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The relative risk of noncervical high-risk human papillomavirus-related (pre)malignancies after recurrent cervical intraepithelial neoplasia grade 3: A population-based study.

Loopik DL, Ebisch RM, IntHout J, Melchers WJ, Massuger LF, Bekkers RL, Siebers AG.

Int J Cancer. 2019 Dec 17. doi: 10.1002/ijc.32834. [Epub ahead of print]


Oral contraceptive and intrauterine device use and the risk of cervical intraepithelial neoplasia grade III or worse: a population-based study.

Loopik DL, IntHout J, Melchers WJG, Massuger LFAG, Bekkers RLM, Siebers AG.

Eur J Cancer. 2020 Jan;124:102-109. doi: 10.1016/j.ejca.2019.10.009. Epub 2019 Nov 21.


Risk prediction of cervical abnormalities: The value of sociodemographic and lifestyle factors in addition to HPV status.

van der Waal D, Bekkers RLM, Dick S, Lenselink CH, Massuger LFAG, Melchers WJG, Schmeink CE, Siebers AG, Broeders MJM.

Prev Med. 2020 Jan;130:105927. doi: 10.1016/j.ypmed.2019.105927. Epub 2019 Nov 19.


Clinical practice variation and overtreatment risk in women with abnormal cervical cytology in the Netherlands; two-step versus see-and-treat approach.

Loopik DL, Siebers AG, Melchers WJG, Massuger LFAG, Bekkers RLM.

Am J Obstet Gynecol. 2019 Oct 21. pii: S0002-9378(19)31221-9. doi: 10.1016/j.ajog.2019.10.004. [Epub ahead of print]


Abdominal radical trachelectomy versus chemotherapy followed by vaginal radical trachelectomy in stage 1B2 (FIGO 2018) cervical cancer. A systematic review on fertility and recurrence rates.

van Kol KGG, Vergeldt TFM, Bekkers RLM.

Gynecol Oncol. 2019 Dec;155(3):515-521. doi: 10.1016/j.ygyno.2019.09.025. Epub 2019 Oct 9.


RNA-based high-risk HPV genotyping and identification of high-risk HPV transcriptional activity in cervical tissues.

van den Heuvel CNAM, Loopik DL, Ebisch RMF, Elmelik D, Andralojc KM, Huynen M, Bulten J, Bekkers RLM, Massuger LFAG, Melchers WJG, Siebers AG, Leenders WPJ.

Mod Pathol. 2019 Sep 19. doi: 10.1038/s41379-019-0369-7. [Epub ahead of print]


Development of the Patient's Experience and Attitude Colposcopy Eindhoven Questionnaire (PEACE-q).

Pop VJM, Wouters T, Bekkers RLM, Spek VRM, Piek JMJ.

BMC Health Serv Res. 2019 Aug 20;19(1):589. doi: 10.1186/s12913-019-4425-2.


Outcome of surgery in advanced ovarian cancer varies between geographical regions; opportunities for improvement in The Netherlands.

Timmermans M, Sonke GS, Slangen BFM, Baalbergen A, Bekkers RLM, Fons G, Gerestein CG, Kruse AJ, Roes EM, Zusterzeel PLM, Van de Vijver KK, Kruitwagen RFPM, van der Aa MA.

Eur J Surg Oncol. 2019 Aug;45(8):1425-1431. doi: 10.1016/j.ejso.2019.04.009. Epub 2019 Apr 12.


Systemic adverse events in imiquimod use for cervical intraepithelial neoplasia - A case series.

Wouters T, Hendriks N, Koeneman M, Kruse AJ, van de Sande A, van Beekhuizen HJ, Gerestein KG, Bekkers RLM, Piek JMJ.

Case Rep Womens Health. 2019 Mar 6;21:e00105. doi: 10.1016/j.crwh.2019.e00105. eCollection 2019 Jan.


Post-Colposcopy Management and Progression Predictors of Biopsy-Proven CIN1 in Women Under 25 Years.

Loopik DL, Bekkers RLM, Massuger LFAG, Melchers WJG, Siebers AG, Bentley JR.

J Obstet Gynaecol Can. 2019 Mar;41(3):292-299. doi: 10.1016/j.jogc.2018.06.021. Epub 2018 Oct 27.


The effect of an animation video on consultation time, anxiety and satisfaction in women with abnormal cervical cytology: Animation video reduces colposcopy time.

Wouters T, Soomers J, Smink M, Smit RA, Plaisier M, Houterman S, Bekkers RL, Schiffer AA, Pop VJ, Piek JMJ.

Prev Med Rep. 2019 Jan 15;13:238-243. doi: 10.1016/j.pmedr.2019.01.005. eCollection 2019 Mar.


Management and treatment of cervical intraepithelial neoplasia in the Netherlands after referral for colposcopy.

Aitken CA, Siebers AG, Matthijsse SM, Jansen EEL, Bekkers RLM, Becker JH, Ter Harmsel B, Roovers JWR, van Kemenade FJ, de Kok IMCM.

Acta Obstet Gynecol Scand. 2019 Jun;98(6):737-746. doi: 10.1111/aogs.13547. Epub 2019 Feb 27.


Performance of human papillomavirus testing on self-collected versus clinician-collected samples for the detection of cervical intraepithelial neoplasia of grade 2 or worse: a randomised, paired screen-positive, non-inferiority trial.

Polman NJ, Ebisch RMF, Heideman DAM, Melchers WJG, Bekkers RLM, Molijn AC, Meijer CJLM, Quint WGV, Snijders PJF, Massuger LFAG, van Kemenade FJ, Berkhof J.

Lancet Oncol. 2019 Feb;20(2):229-238. doi: 10.1016/S1470-2045(18)30763-0. Epub 2019 Jan 15.


Justifying conservative management of CIN2 in women younger than 25 years - A population-based study.

Loopik DL, Bekkers RLM, Massuger LFAG, Melchers WJG, Siebers AG, Bentley J.

Gynecol Oncol. 2019 Jan;152(1):82-86. doi: 10.1016/j.ygyno.2018.10.038. Epub 2018 Nov 7.


Screening for persistent high-risk HPV infections may be a valuable screening method for young women; A retrospective cohort study.

Ebisch RMF, Ketelaars PJW, van der Sanden WMH, Schmeink CE, Lenselink CH, Siebers AG, Massuger LFAG, Melchers WJG, Bekkers RLM.

PLoS One. 2018 Oct 24;13(10):e0206219. doi: 10.1371/journal.pone.0206219. eCollection 2018.


Defining hrHPV genotypes in cervical intraepithelial neoplasia by laser capture microdissection supports reflex triage of self-samples using HPV16/18 and FAM19A4/miR124-2 methylation.

Leeman A, Ebisch RMF, Kasius A, Bosgraaf RP, Jenkins D, van de Sandt MM, de Strooper LMA, Heideman DAM, Snijders PJF, Massuger LFAG, Bekkers RLM, Meijer CJLM, van Kemenade FJ, Quint WGV, Melchers WJG.

Gynecol Oncol. 2018 Nov;151(2):311-318. doi: 10.1016/j.ygyno.2018.09.006. Epub 2018 Sep 13.


Identification and Validation of a 3-Gene Methylation Classifier for HPV-Based Cervical Screening on Self-Samples.

Verlaat W, Snoek BC, Heideman DAM, Wilting SM, Snijders PJF, Novianti PW, van Splunter AP, Peeters CFW, van Trommel NE, Massuger LFAG, Bekkers RLM, Melchers WJG, van Kemenade FJ, Berkhof J, van de Wiel MA, Meijer CJLM, Steenbergen RDM.

Clin Cancer Res. 2018 Jul 15;24(14):3456-3464. doi: 10.1158/1078-0432.CCR-17-3615. Epub 2018 Apr 9.


Presence of koilocytosis in low-grade smears of high-risk HPV-positive women is a negative predictor for cervical intraepithelial neoplasia grade 3 or more.

Siebers AG, van der Linden H, Vedder JEM, Bekkers RLM, Melchers WLG, Bulten J.

Cytopathology. 2018 Jun;29(3):275-280. doi: 10.1111/cyt.12536. Epub 2018 Mar 25.


Para-aortic lymphadenectomy in advanced stage cervical cancer, a protocol for comparing safety, feasibility and diagnostic accuracy of surgical staging versus PET-CT; PALDISC trial.

Tax C, Abbink K, Rovers MM, Bekkers RLM, Zusterzeel PLM.

Pilot Feasibility Stud. 2018 Jan 4;4:27. doi: 10.1186/s40814-017-0218-8. eCollection 2018.


Umbilical cord blood CD34+ progenitor-derived NK cells efficiently kill ovarian cancer spheroids and intraperitoneal tumors in NOD/SCID/IL2Rgnull mice.

Hoogstad-van Evert JS, Cany J, van den Brand D, Oudenampsen M, Brock R, Torensma R, Bekkers RL, Jansen JH, Massuger LF, Dolstra H.

Oncoimmunology. 2017 May 11;6(8):e1320630. doi: 10.1080/2162402X.2017.1320630. eCollection 2017.


The effect of video information on anxiety levels in women attending colposcopy: a randomized controlled trial.

Ketelaars PJW, Buskes MHM, Bosgraaf RP, van Hamont D, Prins JB, Massuger LFAG, Melchers WJG, Bekkers RLM.

Acta Oncol. 2017 Dec;56(12):1728-1733. doi: 10.1080/0284186X.2017.1355108. Epub 2017 Aug 1.


High-risk human papillomavirus detection in self-sampling compared to physician-taken smear in a responder population of the Dutch cervical screening: Results of the VERA study.

Ketelaars PJW, Bosgraaf RP, Siebers AG, Massuger LFAG, van der Linden JC, Wauters CAP, Rahamat-Langendoen JC, van den Brule AJC, IntHout J, Melchers WJG, Bekkers RLM.

Prev Med. 2017 Aug;101:96-101. doi: 10.1016/j.ypmed.2017.05.021. Epub 2017 Jun 1.


Long-Lasting Increased Risk of Human Papillomavirus-Related Carcinomas and Premalignancies After Cervical Intraepithelial Neoplasia Grade 3: A Population-Based Cohort Study.

Ebisch RMF, Rutten DWE, IntHout J, Melchers WJG, Massuger LFAG, Bulten J, Bekkers RLM, Siebers AG.

J Clin Oncol. 2017 Aug 1;35(22):2542-2550. doi: 10.1200/JCO.2016.71.4543. Epub 2017 May 25.


Multimodal Hyperspectroscopic Imaging for Detection of High-Grade Cervical Intraepithelial Neoplasia.

Ebisch RMF, Hermens M, van den Akker PAJ, Massuger LFAG, Melchers WJG, Bekkers RLM.

J Low Genit Tract Dis. 2017 Jul;21(3):166-170. doi: 10.1097/LGT.0000000000000309.


Fifth Ovarian Cancer Consensus Conference of the Gynecologic Cancer InterGroup: first-line interventions.

Karam A, Ledermann JA, Kim JW, Sehouli J, Lu K, Gourley C, Katsumata N, Burger RA, Nam BH, Bacon M, Ng C, Pfisterer J, Bekkers RLM, Casado Herráez A, Redondo A, Fujiwara H, Gleeson N, Rosengarten O, Scambia G, Zhu J, Okamoto A, Stuart G, Ochiai K; participants of the 5th Ovarian Cancer Consensus Conference.

Ann Oncol. 2017 Apr 1;28(4):711-717. doi: 10.1093/annonc/mdx011.


Evaluation of p16/Ki-67 dual-stained cytology as triage test for high-risk human papillomavirus-positive women.

Ebisch RM, van der Horst J, Hermsen M, Rijstenberg LL, Vedder JE, Bulten J, Bosgraaf RP, Verhoef VM, Heideman DA, Snijders PJ, Meijer CJ, van Kemenade FJ, Massuger LF, Melchers WJ, Bekkers RL, Siebers AG.

Mod Pathol. 2017 Jul;30(7):1021-1031. doi: 10.1038/modpathol.2017.16. Epub 2017 Mar 17.


Measuring health-related quality of life in cervical cancer patients: a systematic review of the most used questionnaires and their validity.

Tax C, Steenbergen ME, Zusterzeel PL, Bekkers RL, Rovers MM.

BMC Med Res Methodol. 2017 Jan 26;17(1):15. doi: 10.1186/s12874-016-0289-x. Review.


Clinically applied procedures for human ovarian tissue cryopreservation result in different levels of efficacy and efficiency.

Bastings L, Westphal JR, Beerendonk CC, Bekkers RL, Zusterzeel PL, Hendriks JC, Braat DD, Peek R.

J Assist Reprod Genet. 2016 Dec;33(12):1605-1614. Epub 2016 Oct 6.


Vaginal Radical Trachelectomy for Early-Stage Cervical Cancer: Increased Recurrence Risk for Adenocarcinoma.

Zusterzeel PL, Pol FJ, van Ham M, Zweemer RP, Bekkers RL, Massuger LF, Verheijen RH.

Int J Gynecol Cancer. 2016 Sep;26(7):1293-9. doi: 10.1097/IGC.0000000000000763.


Long-term risk of endometrial cancer following postmenopausal bleeding and reassuring endometrial biopsy.

Visser NC, Sparidaens EM, van den Brink JW, Breijer MC, Boss EA, Veersema S, Siebers AG, Bulten J, Pijnenborg JM, Bekkers RL.

Acta Obstet Gynecol Scand. 2016 Dec;95(12):1418-1424. doi: 10.1111/aogs.13022. Epub 2016 Oct 14.


Alternative Colposcopy Techniques: A Systematic Review and Meta-analysis.

Hermens M, Ebisch RM, Galaal K, Bekkers RL.

Obstet Gynecol. 2016 Oct;128(4):795-803. doi: 10.1097/AOG.0000000000001613. Review.


Triage of high-risk HPV positive women in cervical cancer screening.

Ebisch RM, Siebers AG, Bosgraaf RP, Massuger LF, Bekkers RL, Melchers WJ.

Expert Rev Anticancer Ther. 2016 Oct;16(10):1073-85. doi: 10.1080/14737140.2016.1232166. Epub 2016 Sep 12. Review.


Regression and Progression Predictors of CIN2 in Women Younger Than 25 Years.

Loopik DL, Doucette S, Bekkers RL, Bentley JR.

J Low Genit Tract Dis. 2016 Jul;20(3):213-7. doi: 10.1097/LGT.0000000000000215.


The clinical value of HPV genotyping in triage of women with high-risk-HPV-positive self-samples.

Ebisch RM, de Kuyper-de Ridder GM, Bosgraaf RP, Massuger LF, IntHout J, Verhoef VM, Heideman DA, Snijders PJ, Meijer CJ, van Kemenade FJ, Bulten J, Siebers AG, Bekkers RL, Melchers WJ.

Int J Cancer. 2016 Aug 1;139(3):691-9. doi: 10.1002/ijc.30090. Epub 2016 Apr 7.


Validation of the FAM19A4/mir124-2 DNA methylation test for both lavage- and brush-based self-samples to detect cervical (pre)cancer in HPV-positive women.

De Strooper LMA, Verhoef VMJ, Berkhof J, Hesselink AT, de Bruin HME, van Kemenade FJ, Bosgraaf RP, Bekkers RLM, Massuger LFAG, Melchers WJG, Steenbergen RDM, Snijders PJF, Meijer CJLM, Heideman DAM.

Gynecol Oncol. 2016 May;141(2):341-347. doi: 10.1016/j.ygyno.2016.02.012. Epub 2016 Mar 3.


The sentinel node procedure in early stage cervical cancer, taking the next step; a diagnostic review.

Tax C, Rovers MM, de Graaf C, Zusterzeel PL, Bekkers RL.

Gynecol Oncol. 2015 Dec;139(3):559-67. doi: 10.1016/j.ygyno.2015.09.076. Epub 2015 Sep 28. Review.


Evidence supporting see-and-treat management of cervical intraepithelial neoplasia: a systematic review and meta-analysis.

Ebisch RM, Rovers MM, Bosgraaf RP, van der Pluijm-Schouten HW, Melchers WJ, van den Akker PA, Massuger LF, Bekkers RL.

BJOG. 2016 Jan;123(1):59-66. doi: 10.1111/1471-0528.13530. Epub 2015 Jul 14. Review.


Follow-up of high-risk HPV positive women by combined cytology and bi-marker CADM1/MAL methylation analysis on cervical scrapes.

Verhoef VM, van Kemenade FJ, Rozendaal L, Heideman DA, Bosgraaf RP, Hesselink AT, Melchers WJ, Massuger LF, Bekkers RL, Steenbergen RD, Berkhof J, Snijders PJ, Meijer CJ.

Gynecol Oncol. 2015 Apr;137(1):55-9. doi: 10.1016/j.ygyno.2015.01.550. Epub 2015 Feb 8.


The effect of carbogen breathing and nicotinamide added to standard (chemo)radiation treatment of advanced cervical cancer in Indonesia.

van Weelden WJ, Sekarutami SM, Bekkers RL, Kaanders JH, Bussink J, Gondhowiardjo S, Leer JW, Span PN.

Int J Gynecol Cancer. 2014 Nov;24(9):1628-35. doi: 10.1097/IGC.0000000000000271.


Methylation marker analysis and HPV16/18 genotyping in high-risk HPV positive self-sampled specimens to identify women with high grade CIN or cervical cancer.

Verhoef VM, Heideman DA, van Kemenade FJ, Rozendaal L, Bosgraaf RP, Hesselink AT, Bekkers RL, Massuger LF, Steenbergen RD, Snijders PJ, Berkhof J, Meijer CJ.

Gynecol Oncol. 2014 Oct;135(1):58-63. doi: 10.1016/j.ygyno.2014.08.003. Epub 2014 Aug 8.


DNA methylation analysis in self-sampled brush material as a triage test in hrHPV-positive women.

Boers A, Bosgraaf RP, van Leeuwen RW, Schuuring E, Heideman DA, Massuger LF, Verhoef VM, Bulten J, Melchers WJ, van der Zee AG, Bekkers RL, Wisman GB.

Br J Cancer. 2014 Sep 9;111(6):1095-101. doi: 10.1038/bjc.2014.392. Epub 2014 Jul 17.


Pretreatment retroperitoneal para-aortic lymph node staging in advanced cervical cancer: a review.

Smits RM, Zusterzeel PL, Bekkers RL.

Int J Gynecol Cancer. 2014 Jul;24(6):973-83. doi: 10.1097/IGC.0000000000000177. Review.


Effectiveness of two strategies to follow-up ASC-US and LSIL screening results in The Netherlands using repeat cytology with or without additional hrHPV testing: a retrospective cohort study.

Siebers AG, Arbyn M, Melchers WJ, van Kemenade FJ, Vedder JE, van der Linden H, van Ballegooijen M, Bekkers RL, Bulten J.

Cancer Causes Control. 2014 Sep;25(9):1141-9. doi: 10.1007/s10552-014-0414-2. Epub 2014 Jun 17.


Comparative performance of novel self-sampling methods in detecting high-risk human papillomavirus in 30,130 women not attending cervical screening.

Bosgraaf RP, Verhoef VM, Massuger LF, Siebers AG, Bulten J, de Kuyper-de Ridder GM, Meijer CJ, Snijders PJ, Heideman DA, IntHout J, van Kemenade FJ, Melchers WJ, Bekkers RL.

Int J Cancer. 2015 Feb 1;136(3):646-55. doi: 10.1002/ijc.29026. Epub 2014 Jun 26.


Posttreatment assessment of women at risk of developing high-grade cervical disease: proposal for new guidelines based on data from the Netherlands.

Uijterwaal MH, Kocken M, Berkhof J, Bekkers RL, Verheijen RH, Helmerhorst TJ, Meijer CJ.

J Low Genit Tract Dis. 2014 Oct;18(4):338-43. doi: 10.1097/LGT.0000000000000012. Review.


Reasons for non-attendance to cervical screening and preferences for HPV self-sampling in Dutch women.

Bosgraaf RP, Ketelaars PJ, Verhoef VM, Massuger LF, Meijer CJ, Melchers WJ, Bekkers RL.

Prev Med. 2014 Jul;64:108-13. doi: 10.1016/j.ypmed.2014.04.011. Epub 2014 Apr 13.


Population- and type-specific clustering of multiple HPV types across diverse risk populations in the Netherlands.

Mollers M, Vriend HJ, van der Sande MA, van Bergen JE, King AJ, Lenselink CH, Bekkers RL, Meijer CJ, de Melker HE, Bogaards JA.

Am J Epidemiol. 2014 May 15;179(10):1236-46. doi: 10.1093/aje/kwu038. Epub 2014 Apr 8.


Identification of patients with persistent trophoblastic disease after complete hydatidiform mole by using a normal 24-hour urine hCG regression curve.

van Cromvoirt SM, Thomas CM, Quinn MA, McNally OM, Bekkers RL.

Gynecol Oncol. 2014 Jun;133(3):542-5. doi: 10.1016/j.ygyno.2014.03.018. Epub 2014 Mar 14.


Triage by methylation-marker testing versus cytology in women who test HPV-positive on self-collected cervicovaginal specimens (PROHTECT-3): a randomised controlled non-inferiority trial.

Verhoef VM, Bosgraaf RP, van Kemenade FJ, Rozendaal L, Heideman DA, Hesselink AT, Bekkers RL, Steenbergen RD, Massuger LF, Melchers WJ, Bulten J, Overbeek LI, Berkhof J, Snijders PJ, Meijer CJ.

Lancet Oncol. 2014 Mar;15(3):315-22. doi: 10.1016/S1470-2045(14)70019-1. Epub 2014 Feb 13.


The current position and the future perspectives of cervical cancer screening.

Bosgraaf RP, Siebers AG, De Hullu JA, Massuger LF, Bulten J, Bekkers RL, Melchers WJ.

Expert Rev Anticancer Ther. 2014 Jan;14(1):75-92. doi: 10.1586/14737140.2014.856273. Epub 2013 Nov 28. Review.


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