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Items: 41

1.

Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy.

Driehuis E, Kolders S, Spelier S, Lõhmussaar K, Willems SM, Devriese LA, de Bree R, de Ruiter EJ, Korving J, Begthel H, van Es JH, Geurts V, He GW, van Jaarsveld RH, Oka R, Muraro MJ, Vivié J, Zandvliet MMJM, Hendrickx APA, Iakobachvili N, Sridevi P, Kranenburg O, van Boxtel R, Kops GJPL, Tuveson DA, Peters PJ, van Oudenaarden A, Clevers H.

Cancer Discov. 2019 Jul;9(7):852-871. doi: 10.1158/2159-8290.CD-18-1522. Epub 2019 May 3.

PMID:
31053628
2.

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity.

Kopper O, de Witte CJ, Lõhmussaar K, Valle-Inclan JE, Hami N, Kester L, Balgobind AV, Korving J, Proost N, Begthel H, van Wijk LM, Revilla SA, Theeuwsen R, van de Ven M, van Roosmalen MJ, Ponsioen B, Ho VWH, Neel BG, Bosse T, Gaarenstroom KN, Vrieling H, Vreeswijk MPG, van Diest PJ, Witteveen PO, Jonges T, Bos JL, van Oudenaarden A, Zweemer RP, Snippert HJG, Kloosterman WP, Clevers H.

Nat Med. 2019 May;25(5):838-849. doi: 10.1038/s41591-019-0422-6. Epub 2019 Apr 22.

PMID:
31011202
3.

Mouse and human urothelial cancer organoids: A tool for bladder cancer research.

Mullenders J, de Jongh E, Brousali A, Roosen M, Blom JPA, Begthel H, Korving J, Jonges T, Kranenburg O, Meijer R, Clevers HC.

Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4567-4574. doi: 10.1073/pnas.1803595116. Epub 2019 Feb 20.

4.

Long-term expanding human airway organoids for disease modeling.

Sachs N, Papaspyropoulos A, Zomer-van Ommen DD, Heo I, Böttinger L, Klay D, Weeber F, Huelsz-Prince G, Iakobachvili N, Amatngalim GD, de Ligt J, van Hoeck A, Proost N, Viveen MC, Lyubimova A, Teeven L, Derakhshan S, Korving J, Begthel H, Dekkers JF, Kumawat K, Ramos E, van Oosterhout MF, Offerhaus GJ, Wiener DJ, Olimpio EP, Dijkstra KK, Smit EF, van der Linden M, Jaksani S, van de Ven M, Jonkers J, Rios AC, Voest EE, van Moorsel CH, van der Ent CK, Cuppen E, van Oudenaarden A, Coenjaerts FE, Meyaard L, Bont LJ, Peters PJ, Tans SJ, van Zon JS, Boj SF, Vries RG, Beekman JM, Clevers H.

EMBO J. 2019 Feb 15;38(4). pii: e100300. doi: 10.15252/embj.2018100300. Epub 2019 Jan 14.

5.

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids.

Hu H, Gehart H, Artegiani B, LÖpez-Iglesias C, Dekkers F, Basak O, van Es J, Chuva de Sousa Lopes SM, Begthel H, Korving J, van den Born M, Zou C, Quirk C, Chiriboga L, Rice CM, Ma S, Rios A, Peters PJ, de Jong YP, Clevers H.

Cell. 2018 Nov 29;175(6):1591-1606.e19. doi: 10.1016/j.cell.2018.11.013.

6.

Correction for Muncan et al., "Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-Myc".

Muncan V, Sansom OJ, Tertoolen L, Phesse TJ, Begthel H, Sancho E, Cole AM, Gregorieff A, Moreno de Alboran I, Clevers H, Clarke AR.

Mol Cell Biol. 2018 Nov 28;38(24). pii: e00482-18. doi: 10.1128/MCB.00482-18. Print 2018 Dec 15. No abstract available.

7.

A surgical orthotopic organoid transplantation approach in mice to visualize and study colorectal cancer progression.

Fumagalli A, Suijkerbuijk SJE, Begthel H, Beerling E, Oost KC, Snippert HJ, van Rheenen J, Drost J.

Nat Protoc. 2018 Feb;13(2):235-247. doi: 10.1038/nprot.2017.137. Epub 2018 Jan 4.

PMID:
29300390
8.

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.

Sachs N, de Ligt J, Kopper O, Gogola E, Bounova G, Weeber F, Balgobind AV, Wind K, Gracanin A, Begthel H, Korving J, van Boxtel R, Duarte AA, Lelieveld D, van Hoeck A, Ernst RF, Blokzijl F, Nijman IJ, Hoogstraat M, van de Ven M, Egan DA, Zinzalla V, Moll J, Boj SF, Voest EE, Wessels L, van Diest PJ, Rottenberg S, Vries RGJ, Cuppen E, Clevers H.

Cell. 2018 Jan 11;172(1-2):373-386.e10. doi: 10.1016/j.cell.2017.11.010. Epub 2017 Dec 7.

9.

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids.

Fumagalli A, Drost J, Suijkerbuijk SJ, van Boxtel R, de Ligt J, Offerhaus GJ, Begthel H, Beerling E, Tan EH, Sansom OJ, Cuppen E, Clevers H, van Rheenen J.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2357-E2364. doi: 10.1073/pnas.1701219114. Epub 2017 Mar 7.

10.

Lipid-mediated Wnt protein stabilization enables serum-free culture of human organ stem cells.

Tüysüz N, van Bloois L, van den Brink S, Begthel H, Verstegen MM, Cruz LJ, Hui L, van der Laan LJ, de Jonge J, Vries R, Braakman E, Mastrobattista E, Cornelissen JJ, Clevers H, Ten Berge D.

Nat Commun. 2017 Mar 6;8:14578. doi: 10.1038/ncomms14578.

11.

Correction: The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis.

Mahmoudi T, Boj SF, Hatzis P, Li VS, Taouatas N, Vries RG, Teunissen H, Begthel H, Korving J, Mohammed S, Heck AJ, Clevers H.

PLoS Biol. 2017 Feb 7;15(2):e1002596. doi: 10.1371/journal.pbio.1002596. eCollection 2017 Feb.

12.

Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research.

Tetteh PW, Kretzschmar K, Begthel H, van den Born M, Korving J, Morsink F, Farin H, van Es JH, Offerhaus GJ, Clevers H.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11859-11864. Epub 2016 Oct 5.

13.

Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon.

Sasaki N, Sachs N, Wiebrands K, Ellenbroek SI, Fumagalli A, Lyubimova A, Begthel H, van den Born M, van Es JH, Karthaus WR, Li VS, López-Iglesias C, Peters PJ, van Rheenen J, van Oudenaarden A, Clevers H.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5399-407. doi: 10.1073/pnas.1607327113. Epub 2016 Aug 29.

14.

Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure.

Kuijk EW, Rasmussen S, Blokzijl F, Huch M, Gehart H, Toonen P, Begthel H, Clevers H, Geurts AM, Cuppen E.

Sci Rep. 2016 Feb 26;6:22154. doi: 10.1038/srep22154.

15.

Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters.

Tetteh PW, Basak O, Farin HF, Wiebrands K, Kretzschmar K, Begthel H, van den Born M, Korving J, de Sauvage F, van Es JH, van Oudenaarden A, Clevers H.

Cell Stem Cell. 2016 Feb 4;18(2):203-13. doi: 10.1016/j.stem.2016.01.001. Epub 2016 Jan 28.

16.

ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization.

Bruurs LJ, Donker L, Zwakenberg S, Zwartkruis FJ, Begthel H, Knisely AS, Posthuma G, van de Graaf SF, Paulusma CC, Bos JL.

J Cell Biol. 2015 Sep 28;210(7):1055-63. doi: 10.1083/jcb.201505118.

17.

An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking.

Schneeberger K, Vogel GF, Teunissen H, van Ommen DD, Begthel H, El Bouazzaoui L, van Vugt AH, Beekman JM, Klumperman J, Müller T, Janecke A, Gerner P, Huber LA, Hess MW, Clevers H, van Es JH, Nieuwenhuis EE, Middendorp S.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12408-13. doi: 10.1073/pnas.1516672112. Epub 2015 Sep 21.

18.

Sequential cancer mutations in cultured human intestinal stem cells.

Drost J, van Jaarsveld RH, Ponsioen B, Zimberlin C, van Boxtel R, Buijs A, Sachs N, Overmeer RM, Offerhaus GJ, Begthel H, Korving J, van de Wetering M, Schwank G, Logtenberg M, Cuppen E, Snippert HJ, Medema JP, Kops GJ, Clevers H.

Nature. 2015 May 7;521(7550):43-7. doi: 10.1038/nature14415. Epub 2015 Apr 29.

PMID:
25924068
19.

In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.

Bartfeld S, Bayram T, van de Wetering M, Huch M, Begthel H, Kujala P, Vries R, Peters PJ, Clevers H.

Gastroenterology. 2015 Jan;148(1):126-136.e6. doi: 10.1053/j.gastro.2014.09.042. Epub 2014 Oct 13.

20.

Identification of multipotent luminal progenitor cells in human prostate organoid cultures.

Karthaus WR, Iaquinta PJ, Drost J, Gracanin A, van Boxtel R, Wongvipat J, Dowling CM, Gao D, Begthel H, Sachs N, Vries RGJ, Cuppen E, Chen Y, Sawyers CL, Clevers HC.

Cell. 2014 Sep 25;159(1):163-175. doi: 10.1016/j.cell.2014.08.017. Epub 2014 Sep 4.

21.

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis.

Huch M, Bonfanti P, Boj SF, Sato T, Loomans CJ, van de Wetering M, Sojoodi M, Li VS, Schuijers J, Gracanin A, Ringnalda F, Begthel H, Hamer K, Mulder J, van Es JH, de Koning E, Vries RG, Heimberg H, Clevers H.

EMBO J. 2013 Oct 16;32(20):2708-21. doi: 10.1038/emboj.2013.204. Epub 2013 Sep 17.

22.

The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis.

Mahmoudi T, Boj SF, Hatzis P, Li VS, Taouatas N, Vries RG, Teunissen H, Begthel H, Korving J, Mohammed S, Heck AJ, Clevers H.

PLoS Biol. 2010 Nov 16;8(11):e1000539. doi: 10.1371/journal.pbio.1000539. Erratum in: PLoS Biol. 2017 Feb 7;15(2):e1002596.

23.

Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.

Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgård R, Clevers H.

Science. 2010 Mar 12;327(5971):1385-9. doi: 10.1126/science.1184733.

24.

Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.

Barker N, Huch M, Kujala P, van de Wetering M, Snippert HJ, van Es JH, Sato T, Stange DE, Begthel H, van den Born M, Danenberg E, van den Brink S, Korving J, Abo A, Peters PJ, Wright N, Poulsom R, Clevers H.

Cell Stem Cell. 2010 Jan 8;6(1):25-36. doi: 10.1016/j.stem.2009.11.013.

25.

The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium.

Gregorieff A, Stange DE, Kujala P, Begthel H, van den Born M, Korving J, Peters PJ, Clevers H.

Gastroenterology. 2009 Oct;137(4):1333-45.e1-3. doi: 10.1053/j.gastro.2009.06.044. Epub 2009 Jun 21.

PMID:
19549527
26.

Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.

ten Klooster JP, Jansen M, Yuan J, Oorschot V, Begthel H, Di Giacomo V, Colland F, de Koning J, Maurice MM, Hornbeck P, Clevers H.

Dev Cell. 2009 Apr;16(4):551-62. doi: 10.1016/j.devcel.2009.01.016.

27.

Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine.

Snippert HJ, van Es JH, van den Born M, Begthel H, Stange DE, Barker N, Clevers H.

Gastroenterology. 2009 Jun;136(7):2187-2194.e1. doi: 10.1053/j.gastro.2009.03.002. Epub 2009 Mar 24.

PMID:
19324043
28.

Transcription factor achaete scute-like 2 controls intestinal stem cell fate.

van der Flier LG, van Gijn ME, Hatzis P, Kujala P, Haegebarth A, Stange DE, Begthel H, van den Born M, Guryev V, Oving I, van Es JH, Barker N, Peters PJ, van de Wetering M, Clevers H.

Cell. 2009 Mar 6;136(5):903-12. doi: 10.1016/j.cell.2009.01.031.

29.

Crypt stem cells as the cells-of-origin of intestinal cancer.

Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M, Danenberg E, Clarke AR, Sansom OJ, Clevers H.

Nature. 2009 Jan 29;457(7229):608-11. doi: 10.1038/nature07602. Epub 2008 Dec 17.

PMID:
19092804
30.

MafB oncoprotein detected by immunohistochemistry as a highly sensitive and specific marker for the prognostic unfavorable t(14;20) (q32;q12) in multiple myeloma patients.

Stralen E, Leguit RJ, Begthel H, Michaux L, Buijs A, Lemmens H, Scheiff JM, Doyen C, Pierre P, Forget F, Clevers HC, Bast B.

Leukemia. 2009 Apr;23(4):801-3. doi: 10.1038/leu.2008.284. Epub 2008 Oct 2. No abstract available.

PMID:
18830254
31.

Identification of stem cells in small intestine and colon by marker gene Lgr5.

Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, Clevers H.

Nature. 2007 Oct 25;449(7165):1003-7. Epub 2007 Oct 14.

PMID:
17934449
32.

T-cell factor 4 (Tcf7l2) maintains proliferative compartments in zebrafish intestine.

Muncan V, Faro A, Haramis AP, Hurlstone AF, Wienholds E, van Es J, Korving J, Begthel H, Zivkovic D, Clevers H.

EMBO Rep. 2007 Oct;8(10):966-73. Epub 2007 Sep 7.

33.

Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc.

Muncan V, Sansom OJ, Tertoolen L, Phesse TJ, Begthel H, Sancho E, Cole AM, Gregorieff A, de Alboran IM, Clevers H, Clarke AR.

Mol Cell Biol. 2006 Nov;26(22):8418-26. Epub 2006 Sep 5. Erratum in: Mol Cell Biol. 2018 Nov 28;38(24):.

34.

Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia.

Haramis AP, Hurlstone A, van der Velden Y, Begthel H, van den Born M, Offerhaus GJ, Clevers HC.

EMBO Rep. 2006 Apr;7(4):444-9. Epub 2006 Jan 27.

35.

Expression pattern of Wnt signaling components in the adult intestine.

Gregorieff A, Pinto D, Begthel H, Destrée O, Kielman M, Clevers H.

Gastroenterology. 2005 Aug;129(2):626-38.

PMID:
16083717
36.

EphB receptor activity suppresses colorectal cancer progression.

Batlle E, Bacani J, Begthel H, Jonkheer S, Gregorieff A, van de Born M, Malats N, Sancho E, Boon E, Pawson T, Gallinger S, Pals S, Clevers H.

Nature. 2005 Jun 23;435(7045):1126-30. Erratum in: Nature. 2005 Aug 11;436(7052):881. Jonkeer, Suzanne [corrected to Jonkheer, Suzanne].

PMID:
15973414
37.

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.

van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H, Cozijnsen M, Robine S, Winton DJ, Radtke F, Clevers H.

Nature. 2005 Jun 16;435(7044):959-63.

PMID:
15959515
38.

Wnt signalling induces maturation of Paneth cells in intestinal crypts.

van Es JH, Jay P, Gregorieff A, van Gijn ME, Jonkheer S, Hatzis P, Thiele A, van den Born M, Begthel H, Brabletz T, Taketo MM, Clevers H.

Nat Cell Biol. 2005 Apr;7(4):381-6. Epub 2005 Mar 20.

PMID:
15778706
39.

De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine.

Haramis AP, Begthel H, van den Born M, van Es J, Jonkheer S, Offerhaus GJ, Clevers H.

Science. 2004 Mar 12;303(5664):1684-6.

40.

The Wnt/beta-catenin pathway regulates cardiac valve formation.

Hurlstone AF, Haramis AP, Wienholds E, Begthel H, Korving J, Van Eeden F, Cuppen E, Zivkovic D, Plasterk RH, Clevers H.

Nature. 2003 Oct 9;425(6958):633-7.

41.

Canonical Wnt signals are essential for homeostasis of the intestinal epithelium.

Pinto D, Gregorieff A, Begthel H, Clevers H.

Genes Dev. 2003 Jul 15;17(14):1709-13.

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