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Items: 1 to 50 of 218


Tumor-on-a-chip: a microfluidic model to study cell response to environmental gradients.

Ayuso JM, Virumbrales-Munoz M, McMinn PH, Rehman S, Gomez I, Karim MR, Trusttchel R, Wisinski KB, Beebe DJ, Skala MC.

Lab Chip. 2019 Sep 11. doi: 10.1039/c9lc00270g. [Epub ahead of print]


Effects of culture method on response to EGFR therapy in head and neck squamous cell carcinoma cells.

Ayuso JM, Vitek R, Swick AD, Skala MC, Wisinski KB, Kimple RJ, Lambert PF, Beebe DJ.

Sci Rep. 2019 Aug 28;9(1):12480. doi: 10.1038/s41598-019-48764-3.


Reconfigurable open microfluidics for studying the spatiotemporal dynamics of paracrine signalling.

Yu J, Berthier E, Craig A, de Groot TE, Sparks S, Ingram PN, Jarrard DF, Huang W, Beebe DJ, Theberge AB.

Nat Biomed Eng. 2019 Aug 19. doi: 10.1038/s41551-019-0421-4. [Epub ahead of print]


Centrifugation-Assisted Immiscible Fluid Filtration for Dual-Bioanalyte Extraction.

Juang DS, Berry SM, Li C, Lang JM, Beebe DJ.

Anal Chem. 2019 Sep 17;91(18):11848-11855. doi: 10.1021/acs.analchem.9b02572. Epub 2019 Aug 26.


Automated System for Small-Population Single-Particle Processing Enabled by Exclusive Liquid Repellency.

Li C, Niles DJ, Juang DS, Lang JM, Beebe DJ.

SLAS Technol. 2019 Jun 10:2472630319853219. doi: 10.1177/2472630319853219. [Epub ahead of print]


Human organotypic lymphatic vessel model elucidates microenvironment-dependent signaling and barrier function.

Gong MM, Lugo-Cintron KM, White BR, Kerr SC, Harari PM, Beebe DJ.

Biomaterials. 2019 Sep;214:119225. doi: 10.1016/j.biomaterials.2019.119225. Epub 2019 May 25.


Integrating Electrochemical Immunosensing and Cell Adhesion Technologies for Cancer Cell Detection and Enumeration.

Seenivasan R, Warrick JW, Rodriguez CI, Mattison W, Beebe DJ, Setaluri V, Gunasekaran S.

Electrochim Acta. 2018 Oct 1;286:205-211. doi: 10.1016/j.electacta.2018.08.005. Epub 2018 Aug 4.


Spatial presentation of biological molecules to cells by localized diffusive transfer.

Regier MC, Olszewski E, Carter CC, Aitchison JD, Kaushansky A, Davis J, Berthier E, Beebe DJ, Stevens KR.

Lab Chip. 2019 Jun 11;19(12):2114-2126. doi: 10.1039/c9lc00122k.


User-defined morphogen patterning for directing human cell fate stratification.

Regier MC, Tokar JJ, Warrick JW, Pabon L, Berthier E, Beebe DJ, Stevens KR.

Sci Rep. 2019 Apr 23;9(1):6433. doi: 10.1038/s41598-019-42874-8.


Mammary adipose stromal cells derived from obese women reduce sensitivity to the aromatase inhibitor anastrazole in an organotypic breast model.

Morgan MM, Arendt LM, Alarid ET, Beebe DJ, Johnson BP.

FASEB J. 2019 Jul;33(7):8623-8633. doi: 10.1096/fj.201802347RRR. Epub 2019 Apr 19.


Enabling cell recovery from 3D cell culture microfluidic devices for tumour microenvironment biomarker profiling.

Virumbrales-Muñoz M, Ayuso JM, Lacueva A, Randelovic T, Livingston MK, Beebe DJ, Oliván S, Pereboom D, Doblare M, Fernández L, Ochoa I.

Sci Rep. 2019 Apr 17;9(1):6199. doi: 10.1038/s41598-019-42529-8.


Patient-specific organotypic blood vessels as an in vitro model for anti-angiogenic drug response testing in renal cell carcinoma.

Jiménez-Torres JA, Virumbrales-Muñoz M, Sung KE, Lee MH, Abel EJ, Beebe DJ.

EBioMedicine. 2019 Apr;42:408-419. doi: 10.1016/j.ebiom.2019.03.026. Epub 2019 Mar 20.


Evaluating natural killer cell cytotoxicity against solid tumors using a microfluidic model.

Ayuso JM, Truttschel R, Gong MM, Humayun M, Virumbrales-Munoz M, Vitek R, Felder M, Gillies SD, Sondel P, Wisinski KB, Patankar M, Beebe DJ, Skala MC.

Oncoimmunology. 2018 Dec 12;8(3):1553477. doi: 10.1080/2162402X.2018.1553477. eCollection 2019.


Organotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations.

Ayuso JM, Gillette A, Lugo-Cintrón K, Acevedo-Acevedo S, Gomez I, Morgan M, Heaster T, Wisinski KB, Palecek SP, Skala MC, Beebe DJ.

EBioMedicine. 2018 Nov;37:144-157. doi: 10.1016/j.ebiom.2018.10.046. Epub 2018 Oct 26.


Versatile exclusion-based sample preparation platform for integrated rare cell isolation and analyte extraction.

Pezzi HM, Guckenberger DJ, Schehr JL, Rothbauer J, Stahlfeld C, Singh A, Horn S, Schultz ZD, Bade RM, Sperger JM, Berry SM, Lang JM, Beebe DJ.

Lab Chip. 2018 Nov 6;18(22):3446-3458. doi: 10.1039/c8lc00620b.


Open multi-culture platform for simple and flexible study of multi-cell type interactions.

Álvarez-García YR, Ramos-Cruz KP, Agostini-Infanzón RJ, Stallcop LE, Beebe DJ, Warrick JW, Domenech M.

Lab Chip. 2018 Oct 9;18(20):3184-3195. doi: 10.1039/c8lc00560e.


Interaction with an endothelial lumen increases neutrophil lifetime and motility in response to P aeruginosa.

Hind LE, Ingram PN, Beebe DJ, Huttenlocher A.

Blood. 2018 Oct 25;132(17):1818-1828. doi: 10.1182/blood-2018-05-848465. Epub 2018 Aug 24.


Surface topography and hydrophilicity regulate macrophage phenotype in milled microfluidic systems.

Kosoff D, Yu J, Suresh V, Beebe DJ, Lang JM.

Lab Chip. 2018 Sep 26;18(19):3011-3017. doi: 10.1039/c8lc00431e.


Double-exclusive liquid repellency (double-ELR): an enabling technology for rare phenotype analysis.

Li C, Yu J, Paine P, Juang DS, Berry SM, Beebe DJ.

Lab Chip. 2018 Sep 11;18(18):2710-2719. doi: 10.1039/c8lc00584b.


Mammary fibroblasts reduce apoptosis and speed estrogen-induced hyperplasia in an organotypic MCF7-derived duct model.

Morgan MM, Livingston MK, Warrick JW, Stanek EM, Alarid ET, Beebe DJ, Johnson BP.

Sci Rep. 2018 May 8;8(1):7139. doi: 10.1038/s41598-018-25461-1.


Exclusive Liquid Repellency: An Open Multi-Liquid-Phase Technology for Rare Cell Culture and Single-Cell Processing.

Li C, Yu J, Schehr J, Berry SM, Leal TA, Lang JM, Beebe DJ.

ACS Appl Mater Interfaces. 2018 May 23;10(20):17065-17070. doi: 10.1021/acsami.8b03627. Epub 2018 May 8.


Integration of Magnetic Bead-Based Cell Selection into Complex Isolations.

Pezzi HM, Niles DJ, Schehr JL, Beebe DJ, Lang JM.

ACS Omega. 2018 Apr 30;3(4):3908-3917. doi: 10.1021/acsomega.7b01427. Epub 2018 Apr 6.


Vital ex vivo tissue labeling and pathology-guided micropunching to characterize cellular heterogeneity in the tissue microenvironment.

Johnson BP, Vitek RA, Geiger PG, Huang W, Jarrard DF, Lang JM, Beebe DJ.

Biotechniques. 2018 Jan 1;64(1):13-19. doi: 10.2144/000114626.


An Accessible Organotypic Microvessel Model Using iPSC-Derived Endothelium.

Ingram PN, Hind LE, Jiminez-Torres JA, Huttenlocher A, Beebe DJ.

Adv Healthc Mater. 2018 Jan;7(2). doi: 10.1002/adhm.201700497. Epub 2017 Aug 7.


miFAST: A novel and rapid microRNA target capture method.

Poenitzsch Strong AM, Berry SM, Beebe DJ, Li JL, Spiegelman VS.

Mol Carcinog. 2018 Apr;57(4):559-566. doi: 10.1002/mc.22780. Epub 2018 Feb 12.


Razor-printed sticker microdevices for cell-based applications.

Stallcop LE, Álvarez-García YR, Reyes-Ramos AM, Ramos-Cruz KP, Morgan MM, Shi Y, Li L, Beebe DJ, Domenech M, Warrick JW.

Lab Chip. 2018 Jan 30;18(3):451-462. doi: 10.1039/c7lc00724h.


Microbial volatile communication in human organotypic lung models.

Barkal LJ, Procknow CL, Álvarez-García YR, Niu M, Jiménez-Torres JA, Brockman-Schneider RA, Gern JE, Denlinger LC, Theberge AB, Keller NP, Berthier E, Beebe DJ.

Nat Commun. 2017 Nov 24;8(1):1770. doi: 10.1038/s41467-017-01985-4.


RNA-mediated TILDA for improved cell capacity and enhanced detection of multiply-spliced HIV RNA.

Pezzi HM, Berry SM, Beebe DJ, Striker R.

Integr Biol (Camb). 2017 Nov 13;9(11):876-884. doi: 10.1039/c7ib00112f.


Human papillomavirus oncogenes reprogram the cervical cancer microenvironment independently of and synergistically with estrogen.

Spurgeon ME, den Boon JA, Horswill M, Barthakur S, Forouzan O, Rader JS, Beebe DJ, Roopra A, Ahlquist P, Lambert PF.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9076-E9085. doi: 10.1073/pnas.1712018114. Epub 2017 Oct 9.


Multikingdom microscale models.

Barkal LJ, Berthier E, Theberge AB, Keller NP, Beebe DJ.

PLoS Pathog. 2017 Aug 24;13(8):e1006424. doi: 10.1371/journal.ppat.1006424. eCollection 2017 Aug. Review. No abstract available.


Adaptation of a Simple Microfluidic Platform for High-Dimensional Quantitative Morphological Analysis of Human Mesenchymal Stromal Cells on Polystyrene-Based Substrates.

Lam J, Marklein RA, Jimenez-Torres JA, Beebe DJ, Bauer SR, Sung KE.

SLAS Technol. 2017 Dec;22(6):646-661. doi: 10.1177/2472630317726050. Epub 2017 Aug 21.


Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues.

Powell D, Tauzin S, Hind LE, Deng Q, Beebe DJ, Huttenlocher A.

Cell Rep. 2017 May 23;19(8):1572-1585. doi: 10.1016/j.celrep.2017.04.078.


Interrogating Bronchoalveolar Lavage Samples via Exclusion-Based Analyte Extraction.

Tokar JJ, Warrick JW, Guckenberger DJ, Sperger JM, Lang JM, Ferguson JS, Beebe DJ.

SLAS Technol. 2017 Jun;22(3):348-357. doi: 10.1177/2472630317696780. Epub 2017 Mar 15.


The Influence of Biomaterials on Cytokine Production in 3D Cultures.

Regier MC, Montanez-Sauri SI, Schwartz MP, Murphy WL, Beebe DJ, Sung KE.

Biomacromolecules. 2017 Mar 13;18(3):709-718. doi: 10.1021/acs.biomac.6b01469. Epub 2017 Feb 16.


The Extracellular Matrix of Candida albicans Biofilms Impairs Formation of Neutrophil Extracellular Traps.

Johnson CJ, Cabezas-Olcoz J, Kernien JF, Wang SX, Beebe DJ, Huttenlocher A, Ansari H, Nett JE.

PLoS Pathog. 2016 Sep 13;12(9):e1005884. doi: 10.1371/journal.ppat.1005884. eCollection 2016 Sep.


Magnetic System for Automated Manipulation of Paramagnetic Particles.

Guckenberger DJ, Pezzi HM, Regier MC, Berry SM, Fawcett K, Barrett K, Beebe DJ.

Anal Chem. 2016 Oct 18;88(20):9902-9907. doi: 10.1021/acs.analchem.6b02257. Epub 2016 Oct 3.


A Microfluidic Method to Mimic Luminal Structures in the Tumor Microenvironment.

Jiménez-Torres JA, Beebe DJ, Sung KE.

Methods Mol Biol. 2016;1458:59-69. doi: 10.1007/978-1-4939-3801-8_5.


High Specificity in Circulating Tumor Cell Identification Is Required for Accurate Evaluation of Programmed Death-Ligand 1.

Schehr JL, Schultz ZD, Warrick JW, Guckenberger DJ, Pezzi HM, Sperger JM, Heninger E, Saeed A, Leal T, Mattox K, Traynor AM, Campbell TC, Berry SM, Beebe DJ, Lang JM.

PLoS One. 2016 Jul 26;11(7):e0159397. doi: 10.1371/journal.pone.0159397. eCollection 2016.


Transitions from mono- to co- to tri-culture uniquely affect gene expression in breast cancer, stromal, and immune compartments.

Regier MC, Maccoux LJ, Weinberger EM, Regehr KJ, Berry SM, Beebe DJ, Alarid ET.

Biomed Microdevices. 2016 Aug;18(4):70. doi: 10.1007/s10544-016-0083-x.


Integrated Analysis of Multiple Biomarkers from Circulating Tumor Cells Enabled by Exclusion-Based Analyte Isolation.

Sperger JM, Strotman LN, Welsh A, Casavant BP, Chalmers Z, Horn S, Heninger E, Thiede SM, Tokar J, Gibbs BK, Guckenberger DJ, Carmichael L, Dehm SM, Stephens PJ, Beebe DJ, Berry SM, Lang JM.

Clin Cancer Res. 2017 Feb;23(3):746-756. doi: 10.1158/1078-0432.CCR-16-1021. Epub 2016 Jul 11.


AirJump: Using Interfaces to Instantly Perform Simultaneous Extractions.

Berry SM, Pezzi HM, LaVanway AJ, Guckenberger DJ, Anderson MA, Beebe DJ.

ACS Appl Mater Interfaces. 2016 Jun 22;8(24):15040-5. doi: 10.1021/acsami.6b02555. Epub 2016 Jun 10.


Personalized in vitro cancer models to predict therapeutic response: Challenges and a framework for improvement.

Morgan MM, Johnson BP, Livingston MK, Schuler LA, Alarid ET, Sung KE, Beebe DJ.

Pharmacol Ther. 2016 Sep;165:79-92. doi: 10.1016/j.pharmthera.2016.05.007. Epub 2016 May 21. Review.


High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation.

Zasadil LM, Britigan EM, Ryan SD, Kaur C, Guckenberger DJ, Beebe DJ, Moser AR, Weaver BA.

Mol Biol Cell. 2016 Jul 1;27(13):1981-9. doi: 10.1091/mbc.E15-10-0747. Epub 2016 May 4.


Progress towards understanding heterotypic interactions in multi-culture models of breast cancer.

Regier MC, Alarid ET, Beebe DJ.

Integr Biol (Camb). 2016 Jun 13;8(6):684-92. doi: 10.1039/c6ib00001k. Epub 2016 Apr 21. Review.


Leveraging a high resolution microfluidic assay reveals insights into pathogenic fungal spore germination.

Barkal LJ, Walsh NM, Botts MR, Beebe DJ, Hull CM.

Integr Biol (Camb). 2016 May 16;8(5):603-15. doi: 10.1039/c6ib00012f. Epub 2016 Mar 30.


Stable engineered vascular networks from human induced pluripotent stem cell-derived endothelial cells cultured in synthetic hydrogels.

Zanotelli MR, Ardalani H, Zhang J, Hou Z, Nguyen EH, Swanson S, Nguyen BK, Bolin J, Elwell A, Bischel LL, Xie AW, Stewart R, Beebe DJ, Thomson JA, Schwartz MP, Murphy WL.

Acta Biomater. 2016 Apr 15;35:32-41. doi: 10.1016/j.actbio.2016.03.001. Epub 2016 Mar 2.


Microbial metabolomics in open microscale platforms.

Barkal LJ, Theberge AB, Guo CJ, Spraker J, Rappert L, Berthier J, Brakke KA, Wang CCC, Beebe DJ, Keller NP, Berthier E.

Nat Commun. 2016 Feb 4;7:10610. doi: 10.1038/ncomms10610.


Microfluidic device for simultaneous analysis of neutrophil extracellular traps and production of reactive oxygen species.

Moussavi-Harami SF, Mladinich KM, Sackmann EK, Shelef MA, Starnes TW, Guckenberger DJ, Huttenlocher A, Beebe DJ.

Integr Biol (Camb). 2016 Feb;8(2):243-52. doi: 10.1039/c5ib00225g. Epub 2016 Jan 25.


Surface-tension driven open microfluidic platform for hanging droplet culture.

de Groot TE, Veserat KS, Berthier E, Beebe DJ, Theberge AB.

Lab Chip. 2016 Jan 21;16(2):334-44. doi: 10.1039/c5lc01353d.


Using Exclusion-Based Sample Preparation (ESP) to Reduce Viral Load Assay Cost.

Berry SM, Pezzi HM, Williams ED, Loeb JM, Guckenberger DJ, Lavanway AJ, Puchalski AA, Kityo CM, Mugyenyi PN, Graziano FM, Beebe DJ.

PLoS One. 2015 Dec 2;10(12):e0143631. doi: 10.1371/journal.pone.0143631. eCollection 2015.

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