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Items: 1 to 50 of 179

1.

Leukocytosis and neutrophilia as independent prognostic immunological biomarkers for clinical outcome in the CAO/ARO/AIO-04 randomized phase 3 rectal cancer trial.

Diefenhardt M, Hofheinz RD, Martin D, Beißbarth T, Arnold D, Hartmann A, von der Grün J, Grützmann R, Liersch T, Ströbel P, Grabenbauer GG, Rieger M, Fietkau R, Graeven U, Weitz J, Folprecht G, Ghadimi M, Rödel F, Rödel C, Fokas E; German Rectal Cancer Study Group.

Int J Cancer. 2019 Mar 14. doi: 10.1002/ijc.32274. [Epub ahead of print]

PMID:
30868576
2.

Lack of an Association between the Functional Polymorphism TREM-1 rs2234237 and the Clinical Course of Sepsis among Critically Ill Caucasian Patients-A Monocentric Prospective Genetic Association Study.

Runzheimer J, Mewes C, Büttner B, Hinz J, Popov AF, Ghadimi M, Kristof K, Beissbarth T, Schamroth J, Tzvetkov M, Schmack B, Quintel M, Bergmann I, Mansur A.

J Clin Med. 2019 Mar 3;8(3). pii: E301. doi: 10.3390/jcm8030301.

3.

CTLA-4 Genetic Variants Predict Survival in Patients with Sepsis.

Mewes C, Büttner B, Hinz J, Alpert A, Popov AF, Ghadimi M, Beissbarth T, Tzvetkov M, Jensen O, Runzheimer J, Quintel M, Shen-Orr S, Bergmann I, Mansur A.

J Clin Med. 2019 Jan 10;8(1). pii: E70. doi: 10.3390/jcm8010070.

4.

Anaemia requiring red blood cell transfusion is associated with unfavourable 90-day survival in surgical patients with sepsis.

Kristof K, Büttner B, Grimm A, Mewes C, Schmack B, Popov AF, Ghadimi M, Beissbarth T, Hinz J, Bergmann I, Mansur A.

BMC Res Notes. 2018 Dec 11;11(1):879. doi: 10.1186/s13104-018-3988-z.

5.

PI3K: A master regulator of brain metastasis-promoting macrophages/microglia.

Blazquez R, Wlochowitz D, Wolff A, Seitz S, Wachter A, Perera-Bel J, Bleckmann A, Beißbarth T, Salinas G, Riemenschneider MJ, Proescholdt M, Evert M, Utpatel K, Siam L, Schatlo B, Balkenhol M, Stadelmann C, Schildhaus HU, Korf U, Reinz E, Wiemann S, Vollmer E, Schulz M, Ritter U, Hanisch UK, Pukrop T.

Glia. 2018 Nov;66(11):2438-2455. doi: 10.1002/glia.23485. Epub 2018 Oct 25.

PMID:
30357946
6.

The CTLA-4 rs231775 GG genotype is associated with favorable 90-day survival in Caucasian patients with sepsis.

Mewes C, Büttner B, Hinz J, Alpert A, Popov AF, Ghadimi M, Beissbarth T, Tzvetkov M, Shen-Orr S, Bergmann I, Mansur A.

Sci Rep. 2018 Oct 11;8(1):15140. doi: 10.1038/s41598-018-33246-9.

7.

FGFR3 mRNA overexpression defines a subset of oligometastatic colorectal cancers with worse prognosis.

Fromme JE, Schmitz K, Wachter A, Grzelinski M, Zielinski D, Koppel C, Conradi LC, Homayounfar K, Hugo T, Hugo S, Lukat L, Rüschoff J, Ströbel P, Ghadimi M, Beißbarth T, Reuter-Jessen K, Bleckmann A, Schildhaus HU.

Oncotarget. 2018 Aug 14;9(63):32204-32218. doi: 10.18632/oncotarget.25941. eCollection 2018 Aug 14.

8.

Using RNA-Seq Data for the Detection of a Panel of Clinically Relevant Mutations.

Wolff A, Perera-Bel J, Schildhaus HU, Homayounfar K, Schatlo B, Bleckmann A, Beißbarth T.

Stud Health Technol Inform. 2018;253:217-221.

PMID:
30147077
9.

Comparative proteomics reveals a diagnostic signature for pulmonary head-and-neck cancer metastasis.

Bohnenberger H, Kaderali L, Ströbel P, Yepes D, Plessmann U, Dharia NV, Yao S, Heydt C, Merkelbach-Bruse S, Emmert A, Hoffmann J, Bodemeyer J, Reuter-Jessen K, Lois AM, Dröge LH, Baumeister P, Walz C, Biggemann L, Walter R, Häupl B, Comoglio F, Pan KT, Scheich S, Lenz C, Küffer S, Bremmer F, Kitz J, Sitte M, Beißbarth T, Hinterthaner M, Sebastian M, Lotz J, Schildhaus HU, Wolff H, Danner BC, Brandts C, Büttner R, Canis M, Stegmaier K, Serve H, Urlaub H, Oellerich T.

EMBO Mol Med. 2018 Sep;10(9). pii: e8428. doi: 10.15252/emmm.201708428.

10.

TGFβ1 regulates HGF-induced cell migration and hepatocyte growth factor receptor MET expression via C-ets-1 and miR-128-3p in basal-like breast cancer.

Breunig C, Erdem N, Bott A, Greiwe JF, Reinz E, Bernhardt S, Giacomelli C, Wachter A, Kanthelhardt EJ, Beißbarth T, Vetter M, Wiemann S.

Mol Oncol. 2018 Sep;12(9):1447-1463. doi: 10.1002/1878-0261.12355. Epub 2018 Jul 30.

11.

Association of Plane of Total Mesorectal Excision With Prognosis of Rectal Cancer: Secondary Analysis of the CAO/ARO/AIO-04 Phase 3 Randomized Clinical Trial.

Kitz J, Fokas E, Beissbarth T, Ströbel P, Wittekind C, Hartmann A, Rüschoff J, Papadopoulos T, Rösler E, Ortloff-Kittredge P, Kania U, Schlitt H, Link KH, Bechstein W, Raab HR, Staib L, Germer CT, Liersch T, Sauer R, Rödel C, Ghadimi M, Hohenberger W; German Rectal Cancer Study Group.

JAMA Surg. 2018 Aug 1;153(8):e181607. doi: 10.1001/jamasurg.2018.1607. Epub 2018 Aug 15.

12.

Long-term prognostic impact of surgical complications in the German Rectal Cancer Trial CAO/ARO/AIO-94.

Sprenger T, Beißbarth T, Sauer R, Tschmelitsch J, Fietkau R, Liersch T, Hohenberger W, Staib L, Gaedcke J, Raab HR, Rödel C, Ghadimi M.

Br J Surg. 2018 Oct;105(11):1510-1518. doi: 10.1002/bjs.10877. Epub 2018 May 30.

PMID:
29846017
13.

Novel Breast Imaging and Machine Learning: Predicting Breast Lesion Malignancy at Cone-Beam CT Using Machine Learning Techniques.

Uhlig J, Uhlig A, Kunze M, Beissbarth T, Fischer U, Lotz J, Wienbeck S.

AJR Am J Roentgenol. 2018 Aug;211(2):W123-W131. doi: 10.2214/AJR.17.19298. Epub 2018 May 24.

PMID:
29792725
14.

A comparative study of RNA-Seq and microarray data analysis on the two examples of rectal-cancer patients and Burkitt Lymphoma cells.

Wolff A, Bayerlová M, Gaedcke J, Kube D, Beißbarth T.

PLoS One. 2018 May 16;13(5):e0197162. doi: 10.1371/journal.pone.0197162. eCollection 2018.

15.

Integrative omics - from data to biology.

Dihazi H, Asif AR, Beißbarth T, Bohrer R, Feussner K, Feussner I, Jahn O, Lenz C, Majcherczyk A, Schmidt B, Schmitt K, Urlaub H, Valerius O.

Expert Rev Proteomics. 2018 Jun;15(6):463-466. doi: 10.1080/14789450.2018.1476143. Epub 2018 May 18.

PMID:
29757692
16.

Acute and Long-Term Hemodynamic Effects of MitraClip Implantation on a Preexisting Secondary Right Heart Failure.

Hünlich M, Lubos E, Beuthner BE, Puls M, Bleckmann A, Beißbarth T, Tichelbäcker T, Rudolph V, Baldus S, Schäfer U, Treede H, Von Bardeleben RS, Blankenberg S, Schillinger W.

Biomed Res Int. 2018 Mar 14;2018:6817832. doi: 10.1155/2018/6817832. eCollection 2018.

17.

Isolated metastasis of an EGFR-L858R-mutated NSCLC of the meninges: the potential impact of CXCL12/CXCR4 axis in EGFRmut NSCLC in diagnosis, follow-up and treatment.

Lüke F, Blazquez R, Yamaci RF, Lu X, Pregler B, Hannus S, Menhart K, Hellwig D, Wester HJ, Kropf S, Heudobler D, Grosse J, Moosbauer J, Hutterer M, Hau P, Riemenschneider MJ, Bayerlová M, Bleckmann A, Polzer B, Beißbarth T, Klein CA, Pukrop T.

Oncotarget. 2018 Apr 10;9(27):18844-18857. doi: 10.18632/oncotarget.24787. eCollection 2018 Apr 10.

18.

From somatic variants towards precision oncology: Evidence-driven reporting of treatment options in molecular tumor boards.

Perera-Bel J, Hutter B, Heining C, Bleckmann A, Fröhlich M, Fröhling S, Glimm H, Brors B, Beißbarth T.

Genome Med. 2018 Mar 15;10(1):18. doi: 10.1186/s13073-018-0529-2.

19.

Whither systems medicine?

Apweiler R, Beissbarth T, Berthold MR, Blüthgen N, Burmeister Y, Dammann O, Deutsch A, Feuerhake F, Franke A, Hasenauer J, Hoffmann S, Höfer T, Jansen PL, Kaderali L, Klingmüller U, Koch I, Kohlbacher O, Kuepfer L, Lammert F, Maier D, Pfeifer N, Radde N, Rehm M, Roeder I, Saez-Rodriguez J, Sax U, Schmeck B, Schuppert A, Seilheimer B, Theis FJ, Vera J, Wolkenhauer O.

Exp Mol Med. 2018 Mar 2;50(3):e453. doi: 10.1038/emm.2017.290. Review.

20.

Differences in the Reponses to Apheresis Therapy of Patients With 3 Histopathologically Classified Immunopathological Patterns of Multiple Sclerosis.

Stork L, Ellenberger D, Beißbarth T, Friede T, Lucchinetti CF, Brück W, Metz I.

JAMA Neurol. 2018 Apr 1;75(4):428-435. doi: 10.1001/jamaneurol.2017.4842.

21.

Effects of repeated long-term psychosocial stress and acute cannabinoid exposure on mouse corticostriatal circuitries: Implications for neuropsychiatric disorders.

Tomas-Roig J, Piscitelli F, Gil V, Quintana E, Ramió-Torrentà LL, Del Río JA, Moore TP, Agbemenyah H, Salinas G, Pommerenke C, Lorenzen S, Beißbarth T, Hoyer-Fender S, Di Marzo V, Havemann-Reinecke U.

CNS Neurosci Ther. 2018 Jun;24(6):528-538. doi: 10.1111/cns.12810. Epub 2018 Jan 31.

22.

Colorectal cancer susceptibility loci as predictive markers of rectal cancer prognosis after surgery.

Hu Y, Gaedcke J, Emons G, Beissbarth T, Grade M, Jo P, Yeager M, Chanock SJ, Wolff H, Camps J, Ghadimi BM, Ried T.

Genes Chromosomes Cancer. 2018 Mar;57(3):140-149. doi: 10.1002/gcc.22512. Epub 2017 Nov 28.

23.

Proteomic profiling of breast cancer metabolism identifies SHMT2 and ASCT2 as prognostic factors.

Bernhardt S, Bayerlová M, Vetter M, Wachter A, Mitra D, Hanf V, Lantzsch T, Uleer C, Peschel S, John J, Buchmann J, Weigert E, Bürrig KF, Thomssen C, Korf U, Beissbarth T, Wiemann S, Kantelhardt EJ.

Breast Cancer Res. 2017 Oct 11;19(1):112. doi: 10.1186/s13058-017-0905-7.

24.

Biomarkers predict outcome in Charcot-Marie-Tooth disease 1A.

Fledrich R, Mannil M, Leha A, Ehbrecht C, Solari A, Pelayo-Negro AL, Berciano J, Schlotter-Weigel B, Schnizer TJ, Prukop T, Garcia-Angarita N, Czesnik D, Haberlová J, Mazanec R, Paulus W, Beissbarth T, Walter MC, Triaal C, Hogrel JY, Dubourg O, Schenone A, Baets J, De Jonghe P, Shy ME, Horvath R, Pareyson D, Seeman P, Young P, Sereda MW.

J Neurol Neurosurg Psychiatry. 2017 Nov;88(11):941-952. doi: 10.1136/jnnp-2017-315721. Epub 2017 Aug 31.

PMID:
28860329
25.

The FER rs4957796 TT genotype is associated with unfavorable 90-day survival in Caucasian patients with severe ARDS due to pneumonia.

Hinz J, Büttner B, Kriesel F, Steinau M, Frederik Popov A, Ghadimi M, Beissbarth T, Tzvetkov M, Bergmann I, Mansur A.

Sci Rep. 2017 Aug 29;7(1):9887. doi: 10.1038/s41598-017-08540-7.

26.

Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling.

Emons G, Spitzner M, Reineke S, Möller J, Auslander N, Kramer F, Hu Y, Beissbarth T, Wolff HA, Rave-Fränk M, Heßmann E, Gaedcke J, Ghadimi BM, Johnsen SA, Ried T, Grade M.

Mol Cancer Res. 2017 Nov;15(11):1481-1490. doi: 10.1158/1541-7786.MCR-17-0205. Epub 2017 Aug 15.

27.

The utilization of multidisciplinary tumor boards (MDT) in clinical routine: results of a health care research study focusing on patients with metastasized colorectal cancer.

Lowes M, Kleiss M, Lueck R, Detken S, Koenig A, Nietert M, Beissbarth T, Stanek K, Langer C, Ghadimi M, Conradi LC, Homayounfar K.

Int J Colorectal Dis. 2017 Oct;32(10):1463-1469. doi: 10.1007/s00384-017-2871-z. Epub 2017 Aug 5.

28.

Ror2 Signaling and Its Relevance in Breast Cancer Progression.

Bayerlová M, Menck K, Klemm F, Wolff A, Pukrop T, Binder C, Beißbarth T, Bleckmann A.

Front Oncol. 2017 Jun 26;7:135. doi: 10.3389/fonc.2017.00135. eCollection 2017.

29.

The Prognostic Value of Tyrosine Kinase SRC Expression in Locally Advanced Rectal Cancer.

Rühlmann F, Nietert M, Sprenger T, Wolff HA, Homayounfar K, Middel P, Bohnenberger H, Beissbarth T, Ghadimi BM, Liersch T, Conradi LC.

J Cancer. 2017 Apr 10;8(7):1229-1237. doi: 10.7150/jca.16980. eCollection 2017.

30.

Changes of Microrna Levels in Plasma of Patients with Rectal Cancer during Chemoradiotherapy.

Jo P, Azizian A, Salendo J, Kramer F, Bernhardt M, Wolff HA, Gruber J, Grade M, Beißbarth T, Ghadimi BM, Gaedcke J.

Int J Mol Sci. 2017 May 27;18(6). pii: E1140. doi: 10.3390/ijms18061140.

31.

The adaptation of colorectal cancer cells when forming metastases in the liver: expression of associated genes and pathways in a mouse model.

Bocuk D, Wolff A, Krause P, Salinas G, Bleckmann A, Hackl C, Beissbarth T, Koenig S.

BMC Cancer. 2017 May 19;17(1):342. doi: 10.1186/s12885-017-3342-1.

32.

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.

Mohr S, Doebele C, Comoglio F, Berg T, Beck J, Bohnenberger H, Alexe G, Corso J, Ströbel P, Wachter A, Beissbarth T, Schnütgen F, Cremer A, Haetscher N, Göllner S, Rouhi A, Palmqvist L, Rieger MA, Schroeder T, Bönig H, Müller-Tidow C, Kuchenbauer F, Schütz E, Green AR, Urlaub H, Stegmaier K, Humphries RK, Serve H, Oellerich T.

Cancer Cell. 2017 Apr 10;31(4):549-562.e11. doi: 10.1016/j.ccell.2017.03.001.

33.

Relevance of surgery in patients with non-variceal upper gastrointestinal bleeding.

Dango S, Beißbarth T, Weiss E, Seif Amir Hosseini A, Raddatz D, Ellenrieder V, Lotz J, Ghadimi BM, Beham A.

Langenbecks Arch Surg. 2017 May;402(3):509-519. doi: 10.1007/s00423-017-1552-2. Epub 2017 Jan 14.

PMID:
28091770
34.

Working with Ontologies.

Kramer F, Beißbarth T.

Methods Mol Biol. 2017;1525:123-135.

PMID:
27896720
35.

Repeated adjuvant anti-CEA radioimmunotherapy after resection of colorectal liver metastases: Safety, feasibility, and long-term efficacy results of a prospective phase 2 study.

Sahlmann CO, Homayounfar K, Niessner M, Dyczkowski J, Conradi LC, Braulke F, Meller B, Beißbarth T, Ghadimi BM, Meller J, Goldenberg DM, Liersch T.

Cancer. 2017 Feb 15;123(4):638-649. doi: 10.1002/cncr.30390. Epub 2016 Oct 20.

36.

Neoadjuvant Therapy in Rectal Cancer - Biobanking of Preoperative Tumor Biopsies.

Jo P, Nietert M, Gusky L, Kitz J, Conradi LC, Müller-Dornieden A, Schüler P, Wolff HA, Rüschoff J, Ströbel P, Grade M, Liersch T, Beißbarth T, Ghadimi MB, Sax U, Gaedcke J.

Sci Rep. 2016 Oct 18;6:35589. doi: 10.1038/srep35589.

37.

A simulation framework for correlated count data of features subsets in high-throughput sequencing or proteomics experiments.

Kruppa J, Kramer F, Beißbarth T, Jung K.

Stat Appl Genet Mol Biol. 2016 Oct 1;15(5):401-414. doi: 10.1515/sagmb-2015-0082.

PMID:
27655448
38.

Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma.

Linke F, Harenberg M, Nietert MM, Zaunig S, von Bonin F, Arlt A, Szczepanowski M, Weich HA, Lutz S, Dullin C, Janovská P, Krafčíková M, Trantírek L, Ovesná P, Klapper W, Beissbarth T, Alves F, Bryja V, Trümper L, Wilting J, Kube D.

Leukemia. 2017 Feb;31(2):361-372. doi: 10.1038/leu.2016.232. Epub 2016 Aug 18.

PMID:
27535218
39.

WNT5A: a motility-promoting factor in Hodgkin lymphoma.

Linke F, Zaunig S, Nietert MM, von Bonin F, Lutz S, Dullin C, Janovská P, Beissbarth T, Alves F, Klapper W, Bryja V, Pukrop T, Trümper L, Wilting J, Kube D.

Oncogene. 2017 Jan 5;36(1):13-23. doi: 10.1038/onc.2016.183. Epub 2016 Jun 6.

PMID:
27270428
40.

[Lymph node metastases in ypT1/2 rectal cancer after neoadjuvant chemoradiotherapy : The Achilles heel of organ-preserving operative procedures?].

Sprenger T, Rothe H, Beissbarth T, Conradi LC, Kauffels A, Homayounfar K, Behnes CL, Rödel C, Liersch T, Ghadimi M.

Chirurg. 2016 Jul;87(7):593-601. doi: 10.1007/s00104-016-0170-9. German.

PMID:
27106241
41.

Prognostic Value of MicroRNAs in Preoperative Treated Rectal Cancer.

Azizian A, Epping I, Kramer F, Jo P, Bernhardt M, Kitz J, Salinas G, Wolff HA, Grade M, Beißbarth T, Ghadimi BM, Gaedcke J.

Int J Mol Sci. 2016 Apr 15;17(4):568. doi: 10.3390/ijms17040568.

42.

Computational Identification of Key Regulators in Two Different Colorectal Cancer Cell Lines.

Wlochowitz D, Haubrock M, Arackal J, Bleckmann A, Wolff A, Beißbarth T, Wingender E, Gültas M.

Front Genet. 2016 Apr 5;7:42. doi: 10.3389/fgene.2016.00042. eCollection 2016.

43.

Stage-Dependent Frequency of Lymph Node Metastases in Patients With Rectal Carcinoma After Preoperative Chemoradiation: Results from the CAO/ARO/AIO-94 Trial and From a Comparative Prospective Evaluation With Extensive Pathological Workup.

Sprenger T, Rothe H, Conradi LC, Beissbarth T, Kauffels A, Kitz J, Homayounfar K, Wolff H, Ströbel P, Ghadimi M, Wittekind C, Sauer R, Rödel C, Liersch T.

Dis Colon Rectum. 2016 May;59(5):377-85. doi: 10.1097/DCR.0000000000000570.

PMID:
27050599
44.

Serum peptide reactivities may distinguish neuromyelitis optica subgroups and multiple sclerosis.

Metz I, Beißbarth T, Ellenberger D, Pache F, Stork L, Ringelstein M, Aktas O, Jarius S, Wildemann B, Dihazi H, Friede T, Brück W, Ruprecht K, Paul F.

Neurol Neuroimmunol Neuroinflamm. 2016 Feb 2;3(2):e204. doi: 10.1212/NXI.0000000000000204. eCollection 2016 Apr.

45.

β-catenin-independent WNT signaling and Ki67 in contrast to the estrogen receptor status are prognostic and associated with poor prognosis in breast cancer liver metastases.

Bleckmann A, Conradi LC, Menck K, Schmick NA, Schubert A, Rietkötter E, Arackal J, Middel P, Schambony A, Liersch T, Homayounfar K, Beißbarth T, Klemm F, Binder C, Pukrop T.

Clin Exp Metastasis. 2016 Apr;33(4):309-23. doi: 10.1007/s10585-016-9780-3. Epub 2016 Feb 9.

46.

Social defeat leads to changes in the endocannabinoid system: An overexpression of calreticulin and motor impairment in mice.

Tomas-Roig J, Piscitelli F, Gil V, Del Río JA, Moore TP, Agbemenyah H, Salinas-Riester G, Pommerenke C, Lorenzen S, Beißbarth T, Hoyer-Fender S, Di Marzo V, Havemann-Reinecke U.

Behav Brain Res. 2016 Apr 15;303:34-43. doi: 10.1016/j.bbr.2016.01.036. Epub 2016 Jan 24.

PMID:
26815100
47.
48.

EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair.

Wu Y, Lee SH, Williamson EA, Reinert BL, Cho JH, Xia F, Jaiswal AS, Srinivasan G, Patel B, Brantley A, Zhou D, Shao L, Pathak R, Hauer-Jensen M, Singh S, Kong K, Wu X, Kim HS, Beissbarth T, Gaedcke J, Burma S, Nickoloff JA, Hromas RA.

PLoS Genet. 2015 Dec 18;11(12):e1005675. doi: 10.1371/journal.pgen.1005675. eCollection 2015 Dec.

49.

Newly Constructed Network Models of Different WNT Signaling Cascades Applied to Breast Cancer Expression Data.

Bayerlová M, Klemm F, Kramer F, Pukrop T, Beißbarth T, Bleckmann A.

PLoS One. 2015 Dec 3;10(12):e0144014. doi: 10.1371/journal.pone.0144014. eCollection 2015.

50.

Perioperative Blood Glucose Levels <150 mg/dL are Associated With Improved 5-Year Survival in Patients Undergoing On-Pump Cardiac Surgery: A Prospective, Observational Cohort Study.

Mansur A, Popov AF, Abu Hanna A, Bergmann I, Brandes IF, Beissbarth T, Bauer M, Hinz J.

Medicine (Baltimore). 2015 Nov;94(45):e2035. doi: 10.1097/MD.0000000000002035. Erratum in: Medicine (Baltimore). 2016 Feb;95(8):e2510. Medicine (Baltimore). 2016 Mar 03;95(8):e2510.

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