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Items: 1 to 50 of 114

1.

Author Correction: Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol.

Cameron RB, Peterson YK, Beeson CC, Schnellmann RG.

Sci Rep. 2019 May 1;9(1):6790. doi: 10.1038/s41598-019-42463-9.

2.

An improved method for isolation of mitochondria from cell lines that enables reconstitution of calcium-dependent processes.

Ishii M, Beeson G, Beeson C, Rohrer B.

Anal Biochem. 2019 Jul 15;577:52-58. doi: 10.1016/j.ab.2019.04.012. Epub 2019 Apr 22.

PMID:
31022379
3.

Statin-dependent modulation of mitochondrial metabolism in cancer cells is independent of cholesterol content.

Christie CF, Fang D, Hunt EG, Morris ME, Rovini A, Heslop KA, Beeson GC, Beeson CC, Maldonado EN.

FASEB J. 2019 Apr 5:fj201802723R. doi: 10.1096/fj.201802723R. [Epub ahead of print]

PMID:
30951369
4.

A Cell-Based Approach to Study the Associations Between Mitochondrial Health, Early Life Exposures, and Consequent Health Outcomes.

Il'yasova D, Kinev A, Grégoire R, Beeson CC.

Front Public Health. 2019 Mar 13;7:36. doi: 10.3389/fpubh.2019.00036. eCollection 2019. No abstract available.

5.

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma.

Qie S, Yoshida A, Parnham S, Oleinik N, Beeson GC, Beeson CC, Ogretmen B, Bass AJ, Wong KK, Rustgi AK, Diehl JA.

Nat Commun. 2019 Mar 21;10(1):1296. doi: 10.1038/s41467-019-09179-w.

6.

Proximal Tubule β 2-Adrenergic Receptor Mediates Formoterol-Induced Recovery of Mitochondrial and Renal Function after Ischemia-Reperfusion Injury.

Cameron RB, Gibbs WS, Miller SR, Dupre TV, Megyesi J, Beeson CC, Schnellmann RG.

J Pharmacol Exp Ther. 2019 Apr;369(1):173-180. doi: 10.1124/jpet.118.252833. Epub 2019 Feb 1.

PMID:
30709866
7.

A Screen Using iPSC-Derived Hepatocytes Reveals NAD+ as a Potential Treatment for mtDNA Depletion Syndrome.

Jing R, Corbett JL, Cai J, Beeson GC, Beeson CC, Chan SS, Dimmock DP, Lazcares L, Geurts AM, Lemasters JJ, Duncan SA.

Cell Rep. 2018 Nov 6;25(6):1469-1484.e5. doi: 10.1016/j.celrep.2018.10.036.

8.

Targeting PIM Kinase with PD1 Inhibition Improves Immunotherapeutic Antitumor T-cell Response.

Chatterjee S, Chakraborty P, Daenthanasanmak A, Iamsawat S, Andrejeva G, Luevano LA, Wolf M, Baliga U, Krieg C, Beeson CC, Mehrotra M, Hill EG, Rathmell JC, Yu XZ, Kraft AS, Mehrotra S.

Clin Cancer Res. 2019 Feb 1;25(3):1036-1049. doi: 10.1158/1078-0432.CCR-18-0706. Epub 2018 Oct 16.

PMID:
30327305
9.

5-HT1F receptor regulates mitochondrial homeostasis and its loss potentiates acute kidney injury and impairs renal recovery.

Gibbs WS, Collier JB, Morris M, Beeson CC, Megyesi J, Schnellmann RG.

Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F1119-F1128. doi: 10.1152/ajprenal.00077.2018. Epub 2018 May 30.

PMID:
29846105
10.

HDAC1 localizes to the mitochondria of cardiac myocytes and contributes to early cardiac reperfusion injury.

Herr DJ, Baarine M, Aune SE, Li X, Ball LE, Lemasters JJ, Beeson CC, Chou JC, Menick DR.

J Mol Cell Cardiol. 2018 Jan;114:309-319. doi: 10.1016/j.yjmcc.2017.12.004. Epub 2017 Dec 7.

11.

CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response.

Chatterjee S, Daenthanasanmak A, Chakraborty P, Wyatt MW, Dhar P, Selvam SP, Fu J, Zhang J, Nguyen H, Kang I, Toth K, Al-Homrani M, Husain M, Beeson G, Ball L, Helke K, Husain S, Garrett-Mayer E, Hardiman G, Mehrotra M, Nishimura MI, Beeson CC, Bupp MG, Wu J, Ogretmen B, Paulos CM, Rathmell J, Yu XZ, Mehrotra S.

Cell Metab. 2018 Jan 9;27(1):85-100.e8. doi: 10.1016/j.cmet.2017.10.006. Epub 2017 Nov 9.

12.

Identification of dual mechanisms mediating 5-hydroxytryptamine receptor 1F-induced mitochondrial biogenesis.

Gibbs WS, Garrett SM, Beeson CC, Schnellmann RG.

Am J Physiol Renal Physiol. 2018 Feb 1;314(2):F260-F268. doi: 10.1152/ajprenal.00324.2017. Epub 2017 Oct 18.

13.

A Novel Aza-MBP Altered Peptide Ligand for the Treatment of Experimental Autoimmune Encephalomyelitis.

Trager NNM, Butler JT, Harmon J, Mount J, Podbielska M, Haque A, Banik NL, Beeson CC.

Mol Neurobiol. 2018 Jan;55(1):267-275. doi: 10.1007/s12035-017-0739-4.

14.

Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol.

Cameron RB, Peterson YK, Beeson CC, Schnellmann RG.

Sci Rep. 2017 Sep 5;7(1):10578. doi: 10.1038/s41598-017-11030-5. Erratum in: Sci Rep. 2019 May 1;9(1):6790.

15.

Modulation of Endoplasmic Reticulum Stress Controls CD4+ T-cell Activation and Antitumor Function.

Thaxton JE, Wallace C, Riesenberg B, Zhang Y, Paulos CM, Beeson CC, Liu B, Li Z.

Cancer Immunol Res. 2017 Aug;5(8):666-675. doi: 10.1158/2326-6066.CIR-17-0081. Epub 2017 Jun 22.

16.

Transforming growth factor β1 (TGFβ1) regulates CD44V6 expression and activity through extracellular signal-regulated kinase (ERK)-induced EGR1 in pulmonary fibrogenic fibroblasts.

Ghatak S, Markwald RR, Hascall VC, Dowling W, Lottes RG, Baatz JE, Beeson G, Beeson CC, Perrella MA, Thannickal VJ, Misra S.

J Biol Chem. 2017 Jun 23;292(25):10465-10489. doi: 10.1074/jbc.M116.752451. Epub 2017 Apr 7.

17.

Development of Therapeutics That Induce Mitochondrial Biogenesis for the Treatment of Acute and Chronic Degenerative Diseases.

Cameron RB, Beeson CC, Schnellmann RG.

J Med Chem. 2016 Dec 8;59(23):10411-10434. Epub 2016 Sep 27. Review.

18.

Translocation of iron from lysosomes to mitochondria during acetaminophen-induced hepatocellular injury: Protection by starch-desferal and minocycline.

Hu J, Kholmukhamedov A, Lindsey CC, Beeson CC, Jaeschke H, Lemasters JJ.

Free Radic Biol Med. 2016 Aug;97:418-426. doi: 10.1016/j.freeradbiomed.2016.06.024. Epub 2016 Jun 23.

19.

Increased expression of estrogen-related receptor β during adaptation of adult cardiomyocytes to sustained hypoxia.

Cunningham KF, Beeson GC, Beeson CC, McDermott PJ.

Am J Cardiovasc Dis. 2016 May 18;6(2):46-54. eCollection 2016.

20.

Enhancing NAD+ Salvage Pathway Reverts the Toxicity of Primary Astrocytes Expressing Amyotrophic Lateral Sclerosis-linked Mutant Superoxide Dismutase 1 (SOD1).

Harlan BA, Pehar M, Sharma DR, Beeson G, Beeson CC, Vargas MR.

J Biol Chem. 2016 May 13;291(20):10836-46. doi: 10.1074/jbc.M115.698779. Epub 2016 Mar 21.

21.

5-HT2 Receptor Regulation of Mitochondrial Genes: Unexpected Pharmacological Effects of Agonists and Antagonists.

Harmon JL, Wills LP, McOmish CE, Demireva EY, Gingrich JA, Beeson CC, Schnellmann RG.

J Pharmacol Exp Ther. 2016 Apr;357(1):1-9. doi: 10.1124/jpet.115.228395. Epub 2016 Jan 19.

22.

Mitochondrial Biogenesis as a Pharmacological Target: A New Approach to Acute and Chronic Diseases.

Whitaker RM, Corum D, Beeson CC, Schnellmann RG.

Annu Rev Pharmacol Toxicol. 2016;56:229-49. doi: 10.1146/annurev-pharmtox-010715-103155. Epub 2015 Nov 4. Review.

PMID:
26566156
23.

Reduced Metabolic Capacity in Aged Primary Retinal Pigment Epithelium (RPE) is Correlated with Increased Susceptibility to Oxidative Stress.

Rohrer B, Bandyopadhyay M, Beeson C.

Adv Exp Med Biol. 2016;854:793-8. doi: 10.1007/978-3-319-17121-0_106.

PMID:
26427491
24.

Small Molecules that Protect Mitochondrial Function from Metabolic Stress Decelerate Loss of Photoreceptor Cells in Murine Retinal Degeneration Models.

Beeson C, Lindsey C, Nasarre C, Bandyopadhyay M, Perron N, Rohrer B.

Adv Exp Med Biol. 2016;854:449-54. doi: 10.1007/978-3-319-17121-0_60.

PMID:
26427445
25.

Urinary mitochondrial DNA is a biomarker of mitochondrial disruption and renal dysfunction in acute kidney injury.

Whitaker RM, Stallons LJ, Kneff JE, Alge JL, Harmon JL, Rahn JJ, Arthur JM, Beeson CC, Chan SL, Schnellmann RG.

Kidney Int. 2015 Dec;88(6):1336-1344. doi: 10.1038/ki.2015.240. Epub 2015 Aug 19.

26.

Helicobacter pylori virulence factors affecting gastric proton pump expression and acid secretion.

Hammond CE, Beeson C, Suarez G, Peek RM Jr, Backert S, Smolka AJ.

Am J Physiol Gastrointest Liver Physiol. 2015 Aug 1;309(3):G193-201. doi: 10.1152/ajpgi.00099.2015. Epub 2015 Jun 4.

27.

Assessment of ToxCast Phase II for Mitochondrial Liabilities Using a High-Throughput Respirometric Assay.

Wills LP, Beeson GC, Hoover DB, Schnellmann RG, Beeson CC.

Toxicol Sci. 2015 Aug;146(2):226-34. doi: 10.1093/toxsci/kfv085. Epub 2015 Apr 28.

28.

Estrogen-Related Receptor α (ERRα) is required for adaptive increases in PGC-1 isoform expression during electrically stimulated contraction of adult cardiomyocytes in sustained hypoxic conditions.

Cunningham KF, Beeson GC, Beeson CC, Baicu CF, Zile MR, McDermott PJ.

Int J Cardiol. 2015;187:393-400. doi: 10.1016/j.ijcard.2015.03.353. Epub 2015 Mar 25.

PMID:
25841134
29.

Urinary ATP Synthase Subunit β Is a Novel Biomarker of Renal Mitochondrial Dysfunction in Acute Kidney Injury.

Whitaker RM, Korrapati MC, Stallons LJ, Jesinkey SR, Arthur JM, Beeson CC, Zhong Z, Schnellmann RG.

Toxicol Sci. 2015 May;145(1):108-17. doi: 10.1093/toxsci/kfv038. Epub 2015 Feb 9.

30.

Quantitative analysis of mitochondrial morphology and membrane potential in living cells using high-content imaging, machine learning, and morphological binning.

Leonard AP, Cameron RB, Speiser JL, Wolf BJ, Peterson YK, Schnellmann RG, Beeson CC, Rohrer B.

Biochim Biophys Acta. 2015 Feb;1853(2):348-60. doi: 10.1016/j.bbamcr.2014.11.002. Epub 2014 Nov 13.

31.

ABCD1 deletion-induced mitochondrial dysfunction is corrected by SAHA: implication for adrenoleukodystrophy.

Baarine M, Beeson C, Singh A, Singh I.

J Neurochem. 2015 May;133(3):380-96. doi: 10.1111/jnc.12992. Epub 2015 Jan 13.

32.

Atomoxetine prevents dexamethasone-induced skeletal muscle atrophy in mice.

Jesinkey SR, Korrapati MC, Rasbach KA, Beeson CC, Schnellmann RG.

J Pharmacol Exp Ther. 2014 Dec;351(3):663-73. doi: 10.1124/jpet.114.217380. Epub 2014 Oct 7.

33.

Promoting thiol expression increases the durability of antitumor T-cell functions.

Kesarwani P, Al-Khami AA, Scurti G, Thyagarajan K, Kaur N, Husain S, Fang Q, Naga OS, Simms P, Beeson G, Voelkel-Johnson C, Garrett-Mayer E, Beeson CC, Nishimura MI, Mehrotra S.

Cancer Res. 2014 Nov 1;74(21):6036-6047. doi: 10.1158/0008-5472.CAN-14-1084. Epub 2014 Aug 27.

34.

Mitochondria-targeted catalase reverts the neurotoxicity of hSOD1G⁹³A astrocytes without extending the survival of ALS-linked mutant hSOD1 mice.

Pehar M, Beeson G, Beeson CC, Johnson JA, Vargas MR.

PLoS One. 2014 Jul 23;9(7):e103438. doi: 10.1371/journal.pone.0103438. eCollection 2014.

35.

Agonism of the 5-hydroxytryptamine 1F receptor promotes mitochondrial biogenesis and recovery from acute kidney injury.

Garrett SM, Whitaker RM, Beeson CC, Schnellmann RG.

J Pharmacol Exp Ther. 2014 Aug;350(2):257-64. doi: 10.1124/jpet.114.214700. Epub 2014 May 21.

36.

The Involvement of Calpain in CD4+ T Helper Cell Bias in Multple Sclerosis.

Trager N, Butler JT, Haque A, Ray SK, Beeson C, Banik NL.

J Clin Cell Immunol. 2013 Jun 14;4(4):1000153.

37.

Formoterol restores mitochondrial and renal function after ischemia-reperfusion injury.

Jesinkey SR, Funk JA, Stallons LJ, Wills LP, Megyesi JK, Beeson CC, Schnellmann RG.

J Am Soc Nephrol. 2014 Jun;25(6):1157-62. doi: 10.1681/ASN.2013090952. Epub 2014 Feb 7.

38.

Effects of a novel orally administered calpain inhibitor SNJ-1945 on immunomodulation and neurodegeneration in a murine model of multiple sclerosis.

Trager N, Smith A, Wallace Iv G, Azuma M, Inoue J, Beeson C, Haque A, Banik NL.

J Neurochem. 2014 Jul;130(2):268-79. doi: 10.1111/jnc.12659. Epub 2014 Feb 12.

39.

TGF-β1 stimulates mitochondrial oxidative phosphorylation and generation of reactive oxygen species in cultured mouse podocytes, mediated in part by the mTOR pathway.

Abe Y, Sakairi T, Beeson C, Kopp JB.

Am J Physiol Renal Physiol. 2013 Nov 15;305(10):F1477-90. doi: 10.1152/ajprenal.00182.2013. Epub 2013 Sep 18.

40.

β2-Adrenoceptor agonists in the regulation of mitochondrial biogenesis.

Peterson YK, Cameron RB, Wills LP, Trager RE, Lindsey CC, Beeson CC, Schnellmann RG.

Bioorg Med Chem Lett. 2013 Oct 1;23(19):5376-81. doi: 10.1016/j.bmcl.2013.07.052. Epub 2013 Jul 31.

41.

Systematic study of mitochondrial toxicity of environmental chemicals using quantitative high throughput screening.

Attene-Ramos MS, Huang R, Sakamuru S, Witt KL, Beeson GC, Shou L, Schnellmann RG, Beeson CC, Tice RR, Austin CP, Xia M.

Chem Res Toxicol. 2013 Sep 16;26(9):1323-32. doi: 10.1021/tx4001754. Epub 2013 Aug 15.

42.

High-throughput respirometric assay identifies predictive toxicophore of mitochondrial injury.

Wills LP, Beeson GC, Trager RE, Lindsey CC, Beeson CC, Peterson YK, Schnellmann RG.

Toxicol Appl Pharmacol. 2013 Oct 15;272(2):490-502. doi: 10.1016/j.taap.2013.06.014. Epub 2013 Jun 26.

43.
44.

Early alterations in mitochondrial reserve capacity; a means to predict subsequent photoreceptor cell death.

Perron NR, Beeson C, Rohrer B.

J Bioenerg Biomembr. 2013 Feb;45(1-2):101-9. doi: 10.1007/s10863-012-9477-5. Epub 2012 Oct 23.

45.

LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria.

Beckham TH, Lu P, Jones EE, Marrison T, Lewis CS, Cheng JC, Ramshesh VK, Beeson G, Beeson CC, Drake RR, Bielawska A, Bielawski J, Szulc ZM, Ogretmen B, Norris JS, Liu X.

J Pharmacol Exp Ther. 2013 Jan;344(1):167-78. doi: 10.1124/jpet.112.199216. Epub 2012 Oct 18.

46.

Characterization of functionally distinct mitochondrial subpopulations.

Saunders JE, Beeson CC, Schnellmann RG.

J Bioenerg Biomembr. 2013 Feb;45(1-2):87-99. doi: 10.1007/s10863-012-9478-4. Epub 2012 Oct 19.

47.

Assessment of drug-induced mitochondrial dysfunction via altered cellular respiration and acidification measured in a 96-well platform.

Nadanaciva S, Rana P, Beeson GC, Chen D, Ferrick DA, Beeson CC, Will Y.

J Bioenerg Biomembr. 2012 Aug;44(4):421-37. doi: 10.1007/s10863-012-9446-z. Epub 2012 Jun 12.

PMID:
22689143
48.

Calpain 10 homology modeling with CYGAK and increased lipophilicity leads to greater potency and efficacy in cells.

Smith MA, McInnes C, Whitaker RM, Lindsey CC, Comer RF, Beeson CC, Schnellmann RG.

ACS Chem Biol. 2012 Aug 17;7(8):1410-9. doi: 10.1021/cb300219h. Epub 2012 May 31.

49.

The β2-adrenoceptor agonist formoterol stimulates mitochondrial biogenesis.

Wills LP, Trager RE, Beeson GC, Lindsey CC, Peterson YK, Beeson CC, Schnellmann RG.

J Pharmacol Exp Ther. 2012 Jul;342(1):106-18. doi: 10.1124/jpet.112.191528. Epub 2012 Apr 6.

50.

Integrin-dependent Akt1 activation regulates PGC-1 expression and fatty acid oxidation.

Beeson CC, Beeson GC, Buff H, Eldridge J, Zhang A, Seth A, Demcheva M, Vournakis JN, Muise-Helmericks RC.

J Vasc Res. 2012;49(2):89-100. doi: 10.1159/000332326. Epub 2012 Jan 13.

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