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Items: 28


Drug-induced liver injury in obesity and nonalcoholic fatty liver disease.

Allard J, Le Guillou D, Begriche K, Fromenty B.

Adv Pharmacol. 2019;85:75-107. doi: 10.1016/bs.apha.2019.01.003. Epub 2019 Feb 20. Review.


Moderate chronic ethanol consumption exerts beneficial effects on nonalcoholic fatty liver in mice fed a high-fat diet: possible role of higher formation of triglycerides enriched in monounsaturated fatty acids.

Bucher S, Begriche K, Catheline D, Trak-Smayra V, Tiaho F, Coulouarn C, Pinon G, Lagadic-Gossmann D, Rioux V, Fromenty B.

Eur J Nutr. 2019 Jun 3. doi: 10.1007/s00394-019-02017-1. [Epub ahead of print]


Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyrene/Ethanol CoExposure.

Bucher S, Le Guillou D, Allard J, Pinon G, Begriche K, Tête A, Sergent O, Lagadic-Gossmann D, Fromenty B.

Oxid Med Cell Longev. 2018 Jul 26;2018:4396403. doi: 10.1155/2018/4396403. eCollection 2018.


Drug-Induced Alterations of Mitochondrial DNA Homeostasis in Steatotic and Nonsteatotic HepaRG Cells.

Le Guillou D, Bucher S, Begriche K, Hoët D, Lombès A, Labbe G, Fromenty B.

J Pharmacol Exp Ther. 2018 Jun;365(3):711-726. doi: 10.1124/jpet.117.246751. Epub 2018 Apr 18.


Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity.

Massart J, Begriche K, Moreau C, Fromenty B.

J Clin Transl Res. 2017 Feb;3(Suppl 1):212-232. doi: 10.18053/jctres.03.2017S1.006. Epub 2017 Feb 12.


Mid-infrared fibre evanescent wave spectroscopy of serum allows fingerprinting of the hepatic metabolic status in mice.

Le Corvec M, Allain C, Lardjane S, Cavey T, Turlin B, Fautrel A, Begriche K, Monbet V, Fromenty B, Leroyer P, Guggenbuhl P, Ropert M, Sire O, Loréal O.

Analyst. 2016 Oct 24;141(22):6259-6269.


Chronic and low exposure to a pharmaceutical cocktail induces mitochondrial dysfunction in liver and hyperglycemia: Differential responses between lean and obese mice.

Buron N, Porceddu M, Roussel C, Begriche K, Trak-Smayra V, Gicquel T, Fromenty B, Borgne-Sanchez A.

Environ Toxicol. 2017 Apr;32(4):1375-1389. doi: 10.1002/tox.22331. Epub 2016 Aug 8.


Bisphenol a induces steatosis in HepaRG cells using a model of perinatal exposure.

Bucher S, Jalili P, Le Guillou D, Begriche K, Rondel K, Martinais S, Zalko D, Corlu A, Robin MA, Fromenty B.

Environ Toxicol. 2017 Mar;32(3):1024-1036. doi: 10.1002/tox.22301. Epub 2016 Jun 20.


The effect of water suppression on the hepatic lipid quantification, as assessed by the LCModel, in a preclinical and clinical scenario.

Coum A, Noury F, Bannier E, Begriche K, Fromenty B, Gandon Y, Saint-Jalmes H, Gambarota G.

MAGMA. 2016 Feb;29(1):29-37. doi: 10.1007/s10334-015-0508-1. Epub 2015 Nov 21.


Unravelling the mysterious roles of melanocortin-3 receptors in metabolic homeostasis and obesity using mouse genetics.

Girardet C, Begriche K, Ptitsyn A, Koza RA, Butler AA.

Int J Obes Suppl. 2014 Jul;4(Suppl 1):S37-44. doi: 10.1038/ijosup.2014.10. Epub 2014 Jul 8. Review.


Chronic exposure to low doses of pharmaceuticals disturbs the hepatic expression of circadian genes in lean and obese mice.

Anthérieu S, Le Guillou D, Coulouarn C, Begriche K, Trak-Smayra V, Martinais S, Porceddu M, Robin MA, Fromenty B.

Toxicol Appl Pharmacol. 2014 Apr 1;276(1):63-72. doi: 10.1016/j.taap.2014.01.019. Epub 2014 Feb 11.


Melanocortin-3 receptors and metabolic homeostasis.

Begriche K, Girardet C, McDonald P, Butler AA.

Prog Mol Biol Transl Sci. 2013;114:109-46. doi: 10.1016/B978-0-12-386933-3.00004-2. Review.


Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease.

Begriche K, Massart J, Robin MA, Bonnet F, Fromenty B.

Hepatology. 2013 Oct;58(4):1497-507. doi: 10.1002/hep.26226. Epub 2013 Aug 7. Review.


Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice.

Aubert J, Begriche K, Delannoy M, Morel I, Pajaud J, Ribault C, Lepage S, McGill MR, Lucas-Clerc C, Turlin B, Robin MA, Jaeschke H, Fromenty B.

J Pharmacol Exp Ther. 2012 Sep;342(3):676-87. doi: 10.1124/jpet.112.193813. Epub 2012 May 30.


Melanocortin-3 receptors are involved in adaptation to restricted feeding.

Begriche K, Marston OJ, Rossi J, Burke LK, McDonald P, Heisler LK, Butler AA.

Genes Brain Behav. 2012 Apr;11(3):291-302. doi: 10.1111/j.1601-183X.2012.00766.x. Epub 2012 Feb 6.


Genetic dissection of the functions of the melanocortin-3 receptor, a seven-transmembrane G-protein-coupled receptor, suggests roles for central and peripheral receptors in energy homeostasis.

Begriche K, Levasseur PR, Zhang J, Rossi J, Skorupa D, Solt LA, Young B, Burris TP, Marks DL, Mynatt RL, Butler AA.

J Biol Chem. 2011 Nov 25;286(47):40771-81. doi: 10.1074/jbc.M111.278374. Epub 2011 Oct 7.


Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: mechanisms and pathophysiological role.

Aubert J, Begriche K, Knockaert L, Robin MA, Fromenty B.

Clin Res Hepatol Gastroenterol. 2011 Oct;35(10):630-7. doi: 10.1016/j.clinre.2011.04.015. Epub 2011 Jun 12. Review.


Homeostastic and non-homeostatic functions of melanocortin-3 receptors in the control of energy balance and metabolism.

Begriche K, Sutton GM, Butler AA.

Physiol Behav. 2011 Sep 26;104(4):546-54. doi: 10.1016/j.physbeh.2011.04.007. Epub 2011 Apr 13. Review.


Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver.

Begriche K, Massart J, Robin MA, Borgne-Sanchez A, Fromenty B.

J Hepatol. 2011 Apr;54(4):773-94. doi: 10.1016/j.jhep.2010.11.006. Epub 2010 Nov 17. Review.


The role of melanocortin neuronal pathways in circadian biology: a new homeostatic output involving melanocortin-3 receptors?

Begriche K, Sutton GM, Fang J, Butler AA.

Obes Rev. 2009 Nov;10 Suppl 2:14-24. doi: 10.1111/j.1467-789X.2009.00662.x. Review.


Central nervous system melanocortin-3 receptors are required for synchronizing metabolism during entrainment to restricted feeding during the light cycle.

Sutton GM, Begriche K, Kumar KG, Gimble JM, Perez-Tilve D, Nogueiras R, McMillan RP, Hulver MW, Tschöp MH, Butler AA.

FASEB J. 2010 Mar;24(3):862-72. doi: 10.1096/fj.09-142000. Epub 2009 Oct 16.


Effects of β-aminoisobutyric acid on leptin production and lipid homeostasis: mechanisms and possible relevance for the prevention of obesity.

Begriche K, Massart J, Fromenty B.

Fundam Clin Pharmacol. 2010 Jun;24(3):269-82. doi: 10.1111/j.1472-8206.2009.00765.x. Epub 2009 Sep 3. Review.


Beta-aminoisobutyric acid prevents diet-induced obesity in mice with partial leptin deficiency.

Begriche K, Massart J, Abbey-Toby A, Igoudjil A, Lettéron P, Fromenty B.

Obesity (Silver Spring). 2008 Sep;16(9):2053-67. doi: 10.1038/oby.2008.337.


Partial leptin deficiency favors diet-induced obesity and related metabolic disorders in mice.

Begriche K, Lettéron P, Abbey-Toby A, Vadrot N, Robin MA, Bado A, Pessayre D, Fromenty B.

Am J Physiol Endocrinol Metab. 2008 May;294(5):E939-51. doi: 10.1152/ajpendo.00379.2007. Epub 2008 Mar 18.


High concentrations of stavudine impair fatty acid oxidation without depleting mitochondrial DNA in cultured rat hepatocytes.

Igoudjil A, Massart J, Begriche K, Descatoire V, Robin MA, Fromenty B.

Toxicol In Vitro. 2008 Jun;22(4):887-98. doi: 10.1016/j.tiv.2008.01.011. Epub 2008 Jan 26.


High doses of stavudine induce fat wasting and mild liver damage without impairing mitochondrial respiration in mice.

Igoudjil A, Abbey-Toby A, Begriche K, Grodet A, Chataigner K, Peytavin G, Maachi M, Colin M, Robin MA, Lettéron P, Feldmann G, Pessayre D, Fromenty B.

Antivir Ther. 2007;12(3):389-400.


Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it.

Begriche K, Igoudjil A, Pessayre D, Fromenty B.

Mitochondrion. 2006 Feb;6(1):1-28. Epub 2006 Jan 5. Review.


Effects of zidovudine, stavudine and beta-aminoisobutyric acid on lipid homeostasis in mice: possible role in human fat wasting.

Maisonneuve C, Igoudjil A, Begriche K, Lettéron P, Guimont MC, Bastin J, Laigneau JP, Pessayre D, Fromenty B.

Antivir Ther. 2004 Oct;9(5):801-10.


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