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Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis.

Han T, Jiang S, Zheng H, Yin Q, Xie M, Little MR, Yin X, Chen M, Song SJ, Beg AA, Pandolfi PP, Wan L.

Nat Commun. 2019 Aug 16;10(1):3716. doi: 10.1038/s41467-019-11618-7.


Phase I/Ib Study of Pembrolizumab Plus Vorinostat in Advanced/Metastatic Non-Small Cell Lung Cancer.

Gray JE, Saltos A, Tanvetyanon T, Haura EB, Creelan B, Antonia SJ, Shafique M, Zheng H, Dai W, Saller JJ, Chen Z, Tchekmedyian N, Goas K, Thapa R, Boyle TA, Chen DT, Beg AA.

Clin Cancer Res. 2019 Nov 15;25(22):6623-6632. doi: 10.1158/1078-0432.CCR-19-1305. Epub 2019 Aug 13.


Proteogenomic landscape of squamous cell lung cancer.

Stewart PA, Welsh EA, Slebos RJC, Fang B, Izumi V, Chambers M, Zhang G, Cen L, Pettersson F, Zhang Y, Chen Z, Cheng CH, Thapa R, Thompson Z, Fellows KM, Francis JM, Saller JJ, Mesa T, Zhang C, Yoder S, DeNicola GM, Beg AA, Boyle TA, Teer JK, Ann Chen Y, Koomen JM, Eschrich SA, Haura EB.

Nat Commun. 2019 Aug 8;10(1):3578. doi: 10.1038/s41467-019-11452-x.


MEK Inhibition Modulates Cytokine Response to Mediate Therapeutic Efficacy in Lung Cancer.

Xie M, Zheng H, Madan-Lala R, Dai W, Gimbrone NT, Chen Z, Kinose F, Blackstone SA, Smalley KSM, Cress WD, Haura EB, Rix U, Beg AA.

Cancer Res. 2019 Nov 15;79(22):5812-5825. doi: 10.1158/0008-5472.CAN-19-0698. Epub 2019 Jul 30.


An Intramolecular Salt Bridge Linking TDP43 RNA Binding, Protein Stability, and TDP43-Dependent Neurodegeneration.

Flores BN, Li X, Malik AM, Martinez J, Beg AA, Barmada SJ.

Cell Rep. 2019 Apr 23;27(4):1133-1150.e8. doi: 10.1016/j.celrep.2019.03.093.


Dual phosphorylation of Ric-8A enhances its ability to mediate G protein α subunit folding and to stimulate guanine nucleotide exchange.

Papasergi-Scott MM, Stoveken HM, MacConnachie L, Chan PY, Gabay M, Wong D, Freeman RS, Beg AA, Tall GG.

Sci Signal. 2018 May 29;11(532). pii: eaap8113. doi: 10.1126/scisignal.aap8113.


A Rapid and Facile Pipeline for Generating Genomic Point Mutants in C. elegans Using CRISPR/Cas9 Ribonucleoproteins.

Prior H, MacConnachie L, Martinez JL, Nicholl GCB, Beg AA.

J Vis Exp. 2018 Apr 30;(134). doi: 10.3791/57518.


Highly Efficient, Rapid and Co-CRISPR-Independent Genome Editing in Caenorhabditis elegans.

Prior H, Jawad AK, MacConnachie L, Beg AA.

G3 (Bethesda). 2017 Nov 6;7(11):3693-3698. doi: 10.1534/g3.117.300216.


Pharmacological characterization of the excitatory 'Cys-loop' GABA receptor family in Caenorhabditis elegans.

Nicholl GC, Jawad AK, Weymouth R, Zhang H, Beg AA.

Br J Pharmacol. 2017 May;174(9):781-795. doi: 10.1111/bph.13736. Epub 2017 Mar 10.


Predicting the pathogenicity of aminoacyl-tRNA synthetase mutations.

Oprescu SN, Griffin LB, Beg AA, Antonellis A.

Methods. 2017 Jan 15;113:139-151. doi: 10.1016/j.ymeth.2016.11.013. Epub 2016 Nov 20. Review.


HDAC inhibitors with PD-1 blockade: a promising strategy for treatment of multiple cancer types?

Beg AA, Gray JE.

Epigenomics. 2016 Aug;8(8):1015-7. doi: 10.2217/epi-2016-0066. Epub 2016 Jul 13. No abstract available.


The Rac-GAP alpha2-chimaerin regulates hippocampal dendrite and spine morphogenesis.

Valdez CM, Murphy GG, Beg AA.

Mol Cell Neurosci. 2016 Sep;75:14-26. doi: 10.1016/j.mcn.2016.06.002. Epub 2016 Jun 11.


HDAC Inhibitors Enhance T-Cell Chemokine Expression and Augment Response to PD-1 Immunotherapy in Lung Adenocarcinoma.

Zheng H, Zhao W, Yan C, Watson CC, Massengill M, Xie M, Massengill C, Noyes DR, Martinez GV, Afzal R, Chen Z, Ren X, Antonia SJ, Haura EB, Ruffell B, Beg AA.

Clin Cancer Res. 2016 Aug 15;22(16):4119-32. doi: 10.1158/1078-0432.CCR-15-2584. Epub 2016 Mar 10.


A Sensitive NanoString-Based Assay to Score STK11 (LKB1) Pathway Disruption in Lung Adenocarcinoma.

Chen L, Engel BE, Welsh EA, Yoder SJ, Brantley SG, Chen DT, Beg AA, Cao C, Kaye FJ, Haura EB, Schabath MB, Cress WD.

J Thorac Oncol. 2016 Jun;11(6):838-49. doi: 10.1016/j.jtho.2016.02.009. Epub 2016 Feb 23.


Propelling Immunotherapy Combinations Into the Clinic.

Tchekmedyian N, Gray JE, Creelan BC, Chiappori AA, Beg AA, Soliman H, Perez BA, Antonia SJ.

Oncology (Williston Park). 2015 Dec;29(12):990-1002. Review.


Differential association of STK11 and TP53 with KRAS mutation-associated gene expression, proliferation and immune surveillance in lung adenocarcinoma.

Schabath MB, Welsh EA, Fulp WJ, Chen L, Teer JK, Thompson ZJ, Engel BE, Xie M, Berglund AE, Creelan BC, Antonia SJ, Gray JE, Eschrich SA, Chen DT, Cress WD, Haura EB, Beg AA.

Oncogene. 2016 Jun 16;35(24):3209-16. doi: 10.1038/onc.2015.375. Epub 2015 Oct 19.


Charting Immune Signaling Proteomes En Route to New Therapeutic Strategies.

Haura EB, Beg AA, Rix U, Antonia S.

Cancer Immunol Res. 2015 Jul;3(7):714-20. doi: 10.1158/2326-6066.CIR-15-0094. Epub 2015 Jun 16. Review.


Loss of function mutations in HARS cause a spectrum of inherited peripheral neuropathies.

Safka Brozkova D, Deconinck T, Griffin LB, Ferbert A, Haberlova J, Mazanec R, Lassuthova P, Roth C, Pilunthanakul T, Rautenstrauss B, Janecke AR, Zavadakova P, Chrast R, Rivolta C, Zuchner S, Antonellis A, Beg AA, De Jonghe P, Senderek J, Seeman P, Baets J.

Brain. 2015 Aug;138(Pt 8):2161-72. doi: 10.1093/brain/awv158. Epub 2015 Jun 13.


Spillover transmission is mediated by the excitatory GABA receptor LGC-35 in C. elegans.

Jobson MA, Valdez CM, Gardner J, Garcia LR, Jorgensen EM, Beg AA.

J Neurosci. 2015 Feb 11;35(6):2803-16. doi: 10.1523/JNEUROSCI.4557-14.2015.


α2-chimaerin is required for Eph receptor-class-specific spinal motor axon guidance and coordinate activation of antagonistic muscles.

Kao TJ, Nicholl GC, Johansen JA, Kania A, Beg AA.

J Neurosci. 2015 Feb 11;35(6):2344-57. doi: 10.1523/JNEUROSCI.4151-14.2015.


Interleukin polymorphisms associated with overall survival, disease-free survival, and recurrence in non-small cell lung cancer patients.

Woods NT, Monteiro AN, Thompson ZJ, Amankwah EK, Naas N, Haura EB, Beg AA, Schabath MB.

Mol Carcinog. 2015 Jun;54 Suppl 1:E172-84. doi: 10.1002/mc.22275. Epub 2015 Jan 18.


NF-κB is crucial in proximal T-cell signaling for calcium influx and NFAT activation.

Bronk CC, Yoder S, Hopewell EL, Yang S, Celis E, Yu XZ, Beg AA.

Eur J Immunol. 2014 Dec;44(12):3741-6. doi: 10.1002/eji.201444904. Epub 2014 Oct 22.


Differential requirement for the IKKβ/NF-κB signaling module in regulating TLR- versus RLR-induced type 1 IFN expression in dendritic cells.

Wang X, Wang J, Zheng H, Xie M, Hopewell EL, Albrecht RA, Nogusa S, García-Sastre A, Balachandran S, Beg AA.

J Immunol. 2014 Sep 1;193(5):2538-45. doi: 10.4049/jimmunol.1400675. Epub 2014 Jul 23.


A new role for NFκB in immunosurveillance and its implications for cancer immunotherapy.

Beg AA, Khan T, Antonia SJ.

Oncoimmunology. 2013 Oct 1;2(10):e25963. Epub 2013 Aug 2.


Non-canonical IKKs, IKKϵ and TBK1, as novel therapeutic targets in the treatment of non-small cell lung cancer.

Kim JY, Beg AA, Haura EB.

Expert Opin Ther Targets. 2013 Oct;17(10):1109-12. doi: 10.1517/14728222.2013.833188. Epub 2013 Aug 28.


Pharmacologic inhibition of PKCα and PKCθ prevents GVHD while preserving GVL activity in mice.

Haarberg KM, Li J, Heinrichs J, Wang D, Liu C, Bronk CC, Kaosaard K, Owyang AM, Holland S, Masuda E, Tso K, Blazar BR, Anasetti C, Beg AA, Yu XZ.

Blood. 2013 Oct 3;122(14):2500-11. doi: 10.1182/blood-2012-12-471938. Epub 2013 Aug 1.


TNFRSF10B polymorphisms and haplotypes associated with increased risk of death in non-small cell lung cancer.

Schabath MB, Giuliano AR, Thompson ZJ, Amankwah EK, Gray JE, Fenstermacher DA, Jonathan KA, Beg AA, Haura EB.

Carcinogenesis. 2013 Nov;34(11):2525-30. doi: 10.1093/carcin/bgt244. Epub 2013 Jul 9.


Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells.

Kim JY, Welsh EA, Oguz U, Fang B, Bai Y, Kinose F, Bronk C, Remsing Rix LL, Beg AA, Rix U, Eschrich SA, Koomen JM, Haura EB.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12414-9. doi: 10.1073/pnas.1220674110. Epub 2013 Jul 8.


c-Rel is an essential transcription factor for the development of acute graft-versus-host disease in mice.

Yu Y, Wang D, Kaosaard K, Liu C, Fu J, Haarberg K, Anasetti C, Beg AA, Yu XZ.

Eur J Immunol. 2013 Sep;43(9):2327-37. doi: 10.1002/eji.201243282. Epub 2013 Jul 4.


Lung tumor NF-κB signaling promotes T cell-mediated immune surveillance.

Hopewell EL, Zhao W, Fulp WJ, Bronk CC, Lopez AS, Massengill M, Antonia S, Celis E, Haura EB, Enkemann SA, Chen DT, Beg AA.

J Clin Invest. 2013 Jun;123(6):2509-22. doi: 10.1172/JCI67250. Epub 2013 May 1.


A loss-of-function variant in the human histidyl-tRNA synthetase (HARS) gene is neurotoxic in vivo.

Vester A, Velez-Ruiz G, McLaughlin HM; NISC Comparative Sequencing Program, Lupski JR, Talbot K, Vance JM, Züchner S, Roda RH, Fischbeck KH, Biesecker LG, Nicholson G, Beg AA, Antonellis A.

Hum Mutat. 2013 Jan;34(1):191-9. doi: 10.1002/humu.22210. Epub 2012 Oct 11.


Targeting PKCθ in alloreactivity and graft-versus-host-disease: unanswered questions and therapeutic potential.

Bronk CC, Yu XZ, Beg AA.

Front Immunol. 2012 Aug 14;3:259. doi: 10.3389/fimmu.2012.00259. eCollection 2012.


IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer.

Guo J, Kim D, Gao J, Kurtyka C, Chen H, Yu C, Wu D, Mittal A, Beg AA, Chellappan SP, Haura EB, Cheng JQ.

Oncogene. 2013 Jan 10;32(2):151-9. doi: 10.1038/onc.2012.39. Epub 2012 Feb 13.


IKKβ-induced inflammation impacts the kinetics but not the magnitude of the immune response to a viral vector.

Hopewell EL, Bronk CC, Massengill M, Engelman RW, Beg AA.

Eur J Immunol. 2012 Mar;42(3):681-7. doi: 10.1002/eji.201141910. Epub 2012 Jan 13.


Defining emerging roles for NF-κB in antivirus responses: revisiting the interferon-β enhanceosome paradigm.

Balachandran S, Beg AA.

PLoS Pathog. 2011 Oct;7(10):e1002165. doi: 10.1371/journal.ppat.1002165. Epub 2011 Oct 13. No abstract available.


The Th17 immune response is controlled by the Rel-RORγ-RORγ T transcriptional axis.

Ruan Q, Kameswaran V, Zhang Y, Zheng S, Sun J, Wang J, DeVirgiliis J, Liou HC, Beg AA, Chen YH.

J Exp Med. 2011 Oct 24;208(11):2321-33. doi: 10.1084/jem.20110462. Epub 2011 Oct 17.


NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration.

Mauro C, Leow SC, Anso E, Rocha S, Thotakura AK, Tornatore L, Moretti M, De Smaele E, Beg AA, Tergaonkar V, Chandel NS, Franzoso G.

Nat Cell Biol. 2011 Aug 28;13(10):1272-9. doi: 10.1038/ncb2324.


NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis.

Thapa RJ, Basagoudanavar SH, Nogusa S, Irrinki K, Mallilankaraman K, Slifker MJ, Beg AA, Madesh M, Balachandran S.

Mol Cell Biol. 2011 Jul;31(14):2934-46. doi: 10.1128/MCB.05445-11. Epub 2011 May 16.


Distinct roles for the NF-kappa B RelA subunit during antiviral innate immune responses.

Basagoudanavar SH, Thapa RJ, Nogusa S, Wang J, Beg AA, Balachandran S.

J Virol. 2011 Mar;85(6):2599-610. doi: 10.1128/JVI.02213-10. Epub 2011 Jan 5.


Neuroscience: Angelman syndrome connections.

Scheiffele P, Beg AA.

Nature. 2010 Dec 16;468(7326):907-8. doi: 10.1038/468907a. No abstract available.


Phosphorylation of p50 NF-kappaB at a single serine residue by DNA-dependent protein kinase is critical for VCAM-1 expression upon TNF treatment.

Ju J, Naura AS, Errami Y, Zerfaoui M, Kim H, Kim JG, Abd Elmageed ZY, Abdel-Mageed AB, Giardina C, Beg AA, Smulson ME, Boulares AH.

J Biol Chem. 2010 Dec 24;285(52):41152-60. doi: 10.1074/jbc.M110.158352. Epub 2010 Oct 21.


NF-kappa B RelA subunit is crucial for early IFN-beta expression and resistance to RNA virus replication.

Wang J, Basagoudanavar SH, Wang X, Hopewell E, Albrecht R, García-Sastre A, Balachandran S, Beg AA.

J Immunol. 2010 Aug 1;185(3):1720-9. doi: 10.4049/jimmunol.1000114. Epub 2010 Jul 7.


Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development.

Vang KB, Yang J, Pagán AJ, Li LX, Wang J, Green JM, Beg AA, Farrar MA.

J Immunol. 2010 Apr 15;184(8):4074-7. doi: 10.4049/jimmunol.0903933. Epub 2010 Mar 12.


Targeting the Fanconi anemia/BRCA pathway circumvents drug resistance in multiple myeloma.

Yarde DN, Oliveira V, Mathews L, Wang X, Villagra A, Boulware D, Shain KH, Hazlehurst LA, Alsina M, Chen DT, Beg AA, Dalton WS.

Cancer Res. 2009 Dec 15;69(24):9367-75. doi: 10.1158/0008-5472.CAN-09-2616.


PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice.

Valenzuela JO, Iclozan C, Hossain MS, Prlic M, Hopewell E, Bronk CC, Wang J, Celis E, Engelman RW, Blazar BR, Bevan MJ, Waller EK, Yu XZ, Beg AA.

J Clin Invest. 2009 Dec;119(12):3774-86. doi: 10.1172/JCI39692. Epub 2009 Nov 9.


Interferons direct an effective innate response to Legionella pneumophila infection.

Plumlee CR, Lee C, Beg AA, Decker T, Shuman HA, Schindler C.

J Biol Chem. 2009 Oct 30;284(44):30058-66. doi: 10.1074/jbc.M109.018283. Epub 2009 Aug 31.


Genetic delineation of the pathways mediated by bid and JNK in tumor necrosis factor-alpha-induced liver injury in adult and embryonic mice.

Ni HM, Chen X, Shi YH, Liao Y, Beg AA, Fan J, Yin XM.

J Biol Chem. 2009 Feb 13;284(7):4373-82. doi: 10.1074/jbc.M807259200. Epub 2008 Dec 7.


Protons act as a transmitter for muscle contraction in C. elegans.

Beg AA, Ernstrom GG, Nix P, Davis MW, Jorgensen EM.

Cell. 2008 Jan 11;132(1):149-60. doi: 10.1016/j.cell.2007.10.058.


Mechanism of all-trans retinoic acid effect on tumor-associated myeloid-derived suppressor cells.

Nefedova Y, Fishman M, Sherman S, Wang X, Beg AA, Gabrilovich DI.

Cancer Res. 2007 Nov 15;67(22):11021-8. Erratum in: Cancer Res. 2008 Jan 15;68(2):626.


alpha2-Chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits.

Beg AA, Sommer JE, Martin JH, Scheiffele P.

Neuron. 2007 Sep 6;55(5):768-78.

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