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Items: 1 to 50 of 127

1.

JAK2 mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms.

Nageswara Rao T, Hansen N, Hilfiker J, Rai S, Majewska JM, Leković D, Gezer D, Andina N, Galli S, Cassel T, Geier F, Delezie J, Nienhold R, Hao-Shen H, Beisel C, Di Palma S, Dimeloe S, Trebicka J, Wolf D, Gassmann M, Fan TW, Lane AN, Handschin C, Dirnhofer S, Kröger N, Hess C, Radimerski T, Koschmieder S, Čokić VP, Skoda RC.

Blood. 2019 Sep 11. pii: blood.2019000162. doi: 10.1182/blood.2019000162. [Epub ahead of print]

PMID:
31511238
2.

Temporary adhesion of the proseriate flatworm Minona ileanae.

Pjeta R, Wunderer J, Bertemes P, Hofer T, Salvenmoser W, Lengerer B, Coassin S, Erhart G, Beisel C, Sobral D, Kremser L, Lindner H, Curini-Galletti M, Stelzer CP, Hess MW, Ladurner P.

Philos Trans R Soc Lond B Biol Sci. 2019 Oct 28;374(1784):20190194. doi: 10.1098/rstb.2019.0194. Epub 2019 Sep 9.

PMID:
31495318
3.

Modular one-pot assembly of CRISPR arrays enables library generation and reveals factors influencing crRNA biogenesis.

Liao C, Ttofali F, Slotkowski RA, Denny SR, Cecil TD, Leenay RT, Keung AJ, Beisel CL.

Nat Commun. 2019 Jul 3;10(1):2948. doi: 10.1038/s41467-019-10747-3.

4.

Barriers to genome editing with CRISPR in bacteria.

Vento JM, Crook N, Beisel CL.

J Ind Microbiol Biotechnol. 2019 Jun 5. doi: 10.1007/s10295-019-02195-1. [Epub ahead of print]

PMID:
31165970
5.

An enhanced assay to characterize anti-CRISPR proteins using a cell-free transcription-translation system.

Wandera KG, Collins SP, Wimmer F, Marshall R, Noireaux V, Beisel CL.

Methods. 2019 May 21. pii: S1046-2023(19)30001-5. doi: 10.1016/j.ymeth.2019.05.014. [Epub ahead of print]

PMID:
31121300
6.

The Acidaminococcus sp. Cas12a nuclease recognizes GTTV and GCTV as non-canonical PAMs.

Jacobsen T, Liao C, Beisel CL.

FEMS Microbiol Lett. 2019 Apr 1;366(8). pii: fnz085. doi: 10.1093/femsle/fnz085.

PMID:
31004485
7.

Reference set of Mycobacterium tuberculosis clinical strains: A tool for research and product development.

Borrell S, Trauner A, Brites D, Rigouts L, Loiseau C, Coscolla M, Niemann S, De Jong B, Yeboah-Manu D, Kato-Maeda M, Feldmann J, Reinhard M, Beisel C, Gagneux S.

PLoS One. 2019 Mar 25;14(3):e0214088. doi: 10.1371/journal.pone.0214088. eCollection 2019.

8.

Characterization of the all-E. coli transcription-translation system myTXTL by mass spectrometry.

Garenne D, Beisel CL, Noireaux V.

Rapid Commun Mass Spectrom. 2019 May 15;33(11):1036-1048. doi: 10.1002/rcm.8438.

PMID:
30900355
9.

Neutrophils escort circulating tumour cells to enable cell cycle progression.

Szczerba BM, Castro-Giner F, Vetter M, Krol I, Gkountela S, Landin J, Scheidmann MC, Donato C, Scherrer R, Singer J, Beisel C, Kurzeder C, Heinzelmann-Schwarz V, Rochlitz C, Weber WP, Beerenwinkel N, Aceto N.

Nature. 2019 Feb;566(7745):553-557. doi: 10.1038/s41586-019-0915-y. Epub 2019 Feb 6.

PMID:
30728496
10.

Expression and Mutation Patterns of PBRM1, BAP1 and SETD2 Mirror Specific Evolutionary Subtypes in Clear Cell Renal Cell Carcinoma.

Bihr S, Ohashi R, Moore AL, Rüschoff JH, Beisel C, Hermanns T, Mischo A, Corrò C, Beyer J, Beerenwinkel N, Moch H, Schraml P.

Neoplasia. 2019 Feb;21(2):247-256. doi: 10.1016/j.neo.2018.12.006. Epub 2019 Jan 16.

11.

Distinct timescales of RNA regulators enable the construction of a genetic pulse generator.

Westbrook A, Tang X, Marshall R, Maxwell CS, Chappell J, Agrawal DK, Dunlop MJ, Noireaux V, Beisel CL, Lucks J, Franco E.

Biotechnol Bioeng. 2019 May;116(5):1139-1151. doi: 10.1002/bit.26918. Epub 2019 Feb 4.

PMID:
30636320
12.

Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding.

Gkountela S, Castro-Giner F, Szczerba BM, Vetter M, Landin J, Scherrer R, Krol I, Scheidmann MC, Beisel C, Stirnimann CU, Kurzeder C, Heinzelmann-Schwarz V, Rochlitz C, Weber WP, Aceto N.

Cell. 2019 Jan 10;176(1-2):98-112.e14. doi: 10.1016/j.cell.2018.11.046.

13.

A New Phylogenetic Framework for the Animal-Adapted Mycobacterium tuberculosis Complex.

Brites D, Loiseau C, Menardo F, Borrell S, Boniotti MB, Warren R, Dippenaar A, Parsons SDC, Beisel C, Behr MA, Fyfe JA, Coscolla M, Gagneux S.

Front Microbiol. 2018 Nov 27;9:2820. doi: 10.3389/fmicb.2018.02820. eCollection 2018.

14.

SwissMTB: establishing comprehensive molecular cancer diagnostics in Swiss clinics.

Singer F, Irmisch A, Toussaint NC, Grob L, Singer J, Thurnherr T, Beerenwinkel N, Levesque MP, Dummer R, Quagliata L, Rothschild SI, Wicki A, Beisel C, Stekhoven DJ.

BMC Med Inform Decis Mak. 2018 Oct 29;18(1):89. doi: 10.1186/s12911-018-0680-0.

15.

CRISPR tool puts RNA on the record.

Beisel CL.

Nature. 2018 Oct;562(7727):347-349. doi: 10.1038/d41586-018-06869-1. No abstract available.

PMID:
30323226
16.

The Francisella novicida Cas12a is sensitive to the structure downstream of the terminal repeat in CRISPR arrays.

Liao C, Slotkowski RA, Achmedov T, Beisel CL.

RNA Biol. 2019 Apr;16(4):404-412. doi: 10.1080/15476286.2018.1526537. Epub 2018 Oct 12.

PMID:
30252595
17.

Advances in CRISPR Technologies for Microbial Strain Engineering.

Alper HS, Beisel CL.

Biotechnol J. 2018 Sep;13(9):e1800460. doi: 10.1002/biot.201800460. No abstract available.

PMID:
30175907
18.

Genome Editing with CRISPR-Cas9 in Lactobacillus plantarum Revealed That Editing Outcomes Can Vary Across Strains and Between Methods.

Leenay RT, Vento JM, Shah M, Martino ME, Leulier F, Beisel CL.

Biotechnol J. 2019 Mar;14(3):e1700583. doi: 10.1002/biot.201700583. Epub 2018 Sep 20.

PMID:
30156038
19.

Single-cell mRNA profiling reveals the hierarchical response of miRNA targets to miRNA induction.

Rzepiela AJ, Ghosh S, Breda J, Vina-Vilaseca A, Syed AP, Gruber AJ, Eschbach K, Beisel C, van Nimwegen E, Zavolan M.

Mol Syst Biol. 2018 Aug 27;14(8):e8266. doi: 10.15252/msb.20188266.

20.

Comparative genomics of Mycobacterium africanum Lineage 5 and Lineage 6 from Ghana suggests distinct ecological niches.

Otchere ID, Coscollá M, Sánchez-Busó L, Asante-Poku A, Brites D, Loiseau C, Meehan C, Osei-Wusu S, Forson A, Laryea C, Yahayah AI, Baddoo A, Ansa GA, Aboagye SY, Asare P, Borrell S, Gehre F, Beckert P, Kohl TA, N'dira S, Beisel C, Antonio M, Niemann S, de Jong BC, Parkhill J, Harris SR, Gagneux S, Yeboah-Manu D.

Sci Rep. 2018 Jul 26;8(1):11269. doi: 10.1038/s41598-018-29620-2.

21.

Bacterial Adaptation to the Host's Diet Is a Key Evolutionary Force Shaping Drosophila-Lactobacillus Symbiosis.

Martino ME, Joncour P, Leenay R, Gervais H, Shah M, Hughes S, Gillet B, Beisel C, Leulier F.

Cell Host Microbe. 2018 Jul 11;24(1):109-119.e6. doi: 10.1016/j.chom.2018.06.001. Epub 2018 Jun 28.

22.

Treemmer: a tool to reduce large phylogenetic datasets with minimal loss of diversity.

Menardo F, Loiseau C, Brites D, Coscolla M, Gygli SM, Rutaihwa LK, Trauner A, Beisel C, Borrell S, Gagneux S.

BMC Bioinformatics. 2018 May 2;19(1):164. doi: 10.1186/s12859-018-2164-8.

23.

Mathematical Modeling of RNA-Based Architectures for Closed Loop Control of Gene Expression.

Agrawal DK, Tang X, Westbrook A, Marshall R, Maxwell CS, Lucks J, Noireaux V, Beisel CL, Dunlop MJ, Franco E.

ACS Synth Biol. 2018 May 18;7(5):1219-1228. doi: 10.1021/acssynbio.8b00040. Epub 2018 May 8.

PMID:
29709170
24.

A switch in transcription and cell fate governs the onset of an epigenetically-deregulated tumor in Drosophila.

Torres J, Monti R, Moore AL, Seimiya M, Jiang Y, Beerenwinkel N, Beisel C, Beira JV, Paro R.

Elife. 2018 Mar 21;7. pii: e32697. doi: 10.7554/eLife.32697.

25.

Synthetic Biology Approaches to Engineer Probiotics and Members of the Human Microbiota for Biomedical Applications.

Bober JR, Beisel CL, Nair NU.

Annu Rev Biomed Eng. 2018 Jun 4;20:277-300. doi: 10.1146/annurev-bioeng-062117-121019. Epub 2018 Mar 12. Review.

26.

CRISPR RNA-Dependent Binding and Cleavage of Endogenous RNAs by the Campylobacter jejuni Cas9.

Dugar G, Leenay RT, Eisenbart SK, Bischler T, Aul BU, Beisel CL, Sharma CM.

Mol Cell. 2018 Mar 1;69(5):893-905.e7. doi: 10.1016/j.molcel.2018.01.032.

27.

A detailed cell-free transcription-translation-based assay to decipher CRISPR protospacer-adjacent motifs.

Maxwell CS, Jacobsen T, Marshall R, Noireaux V, Beisel CL.

Methods. 2018 Jul 1;143:48-57. doi: 10.1016/j.ymeth.2018.02.016. Epub 2018 Feb 24.

28.

Rapid and Scalable Characterization of CRISPR Technologies Using an E. coli Cell-Free Transcription-Translation System.

Marshall R, Maxwell CS, Collins SP, Jacobsen T, Luo ML, Begemann MB, Gray BN, January E, Singer A, He Y, Beisel CL, Noireaux V.

Mol Cell. 2018 Jan 4;69(1):146-157.e3. doi: 10.1016/j.molcel.2017.12.007.

29.

TGF-β induces oncofetal fibronectin that, in turn, modulates TGF-β superfamily signaling in endothelial cells.

Ventura E, Weller M, Macnair W, Eschbach K, Beisel C, Cordazzo C, Claassen M, Zardi L, Burghardt I.

J Cell Sci. 2018 Jan 9;131(1). pii: jcs209619. doi: 10.1242/jcs.209619.

30.

Single-cell RNA sequencing reveals developmental heterogeneity among early lymphoid progenitors.

Alberti-Servera L, von Muenchow L, Tsapogas P, Capoferri G, Eschbach K, Beisel C, Ceredig R, Ivanek R, Rolink A.

EMBO J. 2017 Dec 15;36(24):3619-3633. doi: 10.15252/embj.201797105. Epub 2017 Oct 13.

31.

NGS-pipe: a flexible, easily extendable and highly configurable framework for NGS analysis.

Singer J, Ruscheweyh HJ, Hofmann AL, Thurnherr T, Singer F, Toussaint NC, Ng CKY, Piscuoglio S, Beisel C, Christofori G, Dummer R, Hall MN, Krek W, Levesque MP, Manz MG, Moch H, Papassotiropoulos A, Stekhoven DJ, Wild P, Wüst T, Rinn B, Beerenwinkel N.

Bioinformatics. 2018 Jan 1;34(1):107-108. doi: 10.1093/bioinformatics/btx540.

32.

Organ specific gene expression in the regenerating tail of Macrostomum lignano.

Lengerer B, Wunderer J, Pjeta R, Carta G, Kao D, Aboobaker A, Beisel C, Berezikov E, Salvenmoser W, Ladurner P.

Dev Biol. 2018 Jan 15;433(2):448-460. doi: 10.1016/j.ydbio.2017.07.021. Epub 2017 Jul 28.

33.

Toward a genetic tool development pipeline for host-associated bacteria.

Waller MC, Bober JR, Nair NU, Beisel CL.

Curr Opin Microbiol. 2017 Aug;38:156-164. doi: 10.1016/j.mib.2017.05.006. Epub 2017 Jun 15. Review.

34.

An Immune Atlas of Clear Cell Renal Cell Carcinoma.

Chevrier S, Levine JH, Zanotelli VRT, Silina K, Schulz D, Bacac M, Ries CH, Ailles L, Jewett MAS, Moch H, van den Broek M, Beisel C, Stadler MB, Gedye C, Reis B, Pe'er D, Bodenmiller B.

Cell. 2017 May 4;169(4):736-749.e18. doi: 10.1016/j.cell.2017.04.016.

35.

Short DNA containing χ sites enhances DNA stability and gene expression in E. coli cell-free transcription-translation systems.

Marshall R, Maxwell CS, Collins SP, Beisel CL, Noireaux V.

Biotechnol Bioeng. 2017 Sep;114(9):2137-2141. doi: 10.1002/bit.26333. Epub 2017 May 23.

36.

TLR7-mediated activation of XBP1 correlates with the IFNα production in humans.

Beisel C, Ziegler S, Martrus Zapater G, Chapel A, Griesbeck M, Hildebrandt H, Lohse AW, Altfeld M.

Cytokine. 2017 Jun;94:55-58. doi: 10.1016/j.cyto.2017.04.006. Epub 2017 Apr 10.

PMID:
28408069
37.

Heterogeneous treatment effects in stratified clinical trials with time-to-event endpoints.

Beisel C, Benner A, Kunz C, Kopp-Schneider A.

Biom J. 2017 May;59(3):511-530. doi: 10.1002/bimj.201600047. Epub 2017 Mar 6.

PMID:
28263395
38.

Down-regulation of CD73 on B cells of patients with viremic HIV correlates with B cell activation and disease progression.

Kim ES, Ackermann C, Tóth I, Dierks P, Eberhard JM, Wroblewski R, Scherg F, Geyer M, Schmidt RE, Beisel C, Bockhorn M, Haag F, van Lunzen J, Schulze Zur Wiesch J.

J Leukoc Biol. 2017 May;101(5):1263-1271. doi: 10.1189/jlb.5A0816-346R. Epub 2017 Feb 13.

PMID:
28193736
39.

Detailed simulation of cancer exome sequencing data reveals differences and common limitations of variant callers.

Hofmann AL, Behr J, Singer J, Kuipers J, Beisel C, Schraml P, Moch H, Beerenwinkel N.

BMC Bioinformatics. 2017 Jan 3;18(1):8. doi: 10.1186/s12859-016-1417-7.

40.

Deciphering, Communicating, and Engineering the CRISPR PAM.

Leenay RT, Beisel CL.

J Mol Biol. 2017 Jan 20;429(2):177-191. doi: 10.1016/j.jmb.2016.11.024. Epub 2016 Dec 1. Review.

41.

Human pDCs display sex-specific differences in type I interferon subtypes and interferon α/β receptor expression.

Ziegler SM, Beisel C, Sutter K, Griesbeck M, Hildebrandt H, Hagen SH, Dittmer U, Altfeld M.

Eur J Immunol. 2017 Feb;47(2):251-256. doi: 10.1002/eji.201646725. Epub 2017 Jan 3.

42.

A High-Density Map for Navigating the Human Polycomb Complexome.

Hauri S, Comoglio F, Seimiya M, Gerstung M, Glatter T, Hansen K, Aebersold R, Paro R, Gstaiger M, Beisel C.

Cell Rep. 2016 Oct 4;17(2):583-595. doi: 10.1016/j.celrep.2016.08.096.

43.

Profiling of adhesive-related genes in the freshwater cnidarian Hydra magnipapillata by transcriptomics and proteomics.

Rodrigues M, Ostermann T, Kremeser L, Lindner H, Beisel C, Berezikov E, Hobmayer B, Ladurner P.

Biofouling. 2016 Oct;32(9):1115-1129.

44.

The CRISPR RNA-guided surveillance complex in Escherichia coli accommodates extended RNA spacers.

Luo ML, Jackson RN, Denny SR, Tokmina-Lukaszewska M, Maksimchuk KR, Lin W, Bothner B, Wiedenheft B, Beisel CL.

Nucleic Acids Res. 2016 Sep 6;44(15):7385-94. doi: 10.1093/nar/gkw421. Epub 2016 May 12.

45.

Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems.

Leenay RT, Maksimchuk KR, Slotkowski RA, Agrawal RN, Gomaa AA, Briner AE, Barrangou R, Beisel CL.

Mol Cell. 2016 Apr 7;62(1):137-47. doi: 10.1016/j.molcel.2016.02.031. Epub 2016 Mar 31.

46.

Infections complicating severe alcoholic hepatitis: Enterococcus species represent the most frequently identified pathogen.

Beisel C, Blessin U, Schulze Zur Wiesch J, Wehmeyer MH, Lohse AW, Benten D, Kluwe J.

Scand J Gastroenterol. 2016 Jul;51(7):807-13. doi: 10.3109/00365521.2016.1157887. Epub 2016 Mar 22.

PMID:
27000534
47.

Rethinking the Hierarchy of Sugar Utilization in Bacteria.

Beisel CL, Afroz T.

J Bacteriol. 2015 Nov 16;198(3):374-6. doi: 10.1128/JB.00890-15. Print 2016 Feb 1.

48.

Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women.

Griesbeck M, Ziegler S, Laffont S, Smith N, Chauveau L, Tomezsko P, Sharei A, Kourjian G, Porichis F, Hart M, Palmer CD, Sirignano M, Beisel C, Hildebrandt H, Cénac C, Villani AC, Diefenbach TJ, Le Gall S, Schwartz O, Herbeuval JP, Autran B, Guéry JC, Chang JJ, Altfeld M.

J Immunol. 2015 Dec 1;195(11):5327-36. doi: 10.4049/jimmunol.1501684. Epub 2015 Oct 30.

49.

Current and future prospects for CRISPR-based tools in bacteria.

Luo ML, Leenay RT, Beisel CL.

Biotechnol Bioeng. 2016 May;113(5):930-43. doi: 10.1002/bit.25851. Epub 2015 Oct 27. Review.

50.

[Sex differences in infectious diseases and their clinical consequences].

Beisel C, van Lunzen J, Lohse AW, Addo MM, Altfeld M.

Dtsch Med Wochenschr. 2015 Sep;140(18):1385-90. doi: 10.1055/s-0041-104246. Epub 2015 Sep 11. Review. German.

PMID:
26360954

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