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Items: 26


Focal adhesion kinase is required for synovial fibroblast invasion, but not murine inflammatory arthritis.

Shelef MA, Bennin DA, Yasmin N, Warner TF, Ludwig T, Beggs HE, Huttenlocher A.

Arthritis Res Ther. 2014 Oct 4;16(5):464. doi: 10.1186/s13075-014-0464-6.


PTK2b function during fertilization of the mouse oocyte.

Luo J, McGinnis LK, Carlton C, Beggs HE, Kinsey WH.

Biochem Biophys Res Commun. 2014 Aug 1;450(3):1212-7. doi: 10.1016/j.bbrc.2014.03.083. Epub 2014 Mar 22.


The focal adhesion kinase inhibitor PF-562,271 impairs primary CD4+ T cell activation.

Wiemer AJ, Wernimont SA, Cung TD, Bennin DA, Beggs HE, Huttenlocher A.

Biochem Pharmacol. 2013 Sep 15;86(6):770-81. doi: 10.1016/j.bcp.2013.07.024. Epub 2013 Aug 5.


A de novo X;8 translocation creates a PTK2-THOC2 gene fusion with THOC2 expression knockdown in a patient with psychomotor retardation and congenital cerebellar hypoplasia.

Di Gregorio E, Bianchi FT, Schiavi A, Chiotto AM, Rolando M, Verdun di Cantogno L, Grosso E, Cavalieri S, Calcia A, Lacerenza D, Zuffardi O, Retta SF, Stevanin G, Marelli C, Durr A, Forlani S, Chelly J, Montarolo F, Tempia F, Beggs HE, Reed R, Squadrone S, Abete MC, Brussino A, Ventura N, Di Cunto F, Brusco A.

J Med Genet. 2013 Aug;50(8):543-51. doi: 10.1136/jmedgenet-2013-101542. Epub 2013 Jun 7.


Focal adhesion kinase regulates the localization and retention of pro-B cells in bone marrow microenvironments.

Park SY, Wolfram P, Canty K, Harley B, Nombela-Arrieta C, Pivarnik G, Manis J, Beggs HE, Silberstein LE.

J Immunol. 2013 Feb 1;190(3):1094-102. doi: 10.4049/jimmunol.1202639. Epub 2012 Dec 21.


Integrin-linked kinase deletion in the developing lens leads to capsule rupture, impaired fiber migration and non-apoptotic epithelial cell death.

Cammas L, Wolfe J, Choi SY, Dedhar S, Beggs HE.

Invest Ophthalmol Vis Sci. 2012 May 17;53(6):3067-81. doi: 10.1167/iovs.11-9128.


Essential role for focal adhesion kinase in regulating stress hematopoiesis.

Vemula S, Ramdas B, Hanneman P, Martin J, Beggs HE, Kapur R.

Blood. 2010 Nov 18;116(20):4103-15. doi: 10.1182/blood-2010-01-262790. Epub 2010 Jul 27.


Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination.

Chauhan BK, Disanza A, Choi SY, Faber SC, Lou M, Beggs HE, Scita G, Zheng Y, Lang RA.

Development. 2009 Nov;136(21):3657-67. doi: 10.1242/dev.042242.


Focal adhesion kinase (FAK): A regulator of CNS myelination.

Forrest AD, Beggs HE, Reichardt LF, Dupree JL, Colello RJ, Fuss B.

J Neurosci Res. 2009 Nov 15;87(15):3456-64. doi: 10.1002/jnr.22022.


Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling.

Pylayeva Y, Gillen KM, Gerald W, Beggs HE, Reichardt LF, Giancotti FG.

J Clin Invest. 2009 Feb;119(2):252-66. doi: 10.1172/JCI37160. Epub 2009 Jan 19.


Cardiac fibroblasts require focal adhesion kinase for normal proliferation and migration.

Manso AM, Kang SM, Plotnikov SV, Thievessen I, Oh J, Beggs HE, Ross RS.

Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H627-38. doi: 10.1152/ajpheart.00444.2008. Epub 2009 Jan 9.


Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer.

Provenzano PP, Inman DR, Eliceiri KW, Beggs HE, Keely PJ.

Am J Pathol. 2008 Nov;173(5):1551-65. doi: 10.2353/ajpath.2008.080308. Epub 2008 Oct 9.


Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase.

Owen KA, Pixley FJ, Thomas KS, Vicente-Manzanares M, Ray BJ, Horwitz AF, Parsons JT, Beggs HE, Stanley ER, Bouton AH.

J Cell Biol. 2007 Dec 17;179(6):1275-87. Epub 2007 Dec 10.


Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells.

Glodek AM, Le Y, Dykxhoorn DM, Park SY, Mostoslavsky G, Mulligan R, Lieberman J, Beggs HE, Honczarenko M, Silberstein LE.

Leukemia. 2007 Aug;21(8):1723-32. Epub 2007 Jun 14.


Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment.

Hakim ZS, DiMichele LA, Doherty JT, Homeister JW, Beggs HE, Reichardt LF, Schwartz RJ, Brackhan J, Smithies O, Mack CP, Taylor JM.

Mol Cell Biol. 2007 Aug;27(15):5352-64. Epub 2007 May 25.


Reconciling the roles of FAK in osteoblast differentiation, osteoclast remodeling, and bone regeneration.

Kim JB, Leucht P, Luppen CA, Park YJ, Beggs HE, Damsky CH, Helms JA.

Bone. 2007 Jul;41(1):39-51. Epub 2007 Mar 13.


Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics.

Schober M, Raghavan S, Nikolova M, Polak L, Pasolli HA, Beggs HE, Reichardt LF, Fuchs E.

J Cell Biol. 2007 Feb 26;176(5):667-80.


Myocyte-restricted focal adhesion kinase deletion attenuates pressure overload-induced hypertrophy.

DiMichele LA, Doherty JT, Rojas M, Beggs HE, Reichardt LF, Mack CP, Taylor JM.

Circ Res. 2006 Sep 15;99(6):636-45. Epub 2006 Aug 10.


Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation.

Braren R, Hu H, Kim YH, Beggs HE, Reichardt LF, Wang R.

J Cell Biol. 2006 Jan 2;172(1):151-62.


Hair cycle and wound healing in mice with a keratinocyte-restricted deletion of FAK.

Essayem S, Kovacic-Milivojevic B, Baumbusch C, McDonagh S, Dolganov G, Howerton K, Larocque N, Mauro T, Ramirez A, Ramos DM, Fisher SJ, Jorcano JL, Beggs HE, Reichardt LF, Ilic D.

Oncogene. 2006 Feb 16;25(7):1081-9.


Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells.

Tilghman RW, Slack-Davis JK, Sergina N, Martin KH, Iwanicki M, Hershey ED, Beggs HE, Reichardt LF, Parsons JT.

J Cell Sci. 2005 Jun 15;118(Pt 12):2613-23. Epub 2005 May 24.


Control of axonal branching and synapse formation by focal adhesion kinase.

Rico B, Beggs HE, Schahin-Reed D, Kimes N, Schmidt A, Reichardt LF.

Nat Neurosci. 2004 Oct;7(10):1059-69. Epub 2004 Sep 19.


FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies.

Beggs HE, Schahin-Reed D, Zang K, Goebbels S, Nave KA, Gorski J, Jones KR, Sretavan D, Reichardt LF.

Neuron. 2003 Oct 30;40(3):501-14.


NCAM140 interacts with the focal adhesion kinase p125(fak) and the SRC-related tyrosine kinase p59(fyn).

Beggs HE, Baragona SC, Hemperly JJ, Maness PF.

J Biol Chem. 1997 Mar 28;272(13):8310-9.


Selective neural cell adhesion molecule signaling by Src family tyrosine kinases and tyrosine phosphatases.

Maness PF, Beggs HE, Klinz SG, Morse WR.

Perspect Dev Neurobiol. 1996;4(2-3):169-81. Review.


NCAM-dependent neurite outgrowth is inhibited in neurons from Fyn-minus mice.

Beggs HE, Soriano P, Maness PF.

J Cell Biol. 1994 Nov;127(3):825-33.

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