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Items: 9


Murine astrotactins 1 and 2 have a similar membrane topology and mature via endoproteolytic cleavage catalyzed by a signal peptidase.

Lara P, Tellgren-Roth Å, Behesti H, Horn Z, Schiller N, Enquist K, Cammenberg M, Liljenström A, Hatten ME, von Heijne G, Nilsson I.

J Biol Chem. 2019 Mar 22;294(12):4538-4545. doi: 10.1074/jbc.RA118.007093. Epub 2019 Jan 29.


N-cadherin provides a cis and trans ligand for astrotactin that functions in glial-guided neuronal migration.

Horn Z, Behesti H, Hatten ME.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10556-10563. doi: 10.1073/pnas.1811100115. Epub 2018 Sep 27.


ASTN2 modulates synaptic strength by trafficking and degradation of surface proteins.

Behesti H, Fore TR, Wu P, Horn Z, Leppert M, Hull C, Hatten ME.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9717-E9726. doi: 10.1073/pnas.1809382115. Epub 2018 Sep 21.


Bmi1 overexpression in the cerebellar granule cell lineage of mice affects cell proliferation and survival without initiating medulloblastoma formation.

Behesti H, Bhagat H, Dubuc AM, Taylor MD, Marino S.

Dis Model Mech. 2013 Jan;6(1):49-63. doi: 10.1242/dmm.009506. Epub 2012 Oct 12.


Cerebellar stem cells act as medulloblastoma-initiating cells in a mouse model and a neural stem cell signature characterizes a subset of human medulloblastomas.

Sutter R, Shakhova O, Bhagat H, Behesti H, Sutter C, Penkar S, Santuccione A, Bernays R, Heppner FL, Schüller U, Grotzer M, Moch H, Schraml P, Marino S.

Oncogene. 2010 Mar 25;29(12):1845-56. doi: 10.1038/onc.2009.472. Epub 2010 Jan 11.


Loss of Tbx2 delays optic vesicle invagination leading to small optic cups.

Behesti H, Papaioannou VE, Sowden JC.

Dev Biol. 2009 Sep 15;333(2):360-72. doi: 10.1016/j.ydbio.2009.06.026. Epub 2009 Jul 1.


Cerebellar granule cells: insights into proliferation, differentiation, and role in medulloblastoma pathogenesis.

Behesti H, Marino S.

Int J Biochem Cell Biol. 2009 Mar;41(3):435-45. doi: 10.1016/j.biocel.2008.06.017. Epub 2008 Aug 5. Review.


A novel mechanistic spectrum underlies glaucoma-associated chromosome 6p25 copy number variation.

Chanda B, Asai-Coakwell M, Ye M, Mungall AJ, Barrow M, Dobyns WB, Behesti H, Sowden JC, Carter NP, Walter MA, Lehmann OJ.

Hum Mol Genet. 2008 Nov 15;17(22):3446-58. doi: 10.1093/hmg/ddn238. Epub 2008 Aug 11.

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