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Items: 1 to 50 of 104


Pediatric Online Disaster Preparedness Training for Medical and Non-Medical Personnel: A Multi-Level Modeling Analysis.

Pham PK, Behar SM, Berg BM, Upperman JS, Nager AL.

Prehosp Disaster Med. 2018 Aug;33(4):349-354. doi: 10.1017/S1049023X18000596.


Mycobacterium tuberculosis-specific CD4+ and CD8+ T cells differ in their capacity to recognize infected macrophages.

Yang JD, Mott D, Sutiwisesak R, Lu YJ, Raso F, Stowell B, Babunovic GH, Lee J, Carpenter SM, Way SS, Fortune SM, Behar SM.

PLoS Pathog. 2018 May 21;14(5):e1007060. doi: 10.1371/journal.ppat.1007060. eCollection 2018 Feb.


A new vaccine for tuberculosis in rhesus macaques.

Carpenter SM, Behar SM.

Nat Med. 2018 Feb 7;24(2):124-126. doi: 10.1038/nm.4488. No abstract available.


Vaccine-elicited memory CD4+ T cell expansion is impaired in the lungs during tuberculosis.

Carpenter SM, Yang JD, Lee J, Barreira-Silva P, Behar SM.

PLoS Pathog. 2017 Nov 27;13(11):e1006704. doi: 10.1371/journal.ppat.1006704. eCollection 2017 Nov.


Role of Granulocyte-Macrophage Colony-Stimulating Factor Production by T Cells during Mycobacterium tuberculosis Infection.

Rothchild AC, Stowell B, Goyal G, Nunes-Alves C, Yang Q, Papavinasasundaram K, Sassetti CM, Dranoff G, Chen X, Lee J, Behar SM.

MBio. 2017 Oct 24;8(5). pii: e01514-17. doi: 10.1128/mBio.01514-17.


IL-21 signaling is essential for optimal host resistance against Mycobacterium tuberculosis infection.

Booty MG, Barreira-Silva P, Carpenter SM, Nunes-Alves C, Jacques MK, Stowell BL, Jayaraman P, Beamer G, Behar SM.

Sci Rep. 2016 Nov 7;6:36720. doi: 10.1038/srep36720.


Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype.

Smith CM, Proulx MK, Olive AJ, Laddy D, Mishra BB, Moss C, Gutierrez NM, Bellerose MM, Barreira-Silva P, Phuah JY, Baker RE, Behar SM, Kornfeld H, Evans TG, Beamer G, Sassetti CM.

MBio. 2016 Sep 20;7(5). pii: e01516-16. doi: 10.1128/mBio.01516-16.


Inflammatory signaling in human tuberculosis granulomas is spatially organized.

Marakalala MJ, Raju RM, Sharma K, Zhang YJ, Eugenin EA, Prideaux B, Daudelin IB, Chen PY, Booty MG, Kim JH, Eum SY, Via LE, Behar SM, Barry CE 3rd, Mann M, Dartois V, Rubin EJ.

Nat Med. 2016 May;22(5):531-8. doi: 10.1038/nm.4073. Epub 2016 Apr 4.


TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection.

Jayaraman P, Jacques MK, Zhu C, Steblenko KM, Stowell BL, Madi A, Anderson AC, Kuchroo VK, Behar SM.

PLoS Pathog. 2016 Mar 11;12(3):e1005490. doi: 10.1371/journal.ppat.1005490. eCollection 2016 Mar.


Multiple Inflammatory Cytokines Converge To Regulate CD8+ T Cell Expansion and Function during Tuberculosis.

Booty MG, Nunes-Alves C, Carpenter SM, Jayaraman P, Behar SM.

J Immunol. 2016 Feb 15;196(4):1822-31. doi: 10.4049/jimmunol.1502206. Epub 2016 Jan 11.


A Higher Activation Threshold of Memory CD8+ T Cells Has a Fitness Cost That Is Modified by TCR Affinity during Tuberculosis.

Carpenter SM, Nunes-Alves C, Booty MG, Way SS, Behar SM.

PLoS Pathog. 2016 Jan 8;12(1):e1005380. doi: 10.1371/journal.ppat.1005380. eCollection 2016 Jan.


Tuberculosis: Autophagy is not the answer.

Behar SM, Baehrecke EH.

Nature. 2015 Dec 24;528(7583):482-3. doi: 10.1038/nature16324. Epub 2015 Dec 9. No abstract available.


Human and Murine Clonal CD8+ T Cell Expansions Arise during Tuberculosis Because of TCR Selection.

Nunes-Alves C, Booty MG, Carpenter SM, Rothchild AC, Martin CJ, Desjardins D, Steblenko K, Kløverpris HN, Madansein R, Ramsuran D, Leslie A, Correia-Neves M, Behar SM.

PLoS Pathog. 2015 May 6;11(5):e1004849. doi: 10.1371/journal.ppat.1004849. eCollection 2015 May. Erratum in: PLoS Pathog. 2015 Sep;11(9):e1005144.


Orchestration of pulmonary T cell immunity during Mycobacterium tuberculosis infection: immunity interruptus.

Behar SM, Carpenter SM, Booty MG, Barber DL, Jayaraman P.

Semin Immunol. 2014 Dec;26(6):559-77. doi: 10.1016/j.smim.2014.09.003. Epub 2014 Oct 11. Review.


Chromatin decondensation and T cell hyperresponsiveness in diabetes-associated hyperglycemia.

Martinez N, Vallerskog T, West K, Nunes-Alves C, Lee J, Martens GW, Behar SM, Kornfeld H.

J Immunol. 2014 Nov 1;193(9):4457-68. doi: 10.4049/jimmunol.1401125. Epub 2014 Sep 22.


Immunology: Fixing the odds against tuberculosis.

Behar SM, Sassetti CM.

Nature. 2014 Jul 3;511(7507):39-40. doi: 10.1038/nature13512. Epub 2014 Jun 25. No abstract available.


In search of a new paradigm for protective immunity to TB.

Nunes-Alves C, Booty MG, Carpenter SM, Jayaraman P, Rothchild AC, Behar SM.

Nat Rev Microbiol. 2014 Apr;12(4):289-99. doi: 10.1038/nrmicro3230. Epub 2014 Mar 3. Review.


Macrophages clean up: efferocytosis and microbial control.

Martin CJ, Peters KN, Behar SM.

Curr Opin Microbiol. 2014 Feb;17:17-23. doi: 10.1016/j.mib.2013.10.007. Epub 2013 Dec 5. Review.


iNKT cell production of GM-CSF controls Mycobacterium tuberculosis.

Rothchild AC, Jayaraman P, Nunes-Alves C, Behar SM.

PLoS Pathog. 2014 Jan;10(1):e1003805. doi: 10.1371/journal.ppat.1003805. Epub 2014 Jan 2.


Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing.

Zhang YJ, Reddy MC, Ioerger TR, Rothchild AC, Dartois V, Schuster BM, Trauner A, Wallis D, Galaviz S, Huttenhower C, Sacchettini JC, Behar SM, Rubin EJ.

Cell. 2013 Dec 5;155(6):1296-308. doi: 10.1016/j.cell.2013.10.045.


Tolerance has its limits: how the thymus copes with infection.

Nunes-Alves C, Nobrega C, Behar SM, Correia-Neves M.

Trends Immunol. 2013 Oct;34(10):502-10. doi: 10.1016/ Epub 2013 Jul 16. Review.


IL-1β promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation.

Jayaraman P, Sada-Ovalle I, Nishimura T, Anderson AC, Kuchroo VK, Remold HG, Behar SM.

J Immunol. 2013 Apr 15;190(8):4196-204. doi: 10.4049/jimmunol.1202688. Epub 2013 Mar 13.


Antigen-specific CD8(+) T cells and protective immunity to tuberculosis.

Behar SM.

Adv Exp Med Biol. 2013;783:141-63. doi: 10.1007/978-1-4614-6111-1_8. Review.


Dying to live: how the death modality of the infected macrophage affects immunity to tuberculosis.

Divangahi M, Behar SM, Remold H.

Adv Exp Med Biol. 2013;783:103-20. doi: 10.1007/978-1-4614-6111-1_6. Review.


T cells home to the thymus and control infection.

Nobrega C, Nunes-Alves C, Cerqueira-Rodrigues B, Roque S, Barreira-Silva P, Behar SM, Correia-Neves M.

J Immunol. 2013 Feb 15;190(4):1646-58. doi: 10.4049/jimmunol.1202412. Epub 2013 Jan 11.


Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs.

Tatituri RV, Watts GF, Bhowruth V, Barton N, Rothchild A, Hsu FF, Almeida CF, Cox LR, Eggeling L, Cardell S, Rossjohn J, Godfrey DI, Behar SM, Besra GS, Brenner MB, Brigl M.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1827-32. doi: 10.1073/pnas.1220601110. Epub 2013 Jan 10.


The Tim3-galectin 9 pathway induces antibacterial activity in human macrophages infected with Mycobacterium tuberculosis.

Sada-Ovalle I, Chávez-Galán L, Torre-Bouscoulet L, Nava-Gamiño L, Barrera L, Jayaraman P, Torres-Rojas M, Salazar-Lezama MA, Behar SM.

J Immunol. 2012 Dec 15;189(12):5896-902. doi: 10.4049/jimmunol.1200990. Epub 2012 Nov 23.


Efferocytosis is an innate antibacterial mechanism.

Martin CJ, Booty MG, Rosebrock TR, Nunes-Alves C, Desjardins DM, Keren I, Fortune SM, Remold HG, Behar SM.

Cell Host Microbe. 2012 Sep 13;12(3):289-300. doi: 10.1016/j.chom.2012.06.010.


A comparative lipidomics platform for chemotaxonomic analysis of Mycobacterium tuberculosis.

Layre E, Sweet L, Hong S, Madigan CA, Desjardins D, Young DC, Cheng TY, Annand JW, Kim K, Shamputa IC, McConnell MJ, Debono CA, Behar SM, Minnaard AJ, Murray M, Barry CE 3rd, Matsunaga I, Moody DB.

Chem Biol. 2011 Dec 23;18(12):1537-49. doi: 10.1016/j.chembiol.2011.10.013.


Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection.

Nandi B, Behar SM.

J Exp Med. 2011 Oct 24;208(11):2251-62. doi: 10.1084/jem.20110919. Epub 2011 Oct 3.


Emerging Tim-3 functions in antimicrobial and tumor immunity.

Sakuishi K, Jayaraman P, Behar SM, Anderson AC, Kuchroo VK.

Trends Immunol. 2011 Aug;32(8):345-9. doi: 10.1016/ Epub 2011 Jun 21. Review.


Requirement for invariant chain in macrophages for Mycobacterium tuberculosis replication and CD1d antigen presentation.

Sillé FC, Martin C, Jayaraman P, Rothchild A, Fortune S, Besra GS, Behar SM, Boes M.

Infect Immun. 2011 Aug;79(8):3053-63. doi: 10.1128/IAI.01108-10. Epub 2011 May 16.


Critical role for invariant chain in CD1d-mediated selection and maturation of Vα14-invariant NKT cells.

Sillé FC, Martin C, Jayaraman P, Rothchild A, Besra GS, Behar SM, Boes M.

Immunol Lett. 2011 Sep 30;139(1-2):33-41. doi: 10.1016/j.imlet.2011.04.012. Epub 2011 May 5.


Lipids, apoptosis, and cross-presentation: links in the chain of host defense against Mycobacterium tuberculosis.

Behar SM, Martin CJ, Nunes-Alves C, Divangahi M, Remold HG.

Microbes Infect. 2011 Aug;13(8-9):749-56. doi: 10.1016/j.micinf.2011.03.002. Epub 2011 Mar 31. Review.


Cardiolipin binds to CD1d and stimulates CD1d-restricted γδ T cells in the normal murine repertoire.

Dieudé M, Striegl H, Tyznik AJ, Wang J, Behar SM, Piccirillo CA, Levine JS, Zajonc DM, Rauch J.

J Immunol. 2011 Apr 15;186(8):4771-81. doi: 10.4049/jimmunol.1000921. Epub 2011 Mar 9.


Development of a glycoprotein D-expressing dominant-negative and replication-defective herpes simplex virus 2 (HSV-2) recombinant viral vaccine against HSV-2 infection in mice.

Akhrameyeva NV, Zhang P, Sugiyama N, Behar SM, Yao F.

J Virol. 2011 May;85(10):5036-47. doi: 10.1128/JVI.02548-10. Epub 2011 Mar 9.


Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis.

Behar SM, Martin CJ, Booty MG, Nishimura T, Zhao X, Gan HX, Divangahi M, Remold HG.

Mucosal Immunol. 2011 May;4(3):279-87. doi: 10.1038/mi.2011.3. Epub 2011 Feb 9. Review.


Mycobacterium tuberculosis directs immunofocusing of CD8+ T cell responses despite vaccination.

Woodworth JS, Shin D, Volman M, Nunes-Alves C, Fortune SM, Behar SM.

J Immunol. 2011 Feb 1;186(3):1627-37. doi: 10.4049/jimmunol.1002911. Epub 2010 Dec 22.


Tim3 binding to galectin-9 stimulates antimicrobial immunity.

Jayaraman P, Sada-Ovalle I, Beladi S, Anderson AC, Dardalhon V, Hotta C, Kuchroo VK, Behar SM.

J Exp Med. 2010 Oct 25;207(11):2343-54. doi: 10.1084/jem.20100687. Epub 2010 Oct 11.


Evasion of innate immunity by Mycobacterium tuberculosis: is death an exit strategy?

Behar SM, Divangahi M, Remold HG.

Nat Rev Microbiol. 2010 Sep;8(9):668-74. doi: 10.1038/nrmicro2387. Epub 2010 Aug 2. Review.


Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis.

Divangahi M, Desjardins D, Nunes-Alves C, Remold HG, Behar SM.

Nat Immunol. 2010 Aug;11(8):751-8. doi: 10.1038/ni.1904. Epub 2010 Jul 11.


Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function.

Zeissig S, Dougan SK, Barral DC, Junker Y, Chen Z, Kaser A, Ho M, Mandel H, McIntyre A, Kennedy SM, Painter GF, Veerapen N, Besra GS, Cerundolo V, Yue S, Beladi S, Behar SM, Chen X, Gumperz JE, Breckpot K, Raper A, Baer A, Exley MA, Hegele RA, Cuchel M, Rader DJ, Davidson NO, Blumberg RS.

J Clin Invest. 2010 Aug;120(8):2889-99. doi: 10.1172/JCI42703. Epub 2010 Jul 1.


EspA acts as a critical mediator of ESX1-dependent virulence in Mycobacterium tuberculosis by affecting bacterial cell wall integrity.

Garces A, Atmakuri K, Chase MR, Woodworth JS, Krastins B, Rothchild AC, Ramsdell TL, Lopez MF, Behar SM, Sarracino DA, Fortune SM.

PLoS Pathog. 2010 Jun 24;6(6):e1000957. doi: 10.1371/journal.ppat.1000957.


Alpha-galactosylceramide as a therapeutic agent for pulmonary Mycobacterium tuberculosis infection.

Sada-Ovalle I, Sköld M, Tian T, Besra GS, Behar SM.

Am J Respir Crit Care Med. 2010 Sep 15;182(6):841-7. doi: 10.1164/rccm.200912-1921OC. Epub 2010 May 27.


Synovial fibroblasts self-direct multicellular lining architecture and synthetic function in three-dimensional organ culture.

Kiener HP, Watts GF, Cui Y, Wright J, Thornhill TS, Sköld M, Behar SM, Niederreiter B, Lu J, Cernadas M, Coyle AJ, Sims GP, Smolen J, Warman ML, Brenner MB, Lee DM.

Arthritis Rheum. 2010 Mar;62(3):742-52. doi: 10.1002/art.27285.


Vaccine-induced antibody isotypes are skewed by impaired CD4 T cell and invariant NKT cell effector responses in MyD88-deficient mice.

Iweala OI, Smith DW, Matharu KS, Sada-Ovalle I, Nguyen DD, Dekruyff RH, Umetsu DT, Behar SM, Nagler CR.

J Immunol. 2009 Aug 15;183(4):2252-60. doi: 10.4049/jimmunol.0804011. Epub 2009 Jul 20.


Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair.

Divangahi M, Chen M, Gan H, Desjardins D, Hickman TT, Lee DM, Fortune S, Behar SM, Remold HG.

Nat Immunol. 2009 Aug;10(8):899-906. doi: 10.1038/ni.1758. Epub 2009 Jun 28.


Use of the T-SPOT.TB assay to detect latent tuberculosis infection among rheumatic disease patients on immunosuppressive therapy.

Behar SM, Shin DS, Maier A, Coblyn J, Helfgott S, Weinblatt ME.

J Rheumatol. 2009 Mar;36(3):546-51. doi: 10.3899/jrheum.080854. Epub 2009 Feb 17.


Innate invariant NKT cells recognize Mycobacterium tuberculosis-infected macrophages, produce interferon-gamma, and kill intracellular bacteria.

Sada-Ovalle I, Chiba A, Gonzales A, Brenner MB, Behar SM.

PLoS Pathog. 2008 Dec;4(12):e1000239. doi: 10.1371/journal.ppat.1000239. Epub 2008 Dec 12.


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