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Is antibacterial treatment intensity lower in elderly patients? A retrospective cohort study in a German surgical intensive care unit.

Beier D, Weiß C, Hagmann M, Balaban Ü, Thiel M, Schneider-Lindner V.

BMC Health Serv Res. 2019 Jun 10;19(1):367. doi: 10.1186/s12913-019-4204-0.


Loss of function of Colgalt1 disrupts collagen post-translational modification and causes musculoskeletal defects.

Geister KA, Lopez-Jimenez AJ, Houghtaling S, Ho TH, Vanacore R, Beier DR.

Dis Model Mech. 2019 Jun 17;12(6). pii: dmm037176. doi: 10.1242/dmm.037176.


Applicability of the mutation-selection balance model to population genetics of heterozygous protein-truncating variants in humans.

Weghorn D, Balick DJ, Cassa C, Kosmicki JA, Daly MJ, Beier DR, Sunyaev SR.

Mol Biol Evol. 2019 Apr 19. pii: msz092. doi: 10.1093/molbev/msz092. [Epub ahead of print]


Reply to 'Selective effects of heterozygous protein-truncating variants'.

Cassa CA, Weghorn D, Balick DJ, Jordan DM, Nusinow D, Samocha KE, O'Donnell-Luria A, MacArthur DG, Daly MJ, Beier DR, Sunyaev SR.

Nat Genet. 2019 Jan;51(1):3-4. doi: 10.1038/s41588-018-0301-y. No abstract available.


Aberrant neuronal differentiation is common in glioma but is associated neither with epileptic seizures nor with better survival.

Beier CP, Rasmussen T, Dahlrot RH, Tenstad HB, Aarø JS, Sørensen MF, Heimisdóttir SB, Sørensen MD, Svenningsen P, Riemenschneider MJ, Beier D, Kristensen BW.

Sci Rep. 2018 Oct 8;8(1):14965. doi: 10.1038/s41598-018-33282-5.


[Telematics in ambulatory care: Exploring the nurses' perspective].

Dockweiler C, Diedrich L, Palmdorf S, Beier D, Ilic J, Kibbert M, Kirsch J, Hannemann N, Prisett F, Schmitke V, Schmidt C, Spindeler T, Sommer L, Sommer S, Stark AL, Steinkühler C, Stolte J, Hornberg C.

Pflege. 2019 Apr;32(2):87-96. doi: 10.1024/1012-5302/a000648. Epub 2018 Sep 28. German.


A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice.

Abdelhamed Z, Vuong SM, Hill L, Shula C, Timms A, Beier D, Campbell K, Mangano FT, Stottmann RW, Goto J.

Development. 2018 Jan 9;145(1). pii: dev154500. doi: 10.1242/dev.154500.


Optimizing Genomic Methods for Mapping and Identification of Candidate Variants in ENU Mutagenesis Screens Using Inbred Mice.

Geister KA, Timms AE, Beier DR.

G3 (Bethesda). 2018 Feb 2;8(2):401-409. doi: 10.1534/g3.117.300292.


The sibling sRNAs NgncR_162 and NgncR_163 of Neisseria gonorrhoeae participate in the expression control of metabolic, transport and regulatory proteins.

Bauer S, Helmreich J, Zachary M, Kaethner M, Heinrichs E, Rudel T, Beier D.

Microbiology. 2017 Nov;163(11):1720-1734. doi: 10.1099/mic.0.000548. Epub 2017 Oct 23.


Multicenter pilot study of radiochemotherapy as first-line treatment for adults with medulloblastoma (NOA-07).

Beier D, Proescholdt M, Reinert C, Pietsch T, Jones DTW, Pfister SM, Hattingen E, Seidel C, Dirven L, Luerding R, Reijneveld J, Warmuth-Metz M, Bonsanto M, Bremer M, Combs SE, Rieken S, Herrlinger U, Kuntze H, Mayer-Steinacker R, Moskopp D, Schneider T, Beringer A, Schlegel U, Stummer W, Welker H, Weyerbrock A, Paulsen F, Rutkowski S, Weller M, Wick W, Kortmann RD, Bogdahn U, Hau P.

Neuro Oncol. 2018 Feb 19;20(3):400-410. doi: 10.1093/neuonc/nox155. Erratum in: Neuro Oncol. 2018 Feb 19;20(3):434.


Human Embryo Editing: Opportunities and Importance of Transnational Cooperation.

Pei D, Beier DW, Levy-Lahad E, Marchant G, Rossant J, Izpisua Belmonte JC, Lovell-Badge R, Jaenisch R, Charo A, Baltimore D.

Cell Stem Cell. 2017 Oct 5;21(4):423-426. doi: 10.1016/j.stem.2017.09.010.


Imaging Biomarkers for Adult Medulloblastomas: Genetic Entities May Be Identified by Their MR Imaging Radiophenotype.

Keil VC, Warmuth-Metz M, Reh C, Enkirch SJ, Reinert C, Beier D, Jones DTW, Pietsch T, Schild HH, Hattingen E, Hau P.

AJNR Am J Neuroradiol. 2017 Oct;38(10):1892-1898. doi: 10.3174/ajnr.A5313. Epub 2017 Aug 10.


Manual morphometry of hippocampus and amygdala in adults with attention-deficit hyperactivity disorder.

Nickel K, Tebartz van Elst L, Perlov E, Jitten-Schachenmeier R, Beier D, Endres D, Goll P, Philipsen A, Maier S.

Psychiatry Res Neuroimaging. 2017 Sep 30;267:32-35. doi: 10.1016/j.pscychresns.2017.07.001. Epub 2017 Jul 14.


Post-transcriptional regulation of target genes by the sRNA FnrS in Neisseria gonorrhoeae.

Tanwer P, Bauer S, Heinrichs E, Panda G, Saluja D, Rudel T, Beier D.

Microbiology. 2017 Jul;163(7):1081-1092. doi: 10.1099/mic.0.000484. Epub 2017 Jul 21.


Halting Zika's resurgence with new rapid tests for the virus.

Dhillon RS, Srikrishna D, Beier D.

BMJ. 2017 May 31;357:j2657. doi: 10.1136/bmj.j2657. No abstract available.


Generation of a multipurpose Prdm16 mouse allele by targeted gene trapping.

Strassman A, Schnütgen F, Dai Q, Jones JC, Gomez AC, Pitstick L, Holton NE, Moskal R, Leslie ER, von Melchner H, Beier DR, Bjork BC.

Dis Model Mech. 2017 Jul 1;10(7):909-922. doi: 10.1242/dmm.029561. Epub 2017 Apr 19.


Estimating the selective effects of heterozygous protein-truncating variants from human exome data.

Cassa CA, Weghorn D, Balick DJ, Jordan DM, Nusinow D, Samocha KE, O'Donnell-Luria A, MacArthur DG, Daly MJ, Beier DR, Sunyaev SR.

Nat Genet. 2017 May;49(5):806-810. doi: 10.1038/ng.3831. Epub 2017 Apr 3.


Electric Nerve Stimulation Does Not Correctly Predict Needle-Nerve Distance and Potential Local Anesthetic Spread for Interscalene Brachial Plexus Blockade.

Fielmuth S, Szalata M, Sievert H, Beier D, Rehberg S, Hahnenkamp K, Mauermann K, Meissner K.

Anesth Analg. 2017 Aug;125(2):632-634. doi: 10.1213/ANE.0000000000001982.


C-Terminal Region Truncation of RELN Disrupts an Interaction with VLDLR, Causing Abnormal Development of the Cerebral Cortex and Hippocampus.

Ha S, Tripathi PP, Mihalas AB, Hevner RF, Beier DR.

J Neurosci. 2017 Jan 25;37(4):960-971. doi: 10.1523/JNEUROSCI.1826-16.2016.


Immediate versus modified release hydrocortisone in mitotane-treated patients with adrenocortical cancer.

Weigel M, Hahner S, Sherlock M, Agha A, Behan LA, Stewart PM, Arlt W, Beier D, Frey K, Zopf K, Quinkler M.

Clin Endocrinol (Oxf). 2017 Apr;86(4):499-505. doi: 10.1111/cen.13302. Epub 2017 Feb 3.


Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis.

Husson H, Moreno S, Smith LA, Smith MM, Russo RJ, Pitstick R, Sergeev M, Ledbetter SR, Bukanov NO, Lane M, Zhang K, Billot K, Carlson G, Shah J, Meijer L, Beier DR, Ibraghimov-Beskrovnaya O.

Hum Mol Genet. 2016 Jun 1;25(11):2245-2255. Epub 2016 Apr 5.


Dysfunction of intraflagellar transport-A causes hyperphagia-induced obesity and metabolic syndrome.

Jacobs DT, Silva LM, Allard BA, Schonfeld MP, Chatterjee A, Talbott GC, Beier DR, Tran PV.

Dis Model Mech. 2016 Jul 1;9(7):789-98. doi: 10.1242/dmm.025791. Epub 2016 May 11.


Improvement of ENU Mutagenesis Efficiency Using Serial Injection and Mismatch Repair Deficiency Mice.

Gallego-Llamas J, Timms AE, Pitstick R, Peters J, Carlson GA, Beier DR.

PLoS One. 2016 Jul 21;11(7):e0159377. doi: 10.1371/journal.pone.0159377. eCollection 2016.


The Neuroradiological Spectra of Adult and Pediatric Medulloblastoma Differ : Results from a Literature-based Meta-analysis.

Beier D, Kocakaya S, Hau P, Beier CP.

Clin Neuroradiol. 2018 Mar;28(1):99-107. doi: 10.1007/s00062-016-0517-0. Epub 2016 Jun 22.


Mutations in Dnaaf1 and Lrrc48 Cause Hydrocephalus, Laterality Defects, and Sinusitis in Mice.

Ha S, Lindsay AM, Timms AE, Beier DR.

G3 (Bethesda). 2016 Aug 9;6(8):2479-87. doi: 10.1534/g3.116.030791.


Impaired TGF-β induced growth inhibition contributes to the increased proliferation rate of neural stem cells harboring mutant p53.

Kumar P, Naumann U, Aigner L, Wischhusen J, Beier CP, Beier D.

Am J Cancer Res. 2015 Oct 15;5(11):3436-45. eCollection 2015.


Variant mapping and mutation discovery in inbred mice using next-generation sequencing.

Gallego-Llamas J, Timms AE, Geister KA, Lindsay A, Beier DR.

BMC Genomics. 2015 Nov 9;16:913. doi: 10.1186/s12864-015-2173-1.


Indirect consequences of extreme weather and climate events and their associations with physical health in coastal Bangladesh: a cross-sectional study.

Beier D, Brzoska P, Khan MM.

Glob Health Action. 2015 Oct 16;8:29016. doi: 10.3402/gha.v8.29016. eCollection 2015.


Chemotherapy increases long-term survival in patients with adult medulloblastoma--a literature-based meta-analysis.

Kocakaya S, Beier CP, Beier D.

Neuro Oncol. 2016 Mar;18(3):408-16. doi: 10.1093/neuonc/nov185. Epub 2015 Sep 10.


Increased hippocampal volumes in adults with high functioning autism spectrum disorder and an IQ>100: A manual morphometric study.

Maier S, Tebartz van Elst L, Beier D, Ebert D, Fangmeier T, Radtke M, Perlov E, Riedel A.

Psychiatry Res. 2015 Oct 30;234(1):152-5. doi: 10.1016/j.pscychresns.2015.08.002. Epub 2015 Aug 10.


Grhl2 is required in nonneural tissues for neural progenitor survival and forebrain development.

Menke C, Cionni M, Siggers T, Bulyk ML, Beier DR, Stottmann RW.

Genesis. 2015 Sep;53(9):573-582. doi: 10.1002/dvg.22875. Epub 2015 Jul 22.


Chemoresistance and chemotherapy targeting stem-like cells in malignant glioma.

Sørensen MD, Fosmark S, Hellwege S, Beier D, Kristensen BW, Beier CP.

Adv Exp Med Biol. 2015;853:111-38. doi: 10.1007/978-3-319-16537-0_7. Review.


Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease.

Pooler AM, Polydoro M, Maury EA, Nicholls SB, Reddy SM, Wegmann S, William C, Saqran L, Cagsal-Getkin O, Pitstick R, Beier DR, Carlson GA, Spires-Jones TL, Hyman BT.

Acta Neuropathol Commun. 2015 Mar 24;3:14. doi: 10.1186/s40478-015-0199-x.


ENU mutagenesis in the mouse.

Stottmann R, Beier D.

Curr Protoc Mouse Biol. 2014 Jun 16;4(2):25-35. doi: 10.1002/9780470942390.mo140029.


ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning.

Czarnecki PG, Gabriel GC, Manning DK, Sergeev M, Lemke K, Klena NT, Liu X, Chen Y, Li Y, San Agustin JT, Garnaas MK, Francis RJ, Tobita K, Goessling W, Pazour GJ, Lo CW, Beier DR, Shah JV.

Nat Commun. 2015 Jan 20;6:6023. doi: 10.1038/ncomms7023.


ENU Mutagenesis in the Mouse.

Stottmann R, Beier D.

Curr Protoc Hum Genet. 2014 Jul 14;82:15.4.1-10. doi: 10.1002/0471142905.hg1504s82.


Downregulating hedgehog signaling reduces renal cystogenic potential of mouse models.

Tran PV, Talbott GC, Turbe-Doan A, Jacobs DT, Schonfeld MP, Silva LM, Chatterjee A, Prysak M, Allard BA, Beier DR.

J Am Soc Nephrol. 2014 Oct;25(10):2201-12. doi: 10.1681/ASN.2013070735. Epub 2014 Apr 3.


A variable homopolymeric G-repeat defines small RNA-mediated posttranscriptional regulation of a chemotaxis receptor in Helicobacter pylori.

Pernitzsch SR, Tirier SM, Beier D, Sharma CM.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):E501-10. doi: 10.1073/pnas.1315152111. Epub 2014 Jan 13.


YB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells.

Mantwill K, Naumann U, Seznec J, Girbinger V, Lage H, Surowiak P, Beier D, Mittelbronn M, Schlegel J, Holm PS.

J Transl Med. 2013 Sep 18;11:216. doi: 10.1186/1479-5876-11-216.


NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies.

Choi HJ, Lin JR, Vannier JB, Slaats GG, Kile AC, Paulsen RD, Manning DK, Beier DR, Giles RH, Boulton SJ, Cimprich KA.

Mol Cell. 2013 Aug 22;51(4):423-39. doi: 10.1016/j.molcel.2013.08.006.


A forward genetic screen in mice identifies mutants with abnormal cortical patterning.

Ha S, Stottmann RW, Furley AJ, Beier DR.

Cereb Cortex. 2015 Jan;25(1):167-79. doi: 10.1093/cercor/bht209. Epub 2013 Aug 22.


Action of food preservatives on 14-days dental biofilm formation, biofilm vitality and biofilm-derived enamel demineralisation in situ.

Arweiler NB, Netuschil L, Beier D, Grunert S, Heumann C, Altenburger MJ, Sculean A, Nagy K, Al-Ahmad A, Auschill TM.

Clin Oral Investig. 2014 Apr;18(3):829-38. doi: 10.1007/s00784-013-1053-9. Epub 2013 Aug 2.


A mutation in Tubb2b, a human polymicrogyria gene, leads to lethality and abnormal cortical development in the mouse.

Stottmann RW, Donlin M, Hafner A, Bernard A, Sinclair DA, Beier DR.

Hum Mol Genet. 2013 Oct 15;22(20):4053-63. doi: 10.1093/hmg/ddt255. Epub 2013 May 31.


Novel function assignment to a member of the essential HP1043 response regulator family of epsilon-proteobacteria.

Bauer S, Endres M, Lange M, Schmidt T, Schumbrutzki C, Sickmann A, Beier D.

Microbiology. 2013 May;159(Pt 5):880-9. doi: 10.1099/mic.0.066548-0. Epub 2013 Mar 8.


Loss of the ciliary kinase Nek8 causes left-right asymmetry defects.

Manning DK, Sergeev M, van Heesbeen RG, Wong MD, Oh JH, Liu Y, Henkelman RM, Drummond I, Shah JV, Beier DR.

J Am Soc Nephrol. 2013 Jan;24(1):100-12. doi: 10.1681/ASN.2012050490.


A spontaneous Fatp4/Scl27a4 splice site mutation in a new murine model for congenital ichthyosis.

Tao J, Koster MI, Harrison W, Moran JL, Beier DR, Roop DR, Overbeek PA.

PLoS One. 2012;7(11):e50634. doi: 10.1371/journal.pone.0050634. Epub 2012 Nov 30. Erratum in: PLoS One. 2014;9(2):e91624.


Polymorphisms in toll-like receptor 4 underlie susceptibility to tumor induction by the mouse polyomavirus.

Velupillai P, Sung CK, Andrews E, Moran J, Beier D, Kagan J, Benjamin T.

J Virol. 2012 Nov;86(21):11541-7. doi: 10.1128/JVI.01614-12. Epub 2012 Aug 15.


Mutation of the BiP/GRP78 gene causes axon outgrowth and fasciculation defects in the thalamocortical connections of the mammalian forebrain.

Favero CB, Henshaw RN, Grimsley-Myers CM, Shrestha A, Beier DR, Dwyer ND.

J Comp Neurol. 2013 Feb 15;521(3):677-96. doi: 10.1002/cne.23199.


The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking.

Liem KF Jr, Ashe A, He M, Satir P, Moran J, Beier D, Wicking C, Anderson KV.

J Cell Biol. 2012 Jun 11;197(6):789-800. doi: 10.1083/jcb.201110049.

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