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Items: 35

1.

One-pot synthesis of epoxides from benzyl alcohols and aldehydes.

Alfonzo E, Mendoza JWL, Beeler AB.

Beilstein J Org Chem. 2018 Sep 3;14:2308-2312. doi: 10.3762/bjoc.14.205. eCollection 2018.

2.

Synthesis of Complex Stereoheptads en Route to Daphnane Diterpene Orthoesters.

Nguyen LV, Beeler AB.

Org Lett. 2018 Sep 7;20(17):5177-5180. doi: 10.1021/acs.orglett.8b02124. Epub 2018 Aug 17.

PMID:
30118240
3.

Regioselective and Enantioselective Intermolecular Buchner Ring Expansions in Flow.

Fleming GS, Beeler AB.

Org Lett. 2017 Oct 6;19(19):5268-5271. doi: 10.1021/acs.orglett.7b02537. Epub 2017 Sep 11.

PMID:
28892633
4.

A photochemical flow reactor for large scale syntheses of aglain and rocaglate natural product analogues.

Yueh H, Gao Q, Porco JA Jr, Beeler AB.

Bioorg Med Chem. 2017 Dec 1;25(23):6197-6202. doi: 10.1016/j.bmc.2017.06.010. Epub 2017 Jun 11.

5.

Redesign of a Pyrylium Photoredox Catalyst and Its Application to the Generation of Carbonyl Ylides.

Alfonzo E, Alfonso FS, Beeler AB.

Org Lett. 2017 Jun 2;19(11):2989-2992. doi: 10.1021/acs.orglett.7b01222. Epub 2017 May 22.

PMID:
28530103
6.

Identification of Anti-prion Compounds using a Novel Cellular Assay.

Imberdis T, Heeres JT, Yueh H, Fang C, Zhen J, Rich CB, Glicksman M, Beeler AB, Harris DA.

J Biol Chem. 2016 Dec 9;291(50):26164-26176. Epub 2016 Nov 1.

7.

Development of a Potent and Selective HDAC8 Inhibitor.

Ingham OJ, Paranal RM, Smith WB, Escobar RA, Yueh H, Snyder T, Porco JA Jr, Bradner JE, Beeler AB.

ACS Med Chem Lett. 2016 Sep 1;7(10):929-932. eCollection 2016 Oct 13.

8.

Introduction: Photochemistry in Organic Synthesis.

Beeler AB.

Chem Rev. 2016 Sep 14;116(17):9629-30. doi: 10.1021/acs.chemrev.6b00378. No abstract available.

PMID:
27625298
9.

Fine-tuning of macrophage activation using synthetic rocaglate derivatives.

Bhattacharya B, Chatterjee S, Devine WG, Kobzik L, Beeler AB, Porco JA Jr, Kramnik I.

Sci Rep. 2016 Apr 18;6:24409. doi: 10.1038/srep24409.

10.

[2+2] Photocycloaddition of Cinnamates in Flow and Development of a Thiourea Catalyst.

Telmesani R, Park SH, Lynch-Colameta T, Beeler AB.

Angew Chem Int Ed Engl. 2015 Sep 21;54(39):11521-5. doi: 10.1002/anie.201504454. Epub 2015 Jul 1.

PMID:
26136253
11.

Multidimensional reaction screening for photochemical transformations as a tool for discovering new chemotypes.

Martin VI, Goodell JR, Ingham OJ, Porco JA Jr, Beeler AB.

J Org Chem. 2014 May 2;79(9):3838-46. doi: 10.1021/jo500190b. Epub 2014 Apr 16.

12.

Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations.

Leng B, Chichetti S, Su S, Beeler AB, Porco JA Jr.

Beilstein J Org Chem. 2012;8:1338-43. Epub 2012 Aug 20.

13.

Synthesis of azaphilone-based chemical libraries.

Achard M, Beeler AB, Porco JA Jr.

ACS Comb Sci. 2012 Mar 12;14(3):236-44. doi: 10.1021/co300002x. Epub 2012 Feb 24.

14.

Remodelling of the natural product fumagillol employing a reaction discovery approach.

Balthaser BR, Maloney MC, Beeler AB, Porco JA Jr, Snyder JK.

Nat Chem. 2011 Dec;3(12):969-73.

15.

Synthesis and reactivity of bicyclo[3.2.1]octanoid-derived cyclopropanes.

Goodell JR, Poole JL, Beeler AB, Aubé J, Porco JA Jr.

J Org Chem. 2011 Dec 2;76(23):9792-800. doi: 10.1021/jo2018922. Epub 2011 Nov 1.

16.

Discovery of new antimalarial chemotypes through chemical methodology and library development.

Brown LE, Chih-Chien Cheng K, Wei WG, Yuan P, Dai P, Trilles R, Ni F, Yuan J, MacArthur R, Guha R, Johnson RL, Su XZ, Dominguez MM, Snyder JK, Beeler AB, Schaus SE, Inglese J, Porco JA Jr.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6775-80. doi: 10.1073/pnas.1017666108. Epub 2011 Apr 15.

17.

Catalytic enantioselective alkylative dearomatization-annulation: total synthesis and absolute configuration assignment of hyperibone K.

Qi J, Beeler AB, Zhang Q, Porco JA Jr.

J Am Chem Soc. 2010 Oct 6;132(39):13642-4. doi: 10.1021/ja1057828.

18.

Multidimensional Screening and Methodology Development for Condensations Involving Complex 1,2-Diketones.

Goodell JR, Leng B, Snyder TK, Beeler AB, Porco JA Jr.

Synthesis (Stuttg). 2010 Jul 1;2010(13):2254-2270.

19.

Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo[3.2.1]octanoid scaffolds.

Goodell JR, McMullen JP, Zaborenko N, Maloney JR, Ho CX, Jensen KF, Porco JA Jr, Beeler AB.

J Org Chem. 2009 Aug 21;74(16):6169-80. doi: 10.1021/jo901073v.

20.

Tandem processes identified from reaction screening: nucleophilic addition to aryl N-phosphinylimines employing La(III)-TFAA activation.

Kinoshita H, Ingham OJ, Ong WW, Beeler AB, Porco JA Jr.

J Am Chem Soc. 2010 May 12;132(18):6412-8. doi: 10.1021/ja100346w.

21.

A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization.

Kota S, Scampavia L, Spicer T, Beeler AB, Takahashi V, Snyder JK, Porco JA, Hodder P, Strosberg AD.

Assay Drug Dev Technol. 2010 Feb;8(1):96-105. doi: 10.1089/adt.2009.0217.

22.

Reaction discovery employing macrocycles: transannular cyclizations of macrocyclic bis-lactams.

Han C, Rangarajan S, Voukides AC, Beeler AB, Johnson R, Porco JA Jr.

Org Lett. 2009 Jan 15;11(2):413-6. doi: 10.1021/ol802729f.

23.

Library synthesis using 5,6,7,8-tetrahydro-1,6-naphthyridines as scaffolds.

Zhou Y, Beeler AB, Cho S, Wang Y, Franzblau SG, Snyder JK.

J Comb Chem. 2008 Jul-Aug;10(4):534-40. doi: 10.1021/cc800038r. Epub 2008 Jun 3.

PMID:
18517255
24.

Nucleophilic addition to N-phosphinylimines by rare-earth-metal triflate/trifluoroacetic anhydride activation.

Ong WW, Beeler AB, Kesavan S, Panek JS, Porco JA Jr.

Angew Chem Int Ed Engl. 2007;46(39):7470-2. No abstract available.

PMID:
17722135
25.

Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen.

Peng LF, Kim SS, Matchacheep S, Lei X, Su S, Lin W, Runguphan W, Choe WH, Sakamoto N, Ikeda M, Kato N, Beeler AB, Porco JA Jr, Schreiber SL, Chung RT.

Antimicrob Agents Chemother. 2007 Oct;51(10):3756-9. Epub 2007 Aug 6.

26.
27.

Generation of oxamic acid libraries: antimalarials and inhibitors of Plasmodium falciparum lactate dehydrogenase.

Choi SR, Beeler AB, Pradhan A, Watkins EB, Rimoldi JM, Tekwani B, Avery MA.

J Comb Chem. 2007 Mar-Apr;9(2):292-300. Epub 2007 Feb 23.

PMID:
17316052
28.

Discovery of chemical reactions through multidimensional screening.

Beeler AB, Su S, Singleton CA, Porco JA Jr.

J Am Chem Soc. 2007 Feb 7;129(5):1413-9.

PMID:
17263426
29.

Convergent synthesis of complex diketopiperazines derived from pipecolic acid scaffolds and parallel screening against GPCR targets.

Dandapani S, Lan P, Beeler AB, Beischel S, Abbas A, Roth BL, Porco JA Jr, Panek JS.

J Org Chem. 2006 Nov 10;71(23):8934-45.

PMID:
17081025
30.

Synthesis of a library of complex macrodiolides employing cyclodimerization of hydroxy esters.

Beeler AB, Acquilano DE, Su Q, Yan F, Roth BL, Panek JS, Porco JA Jr.

J Comb Chem. 2005 Sep-Oct;7(5):673-81.

PMID:
16153061
31.

Convergent synthesis of a complex oxime library using chemical domain shuffling.

Su S, Acquilano DE, Arumugasamy J, Beeler AB, Eastwood EL, Giguere JR, Lan P, Lei X, Min GK, Yeager AR, Zhou Y, Panek JS, Snyder JK, Schaus SE, Porco JA Jr.

Org Lett. 2005 Jun 23;7(13):2751-4. Erratum in: Org Lett. 2005 Jul 21;7(15):3391.

PMID:
15957938
32.

Chemical library synthesis using convergent approaches.

Beeler AB, Schaus SE, Porco JA Jr.

Curr Opin Chem Biol. 2005 Jun;9(3):277-84. Review.

PMID:
15939329
33.

Synthesis and in vitro biological evaluation of fluoro-substituted-4-phenyl-1,2,3,6-tetrahydropyridines as monoamine oxidase B substrates.

Beeler AB, Gadepalli RS, Steyn S, Castagnoli N, Rimoldi JM.

Bioorg Med Chem. 2003 Nov 17;11(23):5229-34.

PMID:
14604687
34.

Stereochemical diversity through cyclodimerization: synthesis of polyketide-like macrodiolides.

Su Q, Beeler AB, Lobkovsky E, Porco JA Jr, Panek JS.

Org Lett. 2003 Jun 12;5(12):2149-52.

PMID:
12790551
35.

Toxicity of fipronil and its degradation products to Procambarus sp.: field and laboratory studies.

Schlenk D, Huggett DB, Allgood J, Bennett E, Rimoldi J, Beeler AB, Block D, Holder AW, Hovinga R, Bedient P.

Arch Environ Contam Toxicol. 2001 Oct;41(3):325-32.

PMID:
11503069

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