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Items: 1 to 50 of 97

1.

Cationic Oligospermine-Oligonucleotide Conjugates Provide Carrier-free Splice Switching in Monolayer Cells and Spheroids.

Nothisen M, Perche-Létuvée P, Behr JP, Remy JS, Kotera M.

Mol Ther Nucleic Acids. 2018 Dec 7;13:483-492. doi: 10.1016/j.omtn.2018.09.027. Epub 2018 Oct 10.

2.

Structure Tuning of Cationic Oligospermine-siRNA Conjugates for Carrier-Free Gene Silencing.

Nothisen M, Bagilet J, Behr JP, Remy JS, Kotera M.

Mol Pharm. 2016 Aug 1;13(8):2718-28. doi: 10.1021/acs.molpharmaceut.6b00309. Epub 2016 Jul 20.

PMID:
27398779
3.

Sticky siRNAs targeting survivin and cyclin B1 exert an antitumoral effect on melanoma subcutaneous xenografts and lung metastases.

Kedinger V, Meulle A, Zounib O, Bonnet ME, Gossart JB, Benoit E, Messmer M, Shankaranarayanan P, Behr JP, Erbacher P, Bolcato-Bellemin AL.

BMC Cancer. 2013 Jul 9;13:338. doi: 10.1186/1471-2407-13-338.

4.

Systemic delivery of sticky siRNAs targeting the cell cycle for lung tumor metastasis inhibition.

Bonnet ME, Gossart JB, Benoit E, Messmer M, Zounib O, Moreau V, Behr JP, Lenne-Samuel N, Kedinger V, Meulle A, Erbacher P, Bolcato-Bellemin AL.

J Control Release. 2013 Sep 10;170(2):183-90. doi: 10.1016/j.jconrel.2013.05.015. Epub 2013 May 29.

PMID:
23727288
5.

Cell-penetrating cationic siRNA and lipophilic derivatives efficient at nanomolar concentrations in the presence of serum and albumin.

Perche P, Nothisen M, Bagilet J, Behr JP, Kotera M, Remy JS.

J Control Release. 2013 Aug 28;170(1):92-8. doi: 10.1016/j.jconrel.2013.04.013. Epub 2013 Apr 29.

PMID:
23639452
6.

Conjugating phosphospermines to siRNAs for improved stability in serum, intracellular delivery and RNAi-mediated gene silencing.

Paris C, Moreau V, Deglane G, Karim L, Couturier B, Bonnet ME, Kedinger V, Messmer M, Bolcato-Bellemin AL, Behr JP, Erbacher P, Lenne-Samuel N.

Mol Pharm. 2012 Dec 3;9(12):3464-75. doi: 10.1021/mp300278b. Epub 2012 Nov 14.

PMID:
23148419
7.

An amphiphilic dendrimer for effective delivery of small interfering RNA and gene silencing in vitro and in vivo.

Yu T, Liu X, Bolcato-Bellemin AL, Wang Y, Liu C, Erbacher P, Qu F, Rocchi P, Behr JP, Peng L.

Angew Chem Int Ed Engl. 2012 Aug 20;51(34):8478-84. doi: 10.1002/anie.201203920. Epub 2012 Jul 24.

PMID:
22829421
8.

Synthetic gene transfer vectors II: back to the future.

Behr JP.

Acc Chem Res. 2012 Jul 17;45(7):980-4. doi: 10.1021/ar200213g. Epub 2012 Feb 6.

PMID:
22311735
9.

Structurally flexible triethanolamine core PAMAM dendrimers are effective nanovectors for DNA transfection in vitro and in vivo to the mouse thymus.

Liu X, Wu J, Yammine M, Zhou J, Posocco P, Viel S, Liu C, Ziarelli F, Fermeglia M, Pricl S, Victorero G, Nguyen C, Erbacher P, Behr JP, Peng L.

Bioconjug Chem. 2011 Dec 21;22(12):2461-73. doi: 10.1021/bc200275g. Epub 2011 Nov 22.

PMID:
22053932
10.

Clinical adenoviral gene therapy for prostate cancer.

Schenk E, Essand M, Bangma CH; GIANT FP6 Consortium, Barber C, Behr JP, Briggs S, Carlisle R, Cheng WS, Danielsson A, Dautzenberg IJ, Dzojic H, Erbacher P, Fisher K, Frazier A, Georgopoulos LJ, Hoeben R, Kochanek S, Koppers-Lalic D, Kraaij R, Kreppel F, Lindholm L, Magnusson M, Maitland N, Neuberg P, Nilsson B, Ogris M, Remy JS, Scaife M, Schooten E, Seymour L, Totterman T, Uil TG, Ulbrich K, Veldhoven-Zweistra JL, de Vrij J, van Weerden W, Wagner E, Willemsen R.

Hum Gene Ther. 2010 Jul;21(7):807-13. doi: 10.1089/hum.2009.206. Review.

PMID:
20001452
11.

Adenovirus-derived vectors for prostate cancer gene therapy.

de Vrij J, Willemsen RA, Lindholm L, Hoeben RC; GIANT Consortium, Bangma CH, Barber C, Behr JP, Briggs S, Carlisle R, Cheng WS, Dautzenberg IJ, de Ridder C, Dzojic H, Erbacher P, Essand M, Fisher K, Frazier A, Georgopoulos LJ, Jennings I, Kochanek S, Koppers-Lalic D, Kraaij R, Kreppel F, Magnusson M, Maitland N, Neuberg P, Nugent R, Ogris M, Remy JS, Scaife M, Schenk-Braat E, Schooten E, Seymour L, Slade M, Szyjanowicz P, Totterman T, Uil TG, Ulbrich K, van der Weel L, van Weerden W, Wagner E, Zuber G.

Hum Gene Ther. 2010 Jul;21(7):795-805. doi: 10.1089/hum.2009.203. Review.

PMID:
19947826
12.

Cationic siRNAs provide carrier-free gene silencing in animal cells.

Nothisen M, Kotera M, Voirin E, Remy JS, Behr JP.

J Am Chem Soc. 2009 Dec 16;131(49):17730-1. doi: 10.1021/ja908017e.

PMID:
19928854
13.

Zip Nucleic Acids: new high affinity oligonucleotides as potent primers for PCR and reverse transcription.

Moreau V, Voirin E, Paris C, Kotera M, Nothisen M, Rémy JS, Behr JP, Erbacher P, Lenne-Samuel N.

Nucleic Acids Res. 2009 Oct;37(19):e130. doi: 10.1093/nar/gkp661. Epub 2009 Aug 20.

14.

Synthetic viruslike particles for targeted gene delivery to alphavbeta3 integrin-presenting endothelial cells.

Zuber G, Dontenwill M, Behr JP.

Mol Pharm. 2009 Sep-Oct;6(5):1544-52. doi: 10.1021/mp900105q.

PMID:
19685893
15.

Oligonucleotide-oligospermine conjugates (zip nucleic acids): a convenient means of finely tuning hybridization temperatures.

Noir R, Kotera M, Pons B, Remy JS, Behr JP.

J Am Chem Soc. 2008 Oct 8;130(40):13500-5. doi: 10.1021/ja804727a. Epub 2008 Sep 10.

PMID:
18781743
16.

Sticky overhangs enhance siRNA-mediated gene silencing.

Bolcato-Bellemin AL, Bonnet ME, Creusat G, Erbacher P, Behr JP.

Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16050-5. Epub 2007 Oct 3.

17.

Versatile synthesis of oligodeoxyribonucleotide-oligospermine conjugates.

Voirin E, Behr JP, Kotera M.

Nat Protoc. 2007;2(6):1360-7.

PMID:
17545974
18.
19.

Online synthesis of diblock cationic oligonucleotides for enhanced hybridization to their complementary sequence.

Pons B, Kotera M, Zuber G, Behr JP.

Chembiochem. 2006 Aug;7(8):1173-6. No abstract available.

PMID:
16874748
20.

PAMAM dendrimers for efficient siRNA delivery and potent gene silencing.

Zhou J, Wu J, Hafdi N, Behr JP, Erbacher P, Peng L.

Chem Commun (Camb). 2006 Jun 14;(22):2362-4. Epub 2006 May 10.

PMID:
16733580
21.

Eradication of p53-mutated head and neck squamous cell carcinoma xenografts using nonviral p53 gene therapy and photochemical internalization.

Ndoye A, Dolivet G, Høgset A, Leroux A, Fifre A, Erbacher P, Berg K, Behr JP, Guillemin F, Merlin JL.

Mol Ther. 2006 Jun;13(6):1156-62. Epub 2006 Mar 27.

22.

omega-Hydrazino linear polyethylenimine: a monoconjugation building block for nucleic acid delivery.

Pons B, Mouhoubi L, Adib A, Godzina P, Behr JP, Zuber G.

Chembiochem. 2006 Feb;7(2):303-9.

PMID:
16416489
23.
24.

Polyethylenimine (PEI).

Demeneix B, Behr JP.

Adv Genet. 2005;53PA:215-230.

PMID:
16243065
25.

Polyethylenimine (PEI).

Demeneix B, Behr JP.

Adv Genet. 2005;53:217-30. Review.

PMID:
16240995
26.

Intraperitoneal linear polyethylenimine (L-PEI)-mediated gene delivery to ovarian carcinoma nodes in mice.

Louis MH, Dutoit S, Denoux Y, Erbacher P, Deslandes E, Behr JP, Gauduchon P, Poulain L.

Cancer Gene Ther. 2006 Apr;13(4):367-74.

PMID:
16167064
27.

Monomolecular DNA nanoparticles for intravenous delivery of genes.

Chittimalla C, Zammut-Italiano L, Zuber G, Behr JP.

J Am Chem Soc. 2005 Aug 17;127(32):11436-41.

PMID:
16089472
28.

DermaVir: a novel topical vaccine for HIV/AIDS.

Lisziewicz J, Trocio J, Whitman L, Varga G, Xu J, Bakare N, Erbacher P, Fox C, Woodward R, Markham P, Arya S, Behr JP, Lori F.

J Invest Dermatol. 2005 Jan;124(1):160-9.

29.

Towards multifunctional synthetic vectors.

Demeneix B, Hassani Z, Behr JP.

Curr Gene Ther. 2004 Dec;4(4):445-55. Review.

PMID:
15578993
30.

Sustained gene transfer and enhanced cell death following glucosylated-PEI-mediated p53 gene transfer with photochemical internalisation in p53-mutated head and neck carcinoma cells.

Ndoye A, Bouali S, Dolivet G, Leroux A, Erbacher P, Behr JP, Berg K, Guillemin F, Merlin JL.

Int J Oncol. 2004 Dec;25(6):1575-81.

PMID:
15547693
31.

Lipid-mediated siRNA delivery down-regulates exogenous gene expression in the mouse brain at picomolar levels.

Hassani Z, Lemkine GF, Erbacher P, Palmier K, Alfama G, Giovannangeli C, Behr JP, Demeneix BA.

J Gene Med. 2005 Feb;7(2):198-207.

PMID:
15515135
32.

Genuine DNA/polyethylenimine (PEI) complexes improve transfection properties and cell survival.

Erbacher P, Bettinger T, Brion E, Coll JL, Plank C, Behr JP, Remy JS.

J Drug Target. 2004 May;12(4):223-36.

PMID:
15506171
33.

Enhanced gene transfer and cell death following p53 gene transfer using photochemical internalisation of glucosylated PEI-DNA complexes.

Ndoye A, Merlin JL, Leroux A, Dolivet G, Erbacher P, Behr JP, Berg K, Guillemin F.

J Gene Med. 2004 Aug;6(8):884-94.

PMID:
15293347
34.

The cyclin-dependent kinase inhibitor p21(cip1/waf1) enhances the cytotoxicity of ganciclovir in HSV-tk transfected ovarian carcinoma cells.

Ziller C, Lincet H, Muller CD, Staedel C, Behr JP, Poulain L.

Cancer Lett. 2004 Aug 20;212(1):43-52.

PMID:
15246560
35.

A model for non-viral gene delivery: through syndecan adhesion molecules and powered by actin.

Kopatz I, Remy JS, Behr JP.

J Gene Med. 2004 Jul;6(7):769-76.

PMID:
15241784
36.

Intracytoplasmic delivery of anionic proteins.

Dalkara D, Zuber G, Behr JP.

Mol Ther. 2004 Jun;9(6):964-9.

37.

Effective polyethylenimine-mediated gene transfer into human endothelial cells.

Zaric V, Weltin D, Erbacher P, Remy JS, Behr JP, Stephan D.

J Gene Med. 2004 Feb;6(2):176-84.

PMID:
14978771
38.

Targeted gene delivery to cancer cells: directed assembly of nanometric DNA particles coated with folic acid.

Zuber G, Zammut-Italiano L, Dauty E, Behr JP.

Angew Chem Int Ed Engl. 2003 Jun 16;42(23):2666-9. No abstract available.

PMID:
12813749
39.

In vivo growth inhibitory effect of iterative wild-type p53 gene transfer in human head and neck carcinoma xenografts using glucosylated polyethylenimine nonviral vector.

Dolivet G, Merlin JL, Barberi-Heyob M, Ramacci C, Erbacher P, Parache RM, Behr JP, Guillemin F.

Cancer Gene Ther. 2002 Aug;9(8):708-14.

40.

Intracellular delivery of nanometric DNA particles via the folate receptor.

Dauty E, Remy JS, Zuber G, Behr JP.

Bioconjug Chem. 2002 Jul-Aug;13(4):831-9.

PMID:
12121139
41.

Development of plasmid and oligonucleotide nanometric particles.

Dauty E, Behr JP, Remy JS.

Gene Ther. 2002 Jun;9(11):743-8.

42.

Towards synthetic viruses.

Zuber G, Dauty E, Nothisen M, Belguise P, Behr JP.

Adv Drug Deliv Rev. 2001 Nov 19;52(3):245-53. Review.

PMID:
11718949
43.

Recognition of DNA by strand invasion with oligonucleotide-spermine conjugates.

Potier PF, Behr JP.

Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):809-13.

PMID:
11563121
44.

Dimerizable cationic detergents with a low cmc condense plasmid DNA into nanometric particles and transfect cells in culture.

Dauty E, Remy JS, Blessing T, Behr JP.

J Am Chem Soc. 2001 Sep 26;123(38):9227-34.

PMID:
11562201
45.

Induction of potent human immunodeficiency virus type 1-specific T-cell-restricted immunity by genetically modified dendritic cells.

Lisziewicz J, Gabrilovich DI, Varga G, Xu J, Greenberg PD, Arya SK, Bosch M, Behr JP, Lori F.

J Virol. 2001 Aug;75(16):7621-8.

46.

DNA condensation by an oxidizable cationic detergent. Interactions with lipid vesicles.

Lleres D, Dauty E, Behr JP, Mély Y, Duportail G.

Chem Phys Lipids. 2001 May;111(1):59-71.

PMID:
11438284
47.

Inhibition of hepadnaviral replication by polyethylenimine-based intravenous delivery of antisense phosphodiester oligodeoxynucleotides to the liver.

Robaczewska M, Guerret S, Remy JS, Chemin I, Offensperger WB, Chevallier M, Behr JP, Podhajska AJ, Blum HE, Trepo C, Cova L.

Gene Ther. 2001 Jun;8(11):874-81.

48.

Conjugation of folate via gelonin carbohydrate residues retains ribosomal-inactivating properties of the toxin and permits targeting to folate receptor positive cells.

Atkinson SF, Bettinger T, Seymour LW, Behr JP, Ward CM.

J Biol Chem. 2001 Jul 27;276(30):27930-5. Epub 2001 May 18.

49.

Improvement of nonviral p53 gene transfer in human carcinoma cells using glucosylated polyethylenimine derivatives.

Merlin JL, Dolivet G, Dubessy C, Festor E, Parache RM, Verneuil L, Erbacher P, Behr JP, Guillemin F.

Cancer Gene Ther. 2001 Mar;8(3):203-10.

50.

Nonviral gene delivery: Towards artificial viruses.

Belguise-Valladier P, Behr JP.

Cytotechnology. 2001 May;35(3):197-201. doi: 10.1023/A:1013133605406.

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