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Items: 1 to 50 of 129

1.

Rational Design of Small Molecules to Enhance Genome Editing Efficiency by Selectively Targeting Distinct Functional States of CRISPR-Cas12a.

Li W, Chan C, Zeng C, Turk R, Behlke MA, Cheng X, Dong Y.

Bioconjug Chem. 2020 Mar 18;31(3):542-546. doi: 10.1021/acs.bioconjchem.0c00062. Epub 2020 Mar 6.

PMID:
32119776
2.

Chemical Modifications in RNA Interference and CRISPR/Cas Genome Editing Reagents.

Lennox KA, Behlke MA.

Methods Mol Biol. 2020;2115:23-55. doi: 10.1007/978-1-0716-0290-4_2.

PMID:
32006393
3.

Human genetics and neuropathology suggest a link between miR-218 and amyotrophic lateral sclerosis pathophysiology.

Reichenstein I, Eitan C, Diaz-Garcia S, Haim G, Magen I, Siany A, Hoye ML, Rivkin N, Olender T, Toth B, Ravid R, Mandelbaum AD, Yanowski E, Liang J, Rymer JK, Levy R, Beck G, Ainbinder E, Farhan SMK, Lennox KA, Bode NM, Behlke MA, Möller T, Saxena S, Moreno CAM, Costaguta G, van Eijk KR, Phatnani H, Al-Chalabi A, Başak AN, van den Berg LH, Hardiman O, Landers JE, Mora JS, Morrison KE, Shaw PJ, Veldink JH, Pfaff SL, Yizhar O, Gross C, Brown RH Jr, Ravits JM, Harms MB, Miller TM, Hornstein E.

Sci Transl Med. 2019 Dec 18;11(523). pii: eaav5264. doi: 10.1126/scitranslmed.aav5264.

4.

Highly Efficient CRISPR-Cas9-Based Methods for Generating Deletion Mutations and F0 Embryos that Lack Gene Function in Zebrafish.

Hoshijima K, Jurynec MJ, Klatt Shaw D, Jacobi AM, Behlke MA, Grunwald DJ.

Dev Cell. 2019 Dec 2;51(5):645-657.e4. doi: 10.1016/j.devcel.2019.10.004. Epub 2019 Nov 7.

PMID:
31708433
5.

Leukocyte-specific siRNA delivery revealing IRF8 as a potential anti-inflammatory target.

Veiga N, Goldsmith M, Diesendruck Y, Ramishetti S, Rosenblum D, Elinav E, Behlke MA, Benhar I, Peer D.

J Control Release. 2019 Nov 10;313:33-41. doi: 10.1016/j.jconrel.2019.10.001. Epub 2019 Oct 18.

PMID:
31634546
6.

Evaluation and Reduction of CRISPR Off-Target Cleavage Events.

Vakulskas CA, Behlke MA.

Nucleic Acid Ther. 2019 Aug;29(4):167-174. doi: 10.1089/nat.2019.0790. Epub 2019 May 20.

7.

Engineered transfer RNAs for suppression of premature termination codons.

Lueck JD, Yoon JS, Perales-Puchalt A, Mackey AL, Infield DT, Behlke MA, Pope MR, Weiner DB, Skach WR, McCray PB Jr, Ahern CA.

Nat Commun. 2019 Feb 18;10(1):822. doi: 10.1038/s41467-019-08329-4.

8.

Identification of preexisting adaptive immunity to Cas9 proteins in humans.

Charlesworth CT, Deshpande PS, Dever DP, Camarena J, Lemgart VT, Cromer MK, Vakulskas CA, Collingwood MA, Zhang L, Bode NM, Behlke MA, Dejene B, Cieniewicz B, Romano R, Lesch BJ, Gomez-Ospina N, Mantri S, Pavel-Dinu M, Weinberg KI, Porteus MH.

Nat Med. 2019 Feb;25(2):249-254. doi: 10.1038/s41591-018-0326-x. Epub 2019 Jan 28.

PMID:
30692695
9.

Single-Stranded Nucleic Acids Regulate TLR3/4/7 Activation through Interference with Clathrin-Mediated Endocytosis.

Järver P, Dondalska A, Poux C, Sandberg A, Bergenstråhle J, Sköld AE, Dereuddre-Bosquet N, Martinon F, Pålsson S, Zaghloul E, Brodin D, Sander B, Lennox KA, Behlke MA, El-Andaloussi S, Lehtiö J, Lundeberg J, LeGrand R, Spetz AL.

Sci Rep. 2018 Oct 26;8(1):15841. doi: 10.1038/s41598-018-33960-4.

10.

Chemical Modification of CRISPR gRNAs Eliminate type I Interferon Responses in Human Peripheral Blood Mononuclear Cells.

Schubert MS, Cedrone E, Neun B, Behlke MA, Dobrovolskaia MA.

J Cytokine Biol. 2018;3(1). pii: 121. doi: 10.4172/2576-3881.1000121. Epub 2018 Jan 29.

11.

A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells.

Vakulskas CA, Dever DP, Rettig GR, Turk R, Jacobi AM, Collingwood MA, Bode NM, McNeill MS, Yan S, Camarena J, Lee CM, Park SH, Wiebking V, Bak RO, Gomez-Ospina N, Pavel-Dinu M, Sun W, Bao G, Porteus MH, Behlke MA.

Nat Med. 2018 Aug;24(8):1216-1224. doi: 10.1038/s41591-018-0137-0. Epub 2018 Aug 6.

12.

An efficient and scalable pipeline for epitope tagging in mammalian stem cells using Cas9 ribonucleoprotein.

Dewari PS, Southgate B, Mccarten K, Monogarov G, O'Duibhir E, Quinn N, Tyrer A, Leitner MC, Plumb C, Kalantzaki M, Blin C, Finch R, Bressan RB, Morrison G, Jacobi AM, Behlke MA, von Kriegsheim A, Tomlinson S, Krijgsveld J, Pollard SM.

Elife. 2018 Apr 11;7. pii: e35069. doi: 10.7554/eLife.35069.

13.

The Use of CRISPR/Cas9 Gene Editing to Confirm Congenic Contaminations in Host-Pathogen Interaction Studies.

Ferrand J, Croft NP, Pépin G, Diener KR, Wu D, Mangan NE, Pedersen J, Behlke MA, Hayball JD, Purcell AW, Ferrero RL, Gantier MP.

Front Cell Infect Microbiol. 2018 Mar 19;8:87. doi: 10.3389/fcimb.2018.00087. eCollection 2018.

14.

Modified Polyadenylation-Based RT-qPCR Increases Selectivity of Amplification of 3'-MicroRNA Isoforms.

Nejad C, Pépin G, Behlke MA, Gantier MP.

Front Genet. 2018 Jan 24;9:11. doi: 10.3389/fgene.2018.00011. eCollection 2018.

15.

Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins.

Quadros RM, Miura H, Harms DW, Akatsuka H, Sato T, Aida T, Redder R, Richardson GP, Inagaki Y, Sakai D, Buckley SM, Seshacharyulu P, Batra SK, Behlke MA, Zeiner SA, Jacobi AM, Izu Y, Thoreson WB, Urness LD, Mansour SL, Ohtsuka M, Gurumurthy CB.

Genome Biol. 2017 May 17;18(1):92. doi: 10.1186/s13059-017-1220-4.

16.

Rapid Detection of Urinary Tract Infections via Bacterial Nuclease Activity.

Flenker KS, Burghardt EL, Dutta N, Burns WJ, Grover JM, Kenkel EJ, Weaver TM, Mills J, Kim H, Huang L, Owczarzy R, Musselman CA, Behlke MA, Ford B, McNamara JO 2nd.

Mol Ther. 2017 Jun 7;25(6):1353-1362. doi: 10.1016/j.ymthe.2017.03.015. Epub 2017 Apr 5.

17.

Simplified CRISPR tools for efficient genome editing and streamlined protocols for their delivery into mammalian cells and mouse zygotes.

Jacobi AM, Rettig GR, Turk R, Collingwood MA, Zeiner SA, Quadros RM, Harms DW, Bonthuis PJ, Gregg C, Ohtsuka M, Gurumurthy CB, Behlke MA.

Methods. 2017 May 15;121-122:16-28. doi: 10.1016/j.ymeth.2017.03.021. Epub 2017 Mar 27.

18.

Non-nucleotide Modification of Anti-miRNA Oligonucleotides.

Lennox KA, Vakulskas CA, Behlke MA.

Methods Mol Biol. 2017;1517:51-69.

PMID:
27924473
19.

SYVN1, NEDD8, and FBXO2 Proteins Regulate ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitin-mediated Proteasomal Degradation.

Ramachandran S, Osterhaus SR, Parekh KR, Jacobi AM, Behlke MA, McCray PB Jr.

J Biol Chem. 2016 Dec 2;291(49):25489-25504. Epub 2016 Oct 18.

20.

Four Novel Splice-Switch Reporter Cell Lines: Distinct Impact of Oligonucleotide Chemistry and Delivery Vector on Biological Activity.

Rocha CS, Lundin KE, Behlke MA, Zain R, El Andaloussi S, Smith CI.

Nucleic Acid Ther. 2016 Dec;26(6):381-391. Epub 2016 Sep 15.

PMID:
27629437
21.

Functional inhibition of chemokine receptor CCR2 by dicer-substrate-siRNA prevents pain development.

Bégin-Lavallée V, Midavaine É, Dansereau MA, Tétreault P, Longpré JM, Jacobi AM, Rose SD, Behlke MA, Beaudet N, Sarret P.

Mol Pain. 2016 Jun 15;12. pii: 1744806916653969. doi: 10.1177/1744806916653969. Print 2016.

22.

Single-molecule detection and tracking of RNA transcripts in living cells using phosphorothioate-optimized 2'-O-methyl RNA molecular beacons.

Zhao D, Yang Y, Qu N, Chen M, Ma Z, Krueger CJ, Behlke MA, Chen AK.

Biomaterials. 2016 Sep;100:172-83. doi: 10.1016/j.biomaterials.2016.05.022. Epub 2016 May 24.

23.

Cre-dependent DNA recombination activates a STING-dependent innate immune response.

Pépin G, Ferrand J, Höning K, Jayasekara WS, Cain JE, Behlke MA, Gough DJ, G Williams BR, Hornung V, Gantier MP.

Nucleic Acids Res. 2016 Jun 20;44(11):5356-64. doi: 10.1093/nar/gkw405. Epub 2016 May 10.

24.

An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway.

Robertson KA, Hsieh WY, Forster T, Blanc M, Lu H, Crick PJ, Yutuc E, Watterson S, Martin K, Griffiths SJ, Enright AJ, Yamamoto M, Pradeepa MM, Lennox KA, Behlke MA, Talbot S, Haas J, Dölken L, Griffiths WJ, Wang Y, Angulo A, Ghazal P.

PLoS Biol. 2016 Mar 3;14(3):e1002364. doi: 10.1371/journal.pbio.1002364. eCollection 2016 Mar.

25.

Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides.

Lennox KA, Behlke MA.

Nucleic Acids Res. 2016 Jan 29;44(2):863-77. doi: 10.1093/nar/gkv1206. Epub 2015 Nov 17.

26.

Antisense Oligonucleotide-Mediated Transcript Knockdown in Zebrafish.

Pauli A, Montague TG, Lennox KA, Behlke MA, Schier AF.

PLoS One. 2015 Oct 5;10(10):e0139504. doi: 10.1371/journal.pone.0139504. eCollection 2015.

27.

Gβ4γ1 as a modulator of M3 muscarinic receptor signalling and novel roles of Gβ1 subunits in the modulation of cellular signalling.

Khan SM, Min A, Gora S, Houranieh GM, Campden R, Robitaille M, Trieu P, Pétrin D, Jacobi AM, Behlke MA, Angers S, Hébert TE.

Cell Signal. 2015 Aug;27(8):1597-608. doi: 10.1016/j.cellsig.2015.04.007. Epub 2015 Apr 23.

PMID:
25916507
28.

Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors.

Sarvestani ST, Stunden HJ, Behlke MA, Forster SC, McCoy CE, Tate MD, Ferrand J, Lennox KA, Latz E, Williams BR, Gantier MP.

Nucleic Acids Res. 2015 Jan;43(2):1177-88. doi: 10.1093/nar/gku1343. Epub 2014 Dec 24.

29.

Correlating In Vitro Splice Switching Activity With Systemic In Vivo Delivery Using Novel ZEN-modified Oligonucleotides.

Hammond SM, McClorey G, Nordin JZ, Godfrey C, Stenler S, Lennox KA, Smith CI, Jacobi AM, Varela MA, Lee Y, Behlke MA, Wood MJ, Andaloussi SE.

Mol Ther Nucleic Acids. 2014 Nov 25;3:e212. doi: 10.1038/mtna.2014.63.

30.

Real-time imaging of single engineered RNA transcripts in living cells using ratiometric bimolecular beacons.

Song Y, Zhang X, Huang L, Behlke MA, Tsourkas A.

J Vis Exp. 2014 Aug 6;(90):e51544. doi: 10.3791/51544.

31.

Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model.

Bestas B, Moreno PM, Blomberg KE, Mohammad DK, Saleh AF, Sutlu T, Nordin JZ, Guterstam P, Gustafsson MO, Kharazi S, Piątosa B, Roberts TC, Behlke MA, Wood MJ, Gait MJ, Lundin KE, El Andaloussi S, Månsson R, Berglöf A, Wengel J, Smith CI.

J Clin Invest. 2014 Sep;124(9):4067-81. doi: 10.1172/JCI76175. Epub 2014 Aug 8.

32.

Platelet Activating Factor Receptor Activation Improves siRNA Uptake and RNAi Responses in Well-differentiated Airway Epithelia.

Krishnamurthy S, Behlke MA, Apicella MA, McCray PB Jr, Davidson BL.

Mol Ther Nucleic Acids. 2014 Jul 15;3:e175. doi: 10.1038/mtna.2014.26.

33.

Noninvasive imaging of Staphylococcus aureus infections with a nuclease-activated probe.

Hernandez FJ, Huang L, Olson ME, Powers KM, Hernandez LI, Meyerholz DK, Thedens DR, Behlke MA, Horswill AR, McNamara JO 2nd.

Nat Med. 2014 Mar;20(3):301-6. doi: 10.1038/nm.3460. Epub 2014 Feb 2.

34.

Imaging the directed transport of single engineered RNA transcripts in real-time using ratiometric bimolecular beacons.

Zhang X, Zajac AL, Huang L, Behlke MA, Tsourkas A.

PLoS One. 2014 Jan 15;9(1):e85813. doi: 10.1371/journal.pone.0085813. eCollection 2014.

35.

Inosine-mediated modulation of RNA sensing by Toll-like receptor 7 (TLR7) and TLR8.

Sarvestani ST, Tate MD, Moffat JM, Jacobi AM, Behlke MA, Miller AR, Beckham SA, McCoy CE, Chen W, Mintern JD, O'Keeffe M, John M, Williams BR, Gantier MP.

J Virol. 2014 Jan;88(2):799-810. doi: 10.1128/JVI.01571-13. Epub 2013 Nov 13.

36.

In vivo comparison of local versus systemic delivery of immunostimulating siRNA in HPV-driven tumours.

Khairuddin N, Blake SJ, Firdaus F, Steptoe RJ, Behlke MA, Hertzog PJ, McMillan NA.

Immunol Cell Biol. 2014 Feb;92(2):156-63. doi: 10.1038/icb.2013.75. Epub 2013 Nov 12.

PMID:
24217808
37.

Knockdown of β-catenin with dicer-substrate siRNAs reduces liver tumor burden in vivo.

Dudek H, Wong DH, Arvan R, Shah A, Wortham K, Ying B, Diwanji R, Zhou W, Holmes B, Yang H, Cyr WA, Zhou Y, Shah A, Farkiwala R, Lee M, Li Y, Rettig GR, Collingwood MA, Basu SK, Behlke MA, Brown BD.

Mol Ther. 2014 Jan;22(1):92-101. doi: 10.1038/mt.2013.233. Epub 2013 Oct 3.

38.

SNP detection in mRNA in living cells using allele specific FRET probes.

Dahan L, Huang L, Kedmi R, Behlke MA, Peer D.

PLoS One. 2013 Sep 9;8(9):e72389. doi: 10.1371/journal.pone.0072389. eCollection 2013. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/d41768c5-b58a-4355-ad17-166f70e347b8.

39.

Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier.

Lennox KA, Owczarzy R, Thomas DM, Walder JA, Behlke MA.

Mol Ther Nucleic Acids. 2013 Aug 27;2:e117. doi: 10.1038/mtna.2013.46.

40.

Quantitative assessment of ratiometric bimolecular beacons as a tool for imaging single engineered RNA transcripts and measuring gene expression in living cells.

Zhang X, Song Y, Shah AY, Lekova V, Raj A, Huang L, Behlke MA, Tsourkas A.

Nucleic Acids Res. 2013 Aug;41(15):e152. doi: 10.1093/nar/gkt561. Epub 2013 Jun 27.

41.

Spinal NTS2 receptor activation reverses signs of neuropathic pain.

Tétreault P, Beaudet N, Perron A, Belleville K, René A, Cavelier F, Martinez J, Stroh T, Jacobi AM, Rose SD, Behlke MA, Sarret P.

FASEB J. 2013 Sep;27(9):3741-52. doi: 10.1096/fj.12-225540. Epub 2013 Jun 11.

PMID:
23756650
42.

U1 Adaptor Oligonucleotides Targeting BCL2 and GRM1 Suppress Growth of Human Melanoma Xenografts In Vivo.

Goraczniak R, Wall BA, Behlke MA, Lennox KA, Ho ES, Zaphiros NH, Jakubowski C, Patel NR, Zhao S, Magaway C, Subbie SA, Jenny Yu L, Lacava S, Reuhl KR, Chen S, Gunderson SI.

Mol Ther Nucleic Acids. 2013 May 14;2:e92. doi: 10.1038/mtna.2013.24. Erratum in: Mol Ther Nucleic Acids. 2013 Jul 30;2:e111.

43.

Post-transcriptional regulation of cystic fibrosis transmembrane conductance regulator expression and function by microRNAs.

Ramachandran S, Karp PH, Osterhaus SR, Jiang P, Wohlford-Lenane C, Lennox KA, Jacobi AM, Praekh K, Rose SD, Behlke MA, Xing Y, Welsh MJ, McCray PB Jr.

Am J Respir Cell Mol Biol. 2013 Oct;49(4):544-51. doi: 10.1165/rcmb.2012-0430OC.

44.

Efficient delivery of RNA interference oligonucleotides to polarized airway epithelia in vitro.

Ramachandran S, Krishnamurthy S, Jacobi AM, Wohlford-Lenane C, Behlke MA, Davidson BL, McCray PB Jr.

Am J Physiol Lung Cell Mol Physiol. 2013 Jul 1;305(1):L23-32. doi: 10.1152/ajplung.00426.2012. Epub 2013 Apr 26.

45.

Altered Purkinje cell miRNA expression and SCA1 pathogenesis.

Rodriguez-Lebron E, Liu G, Keiser M, Behlke MA, Davidson BL.

Neurobiol Dis. 2013 Jun;54:456-63. doi: 10.1016/j.nbd.2013.01.019. Epub 2013 Jan 30.

46.

Targeting IκB proteins for HIV latency activation: the role of individual IκB and NF-κB proteins.

Fernandez G, Zaikos TD, Khan SZ, Jacobi AM, Behlke MA, Zeichner SL.

J Virol. 2013 Apr;87(7):3966-78. doi: 10.1128/JVI.03251-12. Epub 2013 Jan 30.

47.

Manipulation of Cell Physiology Enables Gene Silencing in Well-differentiated Airway Epithelia.

Krishnamurthy S, Behlke MA, Ramachandran S, Salem AK, McCray PB Jr, Davidson BL.

Mol Ther Nucleic Acids. 2012 Aug 28;1:e41. doi: 10.1038/mtna.2012.36.

48.

Deep Sequencing Analyses of DsiRNAs Reveal the Influence of 3' Terminal Overhangs on Dicing Polarity, Strand Selectivity, and RNA Editing of siRNAs.

Zhou J, Song MS, Jacobi AM, Behlke MA, Wu X, Rossi JJ.

Mol Ther Nucleic Acids. 2012 Apr 3;1:e17. doi: 10.1038/mtna.2012.6.

49.

In vivo SELEX for Identification of Brain-penetrating Aptamers.

Cheng C, Chen YH, Lennox KA, Behlke MA, Davidson BL.

Mol Ther Nucleic Acids. 2013 Jan 8;2:e67. doi: 10.1038/mtna.2012.59.

50.

Alternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins.

Janas MM, Wang B, Harris AS, Aguiar M, Shaffer JM, Subrahmanyam YV, Behlke MA, Wucherpfennig KW, Gygi SP, Gagnon E, Novina CD.

RNA. 2012 Nov;18(11):2041-55. doi: 10.1261/rna.035675.112. Epub 2012 Sep 27. Erratum in: RNA. 2012 Dec;18(12):2345.

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