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Items: 1 to 50 of 57

1.

CD8 T Cell Memory Increases Immunopathology in the Perforin-Deficient Model of Hemophagocytic Lymphohistiocytosis Secondary to TNF-α.

Taylor MD, Burn TN, Wherry EJ, Behrens EM.

Immunohorizons. 2018 Feb;2(2):67-73. doi: 10.4049/immunohorizons.1800003.

2.

Muscularis macrophage development in the absence of an enteric nervous system.

Avetisyan M, Rood JE, Huerta Lopez S, Sengupta R, Wright-Jin E, Dougherty JD, Behrens EM, Heuckeroth RO.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):4696-4701. doi: 10.1073/pnas.1802490115. Epub 2018 Apr 17.

PMID:
29666241
3.

Indeterminate pediatric acute liver failure is uniquely characterized by a CD103+CD8+ T-cell infiltrate.

Chapin CA, Burn T, Meijome T, Loomes KM, Melin-Aldana H, Kreiger PA, Whitington PF, Behrens EM, Alonso EM.

Hepatology. 2018 Mar 30. doi: 10.1002/hep.29901. [Epub ahead of print]

PMID:
29603342
4.

ECSIT links TLR and BMP signaling in FOP connective tissue progenitor cells.

Wang H, Behrens EM, Pignolo RJ, Kaplan FS.

Bone. 2018 Apr;109:201-209. doi: 10.1016/j.bone.2017.12.024. Epub 2017 Dec 27.

PMID:
29288875
5.

Weathering the storm: Improving therapeutic interventions for cytokine storm syndromes by targeting disease pathogenesis.

Weaver LK, Behrens EM.

Curr Treatm Opt Rheumatol. 2017 Mar;3(1):33-48. doi: 10.1007/s40674-017-0059-x. Epub 2017 Feb 7.

6.

Reply.

Canna SW, Girard C, Malle L, de Jesus A, Romberg N, Kelsen J, Surrey LF, Russo P, Sleight A, Schiffrin E, Gabay C, Goldbach-Mansky R, Behrens EM.

J Allergy Clin Immunol. 2017 Jul;140(1):316-317. doi: 10.1016/j.jaci.2017.03.016. Epub 2017 Apr 29. No abstract available.

PMID:
28460789
7.

Review: Cytokine Storm Syndrome: Looking Toward the Precision Medicine Era.

Behrens EM, Koretzky GA.

Arthritis Rheumatol. 2017 Jun;69(6):1135-1143. doi: 10.1002/art.40071. Review. No abstract available.

8.

IL-10 distinguishes a unique population of activated, effector-like CD8+ T cells in murine acute liver inflammation.

Rood JE, Canna SW, Weaver LK, Tobias JW, Behrens EM.

J Leukoc Biol. 2017 Apr;101(4):1037-1044. doi: 10.1189/jlb.3A0916-221RR. Epub 2016 Dec 29.

9.

Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition.

Canna SW, Girard C, Malle L, de Jesus A, Romberg N, Kelsen J, Surrey LF, Russo P, Sleight A, Schiffrin E, Gabay C, Goldbach-Mansky R, Behrens EM.

J Allergy Clin Immunol. 2017 May;139(5):1698-1701. doi: 10.1016/j.jaci.2016.10.022. Epub 2016 Nov 19. No abstract available.

10.

Pediatric acute liver failure of undetermined cause: A research workshop.

Alonso EM, Horslen SP, Behrens EM, Doo E.

Hepatology. 2017 Mar;65(3):1026-1037. doi: 10.1002/hep.28944. Epub 2017 Jan 6. Review.

11.

Editorial: Caught in the Act: Dissecting Natural Killer Cell Function in Systemic Juvenile Idiopathic Arthritis.

Behrens EM.

Arthritis Rheumatol. 2017 Jan;69(1):6-8. doi: 10.1002/art.39934. No abstract available.

12.

TLR9-mediated inflammation drives a Ccr2-independent peripheral monocytosis through enhanced extramedullary monocytopoiesis.

Weaver LK, Chu N, Behrens EM.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10944-9. doi: 10.1073/pnas.1524487113. Epub 2016 Sep 12.

13.

Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility.

Finkel TH, Li J, Wei Z, Wang W, Zhang H, Behrens EM, Reuschel EL, Limou S, Wise C, Punaro M, Becker ML, Munro JE, Flatø B, Førre Ø, Thompson SD, Langefeld CD, Glass DN, Glessner JT, Kim CE, Frackelton E, Shivers DK, Thomas KA, Chiavacci RM, Hou C, Xu K, Snyder J, Qiu H, Mentch F, Wang K, Winkler CA, Lie BA, Ellis JA, Hakonarson H.

BMC Med Genet. 2016 Mar 22;17:24. doi: 10.1186/s12881-016-0285-3.

14.

2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborative Initiative.

Ravelli A, Minoia F, Davì S, Horne A, Bovis F, Pistorio A, Aricò M, Avcin T, Behrens EM, De Benedetti F, Filipovic L, Grom AA, Henter JI, Ilowite NT, Jordan MB, Khubchandani R, Kitoh T, Lehmberg K, Lovell DJ, Miettunen P, Nichols KE, Ozen S, Pachlopnik Schmid J, Ramanan AV, Russo R, Schneider R, Sterba G, Uziel Y, Wallace C, Wouters C, Wulffraat N, Demirkaya E, Brunner HI, Martini A, Ruperto N, Cron RQ; Paediatric Rheumatology International Trials Organisation; Childhood Arthritis and Rheumatology Research Alliance; Pediatric Rheumatology Collaborative Study Group; Histiocyte Society.

Ann Rheum Dis. 2016 Mar;75(3):481-9. doi: 10.1136/annrheumdis-2015-208982.

PMID:
26865703
15.

Expert consensus on dynamics of laboratory tests for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis.

Ravelli A, Minoia F, Davì S, Horne A, Bovis F, Pistorio A, Aricò M, Avcin T, Behrens EM, De Benedetti F, Filipovic A, Grom AA, Henter JI, Ilowite NT, Jordan MB, Khubchandani R, Kitoh T, Lehmberg K, Lovell DJ, Miettunen P, Nichols KE, Ozen S, Pachlopnik Schmid J, Ramanan AV, Russo R, Schneider R, Sterba G, Uziel Y, Wallace C, Wouters C, Wulffraat N, Demirkaya E, Brunner HI, Martini A, Ruperto N, Cron RQ.

RMD Open. 2016 Jan 19;2(1):e000161. doi: 10.1136/rmdopen-2015-000161. eCollection 2016.

16.

Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis.

Das R, Guan P, Sprague L, Verbist K, Tedrick P, An QA, Cheng C, Kurachi M, Levine R, Wherry EJ, Canna SW, Behrens EM, Nichols KE.

Blood. 2016 Mar 31;127(13):1666-75. doi: 10.1182/blood-2015-12-684399. Epub 2016 Jan 29.

17.

ST2 contributes to T-cell hyperactivation and fatal hemophagocytic lymphohistiocytosis in mice.

Rood JE, Rao S, Paessler M, Kreiger PA, Chu N, Stelekati E, Wherry EJ, Behrens EM.

Blood. 2016 Jan 28;127(4):426-35. doi: 10.1182/blood-2015-07-659813. Epub 2015 Oct 30.

18.

BIRC4 Mutation: An Important Rare Cause of Uveitis.

Basiaga ML, Weiss PF, Behrens EM.

J Clin Rheumatol. 2015 Dec;21(8):444-7. doi: 10.1097/RHU.0000000000000327.

19.

Genetic sharing and heritability of paediatric age of onset autoimmune diseases.

Li YR, Zhao SD, Li J, Bradfield JP, Mohebnasab M, Steel L, Kobie J, Abrams DJ, Mentch FD, Glessner JT, Guo Y, Wei Z, Connolly JJ, Cardinale CJ, Bakay M, Li D, Maggadottir SM, Thomas KA, Qui H, Chiavacci RM, Kim CE, Wang F, Snyder J, Flatø B, Førre Ø, Denson LA, Thompson SD, Becker ML, Guthery SL, Latiano A, Perez E, Resnick E, Strisciuglio C, Staiano A, Miele E, Silverberg MS, Lie BA, Punaro M, Russell RK, Wilson DC, Dubinsky MC, Monos DS, Annese V, Munro JE, Wise C, Chapel H, Cunningham-Rundles C, Orange JS, Behrens EM, Sullivan KE, Kugathasan S, Griffiths AM, Satsangi J, Grant SF, Sleiman PM, Finkel TH, Polychronakos C, Baldassano RN, Luning Prak ET, Ellis JA, Li H, Keating BJ, Hakonarson H.

Nat Commun. 2015 Oct 9;6:8442. doi: 10.1038/ncomms9442.

20.

Patient-reported Outcomes across Categories of Juvenile Idiopathic Arthritis.

Taxter AJ, Wileyto EP, Behrens EM, Weiss PF.

J Rheumatol. 2015 Oct;42(10):1914-21. doi: 10.3899/jrheum.150092. Epub 2015 Sep 1.

21.

2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborative Initiative.

Ravelli A, Minoia F, Davì S, Horne A, Bovis F, Pistorio A, Aricò M, Avcin T, Behrens EM, De Benedetti F, Filipovic L, Grom AA, Henter JI, Ilowite NT, Jordan MB, Khubchandani R, Kitoh T, Lehmberg K, Lovell DJ, Miettunen P, Nichols KE, Ozen S, Pachlopnik Schmid J, Ramanan AV, Russo R, Schneider R, Sterba G, Uziel Y, Wallace C, Wouters C, Wulffraat N, Demirkaya E, Brunner HI, Martini A, Ruperto N, Cron RQ; Paediatric Rheumatology International Trials Organisation; Childhood Arthritis and Rheumatology Research Alliance; Pediatric Rheumatology Collaborative Study Group; Histiocyte Society.

Arthritis Rheumatol. 2016 Mar;68(3):566-76. doi: 10.1002/art.39332. Epub 2016 Feb 9.

22.

Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.

Li YR, Li J, Zhao SD, Bradfield JP, Mentch FD, Maggadottir SM, Hou C, Abrams DJ, Chang D, Gao F, Guo Y, Wei Z, Connolly JJ, Cardinale CJ, Bakay M, Glessner JT, Li D, Kao C, Thomas KA, Qiu H, Chiavacci RM, Kim CE, Wang F, Snyder J, Richie MD, Flatø B, Førre Ø, Denson LA, Thompson SD, Becker ML, Guthery SL, Latiano A, Perez E, Resnick E, Russell RK, Wilson DC, Silverberg MS, Annese V, Lie BA, Punaro M, Dubinsky MC, Monos DS, Strisciuglio C, Staiano A, Miele E, Kugathasan S, Ellis JA, Munro JE, Sullivan KE, Wise CA, Chapel H, Cunningham-Rundles C, Grant SF, Orange JS, Sleiman PM, Behrens EM, Griffiths AM, Satsangi J, Finkel TH, Keinan A, Prak ET, Polychronakos C, Baldassano RN, Li H, Keating BJ, Hakonarson H.

Nat Med. 2015 Sep;21(9):1018-27. doi: 10.1038/nm.3933. Epub 2015 Aug 24.

23.

Does Viral Hemorrhagic Fever Represent Reactive Hemophagocytic Syndrome?

Cron RQ, Behrens EM, Shakoory B, Ramanan AV, Chatham WW.

J Rheumatol. 2015 Jul;42(7):1078-80. doi: 10.3899/jrheum.150108. No abstract available.

PMID:
26136549
24.

Kill or be killed.

Behrens EM, Cron RQ.

J Immunol. 2015 Jun 1;194(11):5041-3. doi: 10.4049/jimmunol.1500774. No abstract available.

25.

Toll-like receptor 9 and interferon-γ receptor signaling suppress the B-cell fate of uncommitted progenitors in mice.

Baratono SR, Chu N, Richman LP, Behrens EM.

Eur J Immunol. 2015 May;45(5):1313-25. doi: 10.1002/eji.201445319. Epub 2015 Feb 26.

26.

Genetic defects in cytolysis in macrophage activation syndrome.

Zhang M, Behrens EM, Atkinson TP, Shakoory B, Grom AA, Cron RQ.

Curr Rheumatol Rep. 2014;16(9):439. doi: 10.1007/s11926-014-0439-2. Review.

PMID:
25086802
27.

Hyperinflammation, rather than hemophagocytosis, is the common link between macrophage activation syndrome and hemophagocytic lymphohistiocytosis.

Weaver LK, Behrens EM.

Curr Opin Rheumatol. 2014 Sep;26(5):562-9. doi: 10.1097/BOR.0000000000000093. Review.

28.

Measuring cytotoxicity by bioluminescence imaging outperforms the standard chromium-51 release assay.

Karimi MA, Lee E, Bachmann MH, Salicioni AM, Behrens EM, Kambayashi T, Baldwin CL.

PLoS One. 2014 Feb 19;9(2):e89357. doi: 10.1371/journal.pone.0089357. eCollection 2014.

29.

Brief report: alternative activation of laser-captured murine hemophagocytes.

Canna SW, Costa-Reis P, Bernal WE, Chu N, Sullivan KE, Paessler ME, Behrens EM.

Arthritis Rheumatol. 2014 Jun;66(6):1666-71.

30.

The ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling.

Joshi RP, Schmidt AM, Das J, Pytel D, Riese MJ, Lester M, Diehl JA, Behrens EM, Kambayashi T, Koretzky GA.

Sci Signal. 2013 Nov 26;6(303):ra102. doi: 10.1126/scisignal.2004373.

31.

Chronic non-bacterial osteomyelitis in a patient with common variable immunodeficiency.

Costa-Reis P, Weaver LK, Behrens EM, Sullivan KE.

Joint Bone Spine. 2014 Mar;81(2):193-4. doi: 10.1016/j.jbspin.2013.08.005. Epub 2013 Sep 20. No abstract available.

PMID:
24060398
32.

Interferon-γ mediates anemia but is dispensable for fulminant toll-like receptor 9-induced macrophage activation syndrome and hemophagocytosis in mice.

Canna SW, Wrobel J, Chu N, Kreiger PA, Paessler M, Behrens EM.

Arthritis Rheum. 2013 Jul;65(7):1764-75. doi: 10.1002/art.37958.

33.

Spleen tyrosine kinase (Syk)-dependent calcium signals mediate efficient CpG-induced exocytosis of tumor necrosis factor α (TNFα) in innate immune cells.

Rao S, Liu X, Freedman BD, Behrens EM.

J Biol Chem. 2013 May 3;288(18):12448-58. doi: 10.1074/jbc.M113.454405. Epub 2013 Mar 20.

34.

How to use... antinuclear antibodies in paediatric rheumatic diseases.

Weaver LK, Behrens EM.

Arch Dis Child Educ Pract Ed. 2013 Apr;98(2):64-70. doi: 10.1136/archdischild-2012-303326. No abstract available.

PMID:
23492397
35.

Site-specific accumulation of recently activated CD4+ Foxp3+ regulatory T cells following adoptive transfer.

Lieberman SM, Kim JS, Corbo-Rodgers E, Kambayashi T, Maltzman JS, Behrens EM, Turka LA.

Eur J Immunol. 2012 Jun;42(6):1429-35. doi: 10.1002/eji.201142286.

36.

Myeloid dendritic cells from B6.NZM Sle1/Sle2/Sle3 lupus-prone mice express an IFN signature that precedes disease onset.

Sriram U, Varghese L, Bennett HL, Jog NR, Shivers DK, Ning Y, Behrens EM, Caricchio R, Gallucci S.

J Immunol. 2012 Jul 1;189(1):80-91. doi: 10.4049/jimmunol.1101686. Epub 2012 Jun 1.

37.

Making sense of the cytokine storm: a conceptual framework for understanding, diagnosing, and treating hemophagocytic syndromes.

Canna SW, Behrens EM.

Pediatr Clin North Am. 2012 Apr;59(2):329-44. doi: 10.1016/j.pcl.2012.03.002. Review.

38.

Macrophage activation syndrome as part of systemic juvenile idiopathic arthritis: diagnosis, genetics, pathophysiology and treatment.

Ravelli A, Grom AA, Behrens EM, Cron RQ.

Genes Immun. 2012 Jun;13(4):289-98. doi: 10.1038/gene.2012.3. Epub 2012 Mar 15. Review.

PMID:
22418018
39.

Not all hemophagocytes are created equally: appreciating the heterogeneity of the hemophagocytic syndromes.

Canna SW, Behrens EM.

Curr Opin Rheumatol. 2012 Jan;24(1):113-8. doi: 10.1097/BOR.0b013e32834dd37e. Review.

40.

Enthesitis in an inception cohort of enthesitis-related arthritis.

Weiss PF, Klink AJ, Behrens EM, Sherry DD, Finkel TH, Feudtner C, Keren R.

Arthritis Care Res (Hoboken). 2011 Sep;63(9):1307-12. doi: 10.1002/acr.20508.

41.

Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice.

Behrens EM, Canna SW, Slade K, Rao S, Kreiger PA, Paessler M, Kambayashi T, Koretzky GA.

J Clin Invest. 2011 Jun;121(6):2264-77. doi: 10.1172/JCI43157. Epub 2011 May 16.

42.

1,25 dihydroxyvitamin D3 limits monocyte maturation in lupus sera.

Lerman M, Burnham J, Behrens E.

Lupus. 2011 Jun;20(7):749-53. doi: 10.1177/0961203310394542. Epub 2011 Mar 29.

PMID:
21447602
43.

An international consensus survey of diagnostic criteria for macrophage activation syndrome in systemic juvenile idiopathic arthritis.

Davì S, Consolaro A, Guseinova D, Pistorio A, Ruperto N, Martini A, Cron RQ, Ravelli A; MAS Study Group.

J Rheumatol. 2011 Apr;38(4):764-8. doi: 10.3899/jrheum.100996. Epub 2011 Feb 1.

PMID:
21285158
44.

Successful treatment of severe paediatric rheumatic disease-associated macrophage activation syndrome with interleukin-1 inhibition following conventional immunosuppressive therapy: case series with 12 patients.

Miettunen PM, Narendran A, Jayanthan A, Behrens EM, Cron RQ.

Rheumatology (Oxford). 2011 Feb;50(2):417-9. doi: 10.1093/rheumatology/keq218. Epub 2010 Aug 7. No abstract available.

PMID:
20693540
45.

Apoptotic cell-mediated immunoregulation of dendritic cells does not require iC3b opsonization.

Behrens EM, Ning Y, Muvarak N, Zoltick PW, Flake AW, Gallucci S.

J Immunol. 2008 Sep 1;181(5):3018-26.

46.

Association of the TRAF1-C5 locus on chromosome 9 with juvenile idiopathic arthritis.

Behrens EM, Finkel TH, Bradfield JP, Kim CE, Linton L, Casalunovo T, Frackelton EC, Santa E, Otieno FG, Glessner JT, Chiavacci RM, Grant SF, Hakonarson H.

Arthritis Rheum. 2008 Jul;58(7):2206-7. doi: 10.1002/art.23603. No abstract available.

47.

Identification of novel monosodium urate crystal regulated mRNAs by transcript profiling of dissected murine air pouch membranes.

Pessler F, Mayer CT, Jung SM, Behrens EM, Dai L, Menetski JP, Schumacher HR.

Arthritis Res Ther. 2008;10(3):R64. doi: 10.1186/ar2435. Epub 2008 Jun 3.

48.

Macrophage activation syndrome in rheumatic disease: what is the role of the antigen presenting cell?

Behrens EM.

Autoimmun Rev. 2008 Feb;7(4):305-8. doi: 10.1016/j.autrev.2007.11.025. Epub 2008 Jan 4. Review.

PMID:
18295734
49.

Evaluation of the presentation of systemic onset juvenile rheumatoid arthritis: data from the Pennsylvania Systemic Onset Juvenile Arthritis Registry (PASOJAR).

Behrens EM, Beukelman T, Gallo L, Spangler J, Rosenkranz M, Arkachaisri T, Ayala R, Groh B, Finkel TH, Cron RQ.

J Rheumatol. 2008 Feb;35(2):343-8. Epub 2007 Dec 15.

PMID:
18085728
50.

IL-4 suppresses dendritic cell response to type I interferons.

Sriram U, Biswas C, Behrens EM, Dinnall JA, Shivers DK, Monestier M, Argon Y, Gallucci S.

J Immunol. 2007 Nov 15;179(10):6446-55.

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