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Items: 1 to 50 of 80

1.

Early-life stress influences acute and sensitized responses of adult mice to cocaine by interacting with GABAA α2 receptor expression.

Dixon CI, Walker SE, Swinny J, Belelli D, Lambert JJ, King SL, Stephens DN.

Behav Pharmacol. 2019 Apr;30(2 and 3 - Special Issue):272-281. doi: 10.1097/FBP.0000000000000466.

PMID:
30724801
2.

Early-life adversity selectively impairs α2-GABAA receptor expression in the mouse nucleus accumbens and influences the behavioral effects of cocaine.

Mitchell SJ, Maguire EP, Cunningham L, Gunn BG, Linke M, Zechner U, Dixon CI, King SL, Stephens DN, Swinny JD, Belelli D, Lambert JJ.

Neuropharmacology. 2018 Oct;141:98-112. doi: 10.1016/j.neuropharm.2018.08.021. Epub 2018 Aug 21.

3.

Isotope Dilution-Based Targeted and Nontargeted Carbonyl Neurosteroid/Steroid Profiling.

Sharp S, Mitchell SJ, Vallée M, Kuzmanova E, Cooper M, Belelli D, Lambert JJ, Huang JT.

Anal Chem. 2018 Apr 17;90(8):5247-5255. doi: 10.1021/acs.analchem.8b00055. Epub 2018 Mar 28.

PMID:
29561593
4.

Endogenous neurosteroids influence synaptic GABAA receptors during postnatal development.

Belelli D, Brown AR, Mitchell SJ, Gunn BG, Herd MB, Phillips GD, Seifi M, Swinny JD, Lambert JJ.

J Neuroendocrinol. 2018 Feb;30(2). doi: 10.1111/jne.12537. Review.

PMID:
28905487
5.

Selective inhibition of extra-synaptic α5-GABAA receptors by S44819, a new therapeutic agent.

Etherington LA, Mihalik B, Pálvölgyi A, Ling I, Pallagi K, Kertész S, Varga P, Gunn BG, Brown AR, Livesey MR, Monteiro O, Belelli D, Barkóczy J, Spedding M, Gacsályi I, Antoni FA, Lambert JJ.

Neuropharmacology. 2017 Oct;125:353-364. doi: 10.1016/j.neuropharm.2017.08.012. Epub 2017 Aug 12.

PMID:
28807671
6.

GABAA receptor subtype involvement in addictive behaviour.

Stephens DN, King SL, Lambert JJ, Belelli D, Duka T.

Genes Brain Behav. 2017 Jan;16(1):149-184. doi: 10.1111/gbb.12321. Epub 2016 Sep 20. Review.

7.

During postnatal development endogenous neurosteroids influence GABA-ergic neurotransmission of mouse cortical neurons.

Brown AR, Mitchell SJ, Peden DR, Herd MB, Seifi M, Swinny JD, Belelli D, Lambert JJ.

Neuropharmacology. 2016 Apr;103:163-73. doi: 10.1016/j.neuropharm.2015.11.019. Epub 2015 Dec 2.

8.

A novel GABA(A) alpha 5 receptor inhibitor with therapeutic potential.

Ling I, Mihalik B, Etherington LA, Kapus G, Pálvölgyi A, Gigler G, Kertész S, Gaál A, Pallagi K, Kiricsi P, Szabó É, Szénási G, Papp L, Hársing LG, Lévay G, Spedding M, Lambert JJ, Belelli D, Barkóczy J, Volk B, Simig G, Gacsályi I, Antoni FA.

Eur J Pharmacol. 2015 Oct 5;764:497-507. doi: 10.1016/j.ejphar.2015.07.005. Epub 2015 Jul 11.

PMID:
26169564
9.

Developmentally regulated neurosteroid synthesis enhances GABAergic neurotransmission in mouse thalamocortical neurones.

Brown AR, Herd MB, Belelli D, Lambert JJ.

J Physiol. 2015 Jan 1;593(1):267-84. doi: 10.1113/jphysiol.2014.280263. Epub 2014 Dec 3.

10.

Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.

Seifi M, Brown JF, Mills J, Bhandari P, Belelli D, Lambert JJ, Rudolph U, Swinny JD.

J Neurosci. 2014 Jul 30;34(31):10361-78. doi: 10.1523/JNEUROSCI.0441-14.2014.

11.

Localisation and stress-induced plasticity of GABAA receptor subunits within the cellular networks of the mouse dorsal raphe nucleus.

Corteen NL, Carter JA, Rudolph U, Belelli D, Lambert JJ, Swinny JD.

Brain Struct Funct. 2015 Sep;220(5):2739-63. doi: 10.1007/s00429-014-0824-7. Epub 2014 Jun 29.

PMID:
24973971
12.

GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response.

Gunn BG, Cunningham L, Mitchell SG, Swinny JD, Lambert JJ, Belelli D.

Front Neuroendocrinol. 2015 Jan;36:28-48. doi: 10.1016/j.yfrne.2014.06.001. Epub 2014 Jun 12. Review.

13.
14.

Control of Inhibition by the Direct Action of Cannabinoids on GABAA Receptors.

Golovko T, Min R, Lozovaya N, Falconer C, Yatsenko N, Tsintsadze T, Tsintsadze V, Ledent C, Harvey RJ, Belelli D, Lambert JJ, Rozov A, Burnashev N.

Cereb Cortex. 2015 Sep;25(9):2440-55. doi: 10.1093/cercor/bhu045. Epub 2014 Mar 18.

PMID:
24646614
15.

The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.

16.

Tonic inhibition of accumbal spiny neurons by extrasynaptic α4βδ GABAA receptors modulates the actions of psychostimulants.

Maguire EP, Macpherson T, Swinny JD, Dixon CI, Herd MB, Belelli D, Stephens DN, King SL, Lambert JJ.

J Neurosci. 2014 Jan 15;34(3):823-38. doi: 10.1523/JNEUROSCI.3232-13.2014.

17.

Dysfunctional astrocytic and synaptic regulation of hypothalamic glutamatergic transmission in a mouse model of early-life adversity: relevance to neurosteroids and programming of the stress response.

Gunn BG, Cunningham L, Cooper MA, Corteen NL, Seifi M, Swinny JD, Lambert JJ, Belelli D.

J Neurosci. 2013 Dec 11;33(50):19534-54. doi: 10.1523/JNEUROSCI.1337-13.2013.

18.

Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition.

Anstee QM, Knapp S, Maguire EP, Hosie AM, Thomas P, Mortensen M, Bhome R, Martinez A, Walker SE, Dixon CI, Ruparelia K, Montagnese S, Kuo YT, Herlihy A, Bell JD, Robinson I, Guerrini I, McQuillin A, Fisher EM, Ungless MA, Gurling HM, Morgan MY, Brown SD, Stephens DN, Belelli D, Lambert JJ, Smart TG, Thomas HC.

Nat Commun. 2013;4:2816. doi: 10.1038/ncomms3816.

19.

Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons: a sensitive target for ethanol.

Maguire EP, Mitchell EA, Greig SJ, Corteen N, Balfour DJ, Swinny JD, Lambert JJ, Belelli D.

Neuropsychopharmacology. 2014 Apr;39(5):1232-44. doi: 10.1038/npp.2013.326. Epub 2013 Nov 22.

20.

Extrasynaptic GABA(A) receptors couple presynaptic activity to postsynaptic inhibition in the somatosensory thalamus.

Herd MB, Brown AR, Lambert JJ, Belelli D.

J Neurosci. 2013 Sep 11;33(37):14850-68. doi: 10.1523/JNEUROSCI.1174-13.2013.

21.

GABA-independent GABAA receptor openings maintain tonic currents.

Wlodarczyk AI, Sylantyev S, Herd MB, Kersanté F, Lambert JJ, Rusakov DA, Linthorst AC, Semyanov A, Belelli D, Pavlov I, Walker MC.

J Neurosci. 2013 Feb 27;33(9):3905-14. doi: 10.1523/JNEUROSCI.4193-12.2013.

22.

A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABA(A) receptors.

Jensen ML, Wafford KA, Brown AR, Belelli D, Lambert JJ, Mirza NR.

Br J Pharmacol. 2013 Mar;168(5):1118-32. doi: 10.1111/bph.12001.

23.

Regulation of AMPA receptor surface trafficking and synaptic plasticity by a cognitive enhancer and antidepressant molecule.

Zhang H, Etherington LA, Hafner AS, Belelli D, Coussen F, Delagrange P, Chaouloff F, Spedding M, Lambert JJ, Choquet D, Groc L.

Mol Psychiatry. 2013 Apr;18(4):471-84. doi: 10.1038/mp.2012.80. Epub 2012 Jun 26.

24.

Neurosteroids and GABA(A) Receptor Interactions: A Focus on Stress.

Gunn BG, Brown AR, Lambert JJ, Belelli D.

Front Neurosci. 2011 Dec 5;5:131. doi: 10.3389/fnins.2011.00131. eCollection 2011.

25.

Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells.

Panzanelli P, Gunn BG, Schlatter MC, Benke D, Tyagarajan SK, Scheiffele P, Belelli D, Lambert JJ, Rudolph U, Fritschy JM.

J Physiol. 2011 Oct 15;589(Pt 20):4959-80. doi: 10.1113/jphysiol.2011.216028. Epub 2011 Aug 8.

26.

Cocaine effects on mouse incentive-learning and human addiction are linked to alpha2 subunit-containing GABAA receptors.

Dixon CI, Morris HV, Breen G, Desrivieres S, Jugurnauth S, Steiner RC, Vallada H, Guindalini C, Laranjeira R, Messas G, Rosahl TW, Atack JR, Peden DR, Belelli D, Lambert JJ, King SL, Schumann G, Stephens DN.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2289-94. doi: 10.1073/pnas.0910117107. Epub 2010 Jan 19.

27.

Extrasynaptic GABAA receptors: form, pharmacology, and function.

Belelli D, Harrison NL, Maguire J, Macdonald RL, Walker MC, Cope DW.

J Neurosci. 2009 Oct 14;29(41):12757-63. doi: 10.1523/JNEUROSCI.3340-09.2009. Review.

28.

Neurosteroids: endogenous allosteric modulators of GABA(A) receptors.

Lambert JJ, Cooper MA, Simmons RD, Weir CJ, Belelli D.

Psychoneuroendocrinology. 2009 Dec;34 Suppl 1:S48-58. doi: 10.1016/j.psyneuen.2009.08.009.

PMID:
19758761
29.

Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptors.

Herd MB, Foister N, Chandra D, Peden DR, Homanics GE, Brown VJ, Balfour DJ, Lambert JJ, Belelli D.

Eur J Neurosci. 2009 Mar;29(6):1177-87. doi: 10.1111/j.1460-9568.2009.06680.x.

30.

A transmembrane residue influences the interaction of propofol with the strychnine-sensitive glycine alpha1 and alpha1beta receptor.

Ahrens J, Leuwer M, Stachura S, Krampfl K, Belelli D, Lambert JJ, Haeseler G.

Anesth Analg. 2008 Dec;107(6):1875-83. doi: 10.1213/ane.0b013e3181875a31.

PMID:
19020133
31.

Novel compounds selectively enhance delta subunit containing GABA A receptors and increase tonic currents in thalamus.

Wafford KA, van Niel MB, Ma QP, Horridge E, Herd MB, Peden DR, Belelli D, Lambert JJ.

Neuropharmacology. 2009 Jan;56(1):182-9. doi: 10.1016/j.neuropharm.2008.08.004. Epub 2008 Aug 13.

PMID:
18762200
32.

The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells.

Herd MB, Haythornthwaite AR, Rosahl TW, Wafford KA, Homanics GE, Lambert JJ, Belelli D.

J Physiol. 2008 Feb 15;586(4):989-1004. Epub 2007 Dec 13.

33.

Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones.

Peden DR, Petitjean CM, Herd MB, Durakoglugil MS, Rosahl TW, Wafford K, Homanics GE, Belelli D, Fritschy JM, Lambert JJ.

J Physiol. 2008 Feb 15;586(4):965-87. Epub 2007 Dec 6.

34.

Neurosteroid modulation of GABAA receptors: molecular determinants and significance in health and disease.

Mitchell EA, Herd MB, Gunn BG, Lambert JJ, Belelli D.

Neurochem Int. 2008 Mar-Apr;52(4-5):588-95. Epub 2007 Oct 16. Review.

PMID:
18055067
35.

GABAA and glycine receptor-mediated transmission in rat lamina II neurones: relevance to the analgesic actions of neuroactive steroids.

Mitchell EA, Gentet LJ, Dempster J, Belelli D.

J Physiol. 2007 Sep 15;583(Pt 3):1021-40. Epub 2007 Jul 26.

36.

Neurosteroid modulation of synaptic and extrasynaptic GABA(A) receptors.

Herd MB, Belelli D, Lambert JJ.

Pharmacol Ther. 2007 Oct;116(1):20-34. Epub 2007 Apr 21. Review.

PMID:
17531325
37.

Extrasynaptic GABAA receptors of thalamocortical neurons: a molecular target for hypnotics.

Belelli D, Peden DR, Rosahl TW, Wafford KA, Lambert JJ.

J Neurosci. 2005 Dec 14;25(50):11513-20.

38.

Neuroactive steroids and inhibitory neurotransmission: mechanisms of action and physiological relevance.

Belelli D, Herd MB, Mitchell EA, Peden DR, Vardy AW, Gentet L, Lambert JJ.

Neuroscience. 2006;138(3):821-9. Epub 2005 Nov 28. Review.

PMID:
16310966
39.

The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol.

Borghese CM, Stórustovu Sí, Ebert B, Herd MB, Belelli D, Lambert JJ, Marshall G, Wafford KA, Harris RA.

J Pharmacol Exp Ther. 2006 Mar;316(3):1360-8. Epub 2005 Nov 4.

PMID:
16272217
40.

Neurosteroids: endogenous regulators of the GABA(A) receptor.

Belelli D, Lambert JJ.

Nat Rev Neurosci. 2005 Jul;6(7):565-75. Review.

PMID:
15959466
41.

The interaction of anaesthetic steroids with recombinant glycine and GABAA receptors.

Weir CJ, Ling AT, Belelli D, Wildsmith JA, Peters JA, Lambert JJ.

Br J Anaesth. 2004 May;92(5):704-11. Epub 2004 Mar 19.

42.

Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors.

Caraiscos VB, Elliott EM, You-Ten KE, Cheng VY, Belelli D, Newell JG, Jackson MF, Lambert JJ, Rosahl TW, Wafford KA, MacDonald JF, Orser BA.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3662-7. Epub 2004 Mar 1.

43.

GABAA receptor modulation by the novel intravenous general anaesthetic E-6375.

Pau D, Belelli D, Callachan H, Peden DR, Dunlop JI, Peters JA, Guitart X, Gutierrez B, Lambert JJ.

Neuropharmacology. 2003 Dec;45(8):1029-40.

PMID:
14614946
44.

Neurosteroid modulation of GABAA receptors.

Lambert JJ, Belelli D, Peden DR, Vardy AW, Peters JA.

Prog Neurobiol. 2003 Sep;71(1):67-80. Review.

PMID:
14611869
46.

Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms.

Reynolds DS, Rosahl TW, Cirone J, O'Meara GF, Haythornthwaite A, Newman RJ, Myers J, Sur C, Howell O, Rutter AR, Atack J, Macaulay AJ, Hadingham KL, Hutson PH, Belelli D, Lambert JJ, Dawson GR, McKernan R, Whiting PJ, Wafford KA.

J Neurosci. 2003 Sep 17;23(24):8608-17.

47.

The in vitro and in vivo enantioselectivity of etomidate implicates the GABAA receptor in general anaesthesia.

Belelli D, Muntoni AL, Merrywest SD, Gentet LJ, Casula A, Callachan H, Madau P, Gemmell DK, Hamilton NM, Lambert JJ, Sillar KT, Peters JA.

Neuropharmacology. 2003 Jul;45(1):57-71.

PMID:
12814659
48.

The influence of subunit composition on the interaction of neurosteroids with GABA(A) receptors.

Belelli D, Casula A, Ling A, Lambert JJ.

Neuropharmacology. 2002 Sep;43(4):651-61.

PMID:
12367610
50.

Modulation of native and recombinant GABA(A) receptors by endogenous and synthetic neuroactive steroids.

Lambert JJ, Belelli D, Harney SC, Peters JA, Frenguelli BG.

Brain Res Brain Res Rev. 2001 Nov;37(1-3):68-80. Review.

PMID:
11744075

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