model of calcium-dependent atrial arrhythmias.

Lou Q, Belevych AE, Radwański PB, Liu B, Kalyanasundaram A, Knollmann BC, Fedorov VV, Györke S.

J Physiol. 2015 Mar 15;593(6):1443-58. doi: 10.1113/jphysiol.2014.280784. Epub 2014 Dec 2.


Ibandronate and ventricular arrhythmia risk.

Bonilla IM, Vargas-Pinto P, Nishijima Y, Pedraza-Toscano A, Ho HT, Long VP 3rd, Belevych AE, Glynn P, Houmsse M, Rhodes T, Weiss R, Hund TJ, Hamlin RL, Györke S, Carnes CA.

J Cardiovasc Electrophysiol. 2014 Mar;25(3):299-306. doi: 10.1111/jce.12327. Epub 2013 Dec 20.


Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex1.

Glukhov AV, Kalyanasundaram A, Lou Q, Hage LT, Hansen BJ, Belevych AE, Mohler PJ, Knollmann BC, Periasamy M, Györke S, Fedorov VV.

Eur Heart J. 2015 Mar 14;36(11):686-97. doi: 10.1093/eurheartj/eht452. Epub 2013 Nov 11.


Dietary omega-3 fatty acids promote arrhythmogenic remodeling of cellular Ca2+ handling in a postinfarction model of sudden cardiac death.

Belevych AE, Ho HT, Terentyeva R, Bonilla IM, Terentyev D, Carnes CA, Gyorke S, Billman GE.

PLoS One. 2013 Oct 18;8(10):e78414. doi: 10.1371/journal.pone.0078414. eCollection 2013.


Decreased RyR2 refractoriness determines myocardial synchronization of aberrant Ca2+ release in a genetic model of arrhythmia.

Brunello L, Slabaugh JL, Radwanski PB, Ho HT, Belevych AE, Lou Q, Chen H, Napolitano C, Lodola F, Priori SG, Fedorov VV, Volpe P, Fill M, Janssen PM, Györke S.

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10312-7. doi: 10.1073/pnas.1300052110. Epub 2013 Jun 3.


'Ryanopathy': causes and manifestations of RyR2 dysfunction in heart failure.

Belevych AE, Radwański PB, Carnes CA, Györke S.

Cardiovasc Res. 2013 May 1;98(2):240-7. doi: 10.1093/cvr/cvt024. Epub 2013 Feb 12. Review.


Up-regulation of sarcoplasmic reticulum Ca(2+) uptake leads to cardiac hypertrophy, contractile dysfunction and early mortality in mice deficient in CASQ2.

Kalyanasundaram A, Lacombe VA, Belevych AE, Brunello L, Carnes CA, Janssen PM, Knollmann BC, Periasamy M, Gyørke S.

Cardiovasc Res. 2013 May 1;98(2):297-306. doi: 10.1093/cvr/cvs334. Epub 2012 Nov 6.


Store-dependent deactivation: cooling the chain-reaction of myocardial calcium signaling.

Radwański PB, Belevych AE, Brunello L, Carnes CA, Györke S.

J Mol Cell Cardiol. 2013 May;58:77-83. doi: 10.1016/j.yjmcc.2012.10.008. Epub 2012 Oct 27. Review.


Endurance exercise training normalizes repolarization and calcium-handling abnormalities, preventing ventricular fibrillation in a model of sudden cardiac death.

Bonilla IM, Belevych AE, Sridhar A, Nishijima Y, Ho HT, He Q, Kukielka M, Terentyev D, Terentyeva R, Liu B, Long VP, Györke S, Carnes CA, Billman GE.

J Appl Physiol (1985). 2012 Dec 1;113(11):1772-83. doi: 10.1152/japplphysiol.00175.2012. Epub 2012 Oct 4.


Shortened Ca2+ signaling refractoriness underlies cellular arrhythmogenesis in a postinfarction model of sudden cardiac death.

Belevych AE, Terentyev D, Terentyeva R, Ho HT, Gyorke I, Bonilla IM, Carnes CA, Billman GE, Györke S.

Circ Res. 2012 Feb 17;110(4):569-77. doi: 10.1161/CIRCRESAHA.111.260455. Epub 2012 Jan 5.


MicroRNA-1 and -133 increase arrhythmogenesis in heart failure by dissociating phosphatase activity from RyR2 complex.

Belevych AE, Sansom SE, Terentyeva R, Ho HT, Nishijima Y, Martin MM, Jindal HK, Rochira JA, Kunitomo Y, Abdellatif M, Carnes CA, Elton TS, Györke S, Terentyev D.

PLoS One. 2011;6(12):e28324. doi: 10.1371/journal.pone.0028324. Epub 2011 Dec 6.


Functional consequences of stably expressing a mutant calsequestrin (CASQ2D307H) in the CASQ2 null background.

Kalyanasundaram A, Viatchenko-Karpinski S, Belevych AE, Lacombe VA, Hwang HS, Knollmann BC, Gyorke S, Periasamy M.

Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H253-61. doi: 10.1152/ajpheart.00578.2011. Epub 2011 Oct 7.


The relationship between arrhythmogenesis and impaired contractility in heart failure: role of altered ryanodine receptor function.

Belevych AE, Terentyev D, Terentyeva R, Nishijima Y, Sridhar A, Hamlin RL, Carnes CA, Györke S.

Cardiovasc Res. 2011 Jun 1;90(3):493-502. doi: 10.1093/cvr/cvr025. Epub 2011 Jan 27.


miRNAs got rhythm.

Elton TS, Martin MM, Sansom SE, Belevych AE, Györke S, Terentyev D.

Life Sci. 2011 Feb 28;88(9-10):373-83. doi: 10.1016/j.lfs.2010.11.022. Epub 2010 Dec 3. Review.


Effects of dietary omega-3 fatty acids on ventricular function in dogs with healed myocardial infarctions: in vivo and in vitro studies.

Billman GE, Nishijima Y, Belevych AE, Terentyev D, Xu Y, Haizlip KM, Monasky MM, Hiranandani N, Harris WS, Gyorke S, Carnes CA, Janssen PM.

Am J Physiol Heart Circ Physiol. 2010 Apr;298(4):H1219-28. doi: 10.1152/ajpheart.01065.2009. Epub 2010 Jan 22.


Redox modification of ryanodine receptors underlies calcium alternans in a canine model of sudden cardiac death.

Belevych AE, Terentyev D, Viatchenko-Karpinski S, Terentyeva R, Sridhar A, Nishijima Y, Wilson LD, Cardounel AJ, Laurita KR, Carnes CA, Billman GE, Gyorke S.

Cardiovasc Res. 2009 Dec 1;84(3):387-95. doi: 10.1093/cvr/cvp246. Epub 2009 Jul 17.


miR-1 overexpression enhances Ca(2+) release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2.

Terentyev D, Belevych AE, Terentyeva R, Martin MM, Malana GE, Kuhn DE, Abdellatif M, Feldman DS, Elton TS, Györke S.

Circ Res. 2009 Feb 27;104(4):514-21. doi: 10.1161/CIRCRESAHA.108.181651. Epub 2009 Jan 8.


Redox modification of ryanodine receptors contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure.

Terentyev D, Györke I, Belevych AE, Terentyeva R, Sridhar A, Nishijima Y, de Blanco EC, Khanna S, Sen CK, Cardounel AJ, Carnes CA, Györke S.

Circ Res. 2008 Dec 5;103(12):1466-72. doi: 10.1161/CIRCRESAHA.108.184457. Epub 2008 Nov 13.


Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias.

Lehnart SE, Wehrens XH, Reiken S, Warrier S, Belevych AE, Harvey RD, Richter W, Jin SL, Conti M, Marks AR.

Cell. 2005 Oct 7;123(1):25-35. Erratum in: Cell. 2005 Nov 4;123(3):535-6.


Beta-adrenergic- and muscarinic receptor-induced changes in cAMP activity in adult cardiac myocytes detected with FRET-based biosensor.

Warrier S, Belevych AE, Ruse M, Eckert RL, Zaccolo M, Pozzan T, Harvey RD.

Am J Physiol Cell Physiol. 2005 Aug;289(2):C455-61. Epub 2005 Mar 23.


Protein kinase C regulates functional coupling of beta1-adrenergic receptors to Gi/o-mediated responses in cardiac myocytes.

Belevych AE, Juranek I, Harvey RD.

FASEB J. 2004 Feb;18(2):367-9. Epub 2003 Dec 19.


Muscarinic regulation of cardiac ion channels.

Harvey RD, Belevych AE.

Br J Pharmacol. 2003 Jul;139(6):1074-84. Review.


Genistein inhibits cardiac L-type Ca(2+) channel activity by a tyrosine kinase-independent mechanism.

Belevych AE, Warrier S, Harvey RD.

Mol Pharmacol. 2002 Sep;62(3):554-65.


Developmental changes in the functional characteristics and expression of voltage-gated K+ channel currents in rat aortic myocytes.

Belevych AE, Beck R, Tammaro P, Poston L, Smirnov SV.

Cardiovasc Res. 2002 Apr;54(1):152-61.


Mechanism of effect of extracellular pH on L-type Ca(2+) channel currents in human mesenteric arterial cells.

Smirnov SV, Knock GA, Belevych AE, Aaronson PI.

Am J Physiol Heart Circ Physiol. 2000 Jul;279(1):H76-85.


TTX-sensitive Na(+) and nifedipine-sensitive Ca(2+) channels in rat vas deferens smooth muscle cells.

Belevych AE, Zima AV, Vladimirova IA, Hirata H, Jurkiewicz A, Jurkiewicz NH, Shuba MF.

Biochim Biophys Acta. 1999 Jul 15;1419(2):343-52.

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