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Items: 41

1.

Functional alterations of myeloid cells during the course of Alzheimer's disease.

Thome AD, Faridar A, Beers DR, Thonhoff JR, Zhao W, Wen S, Pascual B, Masdeu JC, Appel SH.

Mol Neurodegener. 2018 Nov 13;13(1):61. doi: 10.1186/s13024-018-0293-1.

2.

Expanded autologous regulatory T-lymphocyte infusions in ALS: A phase I, first-in-human study.

Thonhoff JR, Beers DR, Zhao W, Pleitez M, Simpson EP, Berry JD, Cudkowicz ME, Appel SH.

Neurol Neuroimmunol Neuroinflamm. 2018 May 18;5(4):e465. doi: 10.1212/NXI.0000000000000465. eCollection 2018 Jul.

3.

The Role of Regulatory T Lymphocytes in Amyotrophic Lateral Sclerosis.

Beers DR, Zhao W, Appel SH.

JAMA Neurol. 2018 Jun 1;75(6):656-658. doi: 10.1001/jamaneurol.2018.0043. No abstract available.

PMID:
29507936
4.

An open label study of a novel immunosuppression intervention for the treatment of amyotrophic lateral sclerosis.

Fournier CN, Schoenfeld D, Berry JD, Cudkowicz ME, Chan J, Quinn C, Brown RH, Salameh JS, Tansey MG, Beers DR, Appel SH, Glass JD.

Amyotroph Lateral Scler Frontotemporal Degener. 2018 May;19(3-4):242-249. doi: 10.1080/21678421.2017.1421666. Epub 2018 Jan 8.

PMID:
29308669
5.

Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes.

Zhao W, Beers DR, Hooten KG, Sieglaff DH, Zhang A, Kalyana-Sundaram S, Traini CM, Halsey WS, Hughes AM, Sathe GM, Livi GP, Fan GH, Appel SH.

JAMA Neurol. 2017 Jun 1;74(6):677-685. doi: 10.1001/jamaneurol.2017.0357.

6.

ALS patients' regulatory T lymphocytes are dysfunctional, and correlate with disease progression rate and severity.

Beers DR, Zhao W, Wang J, Zhang X, Wen S, Neal D, Thonhoff JR, Alsuliman AS, Shpall EJ, Rezvani K, Appel SH.

JCI Insight. 2017 Mar 9;2(5):e89530. doi: 10.1172/jci.insight.89530.

7.

A robust, good manufacturing practice-compliant, clinical-scale procedure to generate regulatory T cells from patients with amyotrophic lateral sclerosis for adoptive cell therapy.

Alsuliman A, Appel SH, Beers DR, Basar R, Shaim H, Kaur I, Zulovich J, Yvon E, Muftuoglu M, Imahashi N, Kondo K, Liu E, Shpall EJ, Rezvani K.

Cytotherapy. 2016 Oct;18(10):1312-24. doi: 10.1016/j.jcyt.2016.06.012. Epub 2016 Aug 3.

PMID:
27497700
8.

TDP-43 activates microglia through NF-κB and NLRP3 inflammasome.

Zhao W, Beers DR, Bell S, Wang J, Wen S, Baloh RH, Appel SH.

Exp Neurol. 2015 Nov;273:24-35. doi: 10.1016/j.expneurol.2015.07.019. Epub 2015 Jul 26.

PMID:
26222336
9.

Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis.

Hooten KG, Beers DR, Zhao W, Appel SH.

Neurotherapeutics. 2015 Apr;12(2):364-75. doi: 10.1007/s13311-014-0329-3. Review.

10.

Immune-mediated mechanisms in the pathoprogression of amyotrophic lateral sclerosis.

Zhao W, Beers DR, Appel SH.

J Neuroimmune Pharmacol. 2013 Sep;8(4):888-99. doi: 10.1007/s11481-013-9489-x. Epub 2013 Jul 25. Review.

11.

Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival.

Henkel JS, Beers DR, Wen S, Rivera AL, Toennis KM, Appel JE, Zhao W, Moore DH, Powell SZ, Appel SH.

EMBO Mol Med. 2013 Jan;5(1):64-79. doi: 10.1002/emmm.201201544. Epub 2012 Nov 9. Erratum in: EMBO Mol Med. 2013 Feb;5(2):326.

12.

Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms.

Zhao W, Beers DR, Liao B, Henkel JS, Appel SH.

Neurobiol Dis. 2012 Dec;48(3):418-28. doi: 10.1016/j.nbd.2012.07.008. Epub 2012 Jul 17.

13.

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS.

Liao B, Zhao W, Beers DR, Henkel JS, Appel SH.

Exp Neurol. 2012 Sep;237(1):147-52. doi: 10.1016/j.expneurol.2012.06.011. Epub 2012 Jun 23.

14.

Peripheral nerve inflammation in ALS mice: cause or consequence.

Kano O, Beers DR, Henkel JS, Appel SH.

Neurology. 2012 Mar 13;78(11):833-5. doi: 10.1212/WNL.0b013e318249f776. Epub 2012 Feb 29. No abstract available.

15.

Excess circulating alternatively activated myeloid (M2) cells accelerate ALS progression while inhibiting experimental autoimmune encephalomyelitis.

Vaknin I, Kunis G, Miller O, Butovsky O, Bukshpan S, Beers DR, Henkel JS, Yoles E, Appel SH, Schwartz M.

PLoS One. 2011;6(11):e26921. doi: 10.1371/journal.pone.0026921. Epub 2011 Nov 3.

16.

The microglial-motoneuron dialogue in ALS.

Appel SH, Zhao W, Beers DR, Henkel JS.

Acta Myol. 2011 Jun;30(1):4-8. Review.

17.

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis.

Beers DR, Henkel JS, Zhao W, Wang J, Huang A, Wen S, Liao B, Appel SH.

Brain. 2011 May;134(Pt 5):1293-314. doi: 10.1093/brain/awr074.

18.

Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice.

Beers DR, Zhao W, Liao B, Kano O, Wang J, Huang A, Appel SH, Henkel JS.

Brain Behav Immun. 2011 Jul;25(5):1025-35. doi: 10.1016/j.bbi.2010.12.008. Epub 2010 Dec 19.

19.

T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?

Appel SH, Beers DR, Henkel JS.

Trends Immunol. 2010 Jan;31(1):7-17. doi: 10.1016/j.it.2009.09.003. Epub 2009 Oct 31. Review.

20.

Microglia in ALS: the good, the bad, and the resting.

Henkel JS, Beers DR, Zhao W, Appel SH.

J Neuroimmune Pharmacol. 2009 Dec;4(4):389-98. doi: 10.1007/s11481-009-9171-5. Review.

PMID:
19731042
21.

Extracellular mutant SOD1 induces microglial-mediated motoneuron injury.

Zhao W, Beers DR, Henkel JS, Zhang W, Urushitani M, Julien JP, Appel SH.

Glia. 2010 Jan 15;58(2):231-43. doi: 10.1002/glia.20919.

22.

Decreased mRNA expression of tight junction proteins in lumbar spinal cords of patients with ALS.

Henkel JS, Beers DR, Wen S, Bowser R, Appel SH.

Neurology. 2009 May 5;72(18):1614-6. doi: 10.1212/WNL.0b013e3181a41228. No abstract available.

PMID:
19414730
23.

Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis.

Appel SH, Engelhardt JI, Henkel JS, Siklos L, Beers DR, Yen AA, Simpson EP, Luo Y, Carrum G, Heslop HE, Brenner MK, Popat U.

Neurology. 2008 Oct 21;71(17):1326-34. doi: 10.1212/01.wnl.0000327668.43541.22.

PMID:
18936424
24.

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS.

Beers DR, Henkel JS, Zhao W, Wang J, Appel SH.

Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15558-63. doi: 10.1073/pnas.0807419105. Epub 2008 Sep 22.

25.

Novel therapeutic targets in neurodegenerative diseases: lessons from amyotrophic lateral sclerosis.

Appel SH, Beers DR, Henkel JS, Zhao W.

Curr Neurol Neurosci Rep. 2008 Sep;8(5):353-5. Review. No abstract available.

PMID:
18713569
26.

Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia.

Xiao Q, Zhao W, Beers DR, Yen AA, Xie W, Henkel JS, Appel SH.

J Neurochem. 2007 Sep;102(6):2008-2019. doi: 10.1111/j.1471-4159.2007.04677.x. Epub 2007 Jun 7.

27.

Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis.

Beers DR, Henkel JS, Xiao Q, Zhao W, Wang J, Yen AA, Siklos L, McKercher SR, Appel SH.

Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):16021-6. Epub 2006 Oct 16.

28.

Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia.

Zhao W, Xie W, Xiao Q, Beers DR, Appel SH.

J Neurochem. 2006 Nov;99(4):1176-87. Epub 2006 Oct 2.

29.

The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS.

Henkel JS, Beers DR, Siklós L, Appel SH.

Mol Cell Neurosci. 2006 Mar;31(3):427-37. Epub 2005 Dec 5.

PMID:
16337133
30.

Activated microglia initiate motor neuron injury by a nitric oxide and glutamate-mediated mechanism.

Zhao W, Xie W, Le W, Beers DR, He Y, Henkel JS, Simpson EP, Yen AA, Xiao Q, Appel SH.

J Neuropathol Exp Neurol. 2004 Sep;63(9):964-77.

PMID:
15453095
31.

HFE mutations are not strongly associated with sporadic ALS.

Yen AA, Simpson EP, Henkel JS, Beers DR, Appel SH.

Neurology. 2004 May 11;62(9):1611-2.

PMID:
15136693
32.

Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue.

Henkel JS, Engelhardt JI, Siklós L, Simpson EP, Kim SH, Pan T, Goodman JC, Siddique T, Beers DR, Appel SH.

Ann Neurol. 2004 Feb;55(2):221-35.

PMID:
14755726
33.

PARP expression is increased in astrocytes but decreased in motor neurons in the spinal cord of sporadic ALS patients.

Kim SH, Henkel JS, Beers DR, Sengun IS, Simpson EP, Goodman JC, Engelhardt JI, Siklós L, Appel SH.

J Neuropathol Exp Neurol. 2003 Jan;62(1):88-103.

PMID:
12528821
34.

Immunoglobulin Fc gamma receptor promotes immunoglobulin uptake, immunoglobulin-mediated calcium increase, and neurotransmitter release in motor neurons.

Mohamed HA, Mosier DR, Zou LL, Siklós L, Alexianu ME, Engelhardt JI, Beers DR, Le WD, Appel SH.

J Neurosci Res. 2002 Jul 1;69(1):110-6.

PMID:
12111822
35.

Parvalbumin overexpression alters immune-mediated increases in intracellular calcium, and delays disease onset in a transgenic model of familial amyotrophic lateral sclerosis.

Beers DR, Ho BK, Siklós L, Alexianu ME, Mosier DR, Mohamed AH, Otsuka Y, Kozovska ME, McAlhany RE, Smith RG, Appel SH.

J Neurochem. 2001 Nov;79(3):499-509.

36.

Role of potassium channels in amyloid-induced cell death.

Colom LV, Diaz ME, Beers DR, Neely A, Xie WJ, Appel SH.

J Neurochem. 1998 May;70(5):1925-34.

37.

Spatial recognition memory deficits without notable CNS pathology in rats following herpes simplex encephalitis.

Beers DR, Henkel JS, Kesner RP, Stroop WG.

J Neurol Sci. 1995 Aug;131(2):119-27.

PMID:
7595636
38.

Cloning and restriction endonuclease mapping of herpes simplex virus type-1 strains H129 and +GC.

Kienzle TE, Henkel JS, Ling JY, Banks MC, Beers DR, Jones B, Stroop WG.

Arch Virol. 1995;140(9):1663-75.

PMID:
7487498
39.

Neuropathology of herpes simplex virus encephalitis in a rat seizure model.

Beers DR, Henkel JS, Schaefer DC, Rose JW, Stroop WG.

J Neuropathol Exp Neurol. 1993 May;52(3):241-52.

PMID:
8388040
40.

Dissociation of data-based and expectancy-based memory following hippocampal lesions in rats.

Kesner RP, Beers DR.

Behav Neural Biol. 1988 Jul;50(1):46-60.

PMID:
3401197
41.

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