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Items: 10

1.

Hepatic Organic Anion Transporting Polypeptide-Mediated Clearance in the Beagle Dog: Assessing In Vitro-In Vivo Relationships and Applying Cross-Species Empirical Scaling Factors to Improve Prediction of Human Clearance.

Matsunaga N, Ufuk A, Morse BL, Bedwell DW, Bao J, Mohutsky MA, Hillgren KM, Hall SD, Houston JB, Galetin A.

Drug Metab Dispos. 2019 Mar;47(3):215-226. doi: 10.1124/dmd.118.084194. Epub 2018 Dec 28.

PMID:
30593544
2.

Development of a rapid and sensitive multiple reaction monitoring proteomic approach for quantification of transporters in human liver tissue.

Wang L, Rubadue KJ, Alberts J, Bedwell DW, Ruterbories KJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 1;1061-1062:356-363. doi: 10.1016/j.jchromb.2017.07.051. Epub 2017 Aug 1.

PMID:
28800539
3.

The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2C9 and CYP3A4 Substrates.

Rougée LRA, Mohutsky MA, Bedwell DW, Ruterbories KJ, Hall SD.

Drug Metab Dispos. 2017 Sep;45(9):1008-1018. doi: 10.1124/dmd.117.076331. Epub 2017 Jul 5.

PMID:
28679672
4.

Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.

Chappell MD, Li R, Smith SC, Dressman BA, Tromiczak EG, Tripp AE, Blanco MJ, Vetman T, Quimby SJ, Matt J, Britton TC, Fivush AM, Schkeryantz JM, Mayhugh D, Erickson JA, Bures MG, Jaramillo C, Carpintero M, Diego JE, Barberis M, Garcia-Cerrada S, Soriano JF, Antonysamy S, Atwell S, MacEwan I, Condon B, Sougias C, Wang J, Zhang A, Conners K, Groshong C, Wasserman SR, Koss JW, Witkin JM, Li X, Overshiner C, Wafford KA, Seidel W, Wang XS, Heinz BA, Swanson S, Catlow JT, Bedwell DW, Monn JA, Mitch CH, Ornstein PL.

J Med Chem. 2016 Dec 22;59(24):10974-10993. Epub 2016 Dec 6.

PMID:
28002967
5.

The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2D6 Substrates.

Rougée LR, Mohutsky MA, Bedwell DW, Ruterbories KJ, Hall SD.

Drug Metab Dispos. 2016 Nov;44(11):1819-1827. Epub 2016 Sep 2.

PMID:
27590024
6.

Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats.

Zhou X, Rougée LR, Bedwell DW, Cramer JW, Mohutsky MA, Calvert NA, Moulton RD, Cassidy KC, Yumibe NP, Adams LA, Ruterbories KJ.

Drug Metab Dispos. 2016 Aug;44(8):1184-92. doi: 10.1124/dmd.116.070623. Epub 2016 May 23.

PMID:
27217490
7.

In vitro characterization of the bioconversion of pomaglumetad methionil, a novel metabotropic glutamate 2/3 receptor agonist peptide prodrug.

Moulton RD, Ruterbories KJ, Bedwell DW, Mohutsky MA.

Drug Metab Dispos. 2015 May;43(5):756-61. doi: 10.1124/dmd.114.062893. Epub 2015 Mar 9.

PMID:
25755052
8.

Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics.

Zamek-Gliszczynski MJ, Bedwell DW, Bao JQ, Higgins JW.

Drug Metab Dispos. 2012 Sep;40(9):1825-33. doi: 10.1124/dmd.112.046508. Epub 2012 Jun 18.

PMID:
22711747
9.

Ablation of both organic cation transporter (OCT)1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics.

Higgins JW, Bedwell DW, Zamek-Gliszczynski MJ.

Drug Metab Dispos. 2012 Jun;40(6):1170-7. doi: 10.1124/dmd.112.044875. Epub 2012 Mar 9.

PMID:
22407892
10.

Elimination of matrix-based interferences to a fluorescent nitrite/nitrate assay by a simple filtration procedure.

Bedwell DW, Rivera VR, Merrill GA, Pusateri AE.

Anal Biochem. 2000 Aug 15;284(1):1-5.

PMID:
10933848

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