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Items: 17


Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile.

Tokuhara H, Imaeda Y, Fukase Y, Iwanaga K, Taya N, Watanabe K, Kanagawa R, Matsuda K, Kajimoto Y, Kusumoto K, Kondo M, Snell G, Behnke CA, Kuroita T.

Bioorg Med Chem. 2018 Jul 23;26(12):3261-3286. doi: 10.1016/j.bmc.2018.04.051. Epub 2018 Apr 27.


Novel approach of fragment-based lead discovery applied to renin inhibitors.

Tawada M, Suzuki S, Imaeda Y, Oki H, Snell G, Behnke CA, Kondo M, Tarui N, Tanaka T, Kuroita T, Tomimoto M.

Bioorg Med Chem. 2016 Nov 15;24(22):6066-6074. doi: 10.1016/j.bmc.2016.09.065. Epub 2016 Sep 28.


Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors.

Imaeda Y, Tawada M, Suzuki S, Tomimoto M, Kondo M, Tarui N, Sanada T, Kanagawa R, Snell G, Behnke CA, Kubo K, Kuroita T.

Bioorg Med Chem. 2016 Nov 15;24(22):5771-5780. doi: 10.1016/j.bmc.2016.09.030. Epub 2016 Sep 13.


Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor.

Imaeda Y, Tokuhara H, Fukase Y, Kanagawa R, Kajimoto Y, Kusumoto K, Kondo M, Snell G, Behnke CA, Kuroita T.

ACS Med Chem Lett. 2016 Sep 12;7(10):933-938. eCollection 2016 Oct 13.


The structure of rice weevil pectin methylesterase.

Teller DC, Behnke CA, Pappan K, Shen Z, Reese JC, Reeck GR, Stenkamp RE.

Acta Crystallogr F Struct Biol Commun. 2014 Nov;70(Pt 11):1480-4. doi: 10.1107/S2053230X14020433. Epub 2014 Oct 25.


Spectroradiometric monitoring for open outdoor culturing of algae and cyanobacteria.

Reichardt TA, Collins AM, McBride RC, Behnke CA, Timlin JA.

Appl Opt. 2014 Aug 20;53(24):F31-45. doi: 10.1364/AO.53.000F31.


Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.

Kono M, Matsumoto T, Kawamura T, Nishimura A, Kiyota Y, Oki H, Miyazaki J, Igaki S, Behnke CA, Shimojo M, Kori M.

Bioorg Med Chem. 2013 Jan 1;21(1):28-41. doi: 10.1016/j.bmc.2012.11.006. Epub 2012 Nov 15.


Manipulating fatty acid biosynthesis in microalgae for biofuel through protein-protein interactions.

Blatti JL, Beld J, Behnke CA, Mendez M, Mayfield SP, Burkart MD.

PLoS One. 2012;7(9):e42949. doi: 10.1371/journal.pone.0042949. Epub 2012 Sep 13.


Engineering highly thermostable xylanase variants using an enhanced combinatorial library method.

Hokanson CA, Cappuccilli G, Odineca T, Bozic M, Behnke CA, Mendez M, Coleman WJ, Crea R.

Protein Eng Des Sel. 2011 Aug;24(8):597-605. doi: 10.1093/protein/gzr028. Epub 2011 Jun 26.


Atomic resolution studies of carbonic anhydrase II.

Behnke CA, Le Trong I, Godden JW, Merritt EA, Teller DC, Bajorath J, Stenkamp RE.

Acta Crystallogr D Biol Crystallogr. 2010 May;66(Pt 5):616-27. doi: 10.1107/S0907444910006554. Epub 2010 Apr 21.


Production of therapeutic proteins in algae, analysis of expression of seven human proteins in the chloroplast of Chlamydomonas reinhardtii.

Rasala BA, Muto M, Lee PA, Jager M, Cardoso RM, Behnke CA, Kirk P, Hokanson CA, Crea R, Mendez M, Mayfield SP.

Plant Biotechnol J. 2010 Aug;8(6):719-33. doi: 10.1111/j.1467-7652.2010.00503.x. Epub 2010 Mar 7.


The mechanism of topoisomerase I poisoning by a camptothecin analog.

Staker BL, Hjerrild K, Feese MD, Behnke CA, Burgin AB Jr, Stewart L.

Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15387-92. Epub 2002 Nov 8.


Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs).

Teller DC, Okada T, Behnke CA, Palczewski K, Stenkamp RE.

Biochemistry. 2001 Jul 3;40(26):7761-72. Review. No abstract available.


Crystal structure of rhodopsin: A G protein-coupled receptor.

Palczewski K, Kumasaka T, Hori T, Behnke CA, Motoshima H, Fox BA, Le Trong I, Teller DC, Okada T, Stenkamp RE, Yamamoto M, Miyano M.

Science. 2000 Aug 4;289(5480):739-45.


X-Ray diffraction analysis of three-dimensional crystals of bovine rhodopsin obtained from mixed micelles.

Okada T, Le Trong I, Fox BA, Behnke CA, Stenkamp RE, Palczewski K.

J Struct Biol. 2000 May;130(1):73-80.


Structural determinants of the bifunctional corn Hageman factor inhibitor: x-ray crystal structure at 1.95 A resolution.

Behnke CA, Yee VC, Trong IL, Pedersen LC, Stenkamp RE, Kim SS, Reeck GR, Teller DC.

Biochemistry. 1998 Nov 3;37(44):15277-88.


Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia.

Barry MA, Behnke CA, Eastman A.

Biochem Pharmacol. 1990 Nov 15;40(10):2353-62.


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