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Items: 1 to 50 of 65

1.

Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset.

Hülsdünker J, Ottmüller KJ, Neeff HP, Koyama M, Gao Z, Thomas OS, Follo M, Al-Ahmad A, Prinz G, Duquesne S, Dierbach H, Kirschnek S, Lämmermann T, Blaser MJ, Fife BT, Blazar BR, Beilhack A, Hill GR, Häcker G, Zeiser R.

Blood. 2018 Apr 19;131(16):1858-1869. doi: 10.1182/blood-2017-10-812891. Epub 2018 Feb 20.

PMID:
29463561
2.

BATF-dependent IL-7RhiGM-CSF+ T cells control intestinal graft-versus-host disease.

Ullrich E, Abendroth B, Rothamer J, Huber C, Büttner-Herold M, Buchele V, Vogler T, Longerich T, Zundler S, Völkl S, Beilhack A, Rose-John S, Wirtz S, Weber GF, Ghimire S, Kreutz M, Holler E, Mackensen A, Neurath MF, Hildner K.

J Clin Invest. 2018 Mar 1;128(3):916-930. doi: 10.1172/JCI89242. Epub 2018 Jan 29.

3.

Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration.

Wertheimer T, Velardi E, Tsai J, Cooper K, Xiao S, Kloss CC, Ottmüller KJ, Mokhtari Z, Brede C, deRoos P, Kinsella S, Palikuqi B, Ginsberg M, Young LF, Kreines F, Lieberman SR, Lazrak A, Guo P, Malard F, Smith OM, Shono Y, Jenq RR, Hanash AM, Nolan DJ, Butler JM, Beilhack A, Manley NR, Rafii S, Dudakov JA, van den Brink MRM.

Sci Immunol. 2018 Jan 12;3(19). pii: eaal2736. doi: 10.1126/sciimmunol.aal2736.

4.

Novel GM-CSF signals via IFN-γR/IRF-1 and AKT/mTOR license monocytes for suppressor function.

Ribechini E, Hutchinson JA, Hergovits S, Heuer M, Lucas J, Schleicher U, Jordán Garrote AL, Potter SJ, Riquelme P, Brackmann H, Müller N, Raifer H, Berberich I, Huber M, Beilhack A, Lohoff M, Bogdan C, Eyrich M, Hermanns HM, Geissler EK, Lutz MB.

Blood Adv. 2017 Jun 7;1(14):947-960. doi: 10.1182/bloodadvances.2017006858. eCollection 2017 Jun 13.

5.

Inhibition of focal adhesion kinase overcomes resistance of mantle cell lymphoma to ibrutinib in the bone marrow microenvironment.

Rudelius M, Rosenfeldt MT, Leich E, Rauert-Wunderlich H, Solimando AG, Beilhack A, Ott G, Rosenwald A.

Haematologica. 2018 Jan;103(1):116-125. doi: 10.3324/haematol.2017.177162. Epub 2017 Oct 27.

6.

JAM-A as a prognostic factor and new therapeutic target in multiple myeloma.

Solimando AG, Brandl A, Mattenheimer K, Graf C, Ritz M, Ruckdeschel A, Stühmer T, Mokhtari Z, Rudelius M, Dotterweich J, Bittrich M, Desantis V, Ebert R, Trerotoli P, Frassanito MA, Rosenwald A, Vacca A, Einsele H, Jakob F, Beilhack A.

Leukemia. 2018 Mar;32(3):736-743. doi: 10.1038/leu.2017.287. Epub 2017 Sep 28.

7.

NFATc1 controls the cytotoxicity of CD8+ T cells.

Klein-Hessling S, Muhammad K, Klein M, Pusch T, Rudolf R, Flöter J, Qureischi M, Beilhack A, Vaeth M, Kummerow C, Backes C, Schoppmeyer R, Hahn U, Hoth M, Bopp T, Berberich-Siebelt F, Patra A, Avots A, Müller N, Schulze A, Serfling E.

Nat Commun. 2017 Sep 11;8(1):511. doi: 10.1038/s41467-017-00612-6.

8.

Developmental adaptations of trypanosome motility to the tsetse fly host environments unravel a multifaceted in vivo microswimmer system.

Schuster S, Krüger T, Subota I, Thusek S, Rotureau B, Beilhack A, Engstler M.

Elife. 2017 Aug 15;6. pii: e27656. doi: 10.7554/eLife.27656.

9.

Thrombopoiesis is spatially regulated by the bone marrow vasculature.

Stegner D, vanEeuwijk JMM, Angay O, Gorelashvili MG, Semeniak D, Pinnecker J, Schmithausen P, Meyer I, Friedrich M, Dütting S, Brede C, Beilhack A, Schulze H, Nieswandt B, Heinze KG.

Nat Commun. 2017 Jul 25;8(1):127. doi: 10.1038/s41467-017-00201-7.

10.

Targeting of the WT191-138 fragment to human dendritic cells improves leukemia-specific T-cell responses providing an alternative approach to WT1-based vaccination.

Dagvadorj N, Deuretzbacher A, Weisenberger D, Baumeister E, Trebing J, Lang I, Köchel C, Kapp M, Kapp K, Beilhack A, Hünig T, Einsele H, Wajant H, Grigoleit GU.

Cancer Immunol Immunother. 2017 Mar;66(3):319-332. doi: 10.1007/s00262-016-1938-y. Epub 2016 Nov 28.

PMID:
27896368
11.

Pan-Raf co-operates with PI3K-dependent signalling and critically contributes to myeloma cell survival independently of mutated RAS.

Müller E, Bauer S, Stühmer T, Mottok A, Scholz CJ, Steinbrunn T, Brünnert D, Brandl A, Schraud H, Kreßmann S, Beilhack A, Rosenwald A, Bargou RC, Chatterjee M.

Leukemia. 2017 Apr;31(4):922-933. doi: 10.1038/leu.2016.264. Epub 2016 Sep 30.

PMID:
27686868
12.

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion.

Chopra M, Biehl M, Steinfatt T, Brandl A, Kums J, Amich J, Vaeth M, Kuen J, Holtappels R, Podlech J, Mottok A, Kraus S, Jordán-Garrote AL, Bäuerlein CA, Brede C, Ribechini E, Fick A, Seher A, Polz J, Ottmüller KJ, Baker J, Nishikii H, Ritz M, Mattenheimer K, Schwinn S, Winter T, Schäfer V, Krappmann S, Einsele H, Müller TD, Reddehase MJ, Lutz MB, Männel DN, Berberich-Siebelt F, Wajant H, Beilhack A.

J Exp Med. 2016 Aug 22;213(9):1881-900. doi: 10.1084/jem.20151563. Epub 2016 Aug 15.

13.

Dynamic Immune Cell Recruitment After Murine Pulmonary Aspergillus fumigatus Infection under Different Immunosuppressive Regimens.

Kalleda N, Amich J, Arslan B, Poreddy S, Mattenheimer K, Mokhtari Z, Einsele H, Brock M, Heinze KG, Beilhack A.

Front Microbiol. 2016 Jul 13;7:1107. doi: 10.3389/fmicb.2016.01107. eCollection 2016.

14.

The KISS1 Receptor as an In Vivo Microenvironment Imaging Biomarker of Multiple Myeloma Bone Disease.

Dotterweich J, Tower RJ, Brandl A, Müller M, Hofbauer LC, Beilhack A, Ebert R, Glüer CC, Tiwari S, Schütze N, Jakob F.

PLoS One. 2016 May 9;11(5):e0155087. doi: 10.1371/journal.pone.0155087. eCollection 2016.

15.

MB3W1 is an orthotopic xenograft model for anaplastic medulloblastoma displaying cancer stem cell- and Group 3-properties.

Dietl S, Schwinn S, Dietl S, Riedel S, Deinlein F, Rutkowski S, von Bueren AO, Krauss J, Schweitzer T, Vince GH, Picard D, Eyrich M, Rosenwald A, Ramaswamy V, Taylor MD, Remke M, Monoranu CM, Beilhack A, Schlegel PG, Wölfl M.

BMC Cancer. 2016 Feb 17;16:115. doi: 10.1186/s12885-016-2170-z.

16.

Histidine biosynthesis plays a crucial role in metal homeostasis and virulence of Aspergillus fumigatus.

Dietl AM, Amich J, Leal S, Beckmann N, Binder U, Beilhack A, Pearlman E, Haas H.

Virulence. 2016 May 18;7(4):465-76. doi: 10.1080/21505594.2016.1146848. Epub 2016 Feb 6.

17.

Exploration of Sulfur Assimilation of Aspergillus fumigatus Reveals Biosynthesis of Sulfur-Containing Amino Acids as a Virulence Determinant.

Amich J, Dümig M, O'Keeffe G, Binder J, Doyle S, Beilhack A, Krappmann S.

Infect Immun. 2016 Mar 24;84(4):917-929. doi: 10.1128/IAI.01124-15. Print 2016 Apr.

18.

Chronophin is a glial tumor modifier involved in the regulation of glioblastoma growth and invasiveness.

Schulze M, Fedorchenko O, Zink TG, Knobbe-Thomsen CB, Kraus S, Schwinn S, Beilhack A, Reifenberger G, Monoranu CM, Sirén AL, Jeanclos E, Gohla A.

Oncogene. 2016 Jun 16;35(24):3163-77. doi: 10.1038/onc.2015.376. Epub 2015 Nov 9.

PMID:
26549022
19.

Interleukin-2 critically regulates bone marrow erythropoiesis and prevents anemia development.

Chopra M, Langenhorst D, Beilhack A, Serfling E, Patra AK.

Eur J Immunol. 2015 Dec;45(12):3362-74. doi: 10.1002/eji.201545596. Epub 2015 Oct 15.

20.

Patient-individualized CD8⁺ cytolytic T-cell therapy effectively combats minimal residual leukemia in immunodeficient mice.

Distler E, Albrecht J, Brunk A, Khan S, Schnürer E, Frey M, Mottok A, Jordán-Garrote AL, Brede C, Beilhack A, Mades A, Tomsitz D, Theobald M, Herr W, Hartwig UF.

Int J Cancer. 2016 Mar 1;138(5):1256-68. doi: 10.1002/ijc.29854. Epub 2015 Oct 5.

21.

Treatment with agonistic DR3 antibody results in expansion of donor Tregs and reduced graft-versus-host disease.

Kim BS, Nishikii H, Baker J, Pierini A, Schneidawind D, Pan Y, Beilhack A, Park CG, Negrin RS.

Blood. 2015 Jul 23;126(4):546-57. doi: 10.1182/blood-2015-04-637587. Epub 2015 Jun 10.

22.

Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation-induced intestinal cell death and reduces GVHD.

Chopra M, Brandl A, Siegmund D, Mottok A, Schäfer V, Biehl M, Kraus S, Bäuerlein CA, Ritz M, Mattenheimer K, Schwinn S, Seher A, Grabinger T, Einsele H, Rosenwald A, Brunner T, Beilhack A, Wajant H.

Blood. 2015 Jul 23;126(4):437-44. doi: 10.1182/blood-2015-01-620583. Epub 2015 May 26.

23.

Identification and characterization of the specific murine NK cell subset supporting graft-versus-leukemia- and reducing graft-versus-host-effects.

Meinhardt K, Kroeger I, Bauer R, Ganss F, Ovsiy I, Rothamer J, Büttner M, Atreya I, Waldner M, Bittrich M, Lehmann CH, Rieger MA, Beilhack A, Zeiser R, Edinger M, Dudziak D, Mackensen A, Rehli M, Ullrich E.

Oncoimmunology. 2015 Feb 3;4(1):e981483. eCollection 2015 Jan.

24.

Pathogenic fungi regulate immunity by inducing neutrophilic myeloid-derived suppressor cells.

Rieber N, Singh A, Öz H, Carevic M, Bouzani M, Amich J, Ost M, Ye Z, Ballbach M, Schäfer I, Mezger M, Klimosch SN, Weber AN, Handgretinger R, Krappmann S, Liese J, Engeholm M, Schüle R, Salih HR, Marodi L, Speckmann C, Grimbacher B, Ruland J, Brown GD, Beilhack A, Loeffler J, Hartl D.

Cell Host Microbe. 2015 Apr 8;17(4):507-14. doi: 10.1016/j.chom.2015.02.007. Epub 2015 Mar 12.

25.

Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo.

Ulges A, Klein M, Reuter S, Gerlitzki B, Hoffmann M, Grebe N, Staudt V, Stergiou N, Bohn T, Brühl TJ, Muth S, Yurugi H, Rajalingam K, Bellinghausen I, Tuettenberg A, Hahn S, Reißig S, Haben I, Zipp F, Waisman A, Probst HC, Beilhack A, Buchou T, Filhol-Cochet O, Boldyreff B, Breloer M, Jonuleit H, Schild H, Schmitt E, Bopp T.

Nat Immunol. 2015 Mar;16(3):267-75. doi: 10.1038/ni.3083. Epub 2015 Jan 19.

PMID:
25599562
26.

Selective NFAT targeting in T cells ameliorates GvHD while maintaining antitumor activity.

Vaeth M, Bäuerlein CA, Pusch T, Findeis J, Chopra M, Mottok A, Rosenwald A, Beilhack A, Berberich-Siebelt F.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1125-30. doi: 10.1073/pnas.1409290112. Epub 2015 Jan 12.

27.

European Myeloma Network recommendations on the evaluation and treatment of newly diagnosed patients with multiple myeloma.

Engelhardt M, Terpos E, Kleber M, Gay F, Wäsch R, Morgan G, Cavo M, van de Donk N, Beilhack A, Bruno B, Johnsen HE, Hajek R, Driessen C, Ludwig H, Beksac M, Boccadoro M, Straka C, Brighen S, Gramatzki M, Larocca A, Lokhorst H, Magarotto V, Morabito F, Dimopoulos MA, Einsele H, Sonneveld P, Palumbo A; European Myeloma Network.

Haematologica. 2014 Feb;99(2):232-42. doi: 10.3324/haematol.2013.099358.

28.

Non-invasive bioluminescence imaging to monitor the immunological control of a plasmablastic lymphoma-like B cell neoplasia after hematopoietic cell transplantation.

Chopra M, Kraus S, Schwinn S, Ritz M, Mattenheimer K, Mottok A, Rosenwald A, Einsele H, Beilhack A.

PLoS One. 2013 Dec 12;8(12):e81320. doi: 10.1371/journal.pone.0081320. eCollection 2013.

29.

A novel llama antibody targeting Fn14 exhibits anti-metastatic activity in vivo.

Trebing J, Lang I, Chopra M, Salzmann S, Moshir M, Silence K, Riedel SS, Siegmund D, Beilhack A, Otto C, Wajant H.

MAbs. 2014 Jan-Feb;6(1):297-308.

30.

Tumor necrosis factor induces tumor promoting and anti-tumoral effects on pancreatic cancer via TNFR1.

Chopra M, Lang I, Salzmann S, Pachel C, Kraus S, Bäuerlein CA, Brede C, Garrote AL, Mattenheimer K, Ritz M, Schwinn S, Graf C, Schäfer V, Frantz S, Einsele H, Wajant H, Beilhack A.

PLoS One. 2013 Sep 30;8(9):e75737. doi: 10.1371/journal.pone.0075737. eCollection 2013.

31.

Noninvasive visualization of tumor growth in a human colorectal liver metastases xenograft model using bioluminescence in vivo imaging.

Thalheimer A, Korb D, Bönicke L, Wiegering A, Mühling B, Schneider M, Koch S, Riedel SS, Germer CT, Beilhack A, Brändlein S, Otto C.

J Surg Res. 2013 Nov;185(1):143-51. doi: 10.1016/j.jss.2013.03.024. Epub 2013 Mar 30.

PMID:
23998649
32.

Generation of highly effective and stable murine alloreactive Treg cells by combined anti-CD4 mAb, TGF-β, and RA treatment.

Schliesser U, Chopra M, Beilhack A, Appelt C, Vogel S, Schumann J, Panov I, Vogt K, Schlickeiser S, Olek S, Wood K, Brandt C, Volk HD, Sawitzki B.

Eur J Immunol. 2013 Dec;43(12):3291-305. doi: 10.1002/eji.201243292. Epub 2013 Sep 9.

33.

Src-kinase inhibitors sensitize human cells of myeloid origin to Toll-like-receptor-induced interleukin 12 synthesis.

Wölfl M, Schwinn S, Yoo YE, Reß ML, Braun M, Chopra M, Schreiber SC, Ayala VI, Ohlen C, Eyrich M, Beilhack A, Schlegel PG.

Blood. 2013 Aug 15;122(7):1203-13. doi: 10.1182/blood-2013-03-488072. Epub 2013 Jul 8.

34.

A diagnostic window for the treatment of acute graft-versus-host disease prior to visible clinical symptoms in a murine model.

Bäuerlein CA, Riedel SS, Baker J, Brede C, Garrote AL, Chopra M, Ritz M, Beilhack GF, Schulz S, Zeiser R, Schlegel PG, Einsele H, Negrin RS, Beilhack A.

BMC Med. 2013 May 21;11:134. doi: 10.1186/1741-7015-11-134.

35.

Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis.

Chopra M, Riedel SS, Biehl M, Krieger S, von Krosigk V, Bäuerlein CA, Brede C, Jordan Garrote AL, Kraus S, Schäfer V, Ritz M, Mattenheimer K, Degla A, Mottok A, Einsele H, Wajant H, Beilhack A.

Carcinogenesis. 2013 Jun;34(6):1296-303. doi: 10.1093/carcin/bgt038. Epub 2013 Feb 5.

PMID:
23385062
36.

Non-invasive imaging provides spatiotemporal information on disease progression and response to therapy in a murine model of multiple myeloma.

Riedel SS, Mottok A, Brede C, Bäuerlein CA, Jordán Garrote AL, Ritz M, Mattenheimer K, Rosenwald A, Einsele H, Bogen B, Beilhack A.

PLoS One. 2012;7(12):e52398. doi: 10.1371/journal.pone.0052398. Epub 2012 Dec 26.

37.

The heat shock transcription factor 1 as a potential new therapeutic target in multiple myeloma.

Heimberger T, Andrulis M, Riedel S, Stühmer T, Schraud H, Beilhack A, Bumm T, Bogen B, Einsele H, Bargou RC, Chatterjee M.

Br J Haematol. 2013 Feb;160(4):465-76. doi: 10.1111/bjh.12164. Epub 2012 Dec 18.

PMID:
23252346
38.

Murine anti-third-party central-memory CD8(+) T cells promote hematopoietic chimerism under mild conditioning: lymph-node sequestration and deletion of anti-donor T cells.

Ophir E, Or-Geva N, Gurevich I, Tal O, Eidelstein Y, Shezen E, Margalit R, Lask A, Shakhar G, Hagin D, Bachar-Lustig E, Reich-Zeliger S, Beilhack A, Negrin R, Reisner Y.

Blood. 2013 Feb 14;121(7):1220-8. doi: 10.1182/blood-2012-07-441493. Epub 2012 Dec 5.

39.

Mapping immune processes in intact tissues at cellular resolution.

Brede C, Friedrich M, Jordán-Garrote AL, Riedel SS, Bäuerlein CA, Heinze KG, Bopp T, Schulz S, Mottok A, Kiesel C, Mattenheimer K, Ritz M, von Krosigk V, Rosenwald A, Einsele H, Negrin RS, Harms GS, Beilhack A.

J Clin Invest. 2012 Dec;122(12):4439-46. doi: 10.1172/JCI65100. Epub 2012 Nov 12.

40.

Surface display of Gaussia princeps luciferase allows sensitive fungal pathogen detection during cutaneous aspergillosis.

Donat S, Hasenberg M, Schäfer T, Ohlsen K, Gunzer M, Einsele H, Löffler J, Beilhack A, Krappmann S.

Virulence. 2012 Jan-Feb;3(1):51-61. doi: 10.4161/viru.3.1.18799. Epub 2012 Jan 1.

PMID:
22286700
41.

Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R.

Wilhelm K, Ganesan J, Müller T, Dürr C, Grimm M, Beilhack A, Krempl CD, Sorichter S, Gerlach UV, Jüttner E, Zerweck A, Gärtner F, Pellegatti P, Di Virgilio F, Ferrari D, Kambham N, Fisch P, Finke J, Idzko M, Zeiser R.

Nat Med. 2010 Dec;16(12):1434-8. doi: 10.1038/nm.2242. Epub 2010 Nov 21.

PMID:
21102458
42.

Targeting localized immune suppression within the tumor through repeat cycles of immune cell-oncolytic virus combination therapy.

Thorne SH, Liang W, Sampath P, Schmidt T, Sikorski R, Beilhack A, Contag CH.

Mol Ther. 2010 Sep;18(9):1698-705. doi: 10.1038/mt.2010.140. Epub 2010 Jul 6.

43.

Leading T cells astray.

Beilhack A.

Blood. 2010 Jun 10;115(23):4628-30. doi: 10.1182/blood-2010-03-272963. No abstract available.

44.

NK cells mediate reduction of GVHD by inhibiting activated, alloreactive T cells while retaining GVT effects.

Olson JA, Leveson-Gower DB, Gill S, Baker J, Beilhack A, Negrin RS.

Blood. 2010 May 27;115(21):4293-301. doi: 10.1182/blood-2009-05-222190. Epub 2010 Mar 16.

45.

Direct imaging of immune rejection and memory induction by allogeneic mesenchymal stromal cells.

Zangi L, Margalit R, Reich-Zeliger S, Bachar-Lustig E, Beilhack A, Negrin R, Reisner Y.

Stem Cells. 2009 Nov;27(11):2865-74. doi: 10.1002/stem.217.

46.

Tissue-specific homing and expansion of donor NK cells in allogeneic bone marrow transplantation.

Olson JA, Zeiser R, Beilhack A, Goldman JJ, Negrin RS.

J Immunol. 2009 Sep 1;183(5):3219-28. doi: 10.4049/jimmunol.0804268. Epub 2009 Aug 5.

47.

Plasmacytoid dendritic cells take up opsonized antigen leading to CD4+ and CD8+ T cell activation in vivo.

Björck P, Beilhack A, Herman EI, Negrin RS, Engleman EG.

J Immunol. 2008 Sep 15;181(6):3811-7.

48.

In vivo trafficking and survival of cytokine-induced killer cells resulting in minimal GVHD with retention of antitumor activity.

Nishimura R, Baker J, Beilhack A, Zeiser R, Olson JA, Sega EI, Karimi M, Negrin RS.

Blood. 2008 Sep 15;112(6):2563-74. doi: 10.1182/blood-2007-06-092817. Epub 2008 Jun 18.

49.

Acute graft-versus-host disease-challenge for a broader application of allogeneic hematopoietic cell transplantation.

Zeiser R, Beilhack A, Negrin RS.

Curr Stem Cell Res Ther. 2006 May;1(2):203-12. Review.

PMID:
18220867
50.

Host-derived interleukin-18 differentially impacts regulatory and conventional T cell expansion during acute graft-versus-host disease.

Zeiser R, Zambricki EA, Leveson-Gower D, Kambham N, Beilhack A, Negrin RS.

Biol Blood Marrow Transplant. 2007 Dec;13(12):1427-38. Epub 2007 Oct 29.

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