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Items: 1 to 50 of 65

1.

Genetic deficiency of IFNγ reveals IFNγ-independent manifestations of murine Hemophagocytic Lymphohistiocytosis.

Burn TN, Weaver L, Rood JE, Chu N, Bodansky A, Kreiger PA, Behrens EM.

Arthritis Rheumatol. 2019 Aug 9. doi: 10.1002/art.41076. [Epub ahead of print]

PMID:
31400073
2.

Altered X-chromosome inactivation in T cells may promote sex-biased autoimmune diseases.

Syrett CM, Paneru B, Sandoval-Heglund D, Wang J, Banerjee S, Sindhava V, Behrens EM, Atchison M, Anguera MC.

JCI Insight. 2019 Apr 4;4(7). pii: 126751. doi: 10.1172/jci.insight.126751. eCollection 2019 Apr 4.

3.

Myeloid Folliculin balances mTOR activation to maintain innate immunity homeostasis.

Li J, Wada S, Weaver LK, Biswas C, Behrens EM, Arany Z.

JCI Insight. 2019 Mar 7;5. pii: 126939. doi: 10.1172/jci.insight.126939.

4.

Sterile particle-induced inflammation is mediated by macrophages releasing IL-33 through a Bruton's tyrosine kinase-dependent pathway.

Mishra PK, Palma M, Buechel B, Moore J, Davra V, Chu N, Millman A, Hallab NJ, Kanneganti TD, Birge RB, Behrens EM, Rivera A, Beebe KS, Benevenia J, Gause WC.

Nat Mater. 2019 Mar;18(3):289-297. doi: 10.1038/s41563-018-0271-6. Epub 2019 Jan 21.

5.

Microbiota-dependent signals are required to sustain TLR-mediated immune responses.

Weaver LK, Minichino D, Biswas C, Chu N, Lee JJ, Bittinger K, Albeituni S, Nichols KE, Behrens EM.

JCI Insight. 2019 Jan 10;4(1). pii: 124370. doi: 10.1172/jci.insight.124370. [Epub ahead of print]

6.

Disruption of IL-33 Signaling Limits Early CD8+ T Cell Effector Function Leading to Exhaustion in Murine Hemophagocytic Lymphohistiocytosis.

Rood JE, Burn TN, Neal V, Chu N, Behrens EM.

Front Immunol. 2018 Nov 20;9:2642. doi: 10.3389/fimmu.2018.02642. eCollection 2018.

7.

Brief Report: Interferon-γ-Mediated Immunopathology Potentiated by Toll-Like Receptor 9 Activation in a Murine Model of Macrophage Activation Syndrome.

Weaver LK, Chu N, Behrens EM.

Arthritis Rheumatol. 2019 Jan;71(1):161-168. doi: 10.1002/art.40683. Epub 2018 Nov 24.

PMID:
30073799
8.

Tyrosine 870 of TLR9 is critical for receptor maturation rather than phosphorylation-dependent ligand-induced signaling.

Biswas C, Rao S, Slade K, Hyman D, Dersh D, Mantegazza AR, Zoltick PW, Marks MS, Argon Y, Behrens EM.

PLoS One. 2018 Jul 19;13(7):e0200913. doi: 10.1371/journal.pone.0200913. eCollection 2018.

9.

CD8 T Cell Memory Increases Immunopathology in the Perforin-Deficient Model of Hemophagocytic Lymphohistiocytosis Secondary to TNF-α.

Taylor MD, Burn TN, Wherry EJ, Behrens EM.

Immunohorizons. 2018 Feb;2(2):67-73. doi: 10.4049/immunohorizons.1800003.

10.

Muscularis macrophage development in the absence of an enteric nervous system.

Avetisyan M, Rood JE, Huerta Lopez S, Sengupta R, Wright-Jin E, Dougherty JD, Behrens EM, Heuckeroth RO.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):4696-4701. doi: 10.1073/pnas.1802490115. Epub 2018 Apr 17.

11.

Indeterminate pediatric acute liver failure is uniquely characterized by a CD103+ CD8+ T-cell infiltrate.

Chapin CA, Burn T, Meijome T, Loomes KM, Melin-Aldana H, Kreiger PA, Whitington PF, Behrens EM, Alonso EM.

Hepatology. 2018 Sep;68(3):1087-1100. doi: 10.1002/hep.29901. Epub 2018 Jul 23.

PMID:
29603342
12.

ECSIT links TLR and BMP signaling in FOP connective tissue progenitor cells.

Wang H, Behrens EM, Pignolo RJ, Kaplan FS.

Bone. 2018 Apr;109:201-209. doi: 10.1016/j.bone.2017.12.024. Epub 2017 Dec 27.

PMID:
29288875
13.

Weathering the storm: Improving therapeutic interventions for cytokine storm syndromes by targeting disease pathogenesis.

Weaver LK, Behrens EM.

Curr Treatm Opt Rheumatol. 2017 Mar;3(1):33-48. doi: 10.1007/s40674-017-0059-x. Epub 2017 Feb 7.

14.

Reply.

Canna SW, Girard C, Malle L, de Jesus A, Romberg N, Kelsen J, Surrey LF, Russo P, Sleight A, Schiffrin E, Gabay C, Goldbach-Mansky R, Behrens EM.

J Allergy Clin Immunol. 2017 Jul;140(1):316-317. doi: 10.1016/j.jaci.2017.03.016. Epub 2017 Apr 29. No abstract available.

PMID:
28460789
15.

Review: Cytokine Storm Syndrome: Looking Toward the Precision Medicine Era.

Behrens EM, Koretzky GA.

Arthritis Rheumatol. 2017 Jun;69(6):1135-1143. doi: 10.1002/art.40071. Review. No abstract available.

16.

IL-10 distinguishes a unique population of activated, effector-like CD8+ T cells in murine acute liver inflammation.

Rood JE, Canna SW, Weaver LK, Tobias JW, Behrens EM.

J Leukoc Biol. 2017 Apr;101(4):1037-1044. doi: 10.1189/jlb.3A0916-221RR. Epub 2016 Dec 29.

17.

Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition.

Canna SW, Girard C, Malle L, de Jesus A, Romberg N, Kelsen J, Surrey LF, Russo P, Sleight A, Schiffrin E, Gabay C, Goldbach-Mansky R, Behrens EM.

J Allergy Clin Immunol. 2017 May;139(5):1698-1701. doi: 10.1016/j.jaci.2016.10.022. Epub 2016 Nov 19. No abstract available.

18.

Pediatric acute liver failure of undetermined cause: A research workshop.

Alonso EM, Horslen SP, Behrens EM, Doo E.

Hepatology. 2017 Mar;65(3):1026-1037. doi: 10.1002/hep.28944. Epub 2017 Jan 6. Review.

19.

Editorial: Caught in the Act: Dissecting Natural Killer Cell Function in Systemic Juvenile Idiopathic Arthritis.

Behrens EM.

Arthritis Rheumatol. 2017 Jan;69(1):6-8. doi: 10.1002/art.39934. No abstract available.

20.

TLR9-mediated inflammation drives a Ccr2-independent peripheral monocytosis through enhanced extramedullary monocytopoiesis.

Weaver LK, Chu N, Behrens EM.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10944-9. doi: 10.1073/pnas.1524487113. Epub 2016 Sep 12.

21.

Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility.

Finkel TH, Li J, Wei Z, Wang W, Zhang H, Behrens EM, Reuschel EL, Limou S, Wise C, Punaro M, Becker ML, Munro JE, Flatø B, Førre Ø, Thompson SD, Langefeld CD, Glass DN, Glessner JT, Kim CE, Frackelton E, Shivers DK, Thomas KA, Chiavacci RM, Hou C, Xu K, Snyder J, Qiu H, Mentch F, Wang K, Winkler CA, Lie BA, Ellis JA, Hakonarson H.

BMC Med Genet. 2016 Mar 22;17:24. doi: 10.1186/s12881-016-0285-3.

22.

2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborative Initiative.

Ravelli A, Minoia F, Davì S, Horne A, Bovis F, Pistorio A, Aricò M, Avcin T, Behrens EM, De Benedetti F, Filipovic L, Grom AA, Henter JI, Ilowite NT, Jordan MB, Khubchandani R, Kitoh T, Lehmberg K, Lovell DJ, Miettunen P, Nichols KE, Ozen S, Pachlopnik Schmid J, Ramanan AV, Russo R, Schneider R, Sterba G, Uziel Y, Wallace C, Wouters C, Wulffraat N, Demirkaya E, Brunner HI, Martini A, Ruperto N, Cron RQ; Paediatric Rheumatology International Trials Organisation; Childhood Arthritis and Rheumatology Research Alliance; Pediatric Rheumatology Collaborative Study Group; Histiocyte Society.

Ann Rheum Dis. 2016 Mar;75(3):481-9. doi: 10.1136/annrheumdis-2015-208982.

PMID:
26865703
23.

Expert consensus on dynamics of laboratory tests for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis.

Ravelli A, Minoia F, Davì S, Horne A, Bovis F, Pistorio A, Aricò M, Avcin T, Behrens EM, De Benedetti F, Filipovic A, Grom AA, Henter JI, Ilowite NT, Jordan MB, Khubchandani R, Kitoh T, Lehmberg K, Lovell DJ, Miettunen P, Nichols KE, Ozen S, Pachlopnik Schmid J, Ramanan AV, Russo R, Schneider R, Sterba G, Uziel Y, Wallace C, Wouters C, Wulffraat N, Demirkaya E, Brunner HI, Martini A, Ruperto N, Cron RQ.

RMD Open. 2016 Jan 19;2(1):e000161. doi: 10.1136/rmdopen-2015-000161. eCollection 2016.

24.

Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis.

Das R, Guan P, Sprague L, Verbist K, Tedrick P, An QA, Cheng C, Kurachi M, Levine R, Wherry EJ, Canna SW, Behrens EM, Nichols KE.

Blood. 2016 Mar 31;127(13):1666-75. doi: 10.1182/blood-2015-12-684399. Epub 2016 Jan 29.

25.

ST2 contributes to T-cell hyperactivation and fatal hemophagocytic lymphohistiocytosis in mice.

Rood JE, Rao S, Paessler M, Kreiger PA, Chu N, Stelekati E, Wherry EJ, Behrens EM.

Blood. 2016 Jan 28;127(4):426-35. doi: 10.1182/blood-2015-07-659813. Epub 2015 Oct 30.

26.

BIRC4 Mutation: An Important Rare Cause of Uveitis.

Basiaga ML, Weiss PF, Behrens EM.

J Clin Rheumatol. 2015 Dec;21(8):444-7. doi: 10.1097/RHU.0000000000000327.

27.

Genetic sharing and heritability of paediatric age of onset autoimmune diseases.

Li YR, Zhao SD, Li J, Bradfield JP, Mohebnasab M, Steel L, Kobie J, Abrams DJ, Mentch FD, Glessner JT, Guo Y, Wei Z, Connolly JJ, Cardinale CJ, Bakay M, Li D, Maggadottir SM, Thomas KA, Qui H, Chiavacci RM, Kim CE, Wang F, Snyder J, Flatø B, Førre Ø, Denson LA, Thompson SD, Becker ML, Guthery SL, Latiano A, Perez E, Resnick E, Strisciuglio C, Staiano A, Miele E, Silverberg MS, Lie BA, Punaro M, Russell RK, Wilson DC, Dubinsky MC, Monos DS, Annese V, Munro JE, Wise C, Chapel H, Cunningham-Rundles C, Orange JS, Behrens EM, Sullivan KE, Kugathasan S, Griffiths AM, Satsangi J, Grant SFA, Sleiman PMA, Finkel TH, Polychronakos C, Baldassano RN, Luning Prak ET, Ellis JA, Li H, Keating BJ, Hakonarson H.

Nat Commun. 2015 Oct 9;6:8442. doi: 10.1038/ncomms9442.

28.

Patient-reported Outcomes across Categories of Juvenile Idiopathic Arthritis.

Taxter AJ, Wileyto EP, Behrens EM, Weiss PF.

J Rheumatol. 2015 Oct;42(10):1914-21. doi: 10.3899/jrheum.150092. Epub 2015 Sep 1.

29.

2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborative Initiative.

Ravelli A, Minoia F, Davì S, Horne A, Bovis F, Pistorio A, Aricò M, Avcin T, Behrens EM, De Benedetti F, Filipovic L, Grom AA, Henter JI, Ilowite NT, Jordan MB, Khubchandani R, Kitoh T, Lehmberg K, Lovell DJ, Miettunen P, Nichols KE, Ozen S, Pachlopnik Schmid J, Ramanan AV, Russo R, Schneider R, Sterba G, Uziel Y, Wallace C, Wouters C, Wulffraat N, Demirkaya E, Brunner HI, Martini A, Ruperto N, Cron RQ; Paediatric Rheumatology International Trials Organisation; Childhood Arthritis and Rheumatology Research Alliance; Pediatric Rheumatology Collaborative Study Group; Histiocyte Society.

Arthritis Rheumatol. 2016 Mar;68(3):566-76. doi: 10.1002/art.39332. Epub 2016 Feb 9.

30.

Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.

Li YR, Li J, Zhao SD, Bradfield JP, Mentch FD, Maggadottir SM, Hou C, Abrams DJ, Chang D, Gao F, Guo Y, Wei Z, Connolly JJ, Cardinale CJ, Bakay M, Glessner JT, Li D, Kao C, Thomas KA, Qiu H, Chiavacci RM, Kim CE, Wang F, Snyder J, Richie MD, Flatø B, Førre Ø, Denson LA, Thompson SD, Becker ML, Guthery SL, Latiano A, Perez E, Resnick E, Russell RK, Wilson DC, Silverberg MS, Annese V, Lie BA, Punaro M, Dubinsky MC, Monos DS, Strisciuglio C, Staiano A, Miele E, Kugathasan S, Ellis JA, Munro JE, Sullivan KE, Wise CA, Chapel H, Cunningham-Rundles C, Grant SF, Orange JS, Sleiman PM, Behrens EM, Griffiths AM, Satsangi J, Finkel TH, Keinan A, Prak ET, Polychronakos C, Baldassano RN, Li H, Keating BJ, Hakonarson H.

Nat Med. 2015 Sep;21(9):1018-27. doi: 10.1038/nm.3933. Epub 2015 Aug 24.

31.

Does Viral Hemorrhagic Fever Represent Reactive Hemophagocytic Syndrome?

Cron RQ, Behrens EM, Shakoory B, Ramanan AV, Chatham WW.

J Rheumatol. 2015 Jul;42(7):1078-80. doi: 10.3899/jrheum.150108. No abstract available.

PMID:
26136549
32.

Kill or be killed.

Behrens EM, Cron RQ.

J Immunol. 2015 Jun 1;194(11):5041-3. doi: 10.4049/jimmunol.1500774. No abstract available.

33.

Toll-like receptor 9 and interferon-γ receptor signaling suppress the B-cell fate of uncommitted progenitors in mice.

Baratono SR, Chu N, Richman LP, Behrens EM.

Eur J Immunol. 2015 May;45(5):1313-25. doi: 10.1002/eji.201445319. Epub 2015 Feb 26.

34.

Genetic defects in cytolysis in macrophage activation syndrome.

Zhang M, Behrens EM, Atkinson TP, Shakoory B, Grom AA, Cron RQ.

Curr Rheumatol Rep. 2014;16(9):439. doi: 10.1007/s11926-014-0439-2. Review.

PMID:
25086802
35.

Hyperinflammation, rather than hemophagocytosis, is the common link between macrophage activation syndrome and hemophagocytic lymphohistiocytosis.

Weaver LK, Behrens EM.

Curr Opin Rheumatol. 2014 Sep;26(5):562-9. doi: 10.1097/BOR.0000000000000093. Review.

36.

Measuring cytotoxicity by bioluminescence imaging outperforms the standard chromium-51 release assay.

Karimi MA, Lee E, Bachmann MH, Salicioni AM, Behrens EM, Kambayashi T, Baldwin CL.

PLoS One. 2014 Feb 19;9(2):e89357. doi: 10.1371/journal.pone.0089357. eCollection 2014.

37.

Brief report: alternative activation of laser-captured murine hemophagocytes.

Canna SW, Costa-Reis P, Bernal WE, Chu N, Sullivan KE, Paessler ME, Behrens EM.

Arthritis Rheumatol. 2014 Jun;66(6):1666-71.

38.

The ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling.

Joshi RP, Schmidt AM, Das J, Pytel D, Riese MJ, Lester M, Diehl JA, Behrens EM, Kambayashi T, Koretzky GA.

Sci Signal. 2013 Nov 26;6(303):ra102. doi: 10.1126/scisignal.2004373.

39.

Chronic non-bacterial osteomyelitis in a patient with common variable immunodeficiency.

Costa-Reis P, Weaver LK, Behrens EM, Sullivan KE.

Joint Bone Spine. 2014 Mar;81(2):193-4. doi: 10.1016/j.jbspin.2013.08.005. Epub 2013 Sep 20. No abstract available.

PMID:
24060398
40.

Interferon-γ mediates anemia but is dispensable for fulminant toll-like receptor 9-induced macrophage activation syndrome and hemophagocytosis in mice.

Canna SW, Wrobel J, Chu N, Kreiger PA, Paessler M, Behrens EM.

Arthritis Rheum. 2013 Jul;65(7):1764-75. doi: 10.1002/art.37958.

41.

Spleen tyrosine kinase (Syk)-dependent calcium signals mediate efficient CpG-induced exocytosis of tumor necrosis factor α (TNFα) in innate immune cells.

Rao S, Liu X, Freedman BD, Behrens EM.

J Biol Chem. 2013 May 3;288(18):12448-58. doi: 10.1074/jbc.M113.454405. Epub 2013 Mar 20.

42.

How to use... antinuclear antibodies in paediatric rheumatic diseases.

Weaver LK, Behrens EM.

Arch Dis Child Educ Pract Ed. 2013 Apr;98(2):64-70. doi: 10.1136/archdischild-2012-303326. No abstract available.

PMID:
23492397
43.

Site-specific accumulation of recently activated CD4+ Foxp3+ regulatory T cells following adoptive transfer.

Lieberman SM, Kim JS, Corbo-Rodgers E, Kambayashi T, Maltzman JS, Behrens EM, Turka LA.

Eur J Immunol. 2012 Jun;42(6):1429-35. doi: 10.1002/eji.201142286.

44.

Myeloid dendritic cells from B6.NZM Sle1/Sle2/Sle3 lupus-prone mice express an IFN signature that precedes disease onset.

Sriram U, Varghese L, Bennett HL, Jog NR, Shivers DK, Ning Y, Behrens EM, Caricchio R, Gallucci S.

J Immunol. 2012 Jul 1;189(1):80-91. doi: 10.4049/jimmunol.1101686. Epub 2012 Jun 1.

45.

Making sense of the cytokine storm: a conceptual framework for understanding, diagnosing, and treating hemophagocytic syndromes.

Canna SW, Behrens EM.

Pediatr Clin North Am. 2012 Apr;59(2):329-44. doi: 10.1016/j.pcl.2012.03.002. Review.

46.

Macrophage activation syndrome as part of systemic juvenile idiopathic arthritis: diagnosis, genetics, pathophysiology and treatment.

Ravelli A, Grom AA, Behrens EM, Cron RQ.

Genes Immun. 2012 Jun;13(4):289-98. doi: 10.1038/gene.2012.3. Epub 2012 Mar 15. Review.

PMID:
22418018
47.

Not all hemophagocytes are created equally: appreciating the heterogeneity of the hemophagocytic syndromes.

Canna SW, Behrens EM.

Curr Opin Rheumatol. 2012 Jan;24(1):113-8. doi: 10.1097/BOR.0b013e32834dd37e. Review.

48.

Enthesitis in an inception cohort of enthesitis-related arthritis.

Weiss PF, Klink AJ, Behrens EM, Sherry DD, Finkel TH, Feudtner C, Keren R.

Arthritis Care Res (Hoboken). 2011 Sep;63(9):1307-12. doi: 10.1002/acr.20508.

49.

Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice.

Behrens EM, Canna SW, Slade K, Rao S, Kreiger PA, Paessler M, Kambayashi T, Koretzky GA.

J Clin Invest. 2011 Jun;121(6):2264-77. doi: 10.1172/JCI43157. Epub 2011 May 16.

50.

1,25 dihydroxyvitamin D3 limits monocyte maturation in lupus sera.

Lerman M, Burnham J, Behrens E.

Lupus. 2011 Jun;20(7):749-53. doi: 10.1177/0961203310394542. Epub 2011 Mar 29.

PMID:
21447602

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