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Items: 32


Reduced cognitive function, increased blood-brain-barrier transport and inflammatory responses, and altered brain metabolites in LDLr -/-and C57BL/6 mice fed a western diet.

Rutkowsky JM, Lee LL, Puchowicz M, Golub MS, Befroy DE, Wilson DW, Anderson S, Cline G, Bini J, Borkowski K, Knotts TA, Rutledge JC; Mouse Metabolic Phenotyping Center Imaging Working Group.

PLoS One. 2018 Feb 14;13(2):e0191909. doi: 10.1371/journal.pone.0191909. eCollection 2018.


Assessment of Hepatic Mitochondrial Oxidation and Pyruvate Cycling in NAFLD by (13)C Magnetic Resonance Spectroscopy.

Petersen KF, Befroy DE, Dufour S, Rothman DL, Shulman GI.

Cell Metab. 2016 Jul 12;24(1):167-71. doi: 10.1016/j.cmet.2016.06.005.


Hypophosphatemia promotes lower rates of muscle ATP synthesis.

Pesta DH, Tsirigotis DN, Befroy DE, Caballero D, Jurczak MJ, Rahimi Y, Cline GW, Dufour S, Birkenfeld AL, Rothman DL, Carpenter TO, Insogna K, Petersen KF, Bergwitz C, Shulman GI.

FASEB J. 2016 Oct;30(10):3378-3387. Epub 2016 Jun 23.


Response to burgess.

Befroy DE, Kibbey RG, Perry RJ, Petersen KF, Rothman DL, Shulman GI.

Nat Med. 2015 Feb;21(2):109-10. doi: 10.1038/nm.3790. No abstract available.


Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy.

Befroy DE, Perry RJ, Jain N, Dufour S, Cline GW, Trimmer JK, Brosnan J, Rothman DL, Petersen KF, Shulman GI.

Nat Med. 2014 Jan;20(1):98-102. doi: 10.1038/nm.3415. Epub 2013 Dec 8.


High-intensity interval training increases in vivo oxidative capacity with no effect on P(i)→ATP rate in resting human muscle.

Larsen RG, Befroy DE, Kent-Braun JA.

Am J Physiol Regul Integr Comp Physiol. 2013 Mar 1;304(5):R333-42. doi: 10.1152/ajpregu.00409.2012. Epub 2012 Dec 19.


³¹P-magnetization transfer magnetic resonance spectroscopy measurements of in vivo metabolism.

Befroy DE, Rothman DL, Petersen KF, Shulman GI.

Diabetes. 2012 Nov;61(11):2669-78. doi: 10.2337/db12-0558. Review.


Magnetic resonance spectroscopy studies of human metabolism.

Befroy DE, Shulman GI.

Diabetes. 2011 May;60(5):1361-9. doi: 10.2337/db09-0916. No abstract available.


Regulation of hepatic fat and glucose oxidation in rats with lipid-induced hepatic insulin resistance.

Alves TC, Befroy DE, Kibbey RG, Kahn M, Codella R, Carvalho RA, Falk Petersen K, Shulman GI.

Hepatology. 2011 Apr;53(4):1175-81. doi: 10.1002/hep.24170. Epub 2011 Mar 11.


Intracellular energetics and critical PO2 in resting ischemic human skeletal muscle in vivo.

Lanza IR, Tevald MA, Befroy DE, Kent-Braun JA.

Am J Physiol Regul Integr Comp Physiol. 2010 Nov;299(5):R1415-22. doi: 10.1152/ajpregu.00225.2010. Epub 2010 Sep 1.


Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia.

Mitchell CS, Savage DB, Dufour S, Schoenmakers N, Murgatroyd P, Befroy D, Halsall D, Northcott S, Raymond-Barker P, Curran S, Henning E, Keogh J, Owen P, Lazarus J, Rothman DL, Farooqi IS, Shulman GI, Chatterjee K, Petersen KF.

J Clin Invest. 2010 Apr;120(4):1345-54. doi: 10.1172/JCI38793. Epub 2010 Mar 8.


Assessment of in vivo mitochondrial metabolism by magnetic resonance spectroscopy.

Befroy DE, Falk Petersen K, Rothman DL, Shulman GI.

Methods Enzymol. 2009;457:373-93. doi: 10.1016/S0076-6879(09)05021-6.


Intramyocellular oxygenation during ischemic muscle contractions in vivo.

Tevald MA, Lanza IR, Befroy DE, Kent-Braun JA.

Eur J Appl Physiol. 2009 Jun;106(3):333-43. doi: 10.1007/s00421-009-1021-x. Epub 2009 Mar 11.


Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism.

Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, Liu ZX, Lee HY, Distefano A, Samuel VT, Zhang D, Cline GW, Handschin C, Lin J, Petersen KF, Spiegelman BM, Shulman GI.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19926-31. doi: 10.1073/pnas.0810339105. Epub 2008 Dec 9.


Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals.

Befroy DE, Petersen KF, Dufour S, Mason GF, Rothman DL, Shulman GI.

Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16701-6. doi: 10.1073/pnas.0808889105. Epub 2008 Oct 20.


Contraction frequency modulates muscle fatigue and the rate of myoglobin desaturation during incremental contractions in humans.

Wigmore DM, Befroy DE, Lanza IR, Kent-Braun JA.

Appl Physiol Nutr Metab. 2008 Oct;33(5):915-21. doi: 10.1139/H08-085.


Comparative MR study of hepatic fat quantification using single-voxel proton spectroscopy, two-point dixon and three-point IDEAL.

Kim H, Taksali SE, Dufour S, Befroy D, Goodman TR, Petersen KF, Shulman GI, Caprio S, Constable RT.

Magn Reson Med. 2008 Mar;59(3):521-7. doi: 10.1002/mrm.21561.


The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome.

Petersen KF, Dufour S, Savage DB, Bilz S, Solomon G, Yonemitsu S, Cline GW, Befroy D, Zemany L, Kahn BB, Papademetris X, Rothman DL, Shulman GI.

Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12587-94. Epub 2007 Jul 18.


Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients.

Befroy DE, Petersen KF, Dufour S, Mason GF, de Graaf RA, Rothman DL, Shulman GI.

Diabetes. 2007 May;56(5):1376-81. Epub 2007 Feb 7.


Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis.

Reznick RM, Zong H, Li J, Morino K, Moore IK, Yu HJ, Liu ZX, Dong J, Mustard KJ, Hawley SA, Befroy D, Pypaert M, Hardie DG, Young LH, Shulman GI.

Cell Metab. 2007 Feb;5(2):151-6.


Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men.

Petersen KF, Dufour S, Feng J, Befroy D, Dziura J, Dalla Man C, Cobelli C, Shulman GI.

Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18273-7. Epub 2006 Nov 17.


A randomized controlled study of effects of dietary magnesium oxide supplementation on bone mineral content in healthy girls.

Carpenter TO, DeLucia MC, Zhang JH, Bejnerowicz G, Tartamella L, Dziura J, Petersen KF, Befroy D, Cohen D.

J Clin Endocrinol Metab. 2006 Dec;91(12):4866-72. Epub 2006 Oct 3.


In vivo ATP production during free-flow and ischaemic muscle contractions in humans.

Lanza IR, Wigmore DM, Befroy DE, Kent-Braun JA.

J Physiol. 2006 Nov 15;577(Pt 1):353-67. Epub 2006 Aug 31.


Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.

Morino K, Petersen KF, Dufour S, Befroy D, Frattini J, Shatzkes N, Neschen S, White MF, Bilz S, Sono S, Pypaert M, Shulman GI.

J Clin Invest. 2005 Dec;115(12):3587-93. Epub 2005 Nov 10.


Age-related changes in ATP-producing pathways in human skeletal muscle in vivo.

Lanza IR, Befroy DE, Kent-Braun JA.

J Appl Physiol (1985). 2005 Nov;99(5):1736-44. Epub 2005 Jul 7.


Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.

Samuel VT, Liu ZX, Qu X, Elder BD, Bilz S, Befroy D, Romanelli AJ, Shulman GI.

J Biol Chem. 2004 Jul 30;279(31):32345-53. Epub 2004 May 27.


Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes.

Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI.

N Engl J Med. 2004 Feb 12;350(7):664-71.


Mitochondrial dysfunction in the elderly: possible role in insulin resistance.

Petersen KF, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman DL, DiPietro L, Cline GW, Shulman GI.

Science. 2003 May 16;300(5622):1140-2.


Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy.

Petersen KF, Oral EA, Dufour S, Befroy D, Ariyan C, Yu C, Cline GW, DePaoli AM, Taylor SI, Gorden P, Shulman GI.

J Clin Invest. 2002 May;109(10):1345-50.


The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes.

Mayerson AB, Hundal RS, Dufour S, Lebon V, Befroy D, Cline GW, Enocksson S, Inzucchi SE, Shulman GI, Petersen KF.

Diabetes. 2002 Mar;51(3):797-802.


Osmotic shock: modulation of contractile function, pHi, and ischemic damage in perfused guinea pig heart.

Befroy DE, Powell T, Radda GK, Clarke K.

Am J Physiol. 1999 Apr;276(4):H1236-44. doi: 10.1152/ajpheart.1999.276.4.H1236.


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