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Bronchial Epithelial Calcium Metabolism Impairment in Smokers and Chronic Obstructive Pulmonary Disease. Decreased ORAI3 Signaling.

Petit A, Knabe L, Khelloufi K, Jory M, Gras D, Cabon Y, Begg M, Richard S, Massiera G, Chanez P, Vachier I, Bourdin A.

Am J Respir Cell Mol Biol. 2019 Oct;61(4):501-511. doi: 10.1165/rcmb.2018-0228OC.


Translation of Inhaled Drug Optimization Strategies into Clinical Pharmacokinetics and Pharmacodynamics Using GSK2292767A, a Novel Inhaled Phosphoinositide 3-Kinase δ Inhibitor.

Begg M, Edwards CD, Hamblin JN, Pefani E, Wilson R, Gilbert J, Vitulli G, Mallett D, Morrell J, Hingle MI, Uddin S, Ehtesham F, Marotti M, Harrell A, Newman CF, Fernando D, Clark J, Cahn A, Hessel EM.

J Pharmacol Exp Ther. 2019 Jun;369(3):443-453. doi: 10.1124/jpet.119.257311. Epub 2019 Apr 2.


Relationship between Pharmacokinetics and Pharmacodynamic Responses in Healthy Smokers Informs a Once-Daily Dosing Regimen for Nemiralisib.

Begg M, Wilson R, Hamblin JN, Montembault M, Green J, Deans A, Amour A, Worsley S, Fantom K, Cui Y, Dear G, Ahmad S, Kielkowska A, Clark J, Boyce M, Cahn A, Hessel EM.

J Pharmacol Exp Ther. 2019 Jun;369(3):337-344. doi: 10.1124/jpet.118.255109. Epub 2019 Mar 18.


Use of autologous 99mTechnetium-labelled neutrophils to quantify lung neutrophil clearance in COPD.

Tregay N, Begg M, Cahn A, Farahi N, Povey K, Madhavan S, Simmonds R, Gillett D, Solanki C, Wong A, Maison J, Lennon M, Bradley G, Jarvis E, de Groot M, Wilson F, Babar J, Peters AM, Hessel EM, Chilvers ER.

Thorax. 2019 Jul;74(7):659-666. doi: 10.1136/thoraxjnl-2018-212509. Epub 2019 Jan 23.


A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Crossover Study To Investigate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Repeat Doses of Inhaled Nemiralisib in Adults with Persistent, Uncontrolled Asthma.

Khindri S, Cahn A, Begg M, Montembault M, Leemereise C, Cui Y, Hogg A, Wajdner H, Yang S, Robertson J, Hamblin JN, Ludwig-Sengpiel A, Kornmann O, Hessel EM.

J Pharmacol Exp Ther. 2018 Dec;367(3):405-413. doi: 10.1124/jpet.118.249516. Epub 2018 Sep 14.


Cause and Association: Missing the Forest for the Trees.

Begg MD, March D.

Am J Public Health. 2018 May;108(5):620. doi: 10.2105/AJPH.2018.304366. No abstract available.


Knowledge, Attitude and Practices Regarding Benign Testicular Disorders in the Educated Young Men of Pakistan.

Saleem D, Muneer S, Younus Khan RF, Ochani RK, Ahmed SS, Begg M, Siddiqi TJ, Abbas SR, Naseeb MW, Farooqui MO, Shaikh FH, Kirmani R, Ullah H, Fatima K.

Cureus. 2017 Aug 13;9(8):e1563. doi: 10.7759/cureus.1563.


Safety, pharmacokinetics and dose-response characteristics of GSK2269557, an inhaled PI3Kδ inhibitor under development for the treatment of COPD.

Cahn A, Hamblin JN, Begg M, Wilson R, Dunsire L, Sriskantharajah S, Montembault M, Leemereise CN, Galinanes-Garcia L, Watz H, Kirsten AM, Fuhr R, Hessel EM.

Pulm Pharmacol Ther. 2017 Oct;46:69-77. doi: 10.1016/j.pupt.2017.08.008. Epub 2017 Aug 17.


Orai and TRPC channel characterization in FcεRI-mediated calcium signaling and mediator secretion in human mast cells.

Wajdner HE, Farrington J, Barnard C, Peachell PT, Schnackenberg CG, Marino JP Jr, Xu X, Affleck K, Begg M, Seward EP.

Physiol Rep. 2017 Mar;5(5). pii: e13166. doi: 10.14814/phy2.13166.


Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition.

Juss JK, House D, Amour A, Begg M, Herre J, Storisteanu DM, Hoenderdos K, Bradley G, Lennon M, Summers C, Hessel EM, Condliffe A, Chilvers ER.

Am J Respir Crit Care Med. 2016 Oct 15;194(8):961-973.


2,8-Diazaspiro[4.5]decan-8-yl)pyrimidin-4-amine potent CCR4 antagonists capable of inducing receptor endocytosis.

Shukla L, Ajram LA, Begg M, Evans B, Graves RH, Hodgson ST, Lynn SM, Miah AH, Percy JM, Procopiou PA, Richards SA, Slack RJ.

Eur J Med Chem. 2016 Jun 10;115:14-25. doi: 10.1016/j.ejmech.2016.02.058. Epub 2016 Feb 27.


Epithelial-mesenchymal transition, IP3 receptors and ER-PM junctions: translocation of Ca2+ signalling complexes and regulation of migration.

Okeke E, Parker T, Dingsdale H, Concannon M, Awais M, Voronina S, Molgó J, Begg M, Metcalf D, Knight AE, Sutton R, Haynes L, Tepikin AV.

Biochem J. 2016 Mar 15;473(6):757-67. doi: 10.1042/BJ20150364. Epub 2016 Jan 12.


Graduate Education for the Future: New Models and Methods for the Clinical and Translational Workforce.

Begg MD, Bennett LM, Cicutto L, Gadlin H, Moss M, Tentler J, Schoenbaum E.

Clin Transl Sci. 2015 Dec;8(6):787-92. doi: 10.1111/cts.12359. Epub 2015 Dec 8.


Building Interdisciplinary Research Models Through Interactive Education.

Hessels AJ, Robinson B, O'Rourke M, Begg MD, Larson EL.

Clin Transl Sci. 2015 Dec;8(6):793-9. doi: 10.1111/cts.12354. Epub 2015 Dec 4.


Columbia Public Health Core Curriculum: Short-Term Impact.

Begg MD, Fried LP, Glover JW, Delva M, Wiggin M, Hooper L, Saxena R, de Pinho H, Slomin E, Walker JR, Galea S.

Am J Public Health. 2015 Dec;105(12):e7-13. doi: 10.2105/AJPH.2015.302879.


The role of CRAC channel in asthma.

Kaur M, Birrell MA, Dekkak B, Reynolds S, Wong S, De Alba J, Raemdonck K, Hall S, Simpson K, Begg M, Belvisi MG, Singh D.

Pulm Pharmacol Ther. 2015 Dec;35:67-74. doi: 10.1016/j.pupt.2015.09.002. Epub 2015 Sep 4.


Genome-wide transcription profiling in neutrophils in acute respiratory distress syndrome.

Juss J, Herre J, Begg M, Bradley G, Lennon M, Amour A, House D, Hessel EM, Summers C, Condliffe AM, Chilvers ER.

Lancet. 2015 Feb 26;385 Suppl 1:S55. doi: 10.1016/S0140-6736(15)60370-1.


Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models.

Wen L, Voronina S, Javed MA, Awais M, Szatmary P, Latawiec D, Chvanov M, Collier D, Huang W, Barrett J, Begg M, Stauderman K, Roos J, Grigoryev S, Ramos S, Rogers E, Whitten J, Velicelebi G, Dunn M, Tepikin AV, Criddle DN, Sutton R.

Gastroenterology. 2015 Aug;149(2):481-92.e7. doi: 10.1053/j.gastro.2015.04.015. Epub 2015 Apr 25.


Store-Operated Ca2+ Channels in Mesangial Cells Inhibit Matrix Protein Expression.

Wu P, Wang Y, Davis ME, Zuckerman JE, Chaudhari S, Begg M, Ma R.

J Am Soc Nephrol. 2015 Nov;26(11):2691-702. doi: 10.1681/ASN.2014090853. Epub 2015 Mar 18.


Developing the new Columbia core curriculum: a case study in managing radical curriculum change.

Galea S, Fried LP, Walker JR, Rudenstine S, Glover JW, Begg MD.

Am J Public Health. 2015 Mar;105 Suppl 1:S17-21. doi: 10.2105/AJPH.2014.302470.


Cultural competency training for public health students: integrating self, social, and global awareness into a master of public health curriculum.

Cushman LF, Delva M, Franks CL, Jimenez-Bautista A, Moon-Howard J, Glover J, Begg MD.

Am J Public Health. 2015 Mar;105 Suppl 1:S132-40. doi: 10.2105/AJPH.2014.302506.


The role of Ca2+ influx in endocytic vacuole formation in pancreatic acinar cells.

Voronina S, Collier D, Chvanov M, Middlehurst B, Beckett AJ, Prior IA, Criddle DN, Begg M, Mikoshiba K, Sutton R, Tepikin AV.

Biochem J. 2015 Feb 1;465(3):405-12. doi: 10.1042/BJ20140398.


"Chemokine receptors as therapeutic targets: Why aren't there more drugs?".

Solari R, Pease JE, Begg M.

Eur J Pharmacol. 2015 Jan 5;746:363-7. doi: 10.1016/j.ejphar.2014.06.060. Epub 2014 Jul 10.


Effective practices for teaching the biostatistics core course for the MPH using a competency-based approach.

Sullivan LM, Hooper L, Begg MD.

Public Health Rep. 2014 Jul-Aug;129(4):381-92. No abstract available.


Integrating competencies and learning outcomes in core courses for the MPH.

Hooper L, Begg MD, Sullivan LM.

Public Health Rep. 2014 Jul-Aug;129(4):376-81. No abstract available.


Lead identification of benzimidazolone and azabenzimidazolone arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists.

Miah AH, Abas H, Begg M, Marsh BJ, O'Flynn DE, Ford AJ, Percy JM, Procopiou PA, Richards SA, Rumley SA.

Bioorg Med Chem. 2014 Aug 1;22(15):4298-311. doi: 10.1016/j.bmc.2014.05.021. Epub 2014 May 21.


High glucose and diabetes enhanced store-operated Ca(2+) entry and increased expression of its signaling proteins in mesangial cells.

Chaudhari S, Wu P, Wang Y, Ding Y, Yuan J, Begg M, Ma R.

Am J Physiol Renal Physiol. 2014 May 1;306(9):F1069-80. doi: 10.1152/ajprenal.00463.2013. Epub 2014 Mar 12.


Internalization of the chemokine receptor CCR4 can be evoked by orthosteric and allosteric receptor antagonists.

Ajram L, Begg M, Slack R, Cryan J, Hall D, Hodgson S, Ford A, Barnes A, Swieboda D, Mousnier A, Solari R.

Eur J Pharmacol. 2014 Apr 15;729:75-85. doi: 10.1016/j.ejphar.2014.02.007. Epub 2014 Feb 15.


MPH education for the 21st century: design of Columbia University's new public health curriculum.

Begg MD, Galea S, Bayer R, Walker JR, Fried LP.

Am J Public Health. 2014 Jan;104(1):30-6. doi: 10.2105/AJPH.2013.301518. Epub 2013 Nov 14.


MPH education for the 21st century: motivation, rationale, and key principles for the new Columbia public health curriculum.

Fried LP, Begg MD, Bayer R, Galea S.

Am J Public Health. 2014 Jan;104(1):23-30. doi: 10.2105/AJPH.2013.301399. Epub 2013 Nov 14.


Approaches to preparing young scholars for careers in interdisciplinary team science.

Begg MD, Crumley G, Fair AM, Martina CA, McCormack WT, Merchant C, Patino-Sutton CM, Umans JG.

J Investig Med. 2014 Jan;62(1):14-25. doi: 10.2310/JIM.0000000000000021.


CRAC channel inhibition produces greater anti-inflammatory effects than glucocorticoids in CD8 cells from COPD patients.

Grundy S, Kaur M, Plumb J, Reynolds S, Hall S, House D, Begg M, Ray D, Singh D.

Clin Sci (Lond). 2014 Feb;126(3):223-32. doi: 10.1042/CS20130152.


Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy.

Gerasimenko JV, Gryshchenko O, Ferdek PE, Stapleton E, Hébert TO, Bychkova S, Peng S, Begg M, Gerasimenko OV, Petersen OH.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13186-91. doi: 10.1073/pnas.1300910110. Epub 2013 Jul 22.


Characterization of selective Calcium-Release Activated Calcium channel blockers in mast cells and T-cells from human, rat, mouse and guinea-pig preparations.

Rice LV, Bax HJ, Russell LJ, Barrett VJ, Walton SE, Deakin AM, Thomson SA, Lucas F, Solari R, House D, Begg M.

Eur J Pharmacol. 2013 Mar 15;704(1-3):49-57. doi: 10.1016/j.ejphar.2013.02.022. Epub 2013 Feb 27.


Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists.

Procopiou PA, Barrett JW, Barton NP, Begg M, Clapham D, Copley RC, Ford AJ, Graves RH, Hall DA, Hancock AP, Hill AP, Hobbs H, Hodgson ST, Jumeaux C, Lacroix YM, Miah AH, Morriss KM, Needham D, Sheriff EB, Slack RJ, Smith CE, Sollis SL, Staton H.

J Med Chem. 2013 Mar 14;56(5):1946-60. doi: 10.1021/jm301572h. Epub 2013 Feb 27.


The action of selective CRAC channel blockers is affected by the Orai pore geometry.

Derler I, Schindl R, Fritsch R, Heftberger P, Riedl MC, Begg M, House D, Romanin C.

Cell Calcium. 2013 Feb;53(2):139-51. doi: 10.1016/j.ceca.2012.11.005. Epub 2012 Dec 5.


CRACM/Orai ion channel expression and function in human lung mast cells.

Ashmole I, Duffy SM, Leyland ML, Morrison VS, Begg M, Bradding P.

J Allergy Clin Immunol. 2012 Jun;129(6):1628-35.e2. doi: 10.1016/j.jaci.2012.01.070. Epub 2012 Mar 10.


Identifying and aligning expectations in a mentoring relationship.

Huskins WC, Silet K, Weber-Main AM, Begg MD, Fowler VG Jr, Hamilton J, Fleming M.

Clin Transl Sci. 2011 Dec;4(6):439-47. doi: 10.1111/j.1752-8062.2011.00356.x. Epub 2011 Nov 18.


In vitro characterisation of the duration of action of the histamine-1 receptor antagonist azelastine.

Slack RJ, Hart AD, Luttmann MA, Clark KL, Begg M.

Eur J Pharmacol. 2011 Nov 30;670(2-3):586-92. doi: 10.1016/j.ejphar.2011.09.017. Epub 2011 Sep 21.


Building interdisciplinary research models: a didactic course to prepare interdisciplinary scholars and faculty.

Larson EL, Landers TF, Begg MD.

Clin Transl Sci. 2011 Feb;4(1):38-41. doi: 10.1111/j.1752-8062.2010.00258.x.


Sharing facilities and administrative cost recovery to facilitate interdisciplinary research.

Kulage KM, Larson EL, Begg MD.

Acad Med. 2011 Mar;86(3):394-401. doi: 10.1097/ACM.0b013e31820924ea.


Virtual patients: practical advice for clinical authors using Labyrinth.

Begg M.

Clin Teach. 2010 Sep;7(3):202-5. doi: 10.1111/j.1743-498X.2010.00382.x.


An examination of periodontal treatment, dental care, and pregnancy outcomes in an insured population in the United States.

Albert DA, Begg MD, Andrews HF, Williams SZ, Ward A, Conicella ML, Rauh V, Thomson JL, Papapanou PN.

Am J Public Health. 2011 Jan;101(1):151-6. doi: 10.2105/AJPH.2009.185884. Epub 2010 Nov 18.


eDrugCalc: an online self-assessment package to enhance medical students' drug dose calculation skills.

McQueen DS, Begg MJ, Maxwell SR.

Br J Clin Pharmacol. 2010 Oct;70(4):492-9. doi: 10.1111/j.1365-2125.2010.03609.x.


Identifying interdisciplinary research priorities to prevent and treat pediatric obesity in New York City.

Gallagher D, Larson EL, Wang YH, Richards B, Weng C, Hametz P, Begg MD, Chung WK, Boden-Albala B, Akabas SR.

Clin Transl Sci. 2010 Aug;3(4):172-7. doi: 10.1111/j.1752-8062.2010.00210.x.


Invited commentary: The use of sibship studies to detect familial confounding.

Susser E, Eide MG, Begg M.

Am J Epidemiol. 2010 Sep 1;172(5):537-9. doi: 10.1093/aje/kwq196. Epub 2010 Jul 14.


Online virtual patients - A driver for change in medical and healthcare professional education in developing countries?

Dewhurst D, Borgstein E, Grant ME, Begg M.

Med Teach. 2009 Aug;31(8):721-4.


Primary total hip replacement in childhood, adolescence and young patients: quality and outcome of clinical studies.

Jäger M, Begg MJ, Ready J, Bittersohl B, Millis M, Krauspe R, Thornhill TS.

Technol Health Care. 2008;16(3):195-214.


A comparison of regression approaches for analyzing clustered data.

Desai M, Begg MD.

Am J Public Health. 2008 Aug;98(8):1425-9. doi: 10.2105/AJPH.2006.108233. Epub 2008 Jun 12.

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