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Items: 1 to 50 of 77

1.

The humoral immune response is essential for successful vaccine protection against paratuberculosis in sheep.

Pooley HB, Begg DJ, Plain KM, Whittington RJ, Purdie AC, de Silva K.

BMC Vet Res. 2019 Jul 2;15(1):223. doi: 10.1186/s12917-019-1972-z.

2.

The immunogenicity and tissue reactivity of Mycobacterium avium subsp paratuberculosis inactivated whole cell vaccine is dependent on the adjuvant used.

Begg DJ, Dhungyel O, Naddi A, Dhand NK, Plain KM, de Silva K, Purdie AC, Whittington RJ.

Heliyon. 2019 Jun 18;5(6):e01911. doi: 10.1016/j.heliyon.2019.e01911. eCollection 2019 Jun.

3.

Gene expression profiles during subclinical Mycobacterium avium subspecies paratuberculosis infection in sheep can predict disease outcome.

Purdie AC, Plain KM, Begg DJ, de Silva K, Whittington RJ.

Sci Rep. 2019 Jun 3;9(1):8245. doi: 10.1038/s41598-019-44670-w.

4.

Corrigendum to "Experimental infection model for Johne's disease using a lyophilised, pure culture, seedstock of Mycobacterium avium subspecies paratuberculosis" [Veterinary Microbiology 141 (2010) 301-311].

Begg DJ, de Silva K, Di Fiore L, Taylor DL, Bower K, Zhong L, Kawaji S, Emery D, Whittington RJ.

Vet Microbiol. 2018 Oct;224:119. doi: 10.1016/j.vetmic.2018.08.023. Epub 2018 Sep 5. No abstract available.

PMID:
30193755
5.

Sheep and cattle exposed to Mycobacterium avium subspecies paratuberculosis exhibit altered total serum cholesterol profiles during the early stages of infection.

Johansen MD, de Silva K, Plain KM, Begg DJ, Whittington RJ, Purdie AC.

Vet Immunol Immunopathol. 2018 Aug;202:164-171. doi: 10.1016/j.vetimm.2018.07.009. Epub 2018 Jul 17.

PMID:
30078591
6.

A national serosurvey to determine the prevalence of paratuberculosis in cattle in Bhutan following detection of clinical cases.

Gurung RB, Begg DJ, Whittington RJ.

Vet Med Sci. 2018 Nov;4(4):288-295. doi: 10.1002/vms3.114. Epub 2018 Jul 5.

7.

Immunopathological changes and apparent recovery from infection revealed in cattle in an experimental model of Johne's disease using a lyophilised culture of Mycobacterium avium subspecies paratuberculosis.

Begg DJ, Plain KM, de Silva K, Gurung R, Gunn A, Purdie AC, Whittington RJ.

Vet Microbiol. 2018 Jun;219:53-62. doi: 10.1016/j.vetmic.2018.03.029. Epub 2018 Mar 29.

PMID:
29778205
8.

Integrated vaccine screening system: using cellular functional capacity in vitro to assess genuine vaccine protectiveness in ruminants.

Pooley HB, Plain KM, Purdie AC, Begg DJ, Whittington RJ, de Silva K.

Pathog Dis. 2018 Apr 1;76(3). doi: 10.1093/femspd/fty029.

PMID:
29718267
9.

Protein Kinase G Induces an Immune Response in Cows Exposed to Mycobacterium avium Subsp. paratuberculosis.

Bach H, Richard-Greenblatt M, Bach E, Chaffer M, Lai W, Keefe G, Begg DJ.

Biomed Res Int. 2018 Jan 18;2018:1450828. doi: 10.1155/2018/1450828. eCollection 2018.

10.

Case definition terminology for paratuberculosis (Johne's disease).

Whittington RJ, Begg DJ, de Silva K, Purdie AC, Dhand NK, Plain KM.

BMC Vet Res. 2017 Nov 9;13(1):328. doi: 10.1186/s12917-017-1254-6.

11.

Variation in susceptibility of different breeds of sheep to Mycobacterium avium subspecies paratuberculosis following experimental inoculation.

Begg DJ, Purdie AC, de Silva K, Dhand NK, Plain KM, Whittington RJ.

Vet Res. 2017 Jun 17;48(1):36. doi: 10.1186/s13567-017-0440-7.

12.

Experimental infection of New Zealand Merino sheep with a suspension of Mycobacterium avium subspecies paratuberculosis (Map) strain Telford: Kinetics of the immune response, histopathology and Map culture.

Dukkipati VSR, Ridler AL, Thompson KG, Buddle BM, Hedgespeth BA, Price-Carter M, Begg DJ, Whittington RJ, Gicquel B, Murray A.

Vet Microbiol. 2016 Nov 15;195:136-143. doi: 10.1016/j.vetmic.2016.09.018. Epub 2016 Sep 23.

13.

A Rapid Method for Quantifying Viable Mycobacterium avium subsp. paratuberculosis in Cellular Infection Assays.

Pooley HB, de Silva K, Purdie AC, Begg DJ, Whittington RJ, Plain KM.

Appl Environ Microbiol. 2016 Aug 30;82(18):5553-62. doi: 10.1128/AEM.01668-16. Print 2016 Sep 15.

14.

Evaluation of the limitations and methods to improve rapid phage-based detection of viable Mycobacterium avium subsp. paratuberculosis in the blood of experimentally infected cattle.

Swift BM, Huxley JN, Plain KM, Begg DJ, de Silva K, Purdie AC, Whittington RJ, Rees CE.

BMC Vet Res. 2016 Jun 16;12(1):115. doi: 10.1186/s12917-016-0728-2.

15.

Development of 316v antibody enzyme-linked immunosorbent assay for detection of paratuberculosis in sheep.

Gurung RB, Begg DJ, Purdie AC, Eamens GJ, Whittington RJ.

Rev Sci Tech. 2015 Dec;34(3):869-79.

PMID:
27044158
16.

Macrophage polarization in cattle experimentally exposed to Mycobacterium avium subsp. paratuberculosis.

Thirunavukkarasu S, de Silva K, Begg DJ, Whittington RJ, Plain KM.

Pathog Dis. 2015 Dec;73(9):ftv085. doi: 10.1093/femspd/ftv085. Epub 2015 Oct 9.

17.

Histopathological Characterization of Cutaneous Delayed-type Hypersensitivity and Correlations with Intestinal Pathology and Systemic Immune Responses in Sheep with Paratuberculosis.

Gulliver EL, Plain KM, Begg DJ, Whittington RJ.

J Comp Pathol. 2015 Aug-Oct;153(2-3):67-80. doi: 10.1016/j.jcpa.2015.05.005. Epub 2015 Jul 9.

PMID:
26164087
18.

Specific faecal antibody responses in sheep infected with Mycobacterium avium subspecies paratuberculosis.

Begg DJ, de Silva K, Plain KM, Purdie AC, Dhand N, Whittington RJ.

Vet Immunol Immunopathol. 2015 Aug 15;166(3-4):125-31. doi: 10.1016/j.vetimm.2015.06.011. Epub 2015 Jun 25.

PMID:
26144891
19.

Efficient, validated method for detection of mycobacterial growth in liquid culture media by use of bead beating, magnetic-particle-based nucleic acid isolation, and quantitative PCR.

Plain KM, Waldron AM, Begg DJ, de Silva K, Purdie AC, Whittington RJ.

J Clin Microbiol. 2015 Apr;53(4):1121-8. doi: 10.1128/JCM.03521-14. Epub 2015 Jan 21.

20.

Cellular and humoral immune responses in sheep vaccinated with candidate antigens MAP2698c and MAP3567 from Mycobacterium avium subspecies paratuberculosis.

Gurung RB, Purdie AC, Whittington RJ, Begg DJ.

Front Cell Infect Microbiol. 2014 Jul 16;4:93. doi: 10.3389/fcimb.2014.00093. eCollection 2014.

21.

Immunoreactivity of protein tyrosine phosphatase A (PtpA) in sera from sheep infected with Mycobacterium avium subspecies paratuberculosis.

Gurung RB, Begg DJ, Purdie AC, Bach H, Whittington RJ.

Vet Immunol Immunopathol. 2014 Jul 15;160(1-2):129-32. doi: 10.1016/j.vetimm.2014.03.013. Epub 2014 Apr 3.

PMID:
24788024
22.

Lymphoproliferative and gamma interferon responses to stress-regulated Mycobacterium avium subsp. paratuberculosis recombinant proteins.

Gurung RB, Begg DJ, Purdie AC, de Silva K, Bannantine JP, Whittington RJ.

Clin Vaccine Immunol. 2014 Jun;21(6):831-7. doi: 10.1128/CVI.00775-13. Epub 2014 Apr 2.

23.

Environmental survival of Mycobacterium avium subsp. paratuberculosis in different climatic zones of eastern Australia.

Eppleston J, Begg DJ, Dhand NK, Watt B, Whittington RJ.

Appl Environ Microbiol. 2014 Apr;80(8):2337-42. doi: 10.1128/AEM.03630-13. Epub 2014 Jan 24.

24.

High-throughput direct fecal PCR assay for detection of Mycobacterium avium subsp. paratuberculosis in sheep and cattle.

Plain KM, Marsh IB, Waldron AM, Galea F, Whittington AM, Saunders VF, Begg DJ, de Silva K, Purdie AC, Whittington RJ.

J Clin Microbiol. 2014 Mar;52(3):745-57. doi: 10.1128/JCM.03233-13. Epub 2013 Dec 18.

25.

Pre-licensed driving experience and car crash involvement during the learner and restricted, licence stages of graduated driver licensing: Findings from the New Zealand drivers study.

Begg DJ, Langley JD, Brookland RL, Ameratunga S, Gulliver P.

Accid Anal Prev. 2014 Jan;62:153-60. doi: 10.1016/j.aap.2013.08.027. Epub 2013 Sep 20.

PMID:
24161622
26.

Antigenicity of recombinant maltose binding protein-Mycobacterium avium subsp. paratuberculosis fusion proteins with and without factor Xa cleaving.

Gurung RB, Begg DJ, Purdie AC, Bannantine JP, Whittington RJ.

Clin Vaccine Immunol. 2013 Dec;20(12):1817-26. doi: 10.1128/CVI.00596-13. Epub 2013 Oct 16.

27.

Apoptosis of lymph node and peripheral blood cells in ovine Johne's disease.

de Silva K, Browne S, Begg DJ, Whittington RJ, Emery D.

Vet Immunol Immunopathol. 2013 Nov 15;156(1-2):82-90. doi: 10.1016/j.vetimm.2013.08.001. Epub 2013 Sep 13.

PMID:
24054092
28.

Development and validation of a liquid medium (M7H9C) for routine culture of Mycobacterium avium subsp. paratuberculosis to replace modified Bactec 12B medium.

Whittington RJ, Whittington AM, Waldron A, Begg DJ, de Silva K, Purdie AC, Plain KM.

J Clin Microbiol. 2013 Dec;51(12):3993-4000. doi: 10.1128/JCM.01373-13. Epub 2013 Sep 18.

29.

Can early host responses to mycobacterial infection predict eventual disease outcomes?

de Silva K, Begg DJ, Plain KM, Purdie AC, Kawaji S, Dhand NK, Whittington RJ.

Prev Vet Med. 2013 Nov 1;112(3-4):203-12. doi: 10.1016/j.prevetmed.2013.08.006. Epub 2013 Aug 24.

PMID:
24034815
30.

Antigenicity in sheep of synthetic peptides derived from stress-regulated Mycobacterium avium subsp. paratuberculosis proteins and comparison with recombinant protein and complex native antigens.

Gurung RB, Begg DJ, Purdie AC, Whittington RJ.

Vet Immunol Immunopathol. 2014 Mar 15;158(1-2):46-52. doi: 10.1016/j.vetimm.2013.05.016. Epub 2013 Jun 8.

PMID:
23815825
31.

Validity of using linked hospital and police traffic crash records to analyse motorcycle injury crash characteristics.

Wilson SJ, Begg DJ, Samaranayaka A.

Accid Anal Prev. 2012 Nov;49:30-5. doi: 10.1016/j.aap.2011.03.007. Epub 2011 Apr 3.

PMID:
23036379
32.

Reducing young driver crash casualties in Great Britain - use of routine police crash data to estimate the potential benefits of graduated driver licensing.

Jones SJ, Begg DJ, Palmer SR.

Int J Inj Contr Saf Promot. 2013;20(4):321-30. doi: 10.1080/17457300.2012.726631. Epub 2012 Sep 26.

PMID:
23009650
33.

In silico screened Mycobacterium avium subsp. paratuberculosis (MAP) recombinant proteins upregulated under stress conditions are immunogenic in sheep.

Gurung RB, Purdie AC, Begg DJ, Whittington RJ.

Vet Immunol Immunopathol. 2012 Oct 15;149(3-4):186-96. doi: 10.1016/j.vetimm.2012.06.026. Epub 2012 Jul 7.

PMID:
22868202
34.

Age, period and cohort effects on the incidence of motorcyclist casualties in traffic crashes.

Langley J, Samaranayaka A, Begg DJ.

Inj Prev. 2013 Jun;19(3):153-7. doi: 10.1136/injuryprev-2012-040345. Epub 2012 Jun 30.

35.

Enhancement of the interferon gamma assay to detect paratuberculosis using interleukin-7 and interleukin-12 potentiation.

Plain KM, Begg DJ, de Silva K, Purdie AC, Whittington RJ.

Vet Immunol Immunopathol. 2012 Sep 15;149(1-2):28-37. doi: 10.1016/j.vetimm.2012.05.023. Epub 2012 Jun 9.

PMID:
22749292
36.

In silico identification of epitopes in Mycobacterium avium subsp. paratuberculosis proteins that were upregulated under stress conditions.

Gurung RB, Purdie AC, Begg DJ, Whittington RJ.

Clin Vaccine Immunol. 2012 Jun;19(6):855-64. doi: 10.1128/CVI.00114-12. Epub 2012 Apr 11.

37.

Tissue localisation of Mycobacterium avium subspecies paratuberculosis following artificially induced intracellular and naked bacteraemia.

Bower KL, Begg DJ, Whittington RJ.

Vet Microbiol. 2013 Feb 22;162(1):112-8. doi: 10.1016/j.vetmic.2012.03.007. Epub 2012 Mar 13.

PMID:
22465800
38.

Expression of genes associated with the antigen presentation and processing pathway are consistently regulated in early Mycobacterium avium subsp. paratuberculosis infection.

Purdie AC, Plain KM, Begg DJ, de Silva K, Whittington RJ.

Comp Immunol Microbiol Infect Dis. 2012 Mar;35(2):151-62. doi: 10.1016/j.cimid.2011.12.007. Epub 2012 Jan 10.

PMID:
22239946
39.

Indoleamine 2,3-dioxygenase, tryptophan catabolism, and Mycobacterium avium subsp. paratuberculosis: a model for chronic mycobacterial infections.

Plain KM, de Silva K, Earl J, Begg DJ, Purdie AC, Whittington RJ.

Infect Immun. 2011 Sep;79(9):3821-32. doi: 10.1128/IAI.05204-11. Epub 2011 Jul 5.

40.

Biomarker discovery for ovine paratuberculosis (Johne's disease) by proteomic serum profiling.

Zhong L, Taylor D, Begg DJ, Whittington RJ.

Comp Immunol Microbiol Infect Dis. 2011 Jul;34(4):315-26. doi: 10.1016/j.cimid.2011.03.001. Epub 2011 Apr 9.

PMID:
21481470
41.

Comparative immunological and microbiological aspects of paratuberculosis as a model mycobacterial infection.

Whittington RJ, Begg DJ, de Silva K, Plain KM, Purdie AC.

Vet Immunol Immunopathol. 2012 Jul 15;148(1-2):29-47. doi: 10.1016/j.vetimm.2011.03.003. Epub 2011 Mar 29. Review.

PMID:
21450348
42.

Does a Th1 over Th2 dominancy really exist in the early stages of Mycobacterium avium subspecies paratuberculosis infections?

Begg DJ, de Silva K, Carter N, Plain KM, Purdie A, Whittington RJ.

Immunobiology. 2011 Jul;216(7):840-6. doi: 10.1016/j.imbio.2010.12.004. Epub 2010 Dec 22.

PMID:
21281979
43.

Candidate gene and genome-wide association studies of Mycobacterium avium subsp. paratuberculosis infection in cattle and sheep: a review.

Purdie AC, Plain KM, Begg DJ, de Silva K, Whittington RJ.

Comp Immunol Microbiol Infect Dis. 2011 May;34(3):197-208. doi: 10.1016/j.cimid.2010.12.003. Epub 2011 Jan 8. Review.

PMID:
21216466
44.

A longitudinal study to evaluate the diagnostic potential of a direct faecal quantitative PCR test for Johne's disease in sheep.

Kawaji S, Begg DJ, Plain KM, Whittington RJ.

Vet Microbiol. 2011 Feb 24;148(1):35-44. doi: 10.1016/j.vetmic.2010.07.022. Epub 2010 Aug 5.

PMID:
20729013
45.

Culture of Mycobacterium avium subspecies paratuberculosis (MAP) from blood and extra-intestinal tissues in experimentally infected sheep.

Bower KL, Begg DJ, Whittington RJ.

Vet Microbiol. 2011 Jan 10;147(1-2):127-32. doi: 10.1016/j.vetmic.2010.06.016. Epub 2010 Jun 19.

PMID:
20609533
46.

Toll-like receptor (TLR)6 and TLR1 differentiation in gene expression studies of Johne's disease.

Plain KM, Purdie AC, Begg DJ, de Silva K, Whittington RJ.

Vet Immunol Immunopathol. 2010 Sep 15;137(1-2):142-8. doi: 10.1016/j.vetimm.2010.04.002. Epub 2010 Apr 14.

PMID:
20434222
47.

Optimization of a whole blood gamma interferon assay for the detection of sheep infected with Mycobacterium avium subspecies paratuberculosis.

Bosward KL, Dhand NK, Begg DJ, Thomson PC, Emery DL, Whittington RJ.

J Vet Diagn Invest. 2010 Mar;22(2):210-7.

PMID:
20224078
48.

Optimisation of culture of Mycobacterium avium subspecies paratuberculosis from blood samples.

Bower K, Begg DJ, Whittington RJ.

J Microbiol Methods. 2010 Jan;80(1):93-9. doi: 10.1016/j.mimet.2009.11.005. Epub 2009 Nov 22.

PMID:
19932719
49.

Experimental infection model for Johne's disease using a lyophilised, pure culture, seedstock of Mycobacterium avium subspecies paratuberculosis.

Begg DJ, de Silva K, Di Fiore L, Taylor DL, Bower K, Zhong L, Kawaji S, Emery D, Whittington RJ.

Vet Microbiol. 2010 Mar 24;141(3-4):301-11. doi: 10.1016/j.vetmic.2009.09.007. Epub 2009 Sep 11. Erratum in: Vet Microbiol. 2018 Oct;224:119.

PMID:
19815353
50.

Enzyme-linked immunospot: an alternative method for the detection of interferon gamma in Johne's disease.

Begg DJ, de Silva K, Bosward K, Di Fiore L, Taylor DL, Jungersen G, Whittington RJ.

J Vet Diagn Invest. 2009 Mar;21(2):187-96.

PMID:
19286496

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