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Items: 1 to 50 of 111

1.

RNA sequencing of transplant-stage idiopathic pulmonary fibrosis lung reveals unique pathway regulation.

Sivakumar P, Thompson JR, Ammar R, Porteous M, McCoubrey C, Cantu E 3rd, Ravi K, Zhang Y, Luo Y, Streltsov D, Beers MF, Jarai G, Christie JD.

ERJ Open Res. 2019 Aug 12;5(3). pii: 00117-2019. doi: 10.1183/23120541.00117-2019. eCollection 2019 Jul.

2.

Surfactant protein-D modulation of pulmonary macrophage phenotype is controlled by S-nitrosylation.

Guo CJ, Atochina-Vasserman EN, Abramova E, Smith LC, Beers MF, Gow AJ.

Am J Physiol Lung Cell Mol Physiol. 2019 Nov 1;317(5):L539-L549. doi: 10.1152/ajplung.00506.2018. Epub 2019 Aug 14.

PMID:
31411060
3.

In utero gene editing for monogenic lung disease.

Alapati D, Zacharias WJ, Hartman HA, Rossidis AC, Stratigis JD, Ahn NJ, Coons B, Zhou S, Li H, Singh K, Katzen J, Tomer Y, Chadwick AC, Musunuru K, Beers MF, Morrisey EE, Peranteau WH.

Sci Transl Med. 2019 Apr 17;11(488). pii: eaav8375. doi: 10.1126/scitranslmed.aav8375.

PMID:
30996081
4.

Epithelial Expression of an Interstitial Lung Disease-Associated Mutation in Surfactant Protein-C Modulates Recruitment and Activation of Key Myeloid Cell Populations in Mice.

Venosa A, Katzen J, Tomer Y, Kopp M, Jamil S, Russo SJ, Mulugeta S, Beers MF.

J Immunol. 2019 May 1;202(9):2760-2771. doi: 10.4049/jimmunol.1900039. Epub 2019 Mar 25.

PMID:
30910861
5.

An SFTPC BRICHOS mutant links epithelial ER stress and spontaneous lung fibrosis.

Katzen J, Wagner BD, Venosa A, Kopp M, Tomer Y, Russo SJ, Headen AC, Basil MC, Stark JM, Mulugeta S, Deterding RR, Beers MF.

JCI Insight. 2019 Mar 21;4(6). pii: 126125. doi: 10.1172/jci.insight.126125. eCollection 2019 Mar 21.

6.

Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism.

Hung LY, Sen D, Oniskey TK, Katzen J, Cohen NA, Vaughan AE, Nieves W, Urisman A, Beers MF, Krummel MF, Herbert DR.

Mucosal Immunol. 2019 Jan;12(1):64-76. doi: 10.1038/s41385-018-0096-2. Epub 2018 Oct 18.

7.

Protein kinase R-like endoplasmatic reticulum kinase is a mediator of stretch in ventilator-induced lung injury.

Dolinay T, Aonbangkhen C, Zacharias W, Cantu E, Pogoriler J, Stablow A, Lawrence GG, Suzuki Y, Chenoweth DM, Morrisey E, Christie JD, Beers MF, Margulies SS.

Respir Res. 2018 Aug 22;19(1):157. doi: 10.1186/s12931-018-0856-2.

8.

Expression of mutant Sftpc in murine alveolar epithelia drives spontaneous lung fibrosis.

Nureki SI, Tomer Y, Venosa A, Katzen J, Russo SJ, Jamil S, Barrett M, Nguyen V, Kopp M, Mulugeta S, Beers MF.

J Clin Invest. 2018 Aug 31;128(9):4008-4024. doi: 10.1172/JCI99287. Epub 2018 Aug 13.

9.

Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells.

Jacob A, Morley M, Hawkins F, McCauley KB, Jean JC, Heins H, Na CL, Weaver TE, Vedaie M, Hurley K, Hinds A, Russo SJ, Kook S, Zacharias W, Ochs M, Traber K, Quinton LJ, Crane A, Davis BR, White FV, Wambach J, Whitsett JA, Cole FS, Morrisey EE, Guttentag SH, Beers MF, Kotton DN.

Cell Stem Cell. 2017 Oct 5;21(4):472-488.e10. doi: 10.1016/j.stem.2017.08.014. Epub 2017 Sep 28.

10.

When Is an Alveolar Type 2 Cell an Alveolar Type 2 Cell? A Conundrum for Lung Stem Cell Biology and Regenerative Medicine.

Beers MF, Moodley Y.

Am J Respir Cell Mol Biol. 2017 Jul;57(1):18-27. doi: 10.1165/rcmb.2016-0426PS. Review.

11.

Aberrant lung remodeling in a mouse model of surfactant dysregulation induced by modulation of the Abca3 gene.

Beers MF, Knudsen L, Tomer Y, Maronn J, Zhao M, Ochs M, Mulugeta S.

Ann Anat. 2017 Mar;210:135-146. doi: 10.1016/j.aanat.2016.11.015. Epub 2016 Dec 26.

12.

The biology of the ABCA3 lipid transporter in lung health and disease.

Beers MF, Mulugeta S.

Cell Tissue Res. 2017 Mar;367(3):481-493. doi: 10.1007/s00441-016-2554-z. Epub 2016 Dec 26. Review.

13.

Neutrophils promote alveolar epithelial regeneration by enhancing type II pneumocyte proliferation in a model of acid-induced acute lung injury.

Paris AJ, Liu Y, Mei J, Dai N, Guo L, Spruce LA, Hudock KM, Brenner JS, Zacharias WJ, Mei HD, Slamowitz AR, Bhamidipati K, Beers MF, Seeholzer SH, Morrisey EE, Worthen GS.

Am J Physiol Lung Cell Mol Physiol. 2016 Dec 1;311(6):L1062-L1075. doi: 10.1152/ajplung.00327.2016. Epub 2016 Sep 30.

14.

Impaired Lysosomal Integral Membrane Protein 2-dependent Peroxiredoxin 6 Delivery to Lamellar Bodies Accounts for Altered Alveolar Phospholipid Content in Adaptor Protein-3-deficient pearl Mice.

Kook S, Wang P, Young LR, Schwake M, Saftig P, Weng X, Meng Y, Neculai D, Marks MS, Gonzales L, Beers MF, Guttentag S.

J Biol Chem. 2016 Apr 15;291(16):8414-27. doi: 10.1074/jbc.M116.720201. Epub 2016 Feb 23.

15.

The role of inducible nitric oxide synthase for interstitial remodeling of alveolar septa in surfactant protein D-deficient mice.

Knudsen L, Atochina-Vasserman EN, Massa CB, Birkelbach B, Guo CJ, Scott P, Haenni B, Beers MF, Ochs M, Gow AJ.

Am J Physiol Lung Cell Mol Physiol. 2015 Nov 1;309(9):L959-69. doi: 10.1152/ajplung.00017.2015. Epub 2015 Aug 28.

16.

Lost after translation: insights from pulmonary surfactant for understanding the role of alveolar epithelial dysfunction and cellular quality control in fibrotic lung disease.

Mulugeta S, Nureki S, Beers MF.

Am J Physiol Lung Cell Mol Physiol. 2015 Sep 15;309(6):L507-25. doi: 10.1152/ajplung.00139.2015. Epub 2015 Jul 17. Review.

17.

Surfactant dysfunction and lung inflammation in the female mouse model of lymphangioleiomyomatosis.

Atochina-Vasserman EN, Guo CJ, Abramova E, Golden TN, Sims M, James ML, Beers MF, Gow AJ, Krymskaya VP.

Am J Respir Cell Mol Biol. 2015 Jul;53(1):96-104. doi: 10.1165/rcmb.2014-0224OC.

18.

A non-BRICHOS SFTPC mutant (SP-CI73T) linked to interstitial lung disease promotes a late block in macroautophagy disrupting cellular proteostasis and mitophagy.

Hawkins A, Guttentag SH, Deterding R, Funkhouser WK, Goralski JL, Chatterjee S, Mulugeta S, Beers MF.

Am J Physiol Lung Cell Mol Physiol. 2015 Jan 1;308(1):L33-47. doi: 10.1152/ajplung.00217.2014. Epub 2014 Oct 24.

19.

NOS2 is critical to the development of emphysema in Sftpd deficient mice but does not affect surfactant homeostasis.

Knudsen L, Atochina-Vasserman EN, Guo CJ, Scott PA, Haenni B, Beers MF, Ochs M, Gow AJ.

PLoS One. 2014 Jan 21;9(1):e85722. doi: 10.1371/journal.pone.0085722. eCollection 2014.

20.

Disruption of N-linked glycosylation promotes proteasomal degradation of the human ATP-binding cassette transporter ABCA3.

Beers MF, Zhao M, Tomer Y, Russo SJ, Zhang P, Gonzales LW, Guttentag SH, Mulugeta S.

Am J Physiol Lung Cell Mol Physiol. 2013 Dec;305(12):L970-80. doi: 10.1152/ajplung.00184.2013. Epub 2013 Oct 18.

21.

Lung surfactant protein D (SP-D) response and regulation during acute and chronic lung injury.

Gaunsbaek MQ, Rasmussen KJ, Beers MF, Atochina-Vasserman EN, Hansen S.

Lung. 2013 Jun;191(3):295-303. doi: 10.1007/s00408-013-9452-x. Epub 2013 Feb 24.

22.

Differential alveolar epithelial injury and protein expression in pneumococcal pneumonia.

Tyrrell C, McKechnie SR, Beers MF, Mitchell TJ, McElroy MC.

Exp Lung Res. 2012 Jun;38(5):266-76. doi: 10.3109/01902148.2012.683321.

PMID:
22563685
23.

Surfactant protein D facilitates Cryptococcus neoformans infection.

Geunes-Boyer S, Beers MF, Perfect JR, Heitman J, Wright JR.

Infect Immun. 2012 Jul;80(7):2444-53. doi: 10.1128/IAI.05613-11. Epub 2012 Apr 30.

24.

Surfactant protein-D regulates effector cell function and fibrotic lung remodeling in response to bleomycin injury.

Aono Y, Ledford JG, Mukherjee S, Ogawa H, Nishioka Y, Sone S, Beers MF, Noble PW, Wright JR.

Am J Respir Crit Care Med. 2012 Mar 1;185(5):525-36. doi: 10.1164/rccm.201103-0561OC. Epub 2011 Dec 28.

25.

Multiple ways to die: delineation of the unfolded protein response and apoptosis induced by Surfactant Protein C BRICHOS mutants.

Maguire JA, Mulugeta S, Beers MF.

Int J Biochem Cell Biol. 2012 Jan;44(1):101-12. doi: 10.1016/j.biocel.2011.10.003. Epub 2011 Oct 13.

26.

A nonaggregating surfactant protein C mutant is misdirected to early endosomes and disrupts phospholipid recycling.

Beers MF, Hawkins A, Maguire JA, Kotorashvili A, Zhao M, Newitt JL, Ding W, Russo S, Guttentag S, Gonzales L, Mulugeta S.

Traffic. 2011 Sep;12(9):1196-210. doi: 10.1111/j.1600-0854.2011.01223.x. Epub 2011 Jun 28.

27.

Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs.

Lawson WE, Cheng DS, Degryse AL, Tanjore H, Polosukhin VV, Xu XC, Newcomb DC, Jones BR, Roldan J, Lane KB, Morrisey EE, Beers MF, Yull FE, Blackwell TS.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10562-7. doi: 10.1073/pnas.1107559108. Epub 2011 Jun 13.

28.

The three R's of lung health and disease: repair, remodeling, and regeneration.

Beers MF, Morrisey EE.

J Clin Invest. 2011 Jun;121(6):2065-73. doi: 10.1172/JCI45961. Epub 2011 Jun 1. Review.

29.

Early alveolar epithelial dysfunction promotes lung inflammation in a mouse model of Hermansky-Pudlak syndrome.

Atochina-Vasserman EN, Bates SR, Zhang P, Abramova H, Zhang Z, Gonzales L, Tao JQ, Gochuico BR, Gahl W, Guo CJ, Gow AJ, Beers MF, Guttentag S.

Am J Respir Crit Care Med. 2011 Aug 15;184(4):449-58. doi: 10.1164/rccm.201011-1882OC.

30.

A novel conserved targeting motif found in ABCA transporters mediates trafficking to early post-Golgi compartments.

Beers MF, Hawkins A, Shuman H, Zhao M, Newitt JL, Maguire JA, Ding W, Mulugeta S.

J Lipid Res. 2011 Aug;52(8):1471-82. doi: 10.1194/jlr.M013284. Epub 2011 May 17.

31.

Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD.

Winkler C, Atochina-Vasserman EN, Holz O, Beers MF, Erpenbeck VJ, Krug N, Roepcke S, Lauer G, Elmlinger M, Hohlfeld JM.

Respir Res. 2011 Mar 11;12:29. doi: 10.1186/1465-9921-12-29.

32.

Effect of single vs bilateral lung transplantation on plasma surfactant protein D levels in idiopathic pulmonary fibrosis.

Sims MW, Beers MF, Ahya VN, Kawut SM, Sims KD, Lederer DJ, Palmer SM, Wille K, Lama VN, Shah PD, Orens JB, Bhorade S, Crespo M, Weinacker A, Demissie E, Bellamy S, Christie JD, Ware LB; Lung Transplant Outcomes Group.

Chest. 2011 Aug;140(2):489-496. doi: 10.1378/chest.10-2065. Epub 2011 Feb 24.

33.

ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio.

Meyer NJ, Li M, Feng R, Bradfield J, Gallop R, Bellamy S, Fuchs BD, Lanken PN, Albelda SM, Rushefski M, Aplenc R, Abramova H, Atochina-Vasserman EN, Beers MF, Calfee CS, Cohen MJ, Pittet JF, Christiani DC, O'Keefe GE, Ware LB, May AK, Wurfel MM, Hakonarson H, Christie JD.

Am J Respir Crit Care Med. 2011 May 15;183(10):1344-53. doi: 10.1164/rccm.201005-0701OC. Epub 2011 Jan 21.

34.

Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein.

Zhong Q, Zhou B, Ann DK, Minoo P, Liu Y, Banfalvi A, Krishnaveni MS, Dubourd M, Demaio L, Willis BC, Kim KJ, duBois RM, Crandall ED, Beers MF, Borok Z.

Am J Respir Cell Mol Biol. 2011 Sep;45(3):498-509. doi: 10.1165/rcmb.2010-0347OC. Epub 2010 Dec 17.

35.

Segmental allergen challenge alters multimeric structure and function of surfactant protein D in humans.

Atochina-Vasserman EN, Winkler C, Abramova H, Schaumann F, Krug N, Gow AJ, Beers MF, Hohlfeld JM.

Am J Respir Crit Care Med. 2011 Apr 1;183(7):856-64. doi: 10.1164/rccm.201004-0654OC. Epub 2010 Dec 3.

36.

A non-BRICHOS surfactant protein c mutation disrupts epithelial cell function and intercellular signaling.

Woischnik M, Sparr C, Kern S, Thurm T, Hector A, Hartl D, Liebisch G, Mulugeta S, Beers MF, Schmitz G, Griese M.

BMC Cell Biol. 2010 Nov 20;11:88. doi: 10.1186/1471-2121-11-88.

37.

Endoplasmic reticulum stress induced by surfactant protein C BRICHOS mutants promotes proinflammatory signaling by epithelial cells.

Maguire JA, Mulugeta S, Beers MF.

Am J Respir Cell Mol Biol. 2011 Mar;44(3):404-14. doi: 10.1165/rcmb.2009-0382OC. Epub 2010 May 12.

38.

Review: Chemical and structural modifications of pulmonary collectins and their functional consequences.

Atochina-Vasserman EN, Beers MF, Gow AJ.

Innate Immun. 2010 Jun;16(3):175-82. doi: 10.1177/1753425910368871. Epub 2010 Apr 27. Review.

39.

SP-D-dependent regulation of NO metabolism in lipopolysaccharide-stimulated peritoneal macrophages.

Atochina-Vasserman EN, Abramova EV, Tomer Y, Scott P, Nazarov VA, Kruglov SV, Beers MF, Gow AJ, Malyshev IY.

Bull Exp Biol Med. 2009 Apr;147(4):415-20. English, Russian.

40.

Anterograde transport of surfactant protein C proprotein to distal processing compartments requires PPDY-mediated association with Nedd4 ubiquitin ligases.

Kotorashvili A, Russo SJ, Mulugeta S, Guttentag S, Beers MF.

J Biol Chem. 2009 Jun 12;284(24):16667-78. doi: 10.1074/jbc.M109.002816. Epub 2009 Apr 14.

41.

Immune reconstitution during Pneumocystis lung infection: disruption of surfactant component expression and function by S-nitrosylation.

Atochina-Vasserman EN, Gow AJ, Abramova H, Guo CJ, Tomer Y, Preston AM, Beck JM, Beers MF.

J Immunol. 2009 Feb 15;182(4):2277-87. doi: 10.4049/jimmunol.0802775.

42.

[Antioxidative role of peroxiredoxin 6 in acute lung injury].

Wang Y, Lu Q, Sheldon FS, Ho YS, Phelan SA, Beers MF, Fisher AB.

Zhonghua Er Ke Za Zhi. 2008 Oct;46(10):739-44. Chinese.

PMID:
19099877
43.

Hyperoxia and acute lung injury.

Fisher AB, Beers MF.

Am J Physiol Lung Cell Mol Physiol. 2008 Dec;295(6):L1066; author reply L1067. doi: 10.1152/ajplung.90486.2008. No abstract available.

44.

[Impact of endogenous inflammation caused by adenovirus as a vector in gene therapy: experiment with mice models of acute lung injury].

Wang Y, Lu Q, Teng GL, Sheldon FS, Beers MF, Fisher AB.

Zhonghua Yi Xue Za Zhi. 2008 Jul 8;88(26):1841-5. Chinese.

PMID:
19040021
45.

S-nitrosylation of surfactant protein-D controls inflammatory function.

Guo CJ, Atochina-Vasserman EN, Abramova E, Foley JP, Zaman A, Crouch E, Beers MF, Savani RC, Gow AJ.

PLoS Biol. 2008 Nov 11;6(11):e266. doi: 10.1371/journal.pbio.0060266.

46.

Surfactant protein D protects against acute hyperoxic lung injury.

Jain D, Atochina-Vasserman EN, Tomer Y, Kadire H, Beers MF.

Am J Respir Crit Care Med. 2008 Oct 15;178(8):805-13. doi: 10.1164/rccm.200804-582OC. Epub 2008 Jul 17.

47.

Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D (SP-D) levels: a cross-sectional study.

Sims MW, Tal-Singer RM, Kierstein S, Musani AI, Beers MF, Panettieri RA, Haczku A.

Respir Res. 2008 Jan 28;9:13. doi: 10.1186/1465-9921-9-13.

48.

Selective inhibition of inducible NO synthase activity in vivo reverses inflammatory abnormalities in surfactant protein D-deficient mice.

Atochina-Vasserman EN, Beers MF, Kadire H, Tomer Y, Inch A, Scott P, Guo CJ, Gow AJ.

J Immunol. 2007 Dec 15;179(12):8090-7.

49.

Misfolded BRICHOS SP-C mutant proteins induce apoptosis via caspase-4- and cytochrome c-related mechanisms.

Mulugeta S, Maguire JA, Newitt JL, Russo SJ, Kotorashvili A, Beers MF.

Am J Physiol Lung Cell Mol Physiol. 2007 Sep;293(3):L720-9. Epub 2007 Jun 22.

50.

GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo.

Zhang Y, Rath N, Hannenhalli S, Wang Z, Cappola T, Kimura S, Atochina-Vasserman E, Lu MM, Beers MF, Morrisey EE.

Development. 2007 Jan;134(1):189-98.

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