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Infliximab therapy together with tyrosine kinase inhibition targets leukemic stem cells in chronic myeloid leukemia.

Herrmann O, Kuepper MK, Bütow M, Costa IG, Appelmann I, Beier F, Luedde T, Braunschweig T, Koschmieder S, Brümmendorf TH, Schemionek M.

BMC Cancer. 2019 Jul 4;19(1):658. doi: 10.1186/s12885-019-5871-2.


Effects of continuous high-dose G-CSF administration on hematopoietic stem cell mobilization and telomere length in patients with amyotrophic lateral sclerosis - a pilot study.

Iberl S, Meyer AL, Müller G, Peters S, Johannesen S, Kobor I, Beier F, Brümmendorf TH, Hart C, Schelker R, Herr W, Bogdahn U, Grassinger J.

Cytokine. 2019 Aug;120:192-201. doi: 10.1016/j.cyto.2019.05.003. Epub 2019 May 14.


Cholesterol and cartilage do not mix well.

Beier F.

Nat Rev Rheumatol. 2019 May;15(5):253-254. doi: 10.1038/s41584-019-0204-z. No abstract available.


ECM signaling in cartilage development and endochondral ossification.

Prein C, Beier F.

Curr Top Dev Biol. 2019;133:25-47. doi: 10.1016/bs.ctdb.2018.11.003. Epub 2018 Dec 20.


EGFR Signaling: Friend or Foe for Cartilage?

Qin L, Beier F.

JBMR Plus. 2019 Feb 13;3(2):e10177. doi: 10.1002/jbm4.10177. eCollection 2019 Feb. Review.


Tracking myeloid malignancies by targeted analysis of successive DNA methylation at neighboring CG dinucleotides.

Eipel M, Božić T, Mies A, Beier F, Jost E, Brümmendorf TH, Platzbecker U, Wagner W.

Haematologica. 2019 Aug;104(8):e349-e351. doi: 10.3324/haematol.2018.209734. Epub 2019 Jan 31. No abstract available.


Poly(ester amide) particles for controlled delivery of celecoxib.

Villamagna IJ, Gordon TN, Hurtig MB, Beier F, Gillies ER.

J Biomed Mater Res A. 2019 Jun;107(6):1235-1243. doi: 10.1002/jbm.a.36632. Epub 2019 Feb 22.


Telomere shortening correlates with leukemic stem cell burden at diagnosis of chronic myeloid leukemia.

Bouillon AS, Ventura Ferreira MS, Awad SA, Richter J, Hochhaus A, Kunzmann V, Dengler J, Janssen J, Ossenkoppele G, Westerweel PE, Te Boekhorst PAW, Mahon FX, Hjorth-Hansen H, Isfort S, Fioretos T, Hummel S, Schemionek M, Wilop S, Koschmieder S, Saußele S, Mustjoki S, Beier F, Brümmendorf TH.

Blood Adv. 2018 Jul 10;2(13):1572-1579. doi: 10.1182/bloodadvances.2018017772.


Germ line predisposition to myeloid malignancies appearing in adulthood.

Crysandt M, Brings K, Beier F, Thiede C, Brümmendorf TH, Jost E.

Expert Rev Hematol. 2018 Aug;11(8):625-636. doi: 10.1080/17474086.2018.1494566. Epub 2018 Jul 23. Review.


Influence of Telomere Length in Hepatocytes on Liver Regeneration after Partial Hepatectomy in Rats.

Andert A, Alizai HP, Ulmer TF, Heidenhain C, Ziegler P, Brümmendorf TH, Neumann UP, Beier F, Klink CD.

Eur Surg Res. 2018;59(1-2):83-90. doi: 10.1159/000489090. Epub 2018 Jun 8.


Inactivation of hepatic ATRX in Atrx Foxg1cre mice prevents reversal of aging-like phenotypes by thyroxine.

Rowland ME, Jiang Y, Beier F, Bérubé NG.

Aging (Albany NY). 2018 Jun 7;10(6):1223-1238. doi: 10.18632/aging.101462.


CD57 identifies T cells with functional senescence before terminal differentiation and relative telomere shortening in patients with activated PI3 kinase delta syndrome.

Cura Daball P, Ventura Ferreira MS, Ammann S, Klemann C, Lorenz MR, Warthorst U, Leahy TR, Conlon N, Roche J, Soler-Palacín P, Garcia-Prat M, Fuchs I, Fuchs S, Beier F, Brümmendorf TH, Speckmann C, Olbrich P, Neth O, Schwarz K, Ehl S, Rensing-Ehl A.

Immunol Cell Biol. 2018 Nov;96(10):1060-1071. doi: 10.1111/imcb.12169. Epub 2018 Jun 14.


Recurrent somatic mutations are rare in patients with cryptic dyskeratosis congenita.

Kirschner M, Maurer A, Wlodarski MW, Ventura Ferreira MS, Bouillon AS, Halfmeyer I, Blau W, Kreuter M, Rosewich M, Corbacioglu S, Beck J, Schwarz M, Bittenbring J, Radsak MP, Wilk CM, Koschmieder S, Begemann M, Kurth I, Schemionek M, Brümmendorf TH, Beier F.

Leukemia. 2018 Aug;32(8):1762-1767. doi: 10.1038/s41375-018-0125-x. Epub 2018 Apr 2.


Dicam promotes proliferation and maturation of chondrocyte through Indian hedgehog signaling in primary cilia.

Han S, Park HR, Lee EJ, Jang JA, Han MS, Kim GW, Jeong JH, Choi JY, Beier F, Jung YK.

Osteoarthritis Cartilage. 2018 Jul;26(7):945-953. doi: 10.1016/j.joca.2018.04.008. Epub 2018 Apr 25.


Effects of senolytic drugs on human mesenchymal stromal cells.

Grezella C, Fernandez-Rebollo E, Franzen J, Ventura Ferreira MS, Beier F, Wagner W.

Stem Cell Res Ther. 2018 Apr 18;9(1):108. doi: 10.1186/s13287-018-0857-6.


Lenalidomide enhances MOR202-dependent macrophage-mediated effector functions via the vitamin D pathway.

Busch L, Mougiakakos D, Büttner-Herold M, Müller MJ, Volmer DA, Bach C, Fabri M, Bittenbring JT, Neumann F, Boxhammer R, Nolting J, Bisht S, Böttcher M, Jitschin S, Hoffmann MH, Balzer H, Beier F, Gezer D, Dudziak D, Gelse K, Hennig FF, Pallasch CP, Spriewald B, Mackensen A, Bruns H.

Leukemia. 2018 Nov;32(11):2445-2458. doi: 10.1038/s41375-018-0114-0. Epub 2018 Mar 28.


Nuclear receptors as potential drug targets in osteoarthritis.

Sun MM, Beier F, Ratneswaran A.

Curr Opin Pharmacol. 2018 Jun;40:81-86. doi: 10.1016/j.coph.2018.03.008. Epub 2018 Apr 4. Review.


Experimental investigations on the TMI thresholds of low-NA Yb-doped single-mode fibers.

Beier F, Möller F, Sattler B, Nold J, Liem A, Hupel C, Kuhn S, Hein S, Haarlammert N, Schreiber T, Eberhardt R, Tünnermann A.

Opt Lett. 2018 Mar 15;43(6):1291-1294. doi: 10.1364/OL.43.001291.


Presence of TERT Promoter Mutations is a Secondary Event and Associates with Elongated Telomere Length in Myxoid Liposarcomas.

Ferreira MSV, Crysandt M, Braunschweig T, Jost E, Voss B, Bouillon AS, Knuechel R, Brümmendorf TH, Beier F.

Int J Mol Sci. 2018 Feb 18;19(2). pii: E608. doi: 10.3390/ijms19020608.


Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.

Schrader A, Crispatzu G, Oberbeck S, Mayer P, Pützer S, von Jan J, Vasyutina E, Warner K, Weit N, Pflug N, Braun T, Andersson EI, Yadav B, Riabinska A, Maurer B, Ventura Ferreira MS, Beier F, Altmüller J, Lanasa M, Herling CD, Haferlach T, Stilgenbauer S, Hopfinger G, Peifer M, Brümmendorf TH, Nürnberg P, Elenitoba-Johnson KSJ, Zha S, Hallek M, Moriggl R, Reinhardt HC, Stern MH, Mustjoki S, Newrzela S, Frommolt P, Herling M.

Nat Commun. 2018 Feb 15;9(1):697. doi: 10.1038/s41467-017-02688-6.


Early Changes of Articular Cartilage and Subchondral Bone in The DMM Mouse Model of Osteoarthritis.

Fang H, Huang L, Welch I, Norley C, Holdsworth DW, Beier F, Cai D.

Sci Rep. 2018 Feb 12;8(1):2855. doi: 10.1038/s41598-018-21184-5.


Osteoarthritis, cerebrovascular dysfunction and the common denominator of inflammation: a narrative review.

Al-Khazraji BK, Appleton CT, Beier F, Birmingham TB, Shoemaker JK.

Osteoarthritis Cartilage. 2018 Apr;26(4):462-470. doi: 10.1016/j.joca.2018.01.011. Epub 2018 Feb 2. Review.


Comprehensive characterization of chorionic villi-derived mesenchymal stromal cells from human placenta.

Ventura Ferreira MS, Bienert M, Müller K, Rath B, Goecke T, Opländer C, Braunschweig T, Mela P, Brümmendorf TH, Beier F, Neuss S.

Stem Cell Res Ther. 2018 Feb 5;9(1):28. doi: 10.1186/s13287-017-0757-1.


Extrinsic and Intrinsic Help-Seeking Motivation in the Assessment of Cognitive Decline.

Haussmann R, Mayer-Pelinski R, Borchardt M, Beier F, Helling F, Buthut M, Meissner G, Lange J, Zweiniger A, Donix M.

Am J Alzheimers Dis Other Demen. 2018 Jun;33(4):215-220. doi: 10.1177/1533317518755332. Epub 2018 Jan 29.


Measuring thermal load in fiber amplifiers in the presence of transversal mode instabilities.

Beier F, Plötner M, Sattler B, Stutzki F, Walbaum T, Liem A, Haarlammert N, Schreiber T, Eberhardt R, Tünnermann A.

Opt Lett. 2017 Nov 1;42(21):4311-4314. doi: 10.1364/OL.42.004311.


Rac1 Dosage Is Crucial for Normal Endochondral Bone Growth.

Suzuki D, Bush JR, Bryce DM, Kamijo R, Beier F.

Endocrinology. 2017 Oct 1;158(10):3386-3398. doi: 10.1210/en.2016-1691.


High power sub-ps pulse generation by compression of a frequency comb obtained by a nonlinear broadened two colored seed.

Plötner M, Bock V, Schultze T, Beier F, Schreiber T, Eberhardt R, Tünnermann A.

Opt Express. 2017 Jul 10;25(14):16476-16483. doi: 10.1364/OE.25.016476.


Single mode 4.3 kW output power from a diode-pumped Yb-doped fiber amplifier.

Beier F, Hupel C, Kuhn S, Hein S, Nold J, Proske F, Sattler B, Liem A, Jauregui C, Limpert J, Haarlammert N, Schreiber T, Eberhardt R, Tünnermann A.

Opt Express. 2017 Jun 26;25(13):14892-14899. doi: 10.1364/OE.25.014892.


An approach towards accountability: suggestions for increased reproducibility in surgical destabilization of medial meniscus (DMM) models.

Ratneswaran A, Beier F.

Osteoarthritis Cartilage. 2017 Nov;25(11):1747-1750. doi: 10.1016/j.joca.2017.07.018. Epub 2017 Jul 29. No abstract available.


Evidence for a pre-existing telomere deficit in non-clonal hematopoietic stem cells in patients with acute myeloid leukemia.

Ventura Ferreira MS, Crysandt M, Ziegler P, Hummel S, Wilop S, Kirschner M, Schemionek M, Jost E, Wagner W, Brümmendorf TH, Beier F.

Ann Hematol. 2017 Sep;96(9):1457-1461. doi: 10.1007/s00277-017-3049-z. Epub 2017 Jul 3.


p16, HPV, and Cetuximab: What Is the Evidence?

Bonner JA, Mesia R, Giralt J, Psyrri A, Keilholz U, Rosenthal DI, Beier F, Schulten J, Vermorken JB.

Oncologist. 2017 Jul;22(7):811-822. doi: 10.1634/theoncologist.2016-0433. Epub 2017 May 18. Review.


The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior.

Weinberg F, Reischmann N, Fauth L, Taromi S, Mastroianni J, Köhler M, Halbach S, Becker AC, Deng N, Schmitz T, Uhl FM, Herbener N, Riedel B, Beier F, Swarbrick A, Lassmann S, Dengjel J, Zeiser R, Brummer T.

EBioMedicine. 2017 Jun;20:79-97. doi: 10.1016/j.ebiom.2017.04.015. Epub 2017 Apr 12.


Mosaic expression of Atrx in the mouse central nervous system causes memory deficits.

Tamming RJ, Siu JR, Jiang Y, Prado MA, Beier F, Bérubé NG.

Dis Model Mech. 2017 Feb 1;10(2):119-126. doi: 10.1242/dmm.027482. Epub 2017 Jan 12.


Quality of Life Analysis in Patients With RAS Wild-Type Metastatic Colorectal Cancer Treated With First-Line Cetuximab Plus Chemotherapy.

Yamaguchi K, Ando M, Ooki A, Beier F, Guenther S, von Hohnhorst P, Van Cutsem E.

Clin Colorectal Cancer. 2017 Jun;16(2):e29-e37. doi: 10.1016/j.clcc.2016.07.017. Epub 2016 Aug 9.


Nuclear receptors regulate lipid metabolism and oxidative stress markers in chondrocytes.

Ratneswaran A, Sun MM, Dupuis H, Sawyez C, Borradaile N, Beier F.

J Mol Med (Berl). 2017 Apr;95(4):431-444. doi: 10.1007/s00109-016-1501-5. Epub 2017 Jan 9.


Recent developments in emerging therapeutic targets of osteoarthritis.

Sun MM, Beier F, Pest MA.

Curr Opin Rheumatol. 2017 Jan;29(1):96-102. Review.


Whole-body vibration of mice induces articular cartilage degeneration with minimal changes in subchondral bone.

McCann MR, Yeung C, Pest MA, Ratneswaran A, Pollmann SI, Holdsworth DW, Beier F, Dixon SJ, Séguin CA.

Osteoarthritis Cartilage. 2017 May;25(5):770-778. doi: 10.1016/j.joca.2016.11.001. Epub 2016 Nov 10.


Efficacy, Tolerability, and Biomarker Analyses of Once-Every-2-Weeks Cetuximab Plus First-Line FOLFOX or FOLFIRI in Patients With KRAS or All RAS Wild-Type Metastatic Colorectal Cancer: The Phase 2 APEC Study.

Cheng AL, Cornelio G, Shen L, Price T, Yang TS, Chung IJ, Dai GH, Lin JK, Sharma A, Yeh KH, Ma B, Zaatar A, Guan Z, Masood N, Srimuninnimit V, Yau T, Gibbs P, Wang X, Doval DC, Oh ST, Shim BY, Gorospe C, Wang HM, Sirachainan E, Hill A, Suh KW, Beier F, Chatterjee S, Lim R.

Clin Colorectal Cancer. 2017 Jun;16(2):e73-e88. doi: 10.1016/j.clcc.2016.08.005. Epub 2016 Sep 7.


C57BL/6 mice are resistant to joint degeneration induced by whole-body vibration.

Kerr GJ, McCann MR, Branch JK, Ratneswaran A, Pest MA, Holdsworth DW, Beier F, Dixon SJ, Séguin CA.

Osteoarthritis Cartilage. 2017 Mar;25(3):421-425. doi: 10.1016/j.joca.2016.09.020. Epub 2016 Oct 6.


[(Pan-)cytopenia as first manifestation of kryptic telomeropathies in adults].

Schmitt K, Beier F, Panse J, Brümmendorf TH.

Dtsch Med Wochenschr. 2016 Oct;141(21):1578-1580. Epub 2016 Oct 17. Review. German.


Prognostic and Predictive Relevance of Primary Tumor Location in Patients With RAS Wild-Type Metastatic Colorectal Cancer: Retrospective Analyses of the CRYSTAL and FIRE-3 Trials.

Tejpar S, Stintzing S, Ciardiello F, Tabernero J, Van Cutsem E, Beier F, Esser R, Lenz HJ, Heinemann V.

JAMA Oncol. 2017 Feb 1;3(2):194-201. doi: 10.1001/jamaoncol.2016.3797. Erratum in: JAMA Oncol. 2017 Dec 1;3(12):1742.


FOLFIRI plus cetuximab in patients with liver-limited or non-liver-limited RAS wild-type metastatic colorectal cancer: A retrospective subgroup analysis of the CRYSTAL study.

Köhne CH, Poston G, Folprecht G, Ciardiello F, Ronga P, Beier F, Van Cutsem E.

Eur J Surg Oncol. 2016 Oct;42(10):1540-7. doi: 10.1016/j.ejso.2016.05.038. Epub 2016 Jun 23.


Context-specific protection of TGFα null mice from osteoarthritis.

Usmani SE, Ulici V, Pest MA, Hill TL, Welch ID, Beier F.

Sci Rep. 2016 Jul 26;6:30434. doi: 10.1038/srep30434.


[Treatment of penicillin-sensitive staphylococcus aureus].

Beier F.

Dtsch Med Wochenschr. 2016 May;141(10):674. doi: 10.1055/s-0041-108938. Epub 2016 May 13. German. No abstract available.


Accelerated telomere shortening in peripheral blood lymphocytes after occupational polychlorinated biphenyls exposure.

Ziegler S, Schettgen T, Beier F, Wilop S, Quinete N, Esser A, Masouleh BK, Ferreira MS, Vankann L, Uciechowski P, Rink L, Kraus T, Brümmendorf TH, Ziegler P.

Arch Toxicol. 2017 Jan;91(1):289-300. doi: 10.1007/s00204-016-1725-8. Epub 2016 May 5.


Narrow linewidth, single mode 3 kW average power from a directly diode pumped ytterbium-doped low NA fiber amplifier.

Beier F, Hupel C, Nold J, Kuhn S, Hein S, Ihring J, Sattler B, Haarlammert N, Schreiber T, Eberhardt R, Tünnermann A.

Opt Express. 2016 Mar 21;24(6):6011-20. doi: 10.1364/OE.24.006011.


The first international workshop on the epigenetics of osteoarthritis.

Meulenbelt IM, Bhutani N, den Hollander W, Gay S, Oppermann U, Reynard LN, Skelton AJ, Young DA, Beier F, Loughlin J.

Connect Tissue Res. 2017 Jan;58(1):37-48. doi: 10.3109/03008207.2016.1168409. Epub 2016 Mar 30.


DNA methylation in PRDM8 is indicative for dyskeratosis congenita.

Weidner CI, Lin Q, Birkhofer C, Gerstenmaier U, Kaifie A, Kirschner M, Bruns H, Balabanov S, Trummer A, Stockklausner C, Höchsmann B, Schrezenmeier H, Wlodarski M, Panse J, Brümmendorf TH, Beier F, Wagner W.

Oncotarget. 2016 Mar 8;7(10):10765-72. doi: 10.18632/oncotarget.7458.


Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9.

Schneider RK, Schenone M, Ferreira MV, Kramann R, Joyce CE, Hartigan C, Beier F, Brümmendorf TH, Germing U, Platzbecker U, Büsche G, Knüchel R, Chen MC, Waters CS, Chen E, Chu LP, Novina CD, Lindsley RC, Carr SA, Ebert BL.

Nat Med. 2016 Mar;22(3):288-97. doi: 10.1038/nm.4047. Epub 2016 Feb 15.

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