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Cellular dissection of malaria parasite invasion of human erythrocytes using viable Plasmodium knowlesi merozoites.

Lyth O, Vizcay-Barrena G, Wright KE, Haase S, Mohring F, Najer A, Henshall IG, Ashdown GW, Bannister LH, Drew DR, Beeson JG, Fleck RA, Moon RW, Wilson DW, Baum J.

Sci Rep. 2018 Jul 5;8(1):10165. doi: 10.1038/s41598-018-28457-z.


Factors influencing the induction of high affinity antibodies to Plasmodium falciparum merozoite antigens and how affinity changes over time.

Tijani MK, Reddy SB, Langer C, Beeson JG, Wahlgren M, Nwuba RI, Persson KEM.

Sci Rep. 2018 Jun 13;8(1):9026. doi: 10.1038/s41598-018-27361-w.


The complement system contributes to functional antibody-mediated responses induced by immunization with Plasmodium falciparum malaria sporozoites.

Behet MC, Kurtovic L, van Gemert GJ, Haukes CM, Siebelink-Stoter R, Graumans W, van de Vegte-Bolmer MG, Scholzen A, Langereis JD, Diavatopoulos DA, Beeson JG, Sauerwein RW.

Infect Immun. 2018 May 7. pii: IAI.00920-17. doi: 10.1128/IAI.00920-17. [Epub ahead of print]


Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children.

Kurtovic L, Behet MC, Feng G, Reiling L, Chelimo K, Dent AE, Mueller I, Kazura JW, Sauerwein RW, Fowkes FJI, Beeson JG.

BMC Med. 2018 Apr 30;16(1):61. doi: 10.1186/s12916-018-1054-2.


Human Immunization With a Polymorphic Malaria Vaccine Candidate Induced Antibodies to Conserved Epitopes That Promote Functional Antibodies to Multiple Parasite Strains.

Feng G, Boyle MJ, Cross N, Chan JA, Reiling L, Osier F, Stanisic DI, Mueller I, Anders RF, McCarthy JS, Richards JS, Beeson JG.

J Infect Dis. 2018 Jun 5;218(1):35-43. doi: 10.1093/infdis/jiy170.


Proteome-wide mapping of immune features onto Plasmodium protein three-dimensional structures.

Guy AJ, Irani V, Beeson JG, Webb B, Sali A, Richards JS, Ramsland PA.

Sci Rep. 2018 Mar 12;8(1):4355. doi: 10.1038/s41598-018-22592-3.


Combating low birth weight due to malaria infection in pregnancy.

Beeson JG, Scoullar MJL, Boeuf P.

Sci Transl Med. 2018 Mar 7;10(431). pii: eaat1506. doi: 10.1126/scitranslmed.aat1506. Review.


Effect of nutrient supplementation on the acquisition of humoral immunity to Plasmodium falciparum in young Malawian children.

Barua P, Chandrasiri UP, Beeson JG, Dewey KG, Maleta K, Ashorn P, Rogerson SJ.

Malar J. 2018 Feb 7;17(1):74. doi: 10.1186/s12936-018-2224-6.


Establishment of a yeast-based VLP platform for antigen presentation.

Wetzel D, Rolf T, Suckow M, Kranz A, Barbian A, Chan JA, Leitsch J, Weniger M, Jenzelewski V, Kouskousis B, Palmer C, Beeson JG, Schembecker G, Merz J, Piontek M.

Microb Cell Fact. 2018 Feb 5;17(1):17. doi: 10.1186/s12934-018-0868-0.


Identifying Immune Correlates of Protection Against Plasmodium falciparum Through a Novel Approach to Account for Heterogeneity in Malaria Exposure.

Valmaseda A, Macete E, Nhabomba A, Guinovart C, Aide P, Bardají A, Bassat Q, Nhampossa T, Maculuve S, Casellas A, Quintó L, Sanz S, Jiménez A, Feng G, Langer C, Reiling L, Reddy KS, Pandey A, Chitnis CE, Chauhan VS, Aguilar R, Aponte JJ, Dobaño C, Beeson JG, Gaur D, Menéndez C, Alonso PL, Mayor A.

Clin Infect Dis. 2018 Feb 1;66(4):586-593. doi: 10.1093/cid/cix837.


Evaluating antibody functional activity and strain-specificity of vaccine candidates for malaria in pregnancy using in vitro phagocytosis assays.

Hommel M, Chan JA, Umbers AJ, Langer C, Rogerson SJ, Smith JD, Beeson JG.

Parasit Vectors. 2018 Jan 29;11(1):69. doi: 10.1186/s13071-018-2653-7.


The potential of task shifting selected maternal interventions to auxiliary midwives in Myanmar: a mixed-method study.

Than KK, Tin KN, La T, Thant KS, Myint T, Beeson JG, Luchters S, Morgan A.

BMC Public Health. 2018 Jan 3;18(1):99. doi: 10.1186/s12889-017-5020-2.


Functional Conservation of the AMA1 Host-Cell Invasion Ligand Between P. falciparum and P. vivax: A Novel Platform to Accelerate Vaccine and Drug Development.

Drew DR, Sanders PR, Weiss G, Gilson PR, Crabb BS, Beeson JG.

J Infect Dis. 2018 Jan 17;217(3):498-507. doi: 10.1093/infdis/jix583.


Impaired placental autophagy in placental malaria.

Dimasuay KG, Gong L, Rosario F, McBryde E, Spelman T, Glazier J, Rogerson SJ, Beeson JG, Jansson T, Devenish RJ, Boeuf P.

PLoS One. 2017 Nov 10;12(11):e0187291. doi: 10.1371/journal.pone.0187291. eCollection 2017.


P. falciparum infection and maternofetal antibody transfer in malaria-endemic settings of varying transmission.

McLean ARD, Stanisic D, McGready R, Chotivanich K, Clapham C, Baiwog F, Pimanpanarak M, Siba P, Mueller I, King CL, Nosten F, Beeson JG, Rogerson S, Simpson JA, Fowkes FJI.

PLoS One. 2017 Oct 13;12(10):e0186577. doi: 10.1371/journal.pone.0186577. eCollection 2017.


Declining Malaria Transmission Differentially Impacts the Maintenance of Humoral Immunity to Plasmodium falciparum in Children.

Mugyenyi CK, Elliott SR, Yap XZ, Feng G, Boeuf P, Fegan G, Osier FFH, Fowkes FJI, Avril M, Williams TN, Marsh K, Beeson JG.

J Infect Dis. 2017 Oct 17;216(7):887-898. doi: 10.1093/infdis/jix370.


Declining Transmission and Immunity to Malaria and Emerging Artemisinin Resistance in Thailand: A Longitudinal Study.

Ataíde R, Powell R, Moore K, McLean A, Phyo AP, Nair S, White M, Anderson TJ, Beeson JG, Simpson JA, Nosten F, Fowkes FJI.

J Infect Dis. 2017 Sep 15;216(6):723-731. doi: 10.1093/infdis/jix371.


Identification of Heparin Modifications and Polysaccharide Inhibitors of Plasmodium falciparum Merozoite Invasion That Have Potential for Novel Drug Development.

Boyle MJ, Skidmore M, Dickerman B, Cooper L, Devlin A, Yates E, Horrocks P, Freeman C, Chai W, Beeson JG.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e00709-17. doi: 10.1128/AAC.00709-17. Print 2017 Nov.


Patterns of protective associations differ for antibodies to P. falciparum-infected erythrocytes and merozoites in immunity against malaria in children.

Chan JA, Stanisic DI, Duffy MF, Robinson LJ, Lin E, Kazura JW, King CL, Siba PM, Fowkes FJ, Mueller I, Beeson JG.

Eur J Immunol. 2017 Dec;47(12):2124-2136. doi: 10.1002/eji.201747032. Epub 2017 Sep 13.


Acquisition, maintenance and adaptation of invasion inhibitory antibodies against Plasmodium falciparum invasion ligands involved in immune evasion.

Tijani MK, Babalola OA, Odaibo AB, Anumudu CI, Asinobi AO, Morenikeji OA, Asuzu MC, Langer C, Reiling L, Beeson JG, Wahlgren M, Nwuba RI, Persson KEM.

PLoS One. 2017 Aug 7;12(8):e0182187. doi: 10.1371/journal.pone.0182187. eCollection 2017.


Dichotomous miR expression and immune responses following primary blood-stage malaria.

Burel JG, Apte SH, Groves PL, Boyle MJ, Langer C, Beeson JG, McCarthy JS, Doolan DL.

JCI Insight. 2017 Aug 3;2(15). pii: 93434. doi: 10.1172/jci.insight.93434. [Epub ahead of print]


The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites.

Charnaud SC, Dixon MWA, Nie CQ, Chappell L, Sanders PR, Nebl T, Hanssen E, Berriman M, Chan JA, Blanch AJ, Beeson JG, Rayner JC, Przyborski JM, Tilley L, Crabb BS, Gilson PR.

PLoS One. 2017 Jul 21;12(7):e0181656. doi: 10.1371/journal.pone.0181656. eCollection 2017.


Determinants of knowledge of critical danger signs, safe childbirth and immediate newborn care practices among auxiliary midwives: a cross sectional survey in Myanmar.

Than KK, Morgan A, Pham MD, Beeson JG, Luchters S.

BMJ Open. 2017 Jul 5;7(6):e017180. doi: 10.1136/bmjopen-2017-017180.


Prevention of postpartum haemorrhage by community-based auxiliary midwives in hard-to-reach areas of Myanmar: a qualitative inquiry into acceptability and feasibility of task shifting.

Than KK, Mohamed Y, Oliver V, Myint T, La T, Beeson JG, Luchters S.

BMC Pregnancy Childbirth. 2017 May 17;17(1):146. doi: 10.1186/s12884-017-1324-6.


Antibody Responses to Plasmodium falciparum and Plasmodium vivax and Prospective Risk of Plasmodium spp. Infection Postpartum.

McLean ARD, Boel M, McGready R, Ataide R, Drew D, Tsuboi T, Beeson JG, Nosten F, Simpson JA, Fowkes FJI.

Am J Trop Med Hyg. 2017 May;96(5):1197-1204. doi: 10.4269/ajtmh.16-0690.


Host immunity to Plasmodium falciparum and the assessment of emerging artemisinin resistance in a multinational cohort.

Ataide R, Ashley EA, Powell R, Chan JA, Malloy MJ, O'Flaherty K, Takashima E, Langer C, Tsuboi T, Dondorp AM, Day NP, Dhorda M, Fairhurst RM, Lim P, Amaratunga C, Pukrittayakamee S, Hien TT, Htut Y, Mayxay M, Faiz MA, Beeson JG, Nosten F, Simpson JA, White NJ, Fowkes FJ.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3515-3520. doi: 10.1073/pnas.1615875114. Epub 2017 Mar 13.


The potential benefit of scaling up malaria prevention to reduce low birth weight in Africa.

Beeson JG, Simpson JA.

PLoS Med. 2017 Feb 28;14(2):e1002244. doi: 10.1371/journal.pmed.1002244. eCollection 2017 Feb. No abstract available.


Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight.

Dimasuay KG, Aitken EH, Rosario F, Njie M, Glazier J, Rogerson SJ, Fowkes FJ, Beeson JG, Powell T, Jansson T, Boeuf P.

BMC Med. 2017 Jan 3;15(1):1. doi: 10.1186/s12916-016-0759-3.


Truncated Latrunculins as Actin Inhibitors Targeting Plasmodium falciparum Motility and Host Cell Invasion.

Johnson S, Rahmani R, Drew DR, Williams MJ, Wilkinson M, Tan YH, Huang JX, Tonkin CJ, Beeson JG, Baum J, Smith BJ, Baell JB.

J Med Chem. 2016 Dec 22;59(24):10994-11005. doi: 10.1021/acs.jmedchem.6b01109. Epub 2016 Dec 2.


Plasmodium vivax vaccine research - we've only just begun.

Tham WH, Beeson JG, Rayner JC.

Int J Parasitol. 2017 Feb;47(2-3):111-118. doi: 10.1016/j.ijpara.2016.09.006. Epub 2016 Nov 27. Review.


Evaluating Complement-Mediated Humoral Immunity to P. falciparum Blood Stages.

Boyle MJ, Reiling L, Beeson JG.

EBioMedicine. 2016 Dec;14:9-10. doi: 10.1016/j.ebiom.2016.11.022. Epub 2016 Nov 19. No abstract available.


Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance.

McCallum FJ, Persson KE, Fowkes FJ, Reiling L, Mugyenyi CK, Richards JS, Simpson JA, Williams TN, Gilson PR, Hodder AN, Sanders PR, Anders RF, Narum DL, Chitnis C, Crabb BS, Marsh K, Beeson JG.

J Leukoc Biol. 2017 Apr;101(4):913-925. doi: 10.1189/jlb.5MA0716-294R. Epub 2016 Nov 11.


Association between malaria immunity and pregnancy outcomes among Malawian pregnant women receiving nutrient supplementation.

Chandrasiri UP, Fowkes FJ, Beeson JG, Richards JS, Kamiza S, Maleta K, Ashorn P, Rogerson SJ.

Malar J. 2016 Nov 9;15(1):547.


Functional Antibodies and Protection against Blood-stage Malaria.

Teo A, Feng G, Brown GV, Beeson JG, Rogerson SJ.

Trends Parasitol. 2016 Nov;32(11):887-898. doi: 10.1016/ Epub 2016 Aug 18. Review.


A novel approach to identifying patterns of human invasion-inhibitory antibodies guides the design of malaria vaccines incorporating polymorphic antigens.

Drew DR, Wilson DW, Elliott SR, Cross N, Terheggen U, Hodder AN, Siba PM, Chelimo K, Dent AE, Kazura JW, Mueller I, Beeson JG.

BMC Med. 2016 Sep 23;14(1):144.


The association between naturally acquired IgG subclass specific antibodies to the PfRH5 invasion complex and protection from Plasmodium falciparum malaria.

Weaver R, Reiling L, Feng G, Drew DR, Mueller I, Siba PM, Tsuboi T, Richards JS, Fowkes FJ, Beeson JG.

Sci Rep. 2016 Sep 8;6:33094. doi: 10.1038/srep33094.


Antibody responses to Plasmodium falciparum and Plasmodium vivax blood-stage and sporozoite antigens in the postpartum period.

McLean AR, Boel ME, McGready R, Ataide R, Drew D, Tsuboi T, Beeson JG, Nosten F, Simpson JA, Fowkes FJ.

Sci Rep. 2016 Aug 25;6:32159. doi: 10.1038/srep32159.


The global threat of Zika virus to pregnancy: epidemiology, clinical perspectives, mechanisms, and impact.

Boeuf P, Drummer HE, Richards JS, Scoullar MJ, Beeson JG.

BMC Med. 2016 Aug 3;14(1):112. doi: 10.1186/s12916-016-0660-0. Review.


Structure-Activity Studies of β-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction.

Wang G, Drinkwater N, Drew DR, MacRaild CA, Chalmers DK, Mohanty B, Lim SS, Anders RF, Beeson JG, Thompson PE, McGowan S, Simpson JS, Norton RS, Scanlon MJ.

J Mol Biol. 2016 Oct 9;428(20):3986-3998. doi: 10.1016/j.jmb.2016.07.001. Epub 2016 Jul 14.


A malaria vaccine in children with HIV.

Beeson JG, Fowkes FJI.

Lancet Infect Dis. 2016 Oct;16(10):1087-1089. doi: 10.1016/S1473-3099(16)30209-2. Epub 2016 Jul 7. No abstract available.


Infectivity of Plasmodium falciparum in Malaria-Naive Individuals Is Related to Knob Expression and Cytoadherence of the Parasite.

Stanisic DI, Gerrard J, Fink J, Griffin PM, Liu XQ, Sundac L, Sekuloski S, Rodriguez IB, Pingnet J, Yang Y, Zhou Y, Trenholme KR, Wang CY, Hackett H, Chan JA, Langer C, Hanssen E, Hoffman SL, Beeson JG, McCarthy JS, Good MF.

Infect Immun. 2016 Aug 19;84(9):2689-96. doi: 10.1128/IAI.00414-16. Print 2016 Sep.


A single point in protein trafficking by Plasmodium falciparum determines the expression of major antigens on the surface of infected erythrocytes targeted by human antibodies.

Chan JA, Howell KB, Langer C, Maier AG, Hasang W, Rogerson SJ, Petter M, Chesson J, Stanisic DI, Duffy MF, Cooke BM, Siba PM, Mueller I, Bull PC, Marsh K, Fowkes FJ, Beeson JG.

Cell Mol Life Sci. 2016 Nov;73(21):4141-58. doi: 10.1007/s00018-016-2267-1. Epub 2016 May 19.


Merozoite Antigens of Plasmodium falciparum Elicit Strain-Transcending Opsonizing Immunity.

Hill DL, Wilson DW, Sampaio NG, Eriksson EM, Ryg-Cornejo V, Harrison GLA, Uboldi AD, Robinson LJ, Beeson JG, Siba P, Cowman AF, Hansen DS, Mueller I, Schofield L.

Infect Immun. 2016 Jul 21;84(8):2175-2184. doi: 10.1128/IAI.00145-16. Print 2016 Aug.


Strain-transcending immune response generated by chimeras of the malaria vaccine candidate merozoite surface protein 2.

Krishnarjuna B, Andrew D, MacRaild CA, Morales RA, Beeson JG, Anders RF, Richards JS, Norton RS.

Sci Rep. 2016 Feb 11;6:20613. doi: 10.1038/srep20613.


Maternal-foetal transfer of Plasmodium falciparum and Plasmodium vivax antibodies in a low transmission setting.

Charnaud SC, McGready R, Herten-Crabb A, Powell R, Guy A, Langer C, Richards JS, Gilson PR, Chotivanich K, Tsuboi T, Narum DL, Pimanpanarak M, Simpson JA, Beeson JG, Nosten F, Fowkes FJ.

Sci Rep. 2016 Feb 10;6:20859. doi: 10.1038/srep20859.


Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria.

Beeson JG, Drew DR, Boyle MJ, Feng G, Fowkes FJ, Richards JS.

FEMS Microbiol Rev. 2016 May;40(3):343-72. doi: 10.1093/femsre/fuw001. Epub 2016 Jan 31. Review.


Immunity to malaria in an era of declining malaria transmission.

Fowkes FJ, Boeuf P, Beeson JG.

Parasitology. 2016 Feb;143(2):139-53. doi: 10.1017/S0031182015001249. Epub 2016 Jan 7. Review.


Contrasting Patterns of Serologic and Functional Antibody Dynamics to Plasmodium falciparum Antigens in a Kenyan Birth Cohort.

Dent AE, Malhotra I, Wang X, Babineau D, Yeo KT, Anderson T, Kimmel RJ, Angov E, Lanar DE, Narum D, Dutta S, Richards J, Beeson JG, Crabb BS, Cowman AF, Horii T, Muchiri E, Mungai PL, King CL, Kazura JW.

Clin Vaccine Immunol. 2015 Dec 9;23(2):104-16. doi: 10.1128/CVI.00452-15. Print 2016 Feb.


Malaria and Age Variably but Critically Control Hepcidin Throughout Childhood in Kenya.

Atkinson SH, Uyoga SM, Armitage AE, Khandwala S, Mugyenyi CK, Bejon P, Marsh K, Beeson JG, Prentice AM, Drakesmith H, Williams TN.

EBioMedicine. 2015 Aug 8;2(10):1478-86. doi: 10.1016/j.ebiom.2015.08.016. eCollection 2015 Oct.


Insights into the Immunological Properties of Intrinsically Disordered Malaria Proteins Using Proteome Scale Predictions.

Guy AJ, Irani V, MacRaild CA, Anders RF, Norton RS, Beeson JG, Richards JS, Ramsland PA.

PLoS One. 2015 Oct 29;10(10):e0141729. doi: 10.1371/journal.pone.0141729. eCollection 2015.

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