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Items: 12


Phosphorylation of human TRM9L integrates multiple stress-signaling pathways for tumor growth suppression.

Gu C, Ramos J, Begley U, Dedon PC, Fu D, Begley TJ.

Sci Adv. 2018 Jul 11;4(7):eaas9184. doi: 10.1126/sciadv.aas9184. eCollection 2018 Jul.


Mitochondrial ROS control of cancer.

Idelchik MDPS, Begley U, Begley TJ, Melendez JA.

Semin Cancer Biol. 2017 Dec;47:57-66. doi: 10.1016/j.semcancer.2017.04.005. Epub 2017 Apr 23. Review.


Alkbh8 Regulates Selenocysteine-Protein Expression to Protect against Reactive Oxygen Species Damage.

Endres L, Begley U, Clark R, Gu C, Dziergowska A, Małkiewicz A, Melendez JA, Dedon PC, Begley TJ.

PLoS One. 2015 Jul 6;10(7):e0131335. doi: 10.1371/journal.pone.0131335. eCollection 2015.


A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α.

Begley U, Sosa MS, Avivar-Valderas A, Patil A, Endres L, Estrada Y, Chan CT, Su D, Dedon PC, Aguirre-Ghiso JA, Begley T.

EMBO Mol Med. 2013 Mar;5(3):366-83. doi: 10.1002/emmm.201201161. Epub 2013 Feb 4.


Cross-species Functionome analysis identifies proteins associated with DNA repair, translation and aerobic respiration as conserved modulators of UV-toxicity.

Rooney JP, Patil A, Joseph F, Endres L, Begley U, Zappala MR, Cunningham RP, Begley TJ.

Genomics. 2011 Mar;97(3):133-47. doi: 10.1016/j.ygeno.2010.12.005. Epub 2010 Dec 30.


Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival.

Fu D, Brophy JA, Chan CT, Atmore KA, Begley U, Paules RS, Dedon PC, Begley TJ, Samson LD.

Mol Cell Biol. 2010 May;30(10):2449-59. doi: 10.1128/MCB.01604-09. Epub 2010 Mar 22.


Systems based mapping demonstrates that recovery from alkylation damage requires DNA repair, RNA processing, and translation associated networks.

Rooney JP, George AD, Patil A, Begley U, Bessette E, Zappala MR, Huang X, Conklin DS, Cunningham RP, Begley TJ.

Genomics. 2009 Jan;93(1):42-51. doi: 10.1016/j.ygeno.2008.09.001. Epub 2008 Oct 16.


Trm9-catalyzed tRNA modifications link translation to the DNA damage response.

Begley U, Dyavaiah M, Patil A, Rooney JP, DiRenzo D, Young CM, Conklin DS, Zitomer RS, Begley TJ.

Mol Cell. 2007 Dec 14;28(5):860-70.


Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP.

Park HJ, Georgescu SP, Du C, Madias C, Aronovitz MJ, Welzig CM, Wang B, Begley U, Zhang Y, Blaustein RO, Patten RD, Karas RH, Van Tol HH, Osborne TF, Shimano H, Liao R, Link MS, Galper JB.

J Clin Invest. 2008 Jan;118(1):259-71.


3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA.

Park HJ, Kong D, Iruela-Arispe L, Begley U, Tang D, Galper JB.

Circ Res. 2002 Jul 26;91(2):143-50.


Role of sterol regulatory element binding proteins in the regulation of Galpha(i2) expression in cultured atrial cells.

Park HJ, Begley U, Kong D, Yu H, Yin L, Hillgartner FB, Osborne TF, Galper JB.

Circ Res. 2002 Jul 12;91(1):32-7.


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